Research linking multivitamin use to reduced cancer risks
received extensive coverage, particularly online. The news was also featured on
two of last night's national news broadcasts. The CBS Evening News
(10/17, story 7, 0:15, Pelley) reported that "a large study
of multivitamins found that they may slightly lower a healthy man's risk of
developing cancer."
Joseph A. Sparano, Molin Wang, Fengmin Zhao, Vered Stearns, Silvana Martino,
Jennifer A. Ligibel, Edith A. Perez, Tom Saphner, Antonio C. Wolff, George W.
Sledge Jr, William C. Wood, John Fetting and Nancy E. Davidson
A study exploring the relationship between
calorie-restricted diets and lifespan received a significant amount of coverage,
both in print and online, but was not mentioned on any of last night's national
news broadcasts. Many of the articles point out that this study's findings
differ from those of a similar study published just a few years ago.
According
to a large
epidemiological study presented at the 2011 San Antonio Breast Cancer
Symposium researchers found, that women who'd been given a diagnosis of
diabetes in the last four years had a 37% higher risk of developing breast
cancer than those without the blood glucose disorder. The investigators
found that patients who were older than 60 and obese had an even greater risk
(55%) of breast cancer.
33 studies met the inclusion criteria. When data from cohort studies were
pooled a significant dose–response relationships were observed in both the
higher intake of dietary and total β-carotene with reduced breast
cancer risk when data from cohort studies (P trend < 0.01,
P trend = 0.03) and case–control studies (P
trend < 0.01, P trend < 0.01)
were pooled, respectively. Dietary α-carotene intake could reduce the
breast cancer risk. The relationships between dietary and total β-carotene
intake and breast cancer need to be confirmed. No significant association
between dietary intake of β-cryptoxanthin, lutein/+zeaxanthin, and
lycopene and breast cancer was observed. Hu et al 2012 Breast
Cancer Research and Treatment, Volume
131, Number 1, ,
DOI: 10.1007/s10549-011-1723-8
In
addition, "higher-than-normal levels of selenium may contribute to the
development of...hair loss and certain cancers," HealthDay
(2/29, Gordon) reports. "The average daily intake recommendations for
selenium are 60 micrograms per day for men and 53 micrograms per day for
women, according to the research." The study found, however, that
"daily intake of selenium varied from as little as 7 micrograms per day
to as much as 4,990 micrograms per day. In Europe, the average intake was 40
micrograms per day, and in the United States, the average daily intake was
93 micrograms for women and 134 micrograms for men. Selenium supplements are
likely part of this intake," investigators reported.
Researchers
say carrots may contain more potent anti-cancer properties if not cut before
cooking.
BBC
News (6/16) reported, "The anti-cancer properties of carrots are
more potent if the vegetable is not cut up before cooking," according to
research conducted by investigators at Newcastle University. The study,
expected to "be presented at NutrEvent, a conference on nutrition and
health," showed that "when carrots are heated, the heat kills the
cells, so they lose the ability to hold on to the water inside them,
increasing the concentration of falcarinol as the carrots lose water."
But, "the heat also softens the cell walls, allowing water-soluble
compounds such as sugar and vitamin C to be lost via the surface of the
tissue." The investigators discovered that "if the carrot is cut
before being boiled, the surface area becomes much greater -- and so the loss
of nutrients is increased."
“More and more heavy drinking is occurring on college campuses and during
adolescence, and not enough people are considering future risk. But, according
to our research, the lesson is clear: If a female averages a drink per day
between her first period and her first full-term pregnancy, she increases her
risk of breast cancer by 11%,” said coauthor Graham Colditz, MD, DrPH,
Associate Director for Cancer Prevention and Control at Siteman
Cancer Center at Barnes-Jewish Hospital and Washington University School of
Medicine.
The researchers also found that for every bottle of beer, glass of wine, or
shot of liquor consumed daily, a young woman increases her risk of proliferative
benign breast disease by 15%. Although such lesions are noncancerous, their
presence increases breast cancer risk by as much as 500%, said Dr. Liu.
“Parents should educate their daughters about the link between drinking and
risk of breast cancer and breast disease,” she said. “That’s very
important because this time period is very critical.”
The population-based study in the three-county
Seattle–Puget Sound metropolitan area included women aged 55 to 74 years; 880
of the women had invasive ductal breast cancer, 1,027 had invasive lobular
breast cancer, and 856 had no cancer and served as the control group.
Researchers measured the risk of breast cancer and examined the recency and
duration of use of antihypertensive medicationsaccording to a report published
by JAMA
Internal Medicine. According to the results, current use of
calcium-channel blockers for 10 or more years was associated with higher risks
of ductal breast cancer (odds ratio [OR] = 2.4, 95% confidence interval [CI] =
1.2–4.9; P = .04 for trend) and lobular breast cancer (OR = 2.6, 95%
CI = 1.3–5.3; P = .01 for trend). The relationship did not vary much
based on the type of calcium-channel blockers used (short-acting vs long-acting
or dihydropyridines vs nondihydropyridines). Other antihypertensive
medications—diuretics, beta-blockers, and angiotensin II antagonists—were
not associated with increased breast cancer risk, the results indicated.
Research on the potential health risks of CT scans in
children received moderate coverage in print and online, and on one of last
night’s national news broadcasts. Although many sources portrayed the findings
as alarming, they also pointed out that there has been a push in recent years to
reduce unnecessary imaging. Meanwhile, several outlets mentioned the American
College of Radiology’s reaction to the study.
NBC Nightly
News (6/10, story 6, 2:50, Holt, 7.86M) reported on a study suggesting that
children who undergo CT scans may face a higher risk of cancer later in life.
Non-occupational exposure to cadmium has been suspected
to be a risk factor for breast cancer. The present study examined the
association between urinary cadmium level and the risk of breast cancer in a
case–control study among Japanese women. Cases were 153 women newly diagnosed
and histologically confirmed with breast cancer at a general hospital in Gifu,
Japan. A total of 431 controls individually matched to cases by age, menopausal
status, and the period of urine sampling were selected from those who attended a
breast cancer mass screening at this hospital. Urinary cadmium levels were
measured using spot urine samples. Spot urine samples were collected from cases
after surgery but before any cancer therapy.
013, Volume
137, Issue 2
The objective of this study is to examine the association
between vitamin D status and risk of breast cancer in an Australian population
of women. The study design is observational case–control study, performed at
Westmead Breast Cancer Institute, Westmead Hospital, Sydney, Australia. 214
women newly diagnosed with breast cancer were matched to 852 controls, and their
blood samples were tested at the same laboratory between August 2008 and July
2010. Circulating 25-hydroxyvitamin D (25(OH)D) concentration, was defined as
sufficient (≥75 nmol/L), insufficient (50–74 nmol/L), deficient (25–49
nmol/L) or severely deficient (<25 nmol/L). The difference in median 25(OH)D
concentration between cases and controls was reported, and the Mann–Whitney U
test was used to determine the significance of the difference. Odds ratios and
95 % confidence intervals for the risk of breast cancer were estimated by Cox
regression. Median plasma 25(OH)D was significantly lower in cases versus
controls overall (53.0 vs 62.0 nmol/L, P <
0.001) and during summer (53.0 vs 68.0 nmol/L, P
< 0.001) and winter (54.5 vs 63.0 nmol/L, P <
0.001). Median 25(OH)D was also lower in cases when stratified by BMI (<30,
≥30) and age group (<50, ≥50 years) compared to matched controls,
although the difference failed to reach statistical significance. In a Cox
regression model, plasma 25(OH)D was inversely associated with the odds ratio of
breast cancer. Compared to subjects with sufficient 25(OH)D concentration, the
odds ratios of breast cancer were 2.3 (95 % CI 1.3–4.3), 2.5 (95 % CI
1.6–3.9) and 2.5 (95 % CI 1.6–3.8) for subjects categorised as severely
deficient, deficient or insufficient vitamin D status, respectively. The results
of this observational case–control study indicate that a 25(OH)D concentration
below 75 nmol/L at diagnosis was associated with a significantly higher risk of
breast cancer. These results support previous research which has shown that
lower 25(OH)D concentrations are associated with increased risk of breast
cancer.
Women
Exposed To Certain Chemicals At Work May Face Higher Breast Cancer Risk.
BBC
News (11/20) reports, "Women working in jobs where they are
exposed to certain chemicals may have a greater risk of developing breast
cancer, a study suggests." Investigators who "studied more than
2,000 women" found that those "who worked for 10 years in jobs
classified as 'highly exposed' increased their risk by 42%."
FOX
News (11/19), citing the BBC News article, reports, "The jobs
that were associated with the greatest breast cancer risk included plastic
manufacturing for the auto industry, farming and metal working."
Junk Food
May Boost Already High Risk Of Colon Cancer In Lynch Syndrome Patients.
Reuters
(12/18, Grens) reports that, according to a study published online in
Cancer, individuals with Lynch syndrome who consume high amounts of junk
food may have an even higher risk of developing colon cancer.
HealthDay
(12/18) reports, "The study included 486 people with Lynch
syndrome" who "provided information about their eating habits and
were followed for an average of 20 months." Over that period,
"colorectal polyps (precancerous growths) were detected in 58 of the
patients."
MedPage
Today (12/18, Walsh) reports that "those whose diets featured a
major snack component - chips, fast food, and sweets - had an increased risk
of developing colorectal adenomas (adjusted hazard ratio 2.16, 95% CI 1.03
to 4.49)." Meanwhile, "those whose diet was considered
"prudent," featuring a high percentage of fruit and vegetables,
whole grains, and fish, tended to have modest, though nonsignificant,
decrease in risk (aHR 0.73, 95% CI 0.32 to 1.66), the researchers
reported."
Men Working
Night Shifts May Have Higher Risk For Certain Cancers.
Medscape
(11/1, Chustecka, Subscription Publication) reports, "Men working at
night had approximately double the risk of those who did not work the night
shift for many different cancers, according to a Canadian case–control study
published in November 1 issue of the American Journal of Epidemiology."
Investigators "compared 3137 men with cancer and 512 matched control
subjects who completed a detailed questionnaire about occupational work and
lifestyle from 1979 to 1985." The researchers found that, "compared
with men who never worked at night, men who worked night shifts had an
increased risk for prostate cancer (odds ratio [OR], 2.77), non-Hodgkin's
lymphoma (OR, 2.31), pancreatic cancer (OR, 2.27), rectal cancer (OR, 2.09),
colon cancer (OR, 2.03), bladder cancer (OR, 1.74), and lung cancer (OR,
1.76)."
Study Shows
Racial Difference In Breast Cancer Risk From Eating Red Meat.
HealthDay
(11/5, Dotinga) reports on a study presented at the American Institute for
Cancer Research meeting finding that "eating red meat and poultry seems to
boost the risk of breast cancer in white women - but not black women." The
study was based on data from "questionnaires that were answered by 976
black women and 873 white women with breast cancer, and 1,165 black women and
865 white women without cancer." It found that "among white women,
those who ate the most unprocessed red meat and poultry seemed to have a higher
breast cancer risk than those who ate the least," while "no
association was found among black women other than a suggestion that red meat
consumption might reduce the risk of one kind of tumor."
Glycemic
Load, High BMI Raise Colon Cancer Recurrence Risk.
Medwire
(11/9, Oswald) reports that "increased glycemic loads and high
carbohydrate consumption may increase the risk for colon cancer
recurrence" and "the impact of these dietary factors on survival
primarily affected overweight and obese patients." The study "found
that patients in the lowest quintile for dietary glycemic load had a 79%
increased chance of disease-free survival compared with those in the highest
quintile (48 vs 36%)" and "patients in the highest quintile of
carbohydrate consumption had an 80% increased risk for cancer recurrence or
death from any cause compared with patients in the lowest quintile (49 vs
34%)." However, while those with a BMI of 25 kg/m2 or more had a 2.3-fold
increase in risk if they were in the highest quintile for glycemic load, there
was no statistical relationship between glycemic index for patients with a
lower BMI. The study appears in the Journal of the National Cancer Institute.
Reuters
(7/27) reports that, according to a study
published in the American Journal of Clinical Nutrition, postmenopausal women
who consume a diet high in carbohydrates may face an increased risk of
ER-negative breast cancers. The study involved approximately 335,000 European
women
Study Links
Night Shift To Men's Risk For Developing Cancer.
The Daily
Telegraph (UK) (10/23, Smith) reports, "Men who work nights are
almost three times as likely to develop prostate cancer as those who do day
shifts," according to research published in the American Journal of
Epidemiology." Investigators "found night shifts almost trebled the
risk of prostate cancer and doubled a man's chances of bowel cancer. Night
workers were also 76 per cent more likely to suffer lung cancer and 70 per cent
more at risk of a tumor in the bladder."
Endometrial
Cancer Diagnosis Increases Risk Of Colon Cancer.
MedPage
Today (10/25, Bankhead) reports that "a history of endometrial
cancer at a younger age quadrupled the likelihood of a subsequent diagnosis of
colorectal cancer, a retrospective analysis of administrative data showed."
MedPage quotes researcher Harminder Singh, MD, as telling an American College of
Gastroenterology meeting, "Colorectal cancer screening with colonoscopy
should be considered soon after diagnosis of endometrial cancer for all
women." MedPage notes that diagnosis of endometrial cancer "at age 50
or younger was associated with a hazard ratio of 4.41 for colorectal cancer (95%
CI 1.47 to 13.26); diagnosis of endometrial cancer after 50 did not affect the
hazard for colorectal cancer."
Smoky Coal Associated with Increased Risk of Lung Cancer in Rural
China
Results from a large retrospective cohort study conducted in China suggest
that use of smoky (bituminous) coal substantially increases the lifetime
risk of developing lung
cancer. The findings
appeared August 29 in the British Medical Journal.
Researchers compared deaths from lung cancer between lifelong users of smoky
coal and of smokeless (anthracitic) coal for cooking and heating in Xuanwei
County, Yunnan Province. More than 37,000 people were followed from 1976 to
1996, and more than 2,000 deaths from lung cancer were recorded during that
time.
After accounting for other risk
factors, including tobacco use, users of smoky coal had a 30-fold greater
risk of developing lung cancer than users of smokeless coal. The absolute
risk of lung cancer death before age 70 among smoky coal users was 18
percent for men and 20 percent for women, with most of these deaths in
nonsmokers. By contrast, the risk was less than 0.5 percent among users of
smokeless coal.
“The risks from smoky coal are almost as high as those reported for heavy
smoking in Western countries and likely represent one of the strongest effects
of environmental pollution reported for cancer risk,” said co-author Dr. Qing
Lan of NCI’s Division of Cancer Epidemiology
and Genetics
Associations of type 2 diabetes and diabetes
treatment with breast cancer risk and mortality: a population-based cohort
study among British women; Redaniel
MT, Jeffreys M, May MT, Ben-Shlomo Y, Martin RM; Cancer Causes and Control
(Sep 2012)
There is great interest in whether type 2 diabetes and its treatments
alter breast cancer risk and prognosis, but previous studies are inconclusive.
We conducted a cohort study within the UK General Practice Research Database to
investigate associations of type 2 diabetes and patterns of diabetes treatment
with breast cancer risk and all-cause mortality. METHODS: We identified 52,657
women with type 2 diabetes, diagnosed between 1987 and 2007, and 30,210 randomly
selected women without diabetes. We performed a time-dependent analysis using
Cox proportional hazards models. RESULTS: Diabetes was associated with a 29 %
increased overall breast cancer risk (95 % CI: 1.16-1.44), but the association
markedly attenuated when adjusted for age, period of cohort entry, region, and
body mass index (BMI) (HR: 1.12; 95 % CI: 0.98-1.29). Women with breast cancer
and pre-existing diabetes had a 49 % (95 % CI: 1.17-1.88) increased all-cause
mortality risk compared with women with breast cancer but without diabetes,
after controlling for age, period, region, BMI, smoking, alcohol, and
deprivation. Compared with sulfonylurea, we found weak evidence that metformin
monotherapy (HR: 1.04; 95 % CI: 0.79-1.37) and insulin (HR: 1.33; 95 % CI:
0.63-2.83) modified breast cancer risk among women with diabetes. CONCLUSIONS:
We found weak evidence that diabetes is associated with a small increased risk
of breast cancer. Among treated women, there is no evidence that anti-diabetes
treatments modify the risk of developing breast cancer, with wide confidence
intervals indicating imprecise effect estimates. Women with breast cancer and
diabetes, however, had an increased all-cause mortality risk highlighting the
potential importance of maintaining adequate glycemic control alongside
anti-cancer treatments and subsequent follow-up.
Obesity May
Promote Growth Of Existing Tumors Regardless Of Diet.
HealthDay
(10/16) reports, "Being obese promotes the growth of existing tumors
regardless of diet, according to a new animal study that may shed light on why
obese cancer patients often have worse outcomes than lean patients."
Researchers "found that tumors grew much faster in obese mice than in lean
mice that ate the same diet." The investigators "also found that obese
mice had far more white adipose tissue cells (adipose stromal cells) than lean
mice, which led them to focus on these cells." The findings were published
in Cancer Research
Collaborative
modeling of the impact of obesity on race-specific breast cancer incidence
and mortality |
Yaojen
Chang, Clyde B. Schechter, Nicolien T. van Ravesteyn, Aimee M. Near,
Eveline A. M. Heijnsdijk, Lucile Adams-Campbell, David Levy, Harry J. de
Koning & Jeanne S. Mandelblatt
December 2012, Volume
136, Issue
3, pp 823-835, |
Radiation from conventional x-rays, mammograms,
and other diagnostic tests before age 30 may increase the risk of breast
cancer in women who carry BRCA1
or BRCA2
gene mutations. In a large, retrospective
cohort study, this increased risk was seen at radiation doses considerably
lower than those associated with increased risk of breast cancer in other
cohorts exposed to radiation.
The findings, from
an analysis of women in France, the Netherlands, and the United Kingdom who
participated in the GENE-RAD-RISK study, were reported September 6 in the British
Medical Journal.
Exposure to ionizing
radiation is an established risk
factor for breast cancer, particularly when the exposure occurs at an early
age. Because the BRCA1 and BRCA2 proteins are important in repairing DNA damage,
including damage caused by radiation, researchers have hypothesized that
carriers of a mutation in one of these genes might be more sensitive than the
general population to ionizing radiation. But previous studies designed to
answer this question have yielded inconsistent results.
The new study, led by Dr. Flora van Leeuwen of the Netherlands Cancer
Institute in Amsterdam, focused on 1,122 women aged 18 or older who were known
to carry a BRCA1 or BRCA2 mutation. The women reported their
histories of all diagnostic procedures involving radiation to the chest or
shoulders. Researchers used this information to estimate the cumulative dose of
radiation to the breast for each woman. They then used national registries
Chemicals In
Consumer Products Said To Pose Health Threat.
ABC World News (4/30, story 6, 2:00, Sawyer)
reported in its "Consumer Watchdog" feature, "120 chemicals in
care products, cream, shampoos, used every day by women, most of them untested
and a lot by men as well." ABC (Avila) added, "This average woman
applies twelve beauty products to her body every day, 120 chemicals. For men,
it's six cosmetics and 80 chemicals, and few...think much about what's in
them." Avila lists and describes some of the chemicals: "formaldehyde,
a known carcinogen; dioxin in some shampoo; lead on your lips; parabens,
possibly linked to cancer, in deodorant; even mercury, in skin-lightening
creams; toluene, known to cause headaches in nail polish; and diethyl phthalate,
linked to allergies, hormone disruption and dermatitis in perfume." Because
"Europe has banned 1,200 such chemicals, and the United States, only
ten...critics say cosmetic makers mix a riskier brew of the same product for
domestic use." Avila concludes, "If you cannot pronounce it, best not
to use it."
Smoking,
Drinking May Be Linked To Earlier Pancreatic Cancer Diagnosis.
Reuters
(9/19, Norton) reports that, according to a study
published online in the American Journal of Gastroenterology, individuals who
smoke or consume large amounts of alcohol may develop pancreatic cancer at a
younger age than individuals who are nonsmokers and nondrinkers. Investigators
looked at data on more than 800 individuals treated for pancreatic cancer. The
researchers found that smokers were diagnosed at around age 62, while
non-smokers were generally diagnosed at age 70. The investigators reported that
heavy drinkers were on average diagnosed at age 61, while non-drinkers were
diagnosed nearly one decade later.
Oral Health
May Be Linked To Pancreatic Cancer Risk.
Huffington
Post (9/19) reports, "The health of your mouth could potentially be
linked with your cancer risk, a new study in the journal Gut suggests."
Investigators "found that high antibody levels against strains of the oral
bacteria Porphyromonas gingivalis are linked with a doubled risk of pancreatic
cancer."
Company To
Remove Potential Carcinogens From Product Ingredients.
ABC World News (8/15, story 9, 0:25,, Sawyer)
reported, "There is a big announcement tonight from Johnson & Johnson.
The company says it will change the ingredients in all its cosmetics, creams and
baby items to guarantee they no longer contain even trace amounts of chemicals
that could be linked to cancer. The company's been under pressure to make its
products safer."
According to the AP
(8/16, Johnson), J&J released a statement saying it is planning to
"remove potentially cancer-causing and other dangerous chemicals from
nearly all its adult toiletries and cosmetic products worldwide." Late last
year, the company "pledged to remove 'chemicals of concern' from its baby
products around the world after being pressed to do so for more than three years
by a large coalition of health and environmental groups." And on Tuesday,
J&J reiterated that vow, saying it "remains on track to have baby
products...reformulated with safer ingredients by the end of 2013"; and it
expects to have its adult products "reformulated by the end of 2015."
Additionally, J&J on Wednesday, "launched a website,
safetyandcarecommitment.com" to keep consumers informed on "what it
does to ensure its ingredients are safe and of high quality."
On the front page of its Business Day section, the New
York Times (8/16, B1, Thomas, Subscription Publication) reports that
among the ingredients J&J plans to remove is formaldehyde, which "last
year was identified by government scientists as a carcinogen," and is
released by common preservatives such as "quaternium-15 and DMDM hydantoin,"
and "1,4 dioxane," which is "created during a process commonly
used to make other ingredients gentler on the skin." The company also plans
to get rid of "phthalates, which have a variety of uses, like lessening the
stiffening effects of hair spray; several fragrance ingredients"; triclosan,
an antibacterial; and parabens, a preservative.
Pan-Frying
Meat May Increase Prostate Cancer Risk.
HealthDay
(9/10, Dallas) reports, "Pan-frying red meat may increase men's risk for
prostate cancer by up to 40 percent," according to a study that
"appeared recently online" in the journal Carcinogenesis. Researchers
"examined data on nearly 2,000 men involved" in a prostate cancer
study in which "more than half of the men were diagnosed with advanced
forms" of the disease. "We found that men who ate more than 1.5
servings of pan-fried red meat per week increased their risk of advanced
prostate cancer by 30 percent," said study leader Mariana Stern of the Keck
School of Medicine at USC. In addition, she said men who "ate more than 2.5
servings of red meat cooked at high temperatures were 40 percent more likely to
have advanced prostate cancer." the study found that hamburgers were
especially "linked to an increased risk of prostate cancer" and the
risk was "greatest among Hispanic men."
Marijuana Use
May Be Linked To Increased Risk Of Testicular Cancer.
The Washington
Post (9/10, Huget) "Checkup" blog reports, "Men who have
smoked marijuana are twice as likely to be diagnosed with testicular cancer than
men who have never done so," according to a study published in Cancer.
Investigators "compared 163 men who had been diagnosed with testicular
cancer to 292 men (of similar ages and race/ethnicity) who had not."
Participants "were asked about their health history, education and use of
recreational drugs such as marijuana and cocaine, among other things."
MedPage
Today (9/10, Smith) reports that the researchers found that participants
"who reported ever using marijuana had nearly twice the risk of testicular
germ cell tumors as those who had never used the drug." The investigators
also reported that "ever using cocaine was associated with a 46% reduction
in the risk of the disease."
California
Watch (9/10, Rust) reports that the study's lead author, Victoria
Cortessis, said, "We do not know what marijuana triggers in the testes that
may lead to carcinogenesis, although we speculate that it may be acting
through...the cellular network that responds to the active ingredient in
marijuana, since this system has been shown to be important in the formation of
sperm."
Higher BMI
Associated With More Advanced Thyroid Cancer At Time Of Diagnosis.
HealthDay
(5/22, Preidt) reports, "Obese patients are more likely than other patients
to have advanced, aggressive forms of papillary thyroid cancer when they're
diagnosed with the disease," according to a study
published online May 21 in the Archives of Surgery. "For the study, the
researchers reviewed the medical records of nearly 450 patients with an average
age of 48 who had surgery to remove most or all of the thyroid gland as an
initial treatment for papillary thyroid cancer or its variations."
Investigators found that "higher body-mass index (BMI) was associated with
more advanced cancer at the time of diagnosis," with "obese and
morbidly obese patients...more likely to have stage 3 or stage 4 cancer"
and a much higher likelihood of aggressive disease.
GAO
Recommends Reassessing Cellphone Exposure Limits.
The Washington
Post (8/8, Tsukayama) "Post Tech" blog reports, "Mobile
phone exposure limits and testing requirements should be reassessed, according
to a Government Accountability Office study released Tuesday. ... Its findings
may prompt the Federal Communications Commission to update its standards to
more accurately reflect how people use their cellphones."
Bloomberg
News (8/8, Shields) reports, "Limits set in 1996" by the FFC
"may not reflect recent research on radio-frequency energy from phones,
and testing requirements may not identify maximum exposure in all usage
conditions, the agency said in a July 24 study released today." According
to the GAO, the FCC "doesn't test for devices carried against the
body."
The
Hill (8/8, Trujillo) "Hillicon Valley" blog adds that while
"other international organizations and countries have updated their
standards," the FCC has not.
Reuters
(8/8, Melvin) reports that the FCC must now vote whether to revisit cell phone
emission standards, and then enter a period of public comment. CQ
(8/8, Brandeisky, Subscription Publication) also reports on the story.
Small Study:
Variant Of Vitamin D Receptor May Be Linked To Breast Cancer Risk.
The San
Francisco Chronicle (8/8, Colliver) reports, "New research may
start to shed light on why Marin County [California] has one of the highest
rates of breast cancer in the world, and the answer may be related to vitamin
D." According to the Chronicle, "a small pilot study of Marin County
women determined through testing to be at high risk for breast cancer found them
to be almost twice as likely to have a variant of a vitamin D receptor as the
overall population of 338 in the study." This marks "the first time a
study has linked this vitamin D receptor -- a protein molecule that signals the
cell to activate vitamin D -- with higher risk for breast cancer in Marin County
women, the authors said."
Ingredient In
Weight-Loss Supplement May Increase Risk Of Urothelial Cancer.
The Los
Angeles Times (4/10, Kaplan) "Booster Shots" blog reports,
"A study published online Monday by the Proceedings of the National Academy
of Sciences reports that people who thought they were taking a harmless
weight-loss supplement wound up with a type of bladder cancer as a result."
Investigators "compared 151 patients with the urothelial cancers to a
'control' group of 25 patients with a type of kidney cancer called renal cell
carcinoma." The researchers "found that aristolochic acid prompted a
specific type of mutation on a tumor suppressor gene known as TP53 – a
mutation that leads to urothelial cancer."
Alcohol
Consumption Linked To Higher Risk Of Benign Breast Disease In Teens.
MedPage
Today (4/10, Phend) reports, "Drinking alcohol was associated
with an increased risk of benign breast disease in adolescent women that may
not be alleviated with increased folate intake," according to a study
published in Pediatrics. Investigators found that "proliferative benign
breast disease was 15% more likely with each roughly one drink more per day
women averaged from age 18 to 22 (95% CI, 1.03 to 1.28)." A "greater
intake of folate in the teen years -- a nutrient key in DNA repair but thought
to be impaired in metabolism by alcohol -- didn't appear to help mitigate the
risk in the observational cohort studied." HealthDay
(4/10, Doheny) also covers the story.
Omega-3s May
Increase Risk For Developing Prostate Cancer.
HealthDay
(4/25, Preidt) reported that high levels of "heart-healthy omega-3 fatty
acids in the blood may be associated with an increased risk for developing
aggressive prostate cancer, while elevated levels of unhealthy trans-fatty acids
may lower the risk," according to a study in the American Journal of
Epidemiology. Researchers examined data from a "US-wide study of more than
3,400 men, and found that those with the highest blood percentages of
docosahexaenoic acid (DHA) were two-and-a-half times more likely to develop
aggressive prostate cancer than those with the lowest DHA levels." The
study also found that the risk of aggresive prostate cancer was "50-percent
lower in men with the highest blood levels of trans-fatty acids."
Red,
Grilled, Barbequed Meat May Be Linked To Kidney Cancer.
Reuters
(12/29, Pittman) reports a study
in the American Journal of Clinical Nutrition suggesting that people who eat
high amounts of red, grilled, or barbequed meat may be at higher risk of
kidney cancer. In a study of 500,000 US adults, it was found that eating the
most red meat was linked with papillary cancers, but not clear-cell kidney
cancers. Participants who ate high amounts of well-done grilled and barbecued
meat likewise had an increased risk of kidney cancer. Researchers said the
reason for the association is unclear and emphasized that the data do not
prove causation.
Alcohol May
Increase Breast Cancer Risk In Teens With Family History Of Disease.
The Los
Angeles Times (11/15, Roan) "Booster Shots" blog reports,
"Teenage girls who drink alcohol and have a family history of breast cancer
are increasing their own risk of the disease," according to a study
published online in the journal Cancer.
Medscape
(11/15, Franklin) reports that investigators "studied data from 9037 girls
from all 50 states." Participants "completed annual questionnaires
from 1996 to 2001, and then again in 2003, 2005, and 2007."
HealthDay
(11/15, Dotinga) reports that the researchers "focused on 67 participants
who were later diagnosed between the ages of 18 and 27 with benign breast
disease, a large class of conditions that can cause breast lumps or pain and can
be a risk factor for breast cancer." The investigators "found that
women who have a family history of breast cancer or breast disease were about
twice as likely to develop both benign breast disease and breast cancer than
women with no family history of the disease." The "risk of benign
breast disease rose along with how much alcohol the young women consumed,
according to the study."
Trace Elements
Associated With Exocrine Pancreatic Cancer.
MedPage
Today (12/20, Pal) reports, "Higher levels of cadmium, arsenic, and
lead in the body appear to be associated with an increased risk of pancreatic
cancer," according to a study published in the journal Gut. After analyzing
"toenail clippings obtained from 118 EPC case patients during the PANKRAS 2
Study, conducted in 1992-1995," researchers observed "significantly
increased risks of exocrine pancreatic cancer (EPC)...among subjects whose
concentrations of cadmium (OR 3.58, 95% CI 1.86 to 6.88, P=5X10-6), arsenic (OR
2.02, 95% CI 1.08 to 3.78, P=0.009), and lead (OR 6.26, 95% CI 2.71 to 14.47;
P=3X10-5) were in the highest quartile."
Shingles May
Not Be Linked To Higher Cancer Risk Later In Life.
Reuters
(9/18, Norton) reports that, according to a study
published online Sept. 17 in the Canadian Medical Association Journal,
individuals who develop shingles may not face a higher risk of developing cancer
later in life.
Medscape
(9/18, Lewis) reports that investigators "conducted a retrospective cohort
study, using de-identified data from a national health registry, on 35,871
patients 20 years or older (range, 20 - 101 years; median age, 52 years)
diagnosed with herpes zoster from 2000 to 2008."
HealthDay
(9/18, Dallas) reports that "after taking their other illnesses, such as
diabetes and heart disease, into account," the researchers saw "no
increased risk of cancer...in these patients."
Chronic
Drinkers Who Stop Imbibing May Cut Esophageal Cancer Risk.
HealthDay
(9/18, Dallas) reports, "Chronic drinkers who stop consuming alcohol can
cut their risk for esophageal cancer in half within four to five years,
according to a new evidence review" published in the journal Addiction.
Investigators who analyzed data from "nine studies...found drinkers' risk
of this type of cancer is reversible if they stop drinking, but it takes them up
to 16 years to return to the risk level of people who don't drink."
Report
Addresses Environmental Impact On Breast Cancer Risk.
According to NBC Nightly News (12/7, story 7,
2:30, Williams), "a new report" has "set out to address
fears...that things in the environment, things people use every day could cause
breast cancer," and the "conclusions won't sit well with some women
who are certain there is a link."
The Los
Angeles Times (12/8, Healy, Times) reports, "The report, 20 months
in the making, acknowledges there are many unknowns. It calls on the Food and
Drug Administration to require better proof from drug makers, before and after
market approval, that their products do not increase women's risk of breast
cancer."
USA
Today (12/8, Szabo) reports, "Researchers studying the
environmental causes of breast cancer need to look at a whole lifetime of toxic
exposures - even in the womb - that may predispose a woman to develop cancer
decades later, says" the "report released Wednesday by" the
Institute of Medicine. The new "report also points out how little chemical
testing is going on. For example, the Food and Drug Administration lacks the
power to test cosmetics and dietary supplements for safety, the report
says."
The AP
(12/8) reports, "By environment they mean everything not governed by genes
- what's in the air and water but also diets, vitamin use and even things like
working night shifts."
Bloomberg
News (12/8, Cortez) reports, "The lack of clear ties between
chemicals and other possibly toxic substances and breast cancer doesn't mean
they are safe, said Irva Hertz-Picciotto, chair of the IOM committee and chief
of environmental and occupational health at the University of California, Davis'
School of Medicine." Although "chemicals including those in gas fumes
and car exhaust such as benzene may trigger tumors, others including BPA and
pesticides have less evidence implicating them...said" David Hunter, a
professor of cancer prevention at Harvard School of Public Health, and a study
author. It is difficult "to get conclusive results because chemicals are so
prevalent, and may be most harmful earlier in life, he said."
The National
Journal (12/8, Sanger-Katz, Subscription Publication) reports that
"the expert panel said that laboratory research suggested" the BPA
could be linked to breast cancer risk "because it can resemble the hormone
estrogen." Irva Herz-Picciotta, the chairwoman of the panel, said, "BPA
is one of those compounds that, in fact, does have estrogenic activity."
The New
York Times (12/8, Grady, Subscription Publication) reports, however,
that the "exhaustive" report "finds evidence strong enough to
make only a few firm recommendations, most already well known and none with a
large proven benefit." According to the Times, "The most consistent
data suggest that women can reduce their risk by avoiding unnecessary medical
radiation, forgoing hormone treatments for menopause that combine estrogen and
progestin, limiting alcohol intake and minimizing weight gain, the report
found." The "overuse of CT scans, which deliver a relatively high dose
of radiation, was a particular concern, but the report stated that women should
not be deterred from having routine mammograms, which use a much smaller
dose."
On its
website, ABC
News (12/8) reports, "The researchers also found that hair dyes and
ionizing radiation from cell phones and other devices did not impact a woman's
risk for breast cancer." The findings were presented "at the San
Antonio Breast Cancer Symposium."
According to CQ
(12/8, Reichard, Subscription Publication), the report "calls for new ways
of studying the issue, such as 'full life stage' testing of possible
carcinogens," as "an exposure to a substance that at one stage of life
that might lead to the development of breast cancer wouldn't necessarily have
that effect if it occurs at another stage of life, the study's authors
noted." Also covering the story are Medscape
(12/8, Zimmerman, Subscription Publication), MedPage
Today (12/8, Fiore), and HealthDay
(12/8, Salamon).
Vitamin D deficiency
linked to higher risk of Colorectal
Cancer:
A Systematic Review of Prospective Studies
published in the JCO (Ma
et al 2011 29:3775-3782
) evaluated nine studies which analysed
Vitamin D intake and serum blood levels of 25-hydroxyvitamin D
[25(OH)D] which covered 1,000,000 participants from several countries. The
pooled RRs of colorectal cancer for the highest versus lowest categories of
vitamin D intake and blood 25(OH)D levels were 0.88 (95% CI, 0.80 to 0.96) and
0.67 (95% CI, 0.54 to 0.80), respectively. There was no heterogeneity among
studies of vitamin D intake (P = .19) or among studies of blood 25(OH)D
levels (P = .96). A 10 ng/mL increment in blood 25(OH)D level conferred
an RR of 0.74 (95% CI, 0.63 to 0.89). They concluded that Vitamin D intake and
blood 25(OH)D levels were inversely associated with the risk of colorectal
cancer in this meta-analysis
Women With
Diabetes May Have Higher Risk Of Breast Cancer.
Reuters
(10/21, Pittman) reports a paper
in Diabetes Care suggesting that women with a recent diabetes diagnosis might be
at elevated risk of breast cancer, compared to women without diabetes. This
could be due to insulin and blood sugar changes that are favorable to tumor
growth. On the other hand, researchers say that this may simply be because a
diabetes diagnosis leads to a large number of tests and exams, which raises the
chance of a cancer being found. It has previously been shown that diabetes
increases the risk of colon, liver, pancreatic, and breast cancer. Researchers
concluded that women with diabetes should be screened regularly for cancers, and
to change behaviors, such as smoking, that lead to high cancer risk
Diabetes Drugs
May Be Linked To Increased Pancreatic Cancer Risk.
Reuters
(2/1, Pittman) reports that, according to research published in the American
Journal of Gastroenterology, most diabetes drugs may be linked to an increased
risk of pancreatic cancer.
Medscape
(2/1, Franklin, Subscription Publication) reports, "Drawing on data from
the United Kingdom–based General Practice Research Database, the
investigators identified a cohort of 2763 patients (1276 men and 1487 women) who
had a first-time diagnosis of pancreatic cancer between 1995 and 2009, along
with 16,578 matched control patients. Of those, 307 (11.1%) of the patients in
the case group had diabetes, as did 1347 (8.1%) in the matched control
patients." In order "to assess the effect of antidiabetic drugs on
pancreatic cancer risk, the investigators stratified patients according to the
duration of use (short-, medium-, or long-term), based on the number of
prescriptions filled for metformin, sulfonylureas, and/or insulin during the
study period."
HealthDay
(2/1, Mozes) reports, "Short-term use of metformin or sulfonylureas and/or
insulin had no appreciable impact on pancreatic cancer risk." But, the
researchers found that "long-term use of each of these medications did
appear to have a sizeable impact on pancreatic cancer risk among
diabetics." Although "female patients saw their risk go down with
metformin treatment and up with sulfonylureas, male patients saw their risk go
up with insulin."
Alcoholics May
Have Higher Death Rates From Certain Cancers.
HealthDay
(11/16, Preidt) reports, "Alcoholics have a higher rate of death from
cancer and other causes than other people," according to a study published
in Alcoholism: Clinical & Experimental Research. Investigators looked at
data on approximately 2,300 individuals who received treatment at an alcohol
center. The researchers "found a higher rate of death among alcoholics than
among the general population for multiple types of cancers, particularly cancers
of the pharynx, oral cavity, liver and larynx." The "risk of death
from cancer of the esophagus, rectum, pancreas and breast was also heightened
among alcoholics."
Study Suggests
Diabetes Tied To Precancerous Colon Growths.
WebMD
(11/7, Laino) reports on study findings presented at a meeting dedicated to
gastroenterology, which found that "people with diabetes may be at
increased risk for precancerous colon growths called adenomas." Colonoscopy
results were compared "from 278 people with diabetes with those from 278
people without the disorder. Nearly all were male, and the average age was
around 65." Twenty nine percent with diabetes had "at least one
adenoma, compared with 21% of those without diabetes." March Seabrook, MD
said if these results are validated "and diabetes does turn out to cause
precancerous colon growths or colon cancer," diabetes may have to be
screened "at a younger age, and at shorter intervals."
UV Lamps Used
To Dry Gel Manicures May Raise Skin Cancer Risk.
The Washington
Post (2/28, Saslow) reviews the safety of ultraviolet lamps in gel
manicures, citing a 2009 Archives of Dermatology article about two women who
developed non-melanoma skin cancer on their hands after such exposure to UV
lamps. Gel manicures require a client to put hands under UV lamps for up to 10
minutes. In the Post, Johns Hopkins University dermatologist Anna M. Bender
says, "Artificial UV light does elevate your risk for developing skin
cancer" and suggests the use of sunscreen.
Sleep
Medications May Be Linked To Increased Death Risk.
ABC World News (2/27, story 8, 2:10, Sawyer)
reported that a new study found "a link between sleeping" aids
"and an increased risk of death." ABC's Dr. Richard Besser said,
"Over two years, people who took sleeping" aids "were at least
three and a half times more likely to die of all causes than those who didn't
take these" tablets. He added, "Short term is fine. If you're having
long term insomnia, it's like a mystery you have to solve."
On its
website, ABC
News (2/27, Salahi) reported that "adults who take" sleep
medications "in even small numbers over their lifetimes may be nearly four
times more likely to die earlier compared to those who are not prescribed"
sleep medications, according to a study
published Monday in the British Medical Journal. "And those prescribed
sleeping" aids "may also be more likely to be diagnosed with cancer,
the study found." The investigators "looked at electronic medical
records of nearly 35,000 patients, fewer than half of whom took such
FDA-approved sleep medications as Ambien [zolpidem], Restoril [temazepam],
Lunesta [eszopiclone], and Sonata [zaleplon]" and "found that even
those who look fewer than 18 sleeping" medications "a year were at
greater risk of death, compared to those who were not prescribed sleeping
aids."
MedPage
Today (2/27, Bankhead) reported, "A prescription for 0.4 to 18
doses per year was associated with a mortality hazard ratio of 3.60 compared
with patients who had no prescriptions for hypnotics" and "the hazard
jumped to 5.32 for patients prescribed more than 132 doses a year," the
researchers reported. "The authors acknowledged limitations to this
research, most notably that residual confounding could not be fully excluded
'due to possible biases affecting which patients were prescribed hypnotics and
due to possible imbalances in surveillance.'" The investigators "also
pointed out that cohort studies may demonstrate an association but do not
necessarily imply causality."
The study
"tracked more than 10,500 people averaging 54 years of age" who
"had a range of underlying health conditions and were prescribed
sleeping" aids "for an average of about 2.5 years between 2002 and
2007," HealthDay
(2/27, Mann) explained. "The researchers compared these patients' risks for
death and cancer against those of people who did not take sleeping" aids.
"Specifically, there were 265 deaths among 4,336 people taking Ambien,
compared with 295 deaths among the 23,671 people who had not taken sedatives or
sleeping" aids.
BBC
News (2/28, Roberts) reports, "This increased risk was irrespective
of other underlying health conditions, such as heart and lung diseases, and
other factors like smoking and alcohol use, which the researchers say they did
their best to rule out." The authors "say it is not yet clear why
people taking sleeping tablets may be at greater risk" but "the drugs
are sedating and this may make users more prone to falls and other
accidents." Sleeping aids "can also alter a person's breathing pattern
as they sleep and they have been linked to increased suicide risk."
Study Suggests
Obesity May Increase Risk Of Colon Cancer.
Reuters
(11/4, Norton) reports on study
results published online Oct. 7 in the American Journal of Epidemiology, which
found that heavier older adults may have a greater risk of developing colon
cancer. The study examined 120,000 Dutch adults between the ages of 55-69 for a
16 year time period. Men who were significantly overweight had a 25% higher
risk. Additionally, waist size played a significant role in cancer risk as those
with the largest bellies had a 63% higher risk. Women with a large waistline had
a higher risk of cancer if they exercised less than 30 minutes a day. But women
with a size 44 pant size who did little exercise had an 83% greater chance of
developing cancer when compared to women with smaller waistlines who exercised
for more than 90 minutes a day.
"The results are in from the biggest study
of its kind in history, by the American Medical Association. 100,000 women
followed over 28 years, and the conclusion? Less than a drink a day even a glass
of wine with dinner, could change the risk of breast cancer." ABC World
News (11/1, story 2, 1:25, Sawyer) aired a second segment on the topic, with
ABC's Dr. Richard Besser commenting on the study.
NBC Nightly
News (11/1, story 7, 2:00, Williams) reported, "This link isn't new
material, but until now, research has focused on higher levels of drinking than
that."
CBS Evening
News (11/1, story 6, 2:20, Pelley) quoted study author Dr. Wendy Chen as
saying, "What was new about our study is that we had enough statistical
power to look at the effect of lower levels of alcohol consumption in breast
cancer risk."
The Washington
Post (11/2, Stein) reports that investigators "analyzed data
collected from 105,986 women ages 30 to 55 who participated in the Nurses'
Health Study, an ongoing project scrutinizing a host of women's health issues,
between 1980 and 2008." Altogether, "7,690 of the women were diagnosed
with invasive breast cancer." Women "who consumed a low level of
alcohol - between about 5 and 10 grams a day, which works out to about three to
six glasses of wine a week - were 15 percent more likely to be diagnosed with
breast cancer."
Bloomberg
News (11/2, Ostrow) reports that "two drinks a day increased the
risk to 51 percent, according to" the study. The investigators also
reported that "no increase in breast cancer risk was seen in the group who
drank less than three glasses of wine a week compared with those who didn't
drink." The research "was funded by the National Institutes of
Health."
The New
York Times (11/2, O'Connor) "Well" blog reports, "The
type of alcohol the women drank did not alter the risk: Red wine raised it just
as much as beer." The investigators "also asked the nurses about
drinking patterns early in adulthood and found strong associations with
increased risk regardless of age."
The AP
(11/2, Tanner) reports, "Given research suggesting that drinking moderate
amounts of alcohol including red wine may protect against heart disease,
deciding whether to avoid alcohol is a personal choice that should be based on a
woman's other risks for breast cancer and heart disease, the researchers
said."
WebMD
(11/2, Boyles) reports that "frequency of drinking -- how often women drank
during the week and when -- did not appear to influence risk. The key component
was how much you consistently drank over time."
HealthDay
(11/2, Goodwin) reports, "One reason for the connection may be that alcohol
raises levels of circulating estrogen, and high levels of estrogen are linked to
breast cancer, Chen said." Also covering the story were Reuters
(11/2, Joelving), BBC
News (11/2), Medscape
(11/2, Mulcahy), and MedPage
Today (11/2, Bankhead).
Researchers
Probe Whether HCAs Raise Cancer Risk From Barbecued Meat.
The Chicago
Tribune (7/3, Conis) reported on research on whether chemical compounds
known as heterocyclic amines, or HCAs, found in barbecued meat increase cancer
risks. In the 1970s, Japanese scientists discovered that the compounds could
damage cellular and bacterial DNA in test tube experiments. Later studies found
that HCAs caused tumors in lab animals. Within the past decade, "a handful
of studies in human populations began to suggest that HCAs might be behind the
observed association between meat consumption and cancers of the pancreas,
prostate and colon." But epidemiologists note that the HCA theory "is
just one of several that could explain the association between meat consumption
and elevated cancer risk" -- others include nitrites, free iron or
polycyclic aromatic hydrocarbons. HCA levels can also be reduced by lowering
cooking time and temperatures, or by marinating or microwaving meat for a few
minutes before grilling it.
Research
Increasingly Suggesting Alcohol Increases Risk Of Certain Cancers.
The Wall
Street Journal (11/1, Beck, Subscription Publication) reports that
research is increasingly suggesting that regular alcohol consumption may be
linked to an increased risk of certain cancers. Even small amounts may increase
the likelihood of developing some cancers, including esophageal cancer. As
little as three alcoholic drinks per week may increase one's breast cancer risk,
according to one study. According to Samir Zakhari, director of the division of
metabolism and health effects at the National Institute on Alcohol Abuse and
Alcoholism, "Cancer doesn't happen overnight." Instead, Zakhari says,
"It's the repeated exposure to alcohol over a long period of time that will
cause damage and it has a cumulative effect."
Consuming Eggs
May Be Linked To Prostate Cancer Lethality.
The UK's Daily
Mail (9/30) reports a study claiming that "men who consumed 2.5
eggs or more a week had an 81 per cent increased risk of lethal prostate cancer
compared to men who consumed less than half an egg a week." Harvard
University School of Public Health researchers "suggested the damage may be
done by the large amounts of cholesterol or choline – a nutrient that
help cells to function properly – that are found in eggs."
Low-Sugar
Fluids May Be Linked To Reduced Bladder Cancer Risk In Men.
HealthDay
(10/26, Dallas) reports, "Men who drink plenty of low-sugar fluids may
reduce their risk for bladder cancer," according to a study presented at
the AACR International Conference on Frontiers in Cancer Prevention Research.
Investigators "evaluated the fluid intake of nearly 48,000 men who were
part of a long-term study" and "found that the men with a high daily
fluid intake, or those who drank more than 10 cups (2,531 milliliters) per day,
had a 24 percent reduced risk for bladder cancer."
West Virginia
Senate Passes Teen Indoor Tanning Ban.
The AP
(2/22) reports, "A measure that would prohibit West Virginia children from
using indoor tanning beds in an effort to combat skin cancer rates among young
adults easily passed the Senate Tuesday and was sent to the House of
Delegates." In a 30-4 vote, the Senate passed a bill that "would
require tanning salons to register with their local health departments. Patrons
would be required to present proof of their age before they could tan. People
younger than 18 would be prohibited." The legislation is supported by the
American Cancer Society, "because teens and young adults are at a 75
percent higher risk of developing melanoma...from just one indoor tanning
session a month than teens who don't use tanning beds."
Modern Shift
Patterns May Not Carry Same Cancer Risks.
HealthDay
(9/30, Dallas) reports that according to a study published online Sept. 27 in
the journal Cancer Epidemiology, Biomarkers & Prevention, "modern shift
patterns may not carry the same risks for cancer as older, more extreme shift
schedules." In a study of 123 hospital "shift workers who wore
light-intensity meters to determine their peak melatonin levels and the overall
change in melatonin levels during winter day and night shifts, as well as summer
day and night shifts," researchers found that "the now common rotating
shift pattern of day-day-night-night may not disrupt circadian rhythm or
melatonin production significantly."
Weight Gain
After Menopause May Increase Risk For Endometrial Cancer.
HealthDay
(10/24, Dallas) reports a study to be presented "at the AACR International
Conference on Frontiers in Cancer Prevention Research in Boston" showing
that after menopause, "women who gained 61 pounds or more were two times
more likely to develop endometrial cancer than women with stable weight."
Researchers attribute this to the fact that "fat tissue is the major source
of circulating estrogen in postmenopausal women, and estrogen promotes the
development of endometrial cancer." They also "noted that more
research is needed to determine if the timing of weight gain and 'yo-yo'
dieting...during adulthood play a role in women's risk for endometrial cancer
and whether or not weight loss reduces this risk."
Diabetes May
Increase Risk Of Colon Cancer.
Reuters
(9/29, Norton) reports findings
published in the American Journal of Gastroenterology in which researchers
analyzed 14 international studies and found that people with diabetes have a 38%
higher risk of being diagnosed with colon cancer than people who do not, and
males with diabetes have a 20% higher risk of rectal cancer. However, it is
unclear what contributes to this increased risk. One theory is that higher
levels of insulin and insulin-like growth factors in people with diabetes may
stimulate cell growth.
Stressed Women
May Show Higher Risk Of Aggressive Breast Tumors.
The Los
Angeles Times (9/20, Kaplan) "Booster Shots" blog reports that
according to a study presented Sept. 19 at the American Association for Cancer
Researcher's conference, University of Illinois-Chicago researchers surveyed 989
women with a recent breast cancer diagnosis and "found that stressed women
were 38% more likely to have cancers that were estrogen receptor-negative."
The study authors acknowledged that it is unclear whether "the women with
more aggressive cancers were already more stressed out before they were told
they had breast cancer" or were stressed during the interview because they
had more aggressive tumors
Vitamin D
Associated With Increased Risk Of Non-Melanoma Skin Cancers.
Bloomberg
News (8/16, Ostrow) reports, "Vitamin D, which some studies have
found may protect against diabetes, heart disease and cancer, appears to raise
the risk of non-melanoma malignancies," according to a study
published online Aug. 15 in the Archives of Dermatology. "An analysis of
data on 3,223 patients found those with the highest amounts of vitamin D from
sun exposure had a 60 percent greater risk of developing the most common form of
skin cancer than those with lowest levels."
HealthDay
(8/16, Gardner) reports that the study "stops short of saying that high
vitamin D levels might actually cause these types of cancer." And,
"because ultraviolet (UV) radiation exposure is necessary for vitamin D
production in the body, it might simply mean that people with more sun exposure
tend to develop more non-melanoma skin cancers." However, "it's
unclear whether it's the damage from UV rays that accounts for the risk, or
rising vitamin D levels that accompany exposure to the rays." MedPage
Today (8/16, Smith) also covers the story.
Cancer
Researchers Say No Amount Of Alcohol Consumption Is Safe.
The Los
Angeles Times (7/11, Brown) "Booster Shots" blog reported that
"in a piece
published Monday, Paule Latino-Martel, a cancer researcher at the French
National Institute for Agricultural Research, and co-authors argued that many
countries' alcohol consumption guidelines...fail to take into account long-term
risks associated with drinking," including an increased risk for
"mouth, throat, breast, colorectal and possibly liver cancers." The
authors stated that "there is no level of alcohol consumption for which the
cancer risk is null," and also noted that the WHO has recently concluded
that alcohol consumption does not prevent heart disease.
Wearing
Flip-Flops, Baseball Caps May Increase Risk Of Skin Cancer.
HealthDay
(7/13, Preidt) reported, "Wearing flip-flops and baseball caps can increase
your risk of skin cancer," warned Rebecca Tung, MD, director of the
dermatology division at Loyola University Medical Center in Maywood, IL. Dr.
Tung explained, "The problem with flip-flops and baseball caps is that they
leave the tips of the ears and the tops of the feet dangerously exposed to sun
damage. The potential for skin cancers in those areas are real, especially on
the tips of the ears." This is because those areas of the body, which have
little protection against the sun's rays, are frequently overlooked when people
apply sunscreen.
Four In 10
People In UK Will Develop Cancer At Some Point.
BBC
News (7/14, Brimelow) reports, "Rising cancer rates mean four in 10
people in the UK get the disease at some point in their lives," Macmillan
Cancer Support, "a health charity, says." The projections "are
drawn from projections published two years ago in the British Journal of Cancer,
which concluded that at the end of 2008 there were two million cancer survivors
in the UK and that the figure was rising every year." The charity
"also looked at recent cancer incidence and mortality statistics for the
UK, indicating that 310,000 people were diagnosed with cancer in 2008."
Metabolic
Syndrome May Raise Liver Cancer Risk.
MedPage
Today (7/27, Bankhead) reported "data
from the National Cancer Institute" published in Hepatology indicated that
"patients with metabolic syndrome had as much as a twofold increased risk
of liver cancer as compared with people who did not have the syndrome."
Specifically, "metabolic syndrome was associated with a significantly
increased risk of both hepatocellular carcinoma (HCC) and intrahepatic
cholangiocarcinoma (ICC)," with a higher HCC risk. Researchers hypothesize
that metabolic syndrome underlies unexplained HCC and ICC cases in the US, and
propose that "approaches to control the recent worldwide epidemic of
metabolic syndrome could contribute to a reduction in the liver cancer
burden." The study authors cautioned that they may have underestimated or
missed the prevalence of smoking, overweight, obesity, and central adiposity.
Farm Workers
May Have Elevated Risks For Blood Cancers.
The UK's Telegraph
(7/28, Beckford) reports that, according to a study published in journal
Occupational and Environmental Medicine, researchers in New Zealand found that
people who worked on farms, especially poultry and beef cattle, had elevated
risks of dying of "blood cancers such as leukaemia, multiple myeloma and
non-Hodgkin's lymphoma." The study authors suggested that this may be due
to early childhood exposure to certain viruses.
Certain
Pesticides Linked To Prostate Cancer Prevalence.
The Los
Angeles Times (8/31, Hennessy-Fiske) reports that according to a study
in the American Journal of Epidemiology, in "173 white and Latino seniors
in Tulare, Fresno and Kern counties who had been diagnosed with prostate
cancer" and 162 control subjects, men "who lived within 500 meters of
places where methyl bromide, captan and eight other organochlorine pesticides
had been applied" were more likely to have prostate cancer. The Times noted
that researchers chose "prostate cancer in part because...the risk factors
are relatively few." However, critics point out that "attempts to
reconstruct exposure in retrospect are extremely uncertain," and that
living near an area doesn't guarantee exposure. The research was funded by the
National Cancer Institute and the National Institute of Environmental Health
Sciences
High vitamin D levels may reduce mortality
among colorectal cancer patients: Reuters
(July 11, 2008)
This article describes a JCO
study indicating that patients with
colorectal cancer with higher plasma
25-hydroxyvitamin D3 (25(OH)D) levels prior
to diagnosis have a significant reduction in
overall mortality. Researchers report
that further research on vitamin D levels in
colorectal cancer patients must be performed
before further recommendations can be
made.
Article:
Reuters; Abstract:
JCO
Colon
Cancer Incidence Increasing.
The UK's Telegraph
(7/27, Adams) reports that male lifetime risk of colon cancer has increased from
one in 29 to one in 15 since 1975, and women's chances have gone from one in 29
to one in 19. According to the Telegraph, weight gain, more drinking, less
exercise, and the fact that people live longer are all contributing to the
increased risk. However, the chance of survival has also increased since 1975.
The Telegraph notes, "The chance of surviving for 10 years after diagnosis
is now close to 90 per cent for those identified early, while overall about half
do." The statistics were published in the British Journal of Cancer. The
UK's Independent
(7/27, Laurance) also covers the story.
Smokeless tobacco increases risk
of oral cancer: Reuters
This article discusses a study
published in the journal Lancet Oncology
showing that the use of chewing tobacco and
snuff increases the risk of oral cancer by
80 percent and esophageal and pancreatic
cancer by 60 percent. The article
notes that the use of smokeless tobacco
products varies widely depending on sex,
age, ethnic origin and economic background,
and is highest in the United States, Sweden
and India.
Article:
Reuters
Researchers
say tanning beds may cause cancer.
The CBS Evening News (7/28, story 8, 2:15, Couric)
reported that, according to a paper published online July 29 in The Lancet
Oncology, tanning beds may "pose as big a risk as tobacco and
asbestos." Medical correspondent Jon LaPook, MD, explained that the
"international panel of cancer experts upgraded the warning on tanning beds
from probably to definitely able to cause cancer."
The AP
(7/29, Cheng) points out that "a new analysis of about 20 studies concludes
the risk of skin cancer jumps by 75 percent when people start using tanning beds
before age 30." In addition, researchers from the International Agency for
Research on Cancer (IARC), the "cancer arm" of the World Health
Organization, "found that all types of ultraviolet radiation caused
worrying mutations in mice, proof the radiation is carcinogenic. Previously,
only one type of ultraviolet radiation was thought to be lethal." Now,
"the new classification means tanning beds and other sources of ultraviolet
radiation are definite causes of cancer, alongside tobacco, the hepatitis B
virus, and chimney sweeping, among others."
Canada's CBC
News (7/29) explains that "until now, only UVB radiation from solar
rays was known to cause a genetic mutation," but the IARC team "found
the same mutation in the skin of mice treated with UVA." Therefore,
"the agency decided to reclassify all types of ultraviolet radiation -- UVA,
UVB, and UVC -- as carcinogenic to humans, or Group 1 carcinogens. Previously,
the three UV types were grouped as probable carcinogens." CBC points out
that the "WHO has warned people younger than 18 to avoid tanning
beds."
According to HealthDay
(7/28, Reinberg), the Food and Drug Administration "is considering
strengthening its warnings about the risk of skin cancer and eye damage"
related to tanning bed use, the agency said. New York's Newsday
(7/29, Altherr), BBC
News (7/29), and the Minneapolis
Star Tribune (7/29), as well as the UK's Sun
(7/29), Press
Association (7/29), and Daily
Telegraph (7/29) also covered the story.
Long-Term
Sedentary Jobs Linked To Cancer, Heart Disease Risk.
The Wall
Street Journal (6/21, Lukits, Subscription Publication) reports that,
according to a study published in the American Journal of Epidemiology,
sedentary behaviors, particularly those that require minimal energy expenditure,
may increase the risk of developing chronic diseases including colon cancer and
heart disease. Researchers collected data from 2005 to 2007 on 918 colon-cancer
patients and 1,021 controls and found that those who spent 10 or more years in
sedentary jobs had a twofold risk of colon cancer and a 44% increased risk of
rectal cancer, compared with those whose occupations were never sedentary.
Notably, those with jobs requiring heavy physical activity had a 44% decreased
risk of colon cancer.
Chemical
used in making rubber linked to increased
cancer risk
This
article reports that workers exposed to
2-mercaptobenzothiazole (MBT), a chemical
used in the manufacturing process of rubber,
are twice as likely to develop colon cancer
and four times as likely to develop bone
marrow cancer, compared to the general
population. The article notes that
researchers believe the increased risk of
cancer may be associated with length of
exposure to MBT, though further confirmatory
research is being conducted.
Article: Reuters
Granite used in kitchen
countertops may emit cancer-causing gas: The
New York Times
This article discusses that some granite
kitchen countertops may emit dangerous
levels of radon, a radioactive gas that can
cause lung cancer. The article notes
that marble industry officials claim that
the amount of radioactive materials found in
granite countertops is not enough to pose a
health risk, though researchers are
conducting studies of granite widely used in
kitchen counters. Article:
The New York Times
Estrogen-like
compounds in skin moisturizers may increase
breast cancer risk: Reuters
This article
reports on research from the San Antonio
Breast Cancer Symposium finding that six
widely available moisturizers contain
estriol or estrone, two estrogen-like
compounds that could increase breast cancer
risk if absorbed through the skin. One
researcher urged women with breast cancer to
forgo using these topical moisturizers, as
they may interfere with their
treatment. Article:
Reuters
Researchers
See No Increased Cancer Risk Among Statin Users.
HealthDay
(7/18, Mann) reported that "a large, new study" published in the
Journal of the American College of Cardiology "appears to quell concerns
that taking statins might raise the risk of cancer." For roughly
"91,000 adults whose full medical records were available via an electronic
database, researchers report there was no significant difference in cancer risk
among those who took statins and those who didn't." The investigators found
that, "after an average of five years of follow-up among nearly 46,000
pairs of people who either used the cholesterol-lowering drugs or did not use
them, 11.37 percent of participants taking a statin developed cancer, compared
to 11.11 percent of those individuals not taking a statin."
Heavy Drinking
Only Increases Risk For Some Esophageal Cancers.
Medscape
(3/18, Barclay, subscription required) reported that higher alcohol consumption
is "associated with an increased risk" for esophageal squamous cell
carcinoma (OSCC), but not with esophageal adenocarcinoma (OA) or adjacent tumors
at the esophagogastric junction (OGJA), according to an analysis
in the journal Gut. Researchers extracted data from seven studies comprised of
10,854 controls, 1,821 OA patients, 1,837 OGJA patients, and 1,016 OSCC
patients. For increasing levels of "any of the alcohol intake measures
evaluated, there was no apparent increase in the risk" for OA or OGJA. For
the "highest-frequency category (defined as ≥ 7 drinks per day), the
OR" was 0.97 for OA and 0.77 for OGJA. In contrast, however, alcohol intake
was "strongly associated with an increased risk for OSCC, with an OR of
9.62 for seven or more drinks per day."
Study Suggests
Taller Woman May Have Higher Risk For Developing Common Cancers.
The Wall
Street Journal (7/21, Stovall, Subscription Publication) reports,
reports that for every four inches above five feet a woman is, she has a 16%
increase risk of developing cancer, according to a study
in The Lancet Oncology
Bloomberg
News (7/21, Mead) reports that the researchers "studied more than 1
million women in the UK who reported an average height of 161 centimeters to the
state-run National Health Service between 1996 and 2001." They found more
than "97,000 incidents of cancer by June 2008"; and every "10
centimeters of height translated to an 17-percent increase for incidents of
breast cancer, which comprised more than a third of all the observed
malignancies."
The BBC
News (7/21, Gallagher) reports that the researchers found that the
tallest women in the group, those "over 5ft 9in, were 37% more likely to
have developed a tumour than those in the shortest group, under 5ft." They
study authors linked 10 cancers to height: "colon, rectal, malignant
melanoma, breast, endometrial (uterus), ovarian, kidney, lymphoma, non-Hodgkin
lymphoma and leukaemia." Although the study looked "only at women, the
researchers said the height link was also present in men."
The UK's Telegraph
(7/21), MedPage
Today (7/20, Walsh), WebMD
(7/20, Mann), and HealthDay
(7/20, Mozes) also covered the study.
Talc-Based
Powder Use May Increase Ovarian Cancer Risk By 30%.
MedPage
Today (4/7, Bankhead) reported that the "use of talc-based powder
significantly increases the risk of invasive ovarian," according to
findings presented at the American Association for Cancer Research. The
researchers analyzed data from a "case-control study involving more than
2,000 women with ovarian cancer and a similar number of women without the
cancer." Talc applications were estimated from "patient-reported
frequency and duration of use." After adjusting for "age, parity,
oral contraceptive use, tubal ligation," BMI, smoking or alcohol use, and
ethnic/racial or familial breast or ovarian cancer history, the study team
performed analyses for cases of nonmuscinous-invasive, nonserous-invasive, and
serous-invasive cancer. They found that for all analyses, talc use was
associated with "an increased prevalence of ovarian cancer; the magnitude
of the difference between users and nonusers ranged between 20% and 40%, most
often about 30%.
Exposure
To Bright Light During Sleep May Increase Breast Cancer Risk. Today (1/9,
Phend) reported, "Sleeping with the lights on could
increase the risk of breast cancer, results from a large 10-year observational
study suggest." After looking at "more than 1,670 Israeli
women," investigators "found that those routinely exposed to higher
intensity light in their sleeping environment had 22% higher odds of
developing breast cancer than women who slept in full darkness,"
according to the paper in Chronobiology International. "It may be that
leaving the lights on while sleeping interferes with melatonin production,
which, in turn, modulates endogenous estrogen levels," and "several
studies have also associated the circadian rhythm-regulating hormone with a
protective effect against breast cancer."
Having a desk
job may be linked to higher prostate cancer risk.
The UK's Daily
Mail (10/29, Macrae) reports that an "analysis of 45,000 men aged
45 to 79" appearing in the British Journal of Cancer found that "those
who had highly physical jobs were 28 percent less likely to develop the disease
than those who spent most of their working lives sitting." The study
further found that "men who walked or cycled for more than an hour a day
having a 14 percent lower risk than those who walked or cycled for 40 minutes or
less a day." The researchers, from the Karolinska Institute in Sweden,
concluded, "Findings from this study show that not sitting for most of the
time during work or occupational activity and longer daily durations of the main
component of active living (walking or cycling) may be associated with reduced
prostate cancer incidence."
Penile
Foreskin May Be Repository For HPV.
HealthDay
(5/17, Salamon) reported that penile foreskin can "harbor the human
papillomavirus (HPV)," which is responsible for genital warts and 70
percent of cervical cancer cases. According to findings presented at the
American Urological Association meeting, about 30 percent of the 40 foreskin
tissue samples examined contained HPV strains. The samples were from males
"between seven months and 82 years old who had undergone circumcision to
treat phimosis." Although none of the patients had "clinical
symptoms of disease," the study team found "low-risk HPV genotypes
in 18.8 percent" of the foreskin tissue samples and "high-risk HPV
in 9.77 percent."
Loss of
spouse may increase cancer risk, research suggests.
Following an article in Bloomberg
News, CBS
News (7/28) reported on its website that "divorce and widowhood
have a lingering, detrimental impact on health -- even after remarriage,"
according to a study expected to appear in the August issue of the Journal of
Health and Social Behavior.
Linda Waite,
PhD, a sociologist at the University of Chicago, and Mary Elizabeth Hughes,
PhD, of Johns Hopkins University, "examined the marital history and
health indicators for 8,652 middle-aged people in research funded by the
National Institute on Aging," according to CNN
(7/28, Park). They found "that divorced or widowed people have 20 percent
more chronic health conditions such as heart disease, diabetes, or cancer than
married people," and they "also have 23 percent more mobility
limitations, such as trouble climbing stairs or walking a block." WebMD
(7/28, Boyles) and the New
York Daily News (7/28, Chernikoff) also cover the story.
People In US
More Likely To Develop Skin Cancer On Left Side Of Body.
USA
Today (6/15, Shorman) reports that, according to a study published
online in April by the Journal of the American Academy of Dermatology,
"people in the USA are more likely to develop skin cancer, such as melanoma
and merkel cell carcinoma, on the left side of their bodies." Investigators
theorize that "driving may be to blame, because the left arm receives more
UV." After analyzing data from a government database, researchers
"found that when skin cancer occurred on one side of the body, 52% of
melanoma cases and 53% of merkel cell carcinomas were on the left side. On the
upper arms, 55% of merkel cell cases developed on the left side." In
Australia, where people drive on the right side of the road, researchers noted a
similar pattern of precancerous skin growths on the right side.
Men With Lean
Physiques At Age 18 May Have Lower Chance Of Dying From Cancer Later In Life.
Bloomberg
News (6/16, Ostrow) reports, "Men with lean physiques at age 18
have a lower chance of dying from cancer later in life than those who are obese
at that age," according to a study published in the Annals of Oncology.
Investigators found that "men with the lowest body mass index at age 18
were 35 percent less likely to die from cancer than those with the highest BMIs."
The researchers also found that "smoking and physical activity as a young
adult didn't affect results." The UK's Telegraph
(6/16, Beckford) also covered the story.
Inactivity May
Pose Greater Cancer Risk Than Cellphones, Coffee.
The AP
(6/16, Marchione) reports that despite all the "recent news about possible
cancer risks from cellphones, coffee, styrene, and formaldehyde in building
materials," health experts say that most people "probably face little
if any danger from these things with ordinary use." Linda Birnbaum from the
National Toxicology Program at the National Institute of Environmental Health
Sciences concurs. The government agency "just declared styrene, an
ingredient in fiberglass boats and Styrofoam, a likely cancer risk. ... Levels
of styrene that leach from food containers 'are hundreds if not thousands of
times lower than have occurred in the occupational setting,' where the chemical
in vapor form poses a possible risk to workers," she said. Experts
emphasize, however, that "inactivity and obesity may pose a greater cancer
risk than chemicals for some people."
Specialists
See Studies Linking Cell Phones To Health Risks As Inconclusive.
Medscape
(6/21, Gandey) reported that the issue of cell phones as a potential health risk
resurfaced recently: A study
in the Journal of the American Medical Association found that using a cell phone
"for as little as 50 minutes at a time appears to affect brain glucose
metabolism," and a World Health Organization panel announced
(pdf) that cell phone use "should be considered 'possibly
carcinogenic.'" The 2B classification "is very weak, and I think
people are now focusing too much on the possibly carcinogenic part," said
neuro-oncologist Lynne Taylor, MD, from Virginia Mason Medical Center in
Seattle. This is "neither new research nor at odds with previous
findings," noted a National Cancer Institute statement. Meanwhile, the
National Institute of Environmental Health Sciences is currently conducting a
large, laboratory
study on "cell phone radiofrequency exposures and potential health
hazards."
FDA Issues New
Guidelines For Sunscreen Labeling.
The Food and Drug Administration's long-awaited announcement
yesterday of significant changes to sunscreen labeling was widely reported both
by television and print media. The changes will empower consumers to make better
decisions in choosing a product to prevent sun damage as well as reduce overall
confusion about sunscreens.
The CBS
Evening News (6/14, story 9, 0:30, Pelley) reported, "The government
put out new rules today for sunscreens. From now on, the gold standard will be
broad-spectrum protection. Manufacturers may put that on the label only if the
sunscreen protects [against] ultraviolet B which causes burning and ultraviolet
A which causes wrinkling." Both forms of UV rays "cause skin cancer,
and only sunscreens with an SPF 15 or higher may claim to lower the risk of
cancer."
On NBC
Nightly News (6/14, lead story, 2:50, Williams), chief medical editor Nancy
Snyderman, MD, explained, "One of the biggest changes is this, a drug facts
label showing ingredients and differentiating between products that protect
against cancer from those that only prevent sunburn."
On ABC
World News (6/14, lead story, 3:20, Sawyer), correspondent Lisa Stark
pointed out why the change is so important. "Despite the explosion of sales
of sunscreens, there's also been an explosion of skin cancer," as evidenced
by the fact that "cases of the most deadly kind of skin cancer, melanoma,
increased 45% between 1992 and 2004," particularly in young people.
In a follow-on
analysis piece on ABC World News (6/14, story 2, 1:15, Sawyer), chief
health and medical editor Richard Besser, MD, explained that the action taken by
the FDA on sunscreen labeling was "done five years ago" by European
regulators. Besser suggested that consumers looking for sunscreen should examine
"the UVB number. I recommend 30, at least. That will protect you
against that. But for UVA, you need to go to" a list
put together by Consumer Reports specifically for products "tested for UVA.
By next year you'll be able to trust the labels for everything."
The AP
(6/15, Perrone) reports that beginning next summer, if sunscreens do not protect
against both UVA and UVB rays, "or the sun protection factor is below
15," then sunscreens must "carry a warning: 'This product has been
shown only to help prevent sunburn, not skin cancer or early skin aging.'"
Bloomberg
News (6/15, Larkin) reports, "Lawmakers have urged the FDA for more
than a decade to revise sunscreen labels to address cancer-causing UVA rays that
penetrate deeper into skin cells and aren't blocked by window glass."
Unfortunately, "'twenty percent of Americans will develop skin cancer in
their lifetime,' said" Moy at yesterday's press conference at FDA's
headquarters. "Ultraviolet exposure is the most preventable risk factor for
skin cancer."
The Los
Angeles Times (6/15, Maugh) reports that the FDA "has been
considering such regulations since 1978 and released some proposed rules in
2007, but subsequently concluded that the labeling system under consideration
would be too confusing for consumers."
The Washington
Post (6/15, Stein) reports that "the agency is barring the use of
the term 'sunblock' as well as claims that sunscreens are 'waterproof' or 'sweatproof,'
saying those terms are inaccurate." Under the new guidelines,
"sunscreen makers will only be allowed to claim that products are
'water-resistant' and will have to specify whether they work for 40 or 80
minutes." Sunscreens "that do not must carry warnings advising people
to use a water-resistant product if they are going to be exposed to water or
sweat."
On its front
page, the New
York Times (6/15, A1, Harris, Subscription Publication) reports that FDA
"regulators said they had yet to decide whether to end an SPF arms race in
which manufacturers are introducing sunscreens with SPF numbers of 70, 80 and
100, even though such lotions offer little more protection than those with an
SPF of 50." In fact, the FDA "had proposed allowing manufacturers to
use SPF numbers no higher than 50, but that remains only a proposal
(pdf) for which the agency will seek further comment."
USA
Today (6/15, Szabo) reports that currently, "the American Academy
of Dermatology recommends both adults and children use a sunscreen with an SPF
of at least 30."
Also covering
the story are the UK's Financial
Times (6/15, Rappeport, Subscription Publication), the Wall
Street Journal (615, D1, Dooren, Subscription Publication), the Wall
Street Journal (6/15, Hobson, Subscription Publication) "Health
Blog," the Star-Ledger
(6/15, Todd), the CNN
(6/14, Willingham) "The Chart" blog, the Columbus
Dispatch (6/15, Jacobson), the NPR
(6/14, Thrasybule) "Shots" blog, WebMD
(6/14, DeNoon), HealthDay
(6/14, Reinberg), MedPage
Today (6/14, Walker), and Reuters
(6/14). An FDA webcast of the press conference announcing the rule is available
for viewing here.
Updated
Government Carcinogens Report Links Two Common Chemicals With Cancer Risk.
On its website, ABC
News (6/10, Murray) reported that HHS added "eight more substances
to its 'known human carcinogen' or 'reasonably anticipated to be carcinogen'
lists today, one week after a World Health Organization study concluded that
cell phones may cause cancer."
The Los
Angeles Times (6/10, Dennis) "Booster Shots" blog reported
that formaldehyde "now officially falls into the 'known to be a human
carcinogen' category," and styrene can now "officially be described as
'reasonably anticipated' to be cancer-causing," according to the Department
of Health and Human Services' updated " Report
on Carcinogens."
In a
front-page story, the New
York Times (6/13, A1, Harris, Subscription Publication) reports that the
federal government on Friday issued warnings about the "two materials used
daily by millions of Americans." The report by NIH's National Toxicology
Program found evidence that styrene, which is used in "boats, bathtubs, and
in disposable foam plastic cups and plates," may increase the risks of
"cancer of the pancreas and esophagus," the report found. Consumers
can be exposed to styrene from the "fumes of building materials,
photocopiers and tobacco smoke." According to the AP
(6/11), NIH says the greatest exposure to styrene is "through cigarette
smoking."
The Time
(6/10, Walsh) "Healthland" explained that the report found that
"concerning amounts of formaldehyde could be encountered in plywood and
particle boards, as well as in hair salons and in mortuaries," and the
exposure is "most intense" among workers in "some manufacturing
plants." With formaldehyde and styrene, the government also added captafol,
cobalt-tungsten carbide, "certain inhalable glass wool fibers, o-nitrotoluene,"
and riddelliine to its twelfth report, bringing the total to 240 carcinogens.
Notably, studies of mortuary workers "exposed to high levels of
formaldehyde have shown increased incidences of certain kinds of rare nasal
cancers."
The New
York Daily News (6/10) noted that the report also linked formaldehyde to
leukemia. The American Cancer Society "said consumers should not worry
about cups or food containers, but should shelve personal products with
formaldehyde."
The Washington
Post (6/11, Stein) noted that most of the cancer risk evidence
"came from people exposed to relatively high levels in industrial settings.
'A listing...does not by itself mean that a substance will cause cancer,'" said
Dr. John Bucher, associate director of the National Toxicology Program.
Moreover, Dr. Bucher said the updated listings "do not trigger any
immediate new restrictions on the substances, but other government agencies may
use the information in the future as part of their regulatory decisions."
He said individuals can use the list to "make personal choices,"
noting that most people's "routine exposure to the newly listed substances
was probably low."
Bloomberg
News (6/10, Young) pointed out that aristolochic acids, which are
"found in herbal products used to treat arthritis and gout," were also
listed as carcinogens, because they "can cause bladder or urinary-tract
cancer in people with kidney disease." Meanwhile, American Chemistry
Council CEO Cal Dooley released a statement saying the report "makes
'unfounded classifications' about formaldehyde and styrene that will scare
consumers," and the American Composite Manufacturers Association disputed
the styrene and cancer link with a statement saying, "styrene-based
composite material system has been used safely for over 60 years."
Also covering
the updated carcinogens report were Reuters
(6/11, Simao), CNN
(6/11), the Washington
Post (6/12, Stein) "The Checkup" blog, HealthDay
(6/10, Goodwin), and WebMD
(6/10, DeNoon).
Study
Illustrates Association Between Cancer Diagnosis, Bankruptcy.
The Wall
Street Journal (6/8, Feintzeig, Subscription Publication)
"Bankruptcy Beat" blog suggests that those consider restructuring
could learn something from research presented at the American Society of
Clinical Oncology meeting. In the study, which is also published in the Journal
of Clinical Oncology, researchers analyzed National Cancer Institute data and
bankruptcy-court records from Washington state. They found that out of 231,799
patients with cancer, 4,805 (2.1%) sought personal bankruptcy protection within
one to five years following diagnosis. Those most likely to file for bankruptcy
were individuals diagnosed with lung, thyroid, and leukemia and lymphoma
cancers. The study team noted that surgery and chemotherapy increased the
likelihood that patients would seek bankruptcy protection.
Cancer
Patients Struggling As Out-Of-Pocket Healthcare, Drug Expenses Continue To
Escalate. In continuing coverage, HealthDay
(6/7, Preidt) reported that increasing "out-of-pocket expenses" are
forcing many cancer patients in the US to "forgo drugs and doctor
appointments and to cut back on food and other necessities," according to
findings presented at the American Society of Clinical Oncology meeting.
Researchers reviewed data on "216 cancer patients" contacted the
HealthWell Foundation, which "helps underinsured patients afford expensive
medications." Of the all but one patient who had health insurance, 66
percent were "covered by Medicare and 83 percent had prescription drug
coverage." The patients' out-of-pocket costs "averaged $712 a month
for things such as prescription drugs, doctor visit copays, lost wages and
travel to medical appointments. These expenses were a significant problem for 30
percent of the patients and a catastrophic problem for 11 percent,"
according to the study authors.
Metformin diabetes and breast cancer. Breast cancer and associated
diabetes mellitus have gained raising interest as an elevated risk of breast
cancer prognosis resulting in increased mortality in diabetic patients. In this
context, the long-acting insulin analog glargine and other antidiabetics have
been discussed to promote tumorigenesis. In contrast, the biguanide class oral
antidiabetic metformin has been shown capable of enhancing cell cycle arrest and
inducing apoptosis as well as reducing growth factor signaling. Consequently,
several studies are underway to evaluate a possible role of metformin in breast
cancer treatment. Although mechanisms involved are not definitely clear yet,
here, we discuss metformin's anticancer effects including the potential impact
of the immune system
The ABC
News (6/3, Yarber) "Medical Unit" blog reports that "a
new study by the National Cancer Institute of 1,900 post-menopausal women
found that consuming seven to 14 alcoholic drinks per week...carries a 30
percent to 60 percent increase in breast cancer risk." Additionally,
"it was found that these women developed the most common type of breast
cancer called 'estrogen and progesterone hormone receptor positive'
cancer."
Pioglitazone
May Be Linked To Increased Risk Of Bladder Cancer.
Reuters
(6/1) reports that, according to a study published online in BMJ, the diabetes
medication Actos (pioglitazone) may be linked to an increased risk of bladder
cancer.
HealthDay
(6/1, Reinberg) reports that investigators "collected data on nearly
116,000 people treated for diabetes from 1988 to 2009 and listed in the General
Practice Research Database, which contains records from more than 600 medical
offices in the United Kingdom."
MedPage
Today (6/1, Walsh) reports that "patients with type 2 diabetes who
were ever treated with pioglitazone had an 83% higher risk for bladder cancer
(adjusted rate ratio 1.83, 95% CI 1.10 to 3.05) than those who had never used
the thiazolidinedione." The investigators reported that "this was a
drug-specific effect, because patients taking rosiglitazone (Avandia) did not
have an elevated risk (RR 1.14, 95% CI 0.78 to 1.68)." The findings from
"this analysis differed from those of a study being presented this week at
the annual meeting of the American Society of Clinical Oncology, which suggested
that the bladder cancer risk was a class effect for glitazones." Also
covering the story is the UK's Telegraph
(6/1, Adams).
Allergies
May Be Associated With Increased Risk Of Blood Cancers.
The ABC
News (6/3, Martin) "Medical Unit" blog reports that
allergies may be associated with an increased risk of blood cancers, according
to a study. "The study included more than 64,000 patients who were asked
about allergy and asthma symptoms." All participants were "evaluated
seven years later." The researchers found that participants "who had
allergies - specifically allergies to plants, grass, and trees - had a
slightly increased incidence of blood cancers," but those who had
"asthma did not have an increased risk of blood cancer."
Patients Who
Started IVF At Younger Age May Face Higher Breast Cancer Risk.
WebMD
(6/2, Rubin) reported, "Taking all age groups into account, in vitro
fertilization treatment is not linked to an increased risk of breast cancer,
according to a large new study" published online in the journal Fertility
and Sterility. But, "the researchers found that in vitro fertilization,
or IVF, patients who first started infertility treatment at age 24 were about
1 1/2 times more likely to eventually develop breast cancer than women who'd
received other infertility treatments at the same age." While "the
study results should be 'reassuring' to women who begin IVF treatment in their
30s and 40s, 'women should be aware that delivering their first child late in
reproductive life, whether assisted by IVF or not, is associated with an
increased risk of breast cancer,' the researchers write."
Burning
paraffin-wax candles without proper ventilation could raise lung cancer risk,
scientists say.
According to the Wellness blog, hosted by Time
(8/19, Blue), "burning everyday paraffin-wax candles can emit a storm of
toxic chemicals, including toluene and benzene." While "it's nowhere
near as harmful to light an occasional candle as it would be, say, to smoke a
pack of cigarettes a day," researchers at South Carolina State University
"say that frequent candle burning in tight, unventilated areas has been
implicated in lung cancer, asthma, and skin rash."
Speaking
before a chemical society meeting, the researchers explained that the
"candles, which are made from petroleum, are a source of known human
carcinogens and indoor pollution," HealthDay
(8/19, Thompson) reported. So, "lighting many paraffin candles every day
for years or lighting them frequently in an unventilated bathroom around a tub,
for example, may cause problems." However, "candles made from beeswax
or soy, although more expensive, apparently are safer, because they do not
release potentially harmful pollutants." The UK's Daily
Mail (8/20, Macrae) and the Telegraph
(8/20, Alleyne) also cover the study.
Experts urge caution on high
consumption of yerba mate tea:
This article discusses research
suggesting that lifelong drinkers of yerba
mate tea - a tea native to South America
that is gaining popularity for its high
caffeine and antioxidant content - are at
increased risk of developing some cancers.
The article notes two studies finding that
regular consumption of yerba mate increased
risk of lung, respiratory or digestive
cancers by as much as 60 percent. The
article notes, however, that cancer and
epidemiology experts disagree somewhat on
the association between yerba mate
consumption and cancer risk. Los
Angeles Times
Folic
acid supplements associated with increased
prostate cancer risk: These
articles report on a JNCI study finding that
men who took folic acid supplements were
more than twice as likely to develop
prostate cancer, compared with men who took
a placebo. Researchers note that the
estimated prostate cancer risk was 9.7
percent for participants in the folic
acid group and
3.3 percent for the placebo
group . They also found, however,
that prostate
cancer incidence was slightly lower in men
who had
adequate amounts of folate in their diet. HealthDay
News
Report:
Exposure To Oxybenzone Through Normal Sunscreen Use Is Safe.
The New
York Times (6/14, D5, O'Connor, Subscription Publication)
"Really?" column takes on the claim that oxybenzone, "a
chemical in sunscreen, absorbed through the skin, may be even more hazardous
than the sun's rays." A study in rats concluded that animals consuming
large doses of the substance developed side effects, such as abnormal growth
of the uterus. However, "in March, researchers at Memorial
Sloan-Kettering Cancer Center in New York published an independent report
examining all the evidence on the subject and concluded that the alarming
findings from early animal studies relied on unrealistic dosages" that
human beings would never encounter while using sunscreen. The column
concludes, "Exposure to oxybenzone, through normal sunscreen use, is
safe, studies find."
Expert Says
"Dubious" Research Links Sunscreen Compounds, Skin Cancer.
HealthDay
(7/26, Gardner) reported that last spring, the "Environmental Working
Group...called on the US Food and Drug Administration to finish a review of data
on the safety of retinyl palmitate, a derivative of vitamin A added to many
sunscreens" that the group believes "elevates the risk of skin
cancer." The "EWG also objected to oxybenzone (benzophenone-3),
another ingredient of many sunscreens, which it says is a hormone
disruptor." But, the "research behind these allegations...has mostly
been in lab animals and is dubious at best, said Dr. Jeffrey Dover, president of
the American Society for Dermatologic Surgery." Nevertheless, "Shelly
L. Burgess, FDA spokeswoman, on Friday said the FDA is awaiting a final review
of data on retinyl palmitate by the National Toxicology Program of the US
National Institute of Environmental Health Sciences."
Individuals
Living Near Vatican Radio Antennas May Face Increased Cancer Risk.
BBC
News (7/14, Willey) reported, "Some 60 huge steel aerials were
erected on farmland owned by the Vatican during the last century" to
"transmit Vatican Radio programs around the world on medium and short
wave." For the last 10 years, "Italian courts have been
investigating" whether the "abnormally high number of deaths from
cancer among families living near the aerials just north of the Italian capital
can be attributed to electromagnetic radiation." Now, a "300-page
report, ordered by the courts and carried out by Italy's most prestigious cancer
research hospital...concludes that there is a connection between radiation and
the cancer incidents."
The
"claims of Professor Andrea Micheli, from Milan's National Tumor Institute,
focus on 19 child deaths from leukemia or lymphoma between 1980 and 2003 in the
Cesano area," the UK's Independent
(7/15, Day) reports. Micheli "said the raised cancer risk occurred in
children under 14 who lived less than 7.5 miles from the masts," and he
also "found evidence of a link between the radiation and adult cancers --
but only among those who lived much closer to the antennae." Consequently,
"six officials of Vatican Radio have been placed under investigation for
manslaughter." AFP
(7/14) also covered the story
Higher Risk
Of Breast Cancer Following Radiotherapy May Last At Least 40 Years.
Reuters
(7/2) reports that new study suggests that women who receive
above-the-diaphragm radiotherapy for Hodgkin's lymphoma may have an increased
risk of breast cancer that lasts for at least 40 years. Writing in the Journal
of Clinical Oncology, the investigators concluded that such women must be
monitored for at least 40 years, perhaps using more intense viewing screens.
Researchers
Find No Link Between Cell Phone Towers And Children's Cancer Risk.
The AP
(6/23, Cheng) reports that "children whose mothers lived close to a mobile
phone tower while pregnant did not appear to be at any higher risk of cancer
than children whose mothers lived farther away," according to a study
published in the British Medical Journal. Investigators "analyzed 1,397
cancer cases in children up to age four from 1999 to 2001 in the United Kingdom.
Using a national birth registry, they identified 5,588 similar children without
cancer."
The Los
Angeles Times (6/22, Kaplan) "Booster Shots" blog reported
that "the team also gathered detailed data about all 81,781 cellphone
towers that were operational in the country during that time, including each
tower's location, height, output power, and how many antennas it had." The
researchers found that, "in virtually every permutation of their
calculations, there was no correlation between the cellphone towers and the
cancer cases."
Bloomberg
News (6/23, Hallam) reports that "the study is the largest of its
kind, and the findings should put any reports of cancer clusters around
mobile-phone towers into context, the researchers wrote."
The Washington
Post (6/22, Stein) "The Checkup" blog reported that, "in
an editorial accompanying the study, John Bithell of the University of Oxford
said that while the study had some shortcoming, the findings should be
reassuring to people living near cell phone towers."
According to
the UK's Independent
(6/23, Laurance), "reports of clusters of cancer cases among families
living close to the masts led to demands that the masts be moved." However,
"the numbers involved have been too small, and the risks of a biased
selection of cases too high, to draw firm conclusions."
AFP
(6/22) reported that "the authors cautioned that they were unable to get
information about individual exposure among mothers-to-be to a mobile phone
handset. Electromagnetic radiation from a handset during conversation is many
times higher than that from a phone mast." The UK's Press
Association (6/22), HealthDay
(6/22, Reinberg), and Reuters
(6/23, Kelland) also covered the story.
International
Panel Of Experts Categorizes Cell Phones As "Possibly Carcinogenic."
ABC World News (5/31, lead story, 3:10, Sawyer)
reported, "An important new alert about the safety of cell phones and the
possible risk of cancer, brain cancer in particular...comes from the World
Health Organization." NBC Nightly News (5/31, lead story, 3:10,
Williams) reported, the WHO "statement labeling cell phones as a possible
carcinogenic hazard comes from a panel of 31 scientists."
According to
the AP
(6/1, Cheng), the statement was "issued in Lyon, France, on Tuesday by the
International Agency for Research on Cancer" (IARC) after a "weeklong
meeting" during which experts reviewed "possible links between cancer
and the type of electromagnetic radiation found in cellphones, microwaves and
radar." The IARC classified cellphones in "category 2B, meaning they
are possibly carcinogenic" to humans. The assessment now "goes to WHO
and national health agencies for possible guidance on cellphone use."
The Wall
Street Journal (6/1, Martin, Hobson, Subscription Publication) reports
that the IARC working group did not conduct new research. Instead, the panel
reviewed existing literature that focused on the health effects of radio
frequency magnetic fields. Its findings are slated to be published July 1 in
Lancet Oncology.
The New
York Times (5/31, Parker-Pope, Barringer, Subscription Publication)
"Well" blog noted that the panel's decision to "classify
cellphones as 'possibly carcinogenic' was based largely on epidemiological data
showing an increased risk among heavy cellphone users of a rare type of brain
tumor called a glioma." Most "major medical groups," including
the National Cancer Institute, have "said the existing data on cellphones
and health has been reassuring." Earlier this year, the Journal of the
American Medical Association "reported on research
from the National Institutes of Health, which found that less than an hour of
cellphone use can speed up brain activity in the area closest to the phone
antenna."
The Los
Angeles Times (6/1, Roan, Gabler) reports that a 2010 study
(pdf) published in the International Journal of Epidemiology found a "40%
increase risk of gliomas for people who used a cellphone an average of 30
minutes a day over a 10-year period." The Orange
County (CA) Register (5/31, Brennan) reported that the literature review
also indicated "long-term or heavier use" of cell phones may increase
risk for a "cancer type called acoustic neuroma."
Bloomberg
News (5/31, Kresge) reported that the most recent research
"considered dated to 2004, and exposure levels from handsets have dropped
over time," said IARC Working Group Chair Dr. Jonathan Samet from the
University of Southern California. The age of the studies also means the
participants "had used their phones for no more than 10 to 15 years,
leaving open the question of the effect of longer-term exposure," he noted.
Preliminary
Study Suggests Antihistamines May Increase Risk Of Tumor Development.
The CNN
(2/7, Landau) "The Chart" blog reports, "More than dozen small
studies have suggested that people with allergies are less likely to develop
gliomas." However, in an analysis in the journal Cancer Epidemiology,
Biomarkers & Prevention, when researchers looked at information from 419
patients who had glioma and 612 who did not, they found that antihistamine use
"actually increased a person's chance of developing a glioma."
Co-author Dr. Bridget McCarthy of the University of Illinois, theorizes that
certain medications may take "away the protective value of the allergic
reaction against cancer." To further explore these ideas, Dr. Bondy and
colleagues are "recruiting 6,000 cases and 6,000 controls for a
large-scale epidemiological study on protective factors in glioma."
Study Finds
Agent Orange Exposure Increases Prostate Cancer Risk By 49%.
Medscape
(2/24, Fox) reported, "Vietnam veterans who were exposed to the defoliate
Agent Orange are 49% more likely than nonexposed veterans to be diagnosed with
prostate cancer," according to a study presented at the Genitourinary
Cancers Symposium. The researchers reviewed clinical data from 2,270 veterans,
of whom 869 had prostate cancer. After adjusting for "all significant
confounders," they concluded that "veterans with prostate cancer
were 49% more likely to have been exposed to Agent Orange than men who didn't
have cancer." Exposure to Agent Orange was also associated with
"younger age at diagnosis. Men found to have prostate cancer were roughly
five years younger at diagnosis than men without exposure."
People Who
Use Tanning Beds More Likely To Develop Melanoma.
The Chicago
Sun-Times (5/31, Szabo) reported that "since 1992, rates of
melanoma -- once considered an old person's disease -- have risen three
percent a year in white women 15 to 39, the American Cancer Society
says." Unfortunately, "people who have used tanning beds are 74
percent more likely than others to develop melanoma, a 2010 study shows."
For that reason, among others, "the American Medical Association,
American Academy of Pediatrics, American Academy of Dermatology and World
Health Organization all have called on states to ban children under 18 from
tanning salons."
Chemicals in
breast milk may be linked to testicular cancer.
The UK's Press
Association (9/25) reports that, according to a study published online
Sept. 24 in the International Journal of Andrology, "pollutant chemicals in
mothers' breast milk have been linked to an increased rate of testicular
cancer." Researchers found that "Danish men are up to four times more
likely to have testicular cancer as men in neighboring Finland." The
populace "also suffers high rates of other male reproductive disorders,
including poor semen quality and genital abnormalities." There has been
speculation that "man-made pollutants that alter the effect of
hormones" are to blame.
For the study,
investigators "measured levels of 121 chemicals in 68 samples of breast
milk from women in Denmark and Finland," the UK's Telegraph
(9/25) reported. "They found a dramatic difference between the two
countries," as "Danish breast milk had significantly higher levels of
some chemicals, including dioxins, polychlorinated biphenyls (PCBs) and
pesticides, than Finnish breast milk." Still, "why women in Denmark
should have more of the chemicals in their breast milk than their Finnish
neighbors remains unclear." The work "reinforces," however,
"the view that environmental exposure to EDCs may explain some of the
temporal and between-country differences in incidence of male reproductive
disorders." HealthDay
(9/24, Preidt) also covered the story.
Heavy
drinking may be linked to increased risk of high-grade prostate cancer,
research suggests.Heavy drinking, especially when it's beer,
increases the risk for highly aggressive prostate cancer," according to a
University of California-San Francisco study published online in Cancer. The
team "did not set out to determine the effect of alcohol consumption on
prostate cancer risk, but rather to test the effectiveness of finasteride (Proscar,
Propecia), a drug prescribed to prevent prostate cancer." While they
discovered "that heavy drinking reduces the cancer-preventing effect of
finasteride," investigators also developed a better understanding about
the "relationship between alcohol consumption and prostate cancer
risk."
Apparently,
"men who consumed at least 50 grams of alcohol (at least four drinks)
daily doubled their risk of high-grade prostate cancer," a finding that
held true in both the "placebo and finasteride arms of the trial,"
according to MedPage
Today (7/13, Bankhead). "Heavy drinking did not influence the
risk of low-grade cancer in the placebo arm, but significantly increased the
risk in men taking finasteride." The "overall risk increase in the
finasteride group came about from a significant risk reduction in men who
drank less than 50 grams of alcohol, combined with finasteride's lack of
effect among heavier drinkers." Reuters
(7/14) also covers the trial.
Soft drink
consumption may be linked to pancreatic cancer risk.
The Minneapolis
Star Tribune (2/8, Hanson) reports that "a University of Minnesota
study suggests that drinking two or more soft drinks a week nearly doubles the
risk of developing pancreatic cancer." Investigators "studied the
dietary habits of more than 60,000 adults in Singapore for 14 years." The
researchers "found that those who drank high amounts of sugar-sweetened
carbonated beverages were 87 percent more likely to develop pancreatic cancer
than those who did not."
The Washington
Post (2/8, Huget) "The Checkup" blog reported that "the
study, funded by the National Cancer Institute, notes that lifestyles in
Singapore have much in common with those in the US and that the findings should
apply to Caucasians as well as to the Asians who were tracked."
The UK's Daily
Mail (2/8, Derbyshire) reports that "the findings are published in
the journal Cancer Epidemiology, Biomarkers and Prevention." Reuters
(2/8), the UK's Press
Association (2/8), and the UK's Telegraph
(2/8, Alleyne) also cover the story.
Tanning
Increases Teens' Risk Of Getting Melanoma, Dermatologic Surgeon Explains.
The Pittsburgh
Tribune-Review (3/28) reported, "Tanning, whether outdoors in the
sun or indoors, increases a teen's risk of getting melanoma, a potentially
deadly skin cancer," according to Robin Gehris, MD, chief of pediatric
dermatologic surgery at Children's Hospital of Pittsburgh. "Her advice to
teens is to avoid indoor tanning," which "can lead to burning, which
is riskier for cancer on a teen than on an adult." In any case, tanning,
whether outside on the beach or indoors in a tanning bed, causes skin to wrinkle
and age prematurely, Dr. Gehris explained.
Evidence
Linking ELF-MFs To Brain Tumors Considered Insubstantial.
Reuters
(9/10, Harding) reports that since 1979, scientists have been trying to discern
whether improperly laid power lines or kitchen appliances exacerbated children's
cancer risk. Prior studies have established a flimsy association between
extremely low-frequency magnetic fields (ELF-MFs) and leukemia. Now, a review of
10 studies, which is detailed by University of California-Los Angeles
researchers in the American Journal of Epidemiology, indicates that the link
between ELF-MF and brain tumors is even weaker.
Time spent
watching television may be linked to increased risk of cancer death.
The Wall
Street Journal (1/12, Winslow, subscription required) reports that there
may be a link between the time an individual spends watching television and his
or her risk of death, according to a study
published in the journal Circulation.
Bloomberg
News (1/12, Matsuyama, Saminather) reports that investigators
"tracked the TV-viewing habits of 8,800 adults and followed them for six
years."
The study
findings indicated that "every hour of daily TV watching increased the risk
of dying from any cause by 11 percent," HealthDay
(1/11, Reinberg) reported. The researchers found that "for cardiovascular
diseases the increased risk was 18 percent, and for cancer it was nine
percent."
Exposure
To Chlordecone May Be Associated With Greater Risk Of Prostate Cancer.
MedPage
Today (6/21, Neale)
reported that "exposure to the long-banned organochloride insecticide
chlordecone may be associated with a greater chance of developing prostate
cancer," according to a study
published online in the Journal of Clinical Oncology. Investigators found
that, "among residents of Guadeloupe, those who had the highest plasma
levels of the chemical had 1.77-fold (95% CI 1.21 to 2.58) higher odds of
being diagnosed with prostate cancer." These "findings...were
similar when past exposure to chlordecone was assessed using a combination of
years of residence in the French West Indies and plasma concentration of the
insecticide, which was used in that country for over 30 years."
Study
Suggests Chronic Acetaminophen Use May Increase Risk For Developing Blood
Cancers.
Reuters
(5/9, Joelving) reported that chronic users of painkillers containing
acetaminophen may be at slightly higher risk for developing blood cancers,
according to a study
in the Journal of Clinical Oncology. The researchers followed approximately
65,000 older men and women who had used acetaminophen-containing painkillers
over the past 10 years and did not have cancer. Over an average of six years,
however, 577 participants (slightly less than 1%) developed a blood cancer,
such as lymphoma or myelodysplastic syndrome. When the study team looked at
the acetaminophen use, they found that over 9% of those who developed the
blood cancers had used high amounts of the OTC painkiller chronically.
Coffee May
Reduce Risk Of Oral Cavity, Pharynx Cancers.
The Salt
Lake Tribune (6/23) reports that "coffee may protect drinkers from
cancers of the oral cavity and pharynx," according to a study published
online by the journal Cancer Epidemiology, Biomarkers and Prevention.
The CNN
(6/22, Henry) "Paging Dr. Gupta" blog reported that investigators
"looked at nine existing studies and analyzed how much coffee was consumed
by more than 5,000 cancer patients and about 9,000 healthy people." The
investigators "found that regular coffee drinkers -- those who drank more
than four cups of coffee a day -- had a 39 percent decreased risk of two types
of head and neck cancer: oral cavity and pharynx cancers." However,
"coffee did not decrease the risk of a third type of oral cancer --
laryngeal cancer."
The UK's Press
Association (6/23) reports that, according to lead researcher Dr Mia
Hashibe, "Since coffee is so widely used and there is a relatively high
incidence and low survival rate of these forms of cancers, our results have
important public health implications that need to be further addressed."
The UK's Guardian
(6/23, Jha) reports that the research "adds to the growing body of evidence
on the benefits of caffeinated drinks." Researchers "at Imperial
College London also found that people who drank more than five cups of coffee or
tea a day had a decreased risk of a type of brain tumour called a glioma. And,
last year, Harvard University researchers showed that men who drank coffee had a
60% reduced risk of developing aggressive prostate cancer, compared with men who
drank no coffee." Reuters
(6/23) also covers the story.
Study Finds No
Association Between Living Near Nuclear Plants, Childhood Leukemia Risk.
Reuters
(5/6, Kelland) reported that 35-year study has found no evidence to link living
near nuclear power plants with an increased risk for developing childhood
leukemia. Scientists on the Committee of the Medical Aspects of Radiation in the
Environment (COMARE) said that within 3.1 miles of nuclear power stations from
1969 to 2004, they found only 20 cases of childhood leukemia. And, when they
expanded the nuclear power plant radius out to 15.5 miles, they found only 430
cases of childhood leukemia during the same 35 years.
Survey
Indicates Young Women, Teens Continue To Tan Regardless Of Health Risks.
MedPage
Today (5/2, Fiore) reports, "Despite warnings about melanoma risk,
young women and teens still prefer to tan," according to a survey from the
American Academy of Dermatology. The survey found that, "among almost 4,000
girls ages 14 to 22, the vast majority (81%) said they sunbathe outdoors either
frequently or occasionally." In a statement, Ronald Moy, MD, FAAD, AAD
president, said, "Exposure to UV radiation is the leading risk factor for
skin cancer, yet -- despite this knowledge -- droves of teens and young women
are flocking to tanning bed facilities and beaches or pools to tan every
year."
Analysis
Suggests SSRIs May Increase risk For Breast, Ovarian Cancers.
Bloomberg
News (4/7, Lawrence) reports, "Antidepressants may be linked to a
risk of breast and ovarian cancer." According to a study in the journal
PLoS ONE, the "risk of cancer increased 11 percent on average for patients
taking antidepressants." The researchers analyzed "61 studies and
found 20 that identified a link. The connection was stronger" in cases of
selective serotonin reuptake inhibitors (SSRIs). Of 16 studies that looked at
SSRIs, "15 detected a higher chance of cancer. ... 'The findings point to a
need for more research on SSRI use in women and the link to cancer,'" said
lead study author Lisa Cosgrove, a "research lab fellow at Harvard's Edmond
J. Safra Center for Ethics in Cambridge."
Cured meats associated with
increased risk for childhood acute leukemia
This article reports on a BMC
Cancer study finding that Taiwanese children
and teenagers who ate cured meats and fish
more than once a week had a 74 percent
higher risk of developing acute leukemia
than children and
teens who rarely ate those
foods and consumed more vegetable and soy
products. The article notes that cured meats
contain nitrites, precursors to nitrosamines,
which can trigger
tumor growth , while vegetables and
soy contain antioxidants that neutralize
these compounds. The article also
notes that further research is needed to
confirm the preliminary findings.Article: Reuters
Exposure
to nighttime artificial light may increase
prostate cancer risk: The Washington
Post (February 17)
This
article reports on a Chronobiology
International study suggesting that exposure
to artificial light at night may increase a
man's prostate cancer risk. The
article notes that the study analyzed
satellite measurements of nighttime light
emissions and cancer rates in 164 countries,
finding that nations that emit the most
light at night are more likely to have the
highest prostate cancer rates. The
article explains that the Unites States,
which has among the highest nighttime light
emissions, has a prostate cancer rate of
about 125 cases per 100,000, compared with
about 67 per 100,000 among countries with
the lowest nighttime light emissions.
Article: The
Washington Post
Preliminary
Findings Suggest Daily Consumption Of More Than One Alcohol Drink Raises
Cancer Risk.
BBC
News (4/7) reported that "one-in-10 of all cancers in men and
one-in-33 of all cancers in women are caused by past or current alcohol
intake," according to a study in the British Medical Journal. The
researchers found that individuals who drank "more than two standard
drinks a day for men and one drink a day for women were particularly at risk
of alcohol-related cancers." Essentially, alcohol-related cancers which
were "one-in-three in men and one-in-20 in women are caused by any
excessive drinking." The study authors calculated that in 2008,
"current and past drinking habits were responsible for about 13,000 cases
of alcohol-related cancer in the UK, out of a total of 304,000 cancer
cases." The results were gathered as part of a large study following
"363,988 men and women in eight European countries."
According to
Reuters
(4/8, Kelland), the study authors defined a standard drink as one containing
approximately 12 grams of alcohol. This equates to a 125-ml glass of wine or
about half of a pint of beer.
Heavy Beer
Drinkers With ADH1 Gene Variant May Have Increased Risk Of Gastric Cancer.
Medscape
(4/15, Nelson, Subscription Publication) reported that a "genetic variant
might predispose heavy beer drinkers to a higher risk for gastric
cancer," according to findings presented at the American Association for
Cancer Research meeting. The researchers found that drinking "30 g of
pure ethanol/alcohol or more a day derived from beer was associated with a 75%
increased risk for gastric cancer." Notably, when they looked at
interactions between the alcohol dehydrogenase gene cluster (ADH1) "locus
SNPs and baseline alcohol consumption, the authors noted a statistically
significant interaction between rs1230025 and beer consumption." The
presence of "SNP rs230025 was associated with a 30% increased risk for
gastric cancer."
Daily Alcohol
Drinking May Increase Risk For Certain Cancers.
The Los
Angeles Times (4/11, Cevallos) "Booster Shots" blog reports
that cancer risk "increases with every extra daily drink," according
to a study
in the British Medical Journal. The analysis of "364,000 people in eight
countries," found that "44% of cancers of the upper aerodigestive
tract" in men and 25% in women "might be linked to alcohol";
liver cancer "(33% in men, 18% in women)"; colorectal cancer
"(17% in men, 4% in women)"; and about 5% of "breast cancers in
women." The American Cancer Society agrees that alcohol "raises the
risk of cancer in the mouth, throat, voice box and esophagus." Alcohol may
act as a "solvent," to tissue lining, "allowing harmful chemicals
through (especially tobacco from smoking)," ACS explained. Alcohol may also
raise drinkers' cirrhosis risk by "further damaging liver cells"; and
it may "change estrogen levels," increasing breast cancer risk.
US, Canadian
Officials To Analyze Herbicide's Potential Link To Infertility, Cancer.
Reuters
(4/8, Gillam) reported that Although for over 30 years, glyphosate -- an
essential ingredient in Roundup herbicide -- has been promoted a safe element in
global food production, critics say it could cause infertility or cancer. Now,
amid increased pressure from environmentalists, consumer groups and scientists,
the Environmental Protection Agency is conducted an examination and has set a
2015 deadline for determining if glyphosate should continue to be sold as is,
limited, or banned. The EPA is working with Canadian regulators to assess the
herbicide's safety, Meanwhile, there are several pending lawsuits about the
product's health effects.
Research Links
Night Shift To More Than 500 Annual Breast Cancer Deaths In UK.
The UK's Telegraph
(6/20, Adams) reports, "More than 500 women die every year in Britain of
breast cancer brought on by working nights, according to a study" published
in the British Journal of Cancer. Researchers "estimated that around 1,960
breast cancer cases -- or roughly one in 20 -- can be attributed to night shift
work every year." Approximately "550 deaths a year from the disease
can be attributed to shift work, they found."
Link between
cell-phone use, cancer.
NBC Nightly News (9/14, story 6, 2:30, Williams)
reported that people often "worry about whether or not" cell phones
are "safe. It was a concern that led to some sharp questioning on Capitol
Hill in Washington" on Monday. NBC's Bazell added, "Senator Arlen
Specter (D-PA), who has survived two bouts of lymphoma, requested the hearing,
asking whether cell phones might cause cancer." One scientist at the
hearing, "from the cell phone industry...said huge numbers of studies found
no link between cell phone use and cancer." However, "an Israeli
physician, Dr. Siegal Sadetzki, said one study showed preliminary evidence there
might be some risk after ten years of use."
The panel told
the Senate appropriations subcommittee on Labor, Health and Human Services that
"more research is needed to determine whether cell phone radiation is
harmful to humans, especially children," USA
Today (9/15, Cauley) reports. "One thing most panelists agreed on:
Children, because of their thinner skulls, are far more susceptible to radiation
than adults."
Still, the
FDA, on its website, says, "The weight of scientific evidence has not
linked cell phones with any health problems," ABC
News (9/15, De Nies) points out. Likewise, ABC senior health and medical
editor Dr. Richard Besser said, "The best science doesn't show a link
between cell phone use and cancer of any kind. No link whatsoever."
The Pittsburgh
Post-Gazette (9/14) explained that the hearing Monday "was held to
examine whether to provide additional funding to the National Institutes of
Health to study cell phone use as it relates to cancer." Currently, NIH
"is conducting a $24 million study in which mice are exposed to cell-phone
radiation over a period of several years. Results are not due until 2014,
according to testimony from John R. Bucher, associate director of the national
toxicology program for the National Institute of Environmental Health Sciences,
which is part of NIH."
Dr. Bucher
said, "Children have a configuration of their skull that does allow
penetration of cell-phone radiation," CNN
(9/15) reports, but notes, "Bucher stopped short of declaring a causal link
between cell-phone use and human cancer."
Sen. Tom
Harkin (D-IA) -- the new chairman of the Senate Health, Education, Labor, and
Pensions Committee and chairman of the Appropriations Committee's Subcommittee
on Labor, Health and Human Services, and Education -- vowed to continue
investigating a possible link in the HELP committee and with the NIH, according
to Reuters
(9/15, Fox). CBS
News /CNET (9/15, Reardon), and the Dow
Jones Newswire (9/15, Johnson) also cover the story.
Data
Increasingly Confirm Link Between Environmental Exposure, Cancer.
The Forbes
(3/10, Tobias) "Green Conversations" blog notes that a "2009
report by the President's Cancer Panel warns of growing evidence linking
environmental exposures to cancer, recognizing that these risks may be
prevented." Notably, there are "more than 100,000 chemicals in
commercial use," including pesticides; and more data are "emerging
pointing to exposures in humans at younger ages than previously thought."
Such chemicals may even be in the "foods we consume," a point
highlighted in a study by the Department of Health and Human Services, which
"cites two 'linked' reasons why people may get cancer: 'an increasingly
toxic landscape in which we live, both indoors and outdoors, contaminated by
potentially carcinogenic or endocrine-disrupting chemicals and the food we
choose to eat.'" Conversely, according to an "important publication
from the NIH," in the US, "only 41% (of the human population) ever get
cancer."
Experts
Contemplate Cancer Risk From Airport Scans.
MedPage
Today (3/19, Fiore) reported that although "individual cancer risk
from airport x-ray machines is probably small, the large number of Americans
passing through these backscatter x-ray devices every year could result in a
slightly increased population risk." And that could "raise concerns
'about the long-term consequences of an extremely large number of people all
being exposed to a small radiation-induced cancer risk,'" especially
considering that there will be about one billion "passenger scans in the US
alone this year," wrote David Brenner, PhD, DSc, of the Center for
Radiological Research at Columbia University Medical Center in New York. Dr.
Brenner and National Council on Radiation Protection and Measurements Director
David Schauer, ScD, CHP, offered their views on airport scans in this month's
issue of the journal Radiology.
Cancer Risk
From Airport Scanners Very Low, Study Finds.
Bloomberg
News (3/29, Ostrow) reports, "Airport body scanners pose little
radiation risk to travelers, emitting less than 1 percent of the dose a person
would get from cosmic rays while flying at high altitudes," according to an
online-first study
in the Archives of Internal Medicine. The American College of Radiology's Safety
Committee Chair Dr. Richard Morin "said radiation isn't well understood.
'The levels we're talking about are lower than actual background
radiation,'" said Morin, who wasn't involved in the study.
According to
the Boston
Globe (3/28, Kotz) "Daily Dose" blog, the study "equated
the small dose of radiation delivered by the scanner with other radiation doses
from medical devices and our environment." For example, "every time
you fly, you get some extra radiation due to your closer proximity to the sun.
'The backscatter X-ray scans deliver radiation equivalent to around 1 to 3
minutes of flight time,'" wrote the study authors from the University of
California. Their research revealed that "50 airport scans equals the
amount from a single dental X-ray, 1000 scans is equivalent to a chest X-ray,
4000 scans equals a mammogram, and 200,000 scans equals the amount in a single
abdominal computed tomography scan."
Medscape
(4/5, Nelson, Subscription Publication) reported that metabolic syndrome is a
"known risk factor for diabetes and heart disease," but according to
data presented at the American Association for Cancer Research meeting, "it
might also place individuals at higher risk for the development of liver
cancer." The researchers used the Surveillance, Epidemiology, and End
Results Program (SEER) Medicare-linked database to identify "3,649
hepatocellular carcinoma cases and 743 intrahepatic cholangiocarcinoma
cases" and 195,953 individuals "without cancer." They found that
"37.1% of patients with hepatocellular carcinoma and 29.7% with
intrahepatic carcinoma had preexisting metabolic syndrome." In contrast,
only "17.1% of individuals without cancer had metabolic syndrome."
Centre for
Public interest Urges Ban On Caramel Coloring In Soft Drinks Due To Alleged
Cancer Risk.
"In a letter to the US Food and Drug
Administration, the consumer watchdog group Center for Science in the Public
Interest [CSPI] called on officials to ban the use of caramel coloring in
popular soft drinks, citing a possible cancer risk." CSPI "first
petitioned the FDA on the matter in 2011, noting that 2-methylimidazole and
4-methylimidazole, which form when sugar is mixed with ammonia and sulfites to
create caramel coloring, had been shown to cause lung, liver and thyroid cancer
in mice and rats." The group's executive director Michael F. Jacobson,
"in a letter written Monday to FDA Commissioner Dr. Margaret
Hamburg...described recent lab analyses that showed 4-methylimidazole, or 4-MI,
levels in 12-ounce servings of soda that exceeded the 29 microgram limit
recommended by the state of California by nearly five times."
Bloomberg
News (3/6, Armour) reports, however, that an individual "would have
to drink more than a thousand cans of soda in a day to match the doses
administered in studies that showed links to cancer in rodents, Douglas Karas, a
US Food and Drug Administration spokesman, said in a statement." The agency
"has no reason to believe consumers are in danger, the FDA's Karas wrote in
an e-mail. The agency is reviewing the group's petition, he said." Also
covering the story are Reuters
(3/6, Yukhananov) and WebMD
(3/6, DeNoon).
Just One
Alcoholic Drink Daily May Increase Breast Cancer By About 5 Percent.
HealthDay
(3/29, Doheny) reports, "Just one alcoholic drink a day can boost a
woman's risk of breast cancer by about 5 percent, according to a new
review" published in the journal Alcohol and Alcoholism. The researchers
found that "heavier drinking -- three or more drinks a day -- can
increase risk up to 50 percent."
The UK's Telegraph
(3/29, Smith) reports, "Lead author Prof Helmut Seitz wrote: 'Since there
is no threshold level of ethanol for breast cancer risk, the breast is one of
the most sensitive organs for the carcinogenic action of alcohol. Healthy
women should not exceed one drink a day (equivalent to 10–12g of
ethanol).'"
Tanning Bed
Use May Be Associated With Skin Cancer.
Reuters
(3/8, Norton) reports that women who frequent tanning parlors may be more likely
to develop squamous cell carcinoma, melanoma, and, in particular, basal cell
carcinoma, according to a study
published online Feb. 27 in the Journal of Clinical Oncology. The study of some
730,000 nurses tracked for two decades found that those who used sunbeds four
times a year or more in late adolescence through age 35 had a 15% increased
likelihood of getting basal cell carcinoma. The association was greater for
women who used tanning beds more often at younger ages. For example, sunbed use
more than seven times yearly starting during high school or university was
associated with a 73% increased likelihood of developing basal cell carcinoma.
Coke, Pepsi
Change Their Practices In Response to California Law.
The AP
(3/9) reports that "Coca-Cola Co. and PepsiCo Inc. are changing the way
they make the caramel coloring used in their sodas as a result of a California
law that mandates drinks containing a certain level of carcinogens come with a
cancer warning label." The AP mentions that "the Center for Science in
the Public Interest, a consumer advocacy group, in February filed a petition
with the Food and Drug Administration to ban the use of ammonia-sulfite caramel
coloring." The San
Francisco Chronicle (3/9, Shellnutt) also covers this story in its
"Hot Topics" blog.
IVF At A
Younger Age May Be Linked To Increased Breast Cancer Risk.
Reuters
(6/23, Seaman) reported that, according to a study
published online in Fertility and Sterility, undergoing in vitro fertilization (IVF)
at a younger age may be linked to an increased risk of breast cancer, compared
to individuals who never undergo IVF. The researchers arrived at this conclusion
after analyzing data on more than 21,000 women.
Microbe
Fusobacterium Nucleatum May Be Implicated In Colon Cancer.
Medscape
(6/22, Cassels) reports, "Using cutting-edge metagenomics techniques to
explore the pathogens present in colorectal cancer, two research teams working
independently have uncovered a totally unexpected suspect." The researchers
found that "the microbe Fusobacterium nucleatum, which is associated with
inflammatory and infectious diseases, including periodontal disease,
appendicitis, pericarditis, and brain abscesses, might be implicated in colon
cancer." Both "studies were published in Genome Research." The
studies are available here
and here.
FDA Declares
End Of BPA In Baby Bottles, Children's Drinking Cups.
Coverage of the Food and Drug Administration's action
confirming that manufacturers no longer use BPA in baby bottles or children's
drinking cups was widespread and focused on the FDA action, though sources also
noted that the action was taken in response to a request from the American
Chemistry Council. Most sources also explained that the FDA continues to support
the safety of using BPA in food containers. Many cited studies indicating
possible dangers from BPA and the requests for a complete ban on its use in food
containers by the National Resources Defense Council and a few Members of
Congress.
The New
York Times (7/18, A15, Tavernise, Subscription Publication) reports,
"The Food and Drug Administration said Tuesday that baby bottles and
children's drinking cups could no longer contain bisphenol A, or BPA." It
notes that "manufacturers have already stopped using the chemical in baby
bottles and sippy cups, and the F.D.A. said that its decision was a response to
a request by the American Chemistry Council, the chemical industry's main trade
association, that rules allowing BPA in those products be phased out, in part to
boost consumer confidence." FDA spokesman Steven Immergut said that
"the decision did not amount to a reversal of the agency's position on the
chemical," which it declared "safe in 2008, but began expressing
concerns about possible health risks in 2010."
The Wall
Street Journal (7/18, Tomson, Subscription Publication) reports that the
American Chemistry Council explained that it had requested the statement in
order to eliminate "confusion about whether baby bottles and sippy cups
sold in the United States contain BPA." The story notes that the FDA had
rejected an effort by the National Resources Defense Council to end BPA's use in
food containers, and that the American Medical Association has labeled BPA an
"endocrine-disrupting agent" and called for labeling "BPA-containing
products with the potential for human exposure."
The Washington
Post (7/18, Elboghdady) reports that the American Chemistry Council
"said consumer preferences had long ago forced manufacturers to abandon
BPA's use in baby bottles and sippy cups in the United States." The request
was based "solely on a provision that allows anyone to petition for changes
to food additive rules if they can demonstrate that a particular use of the
additive has been abandoned."
The Boston
Globe (7/18, Calvan) reports, "Some consumer health groups
chastised the FDA for moving slowly on the ban."
USA
Today (7/18, Koch) reports, "About a dozen US states, including
California, have banned BPA from children's products. So, too, have Canada, the
European Union and China." FDA spokeswoman Shelly Burgess said, "We
continue to support the safety of BPA for use in products that hold food."
The story says that BPA "has been linked in studies to cancer, birth
defects and reproductive problems."
The AP
(7/18) reports that "the American Chemistry Council, had asked the Food and
Drug Administration to phase out rules allowing BPA in those products in
October, after determining that all manufacturers of bottles and sippy cups had
already abandoned the chemical due to safety concerns." FDA spokesman Allen
Curtis said, "Consumers can be confident that these products do not contain
BPA."
The New
York Daily News (7/18, Boyle) reports, "Studies found contact with
the chemical led to impaired reproductive and nervous systems in rodents, and
the Food and Drug Administration is currently spending $30 million to determine
its effect on humans."
Bloomberg
News (7/18, Flinn) reports, "BPA has been linked to male
infertility, diabetes and cancer. A study in October said exposure in the womb
may cause behavior and emotional problems in young girls."
Older Women
With Diabetes May Have Higher Risk Of Breast Cancer.
BBC
News (9/14) reports, "Post-menopausal women who have Type 2
diabetes appear to have a" higher "risk of developing breast
cancer," according to research published in the British Journal of Cancer.
Investigators looked at data from 40 studies. The researchers found that
"post-menopausal women with Type 2 diabetes had a 27% increased risk of
breast cancer." However, "there was no link for pre-menopausal women
or those with Type 1 diabetes."
Higher
Fruit, Vegetable Consumption Linked To Lower Risk For Estrogen
Receptor-Negative Breast Cancer.
HealthDay
(1/26) reports, "Eating plenty of fruits and vegetables may lower women's
risk for a tough-to-treat form of breast cancer, but it does not reduce their
odds of getting breast cancer overall," according to a study published in
the Journal of the National Cancer Institute. Investigators "analyzed
data from 20 prior studies of women who were followed for a maximum of 11 to
20 years." The researchers "found a statistically significant link
between higher fruit and vegetable consumption and a lower risk for estrogen
receptor-negative breast cancer, but not with a lower risk of estrogen
receptor-positive breast cancers (those that do respond to estrogen) or for
breast cancer overall."
PREVENTATIVE
INTERVENTIONS
Metformin
Use Reduces All-Cause and Prostate Cancer-Specific Mortality in Men With
Diabetes
In a study reported in Journal of Clinical Oncology, David
Margel, MD, PhD, of University of Toronto and colleagues examined the
effect of duration of antidiabetic medication exposure after prostate cancer
diagnosis on all-cause and prostate cancer-specific mortality in men with
diabetes. They found that increased duration of metformin use was associated
with significantly reduced risk of prostate cancer-specific and all-cause
mortality.
Omega-3 polyunsaturated fatty
acids selectively inhibit growth in neoplastic oral keratinocytes by
differentially activating ERK1/2
Carcinogenesis
(2013) doi: 10.1093/carcin/bgt257
First
published online: July 26, 2013
Abstract
The long chain omega-3 polyunsaturated fatty acids (n-3 PUFAs),
eicosapentaenoic acid (EPA) and its metabolite docosahexaenoic acid (DHA),
inhibit cancer formation in vivo but their mechanism of action is
unclear. ERK1/2 activation and inhibition have both been associated with the
induction of tumor cell apoptosis by n-3 PUFAs. We show here that low doses
of EPA, in particular, inhibited the growth of pre-malignant and malignant
keratinocytes more than their normal counterparts by a combination of cell
cycle arrest and apoptosis. The growth inhibition of the oral squamous cell
carcinoma (SCC) lines but not normal keratinocytes, by both n-3 PUFAs was
associated with epidermal growth factor receptor (EGFR) autophosphorylation,
a sustained phosphorylation of ERK1/2 and its downstream target p90RSK but
not with phosphorylation of the PI3 kinase target Akt. Inhibition of EGFR
with either the EGFR kinase inhibitor AG1478, or an EGFR blocking antibody,
inhibited ERK1/2 phosphorylation and the blocking antibody partially
antagonized growth inhibition by EPA, but not by DHA. DHA generated more
reactive oxygen species and activated more JNK than EPA, potentially
explaining its increased toxicity to normal keratinocytes. Our results show
that, in part, EPA specifically inhibits SCC growth and development by
creating a sustained signaling imbalance to amplify the EGFR/ERK/p90RSK
pathway in neoplastic keratinocytes to a supra-optimal level, supporting the
chemopreventative potential of EPA, whose toxicity to normal cells might be
reduced further by blocking its metabolism to DHA. Furthermore, ERK1/2
phosphorylation may have potential as a biomarker of n-3 PUFA function in
vivo.
Drinking
Coffee May Significantly Reduce Risk Of Dying From Mouth Cancer.
HealthDay
(12/12, Dallas) reports that a new study from the American Cancer Society found
that "people who drink more than four cups of caffeinated coffee daily
could significantly reduce their risk of death from certain forms of
cancer." According to the article, the researchers wrote in the study,
which was published online Dec. 9 in the American Journal of Epidemiology, that
"habitual coffee drinkers had about half the risk of dying from cancers of
the mouth and pharynx (part of the throat) than others who never drank coffee or
only had it occasionally." HealthDay details that "in conducting the
study, the researchers analyzed data on almost a million people from an American
Cancer Society study on cancer prevention that began in 1982."
The Daily
Mail (UK) (12/12, Hagan) reports that "the latest findings, by a
team of researchers from the American Cancer Society in Atlanta, Georgia,
suggest it may not be caffeine that protects against the formation of malignant
growths in and around the mouth." The article adds, "instead, they
said, it's likely to be due to some of the hundreds of other naturally-occurring
antioxidant chemicals found in coffee." The researchers wrote, "coffee
contains multiple biologically active compounds that may help to lower the risk
of developing and dying from cancer."
High
Consumption Of Vegetable Fats May Lower Risk Of Prostate Cancer Spread.
Reuters
(6/11, Pittman) reports that, according to research published online in JAMA
Internal Medicine, men with prostate cancer who consume diets with high
amount of vegetable fats may have a lower risk of their disease spreading.
The NPR
(6/11, Aubrey) “The Salt” blog reports that investigators “studied the
fat intake of more than 4,500 men who had been diagnosed with non-metastatic
prostate cancer.”
Bloomberg
News (6/11, Cortez) reports that the researchers found that men who
consumed “an additional serving of oil-based dressing each day were 29
percent less likely to die from prostate cancer, with a 13 percent lower
risk of dying from any causes.” Meanwhile, the researchers found that “a
daily serving of nuts cut prostate cancer death by 18 percent and death from
any cause by 11 percent.”
Also
covering the story are MedPage
Today (6/11, Bankhead), HealthDay
(6/11, Mann), and Medscape
(6/11, Mulcahy).
Moderate
Drinking Before Breast Cancer Diagnosis May Be Linked To Better Survival.
MedPage
Today (4/13, Petrochko) reported, "Women who were moderate drinkers
before being diagnosed with breast cancer appear to have a slight survival
edge," according to a study published online in the Journal of Clinical
Oncology. Investigators found that, "compared with nondrinking controls,
women who consumed three to six drinks weekly had a significant protective
effect on breast cancer survival (HR 0.85, 95% CI 0.75 to 0.95)." The
researchers also found that "post-diagnosis drinking did not affect
disease-related survival, though modest alcohol consumption both before and
after diagnosis was associated with improved cardiovascular and overall
survival outcomes."
Three
Studies Suggest Statins May Play Role In Cancer Treatment.
MedPage
Today (4/13, Smith) reported that "three studies presented...this
week at the annual meeting of the American Association for Cancer Research
suggest – at a casual glance – that" statins may be able to
"play a role in cancer treatment." In one of the studies,
"investigators led by Katherine McGlynn, PhD, of the National Cancer
Institute in Bethesda, Md., used data from a large health maintenance
organization to compare 75 liver cancer patients with 373 matched controls. In
a univariate analysis, statin use was associated with a statistically
significant 40% reduction in the risk of liver cancer." The two other
studies involved patients with breast cancer and ovarian cancer, respectively.
Aspirin Use
May Reduce Melanoma Risk.
CNN
(3/11, Landau) in its "The Chart" blog reports that in a study of
"nearly 60,000 women," ages 50 to 79, Stanford University
researchers found that on average, individuals who took aspirin frequently had
a "21% lower risk of melanoma" than did their peers who did not take
aspirin at all . Although this correlation "is not proof" that
aspirin "is directly responsible for lowering the risk," the study
authors "believe inflammation plays a big role in cancer development, and
aspirin is an anti-inflammatory drug." Moreover, there are previous
studies that also "support the idea that in certain kinds of cancers,
aspirin may be preventative." The blog did not indicate which medical
journal published the study.
Fish Oil
Supplements May Help Prevent Skin Cancer.
The Daily
Telegraph (UK) (2/26, Adams, 871K) reports, "Regularly taking fish
oil supplements could help protect against skin cancer, according to a study
that suggests omega-3 fats help boost the immune system." Investigators
"found that volunteers given omega-3 supplements were better able to ward
off the potential harmful effects of sunshine, than those given a dummy
pill." The researchers "emphasised their study was by no means
conclusive proof of a protective effect, but said it 'adds to the evidence
that omega-3 is a potential nutrient to protect against skin cancer.'"
The findings were published in the American Journal of Clinical Nutrition.
Oral
Bisphosphonates May Be Linked To Reduced Colorectal Cancer Risk.
MedPage
Today (1/25, Bankhead) reported that "postmenopausal women taking
oral bisphosphonates for osteoporosis had almost a 50% reduction in the risk
of colorectal cancer, according to data from a large cohort study"
presented at the Gastrointestinal Cancers Symposium. Investigators reported
that "the case-control study, conducted among over 1,800 Israeli women,
found that the magnitude of the risk reduction increased with length of time
women were on antiresorptive therapy - topping out at almost 80% with more
than three years of bisphosphonate use." These "findings add to the
growing evidence of a chemopreventive potential for bisphosphonates. The same
group previously reported a reduction in the risk of breast cancer among women
taking the bone-friendly drugs."
Prospective cohort study of tea
consumption and risk of digestive system cancers: results from the Shanghai
Women's Health Study1,2,3
- Sarah
Nechuta,
Author Affiliations
-
1From the Division of Epidemiology, Department of Medicine,
Vanderbilt University School of Medicine, Nashville, TN (SN, X-OS, GY,
HC, and WZ); the Department of Epidemiology, Shanghai Cancer
Institute, Shanghai, China (H-LL, Y-BX, and Y-TG); and the Division of
Cancer Epidemiology and Genetics, National Cancer Institute,
Rockville, MD (B-TJ and W-HC).
+ Author
Notes
-
↵2
Supported by the National Cancer Institute (grant number R37 CA70867).
-
↵3
Address correspondence to W Zheng, Vanderbilt Epidemiology Center and
Vanderbilt-Ingram Cancer Center, Vanderbilt University School of
Medicine, Eighth Floor, Suite 800, 2525 West End Avenue, Nashville, TN
37203-1738. E-mail: wei.zheng@vanderbilt.edu.
AbstractFirst published October
10, 2012, doi: 10.3945/ajcn.111.031419 Am
J Clin Nutr
November 2012 vol. 96 no.
5 1056-1063
Background: Data from in vitro and animal
studies support a protective role for tea in the etiology of digestive
system cancers; however, results from prospective cohort studies have been
inconsistent. In addition, to our knowledge, no study has investigated the
association of tea consumption with the incidence of all digestive system
cancers in Chinese women.
Objective: We investigated the association of
regular tea intake (≥3 times/wk for >6 mo) with risk of digestive
system cancers.
Design: We used the Shanghai Women's Health
Study, a population-based prospective cohort study of middle-aged and older
Chinese women who were recruited in 1996–2000. Adjusted HRs and associated
95% CIs were derived from Cox regression models.
Results: After a mean follow-up of 11 y, 1255
digestive system cancers occurred (stomach, esophagus, colorectal, liver,
pancreas, and gallbladder/bile duct cancers) in 69,310 nonsmoking and
non–alcohol-drinking women. In comparison with women who never drank tea,
regular tea intake (mostly green tea) was associated with reduced risk of
all digestive system cancers combined (HR: 0.86; 95% CI: 0.74, 0.98), and
the reduction in risk increased as the amount and years of tea consumption
increased (P-trend = 0.01 and P-trend < 0.01,
respectively). For example, women who consumed ≥150 g tea/mo
(∼2–3 cups/d) had a 21% reduced risk of digestive system cancers
combined (HR: 0.79; 95% CI: 0.63, 0.99). The inverse association was found
primarily for colorectal and stomach/esophageal cancers.
Conclusion: In this large prospective cohort
study, tea consumption was associated with reduced risk of colorectal and
stomach/esophageal cancers in Chinese women
Higher Levels
Of Carotenoids May Be Linked To Lower Breast Cancer Risk.
WebMD
(12/4, Boyles) reports, "A new study suggests that women with higher levels
of carotenoids (nutrients found in fruits and vegetables) have a lower risk of
breast cancer - especially cancers that are harder to treat and have a poorer
prognosis."
HealthDay
(12/7, Preidt) reports that investigators "analyzed data from thousands of
women who took part in eight previous studies on carotenoid levels and breast
cancer." The researchers "found a statistically significant
association between higher levels of carotenoids and reduced breast cancer risk,
especially so-called ER-negative breast cancers - tumors that aren't reliant on
estrogen to fuel their growth." These "findings highlight carotenoid
levels as one of the first modifiable risk factors to be identified for
ER-negative breast cancers, the team said." The research was published in
the Journal of the National Cancer Institute.
Critical role for reactive oxygen species
in apoptosis induction and cell migration inhibition by diallyl trisulfide, a
cancer chemopreventive component of garlic breast Cancer research and
Treatments 2013 vol 138 issue 1 pp 69-79
Diallyl trisulfide (DATS) is a structurally simple but
biologically active constituent of processed garlic with in vivo activity
against chemically induced as well as oncogene-driven cancer in experimental
rodents. This study offers novel insights into the mechanisms underlying
anticancer effects of DATS using human breast cancer cells as a model. Exposure
of human breast cancer cells (MCF-7 and MDA-MB-231) and a cell line derived from
spontaneously developing mammary tumor of a transgenic mouse (BRI-JM04) to DATS
resulted in a dose-dependent inhibition of cell viability that was accompanied
by apoptosis induction. A non-tumorigenic normal human mammary cell line
(MCF-10A) was resistant to growth inhibition and apoptosis induction by DATS.
The DATS-induced apoptosis in MDA-MB-231, MCF-7, and BRI-JM04 cells was
associated with reactive oxygen species (ROS) production as evidenced by
fluorescence microscopy and flow cytometry using a chemical probe (MitoSOX Red).
Overexpression of Cu,Zn-superoxide dismutase (Cu,Zn-SOD) as well as Mn-SOD
conferred significant protection against DATS-induced ROS production and
apoptotic cell death in MDA-MB-231 and MCF-7 cells. Activation of Bak, but not
Bax, resulting from DATS treatment was markedly suppressed by overexpression of
Mn-SOD. The DATS treatment caused ROS generation, but not activation of Bax or
Bak, in MCF-10A cells. Furthermore, the DATS-mediated inhibition of cell
migration was partially but significantly attenuated by Cu,Zn-SOD and Mn-SOD
overexpression in association with changes in levels of proteins involved in
epithelial–mesenchymal transition. The DATS-mediated induction of heme
oxygenase-1 was partially attenuated by overexpression of Mn-SOD. These results
provide novel mechanistic insights indicating a critical role for ROS in
anticancer effects of DATS.
Long-Term
Use Of Low-Dose Aspirin Linked To Lower Colon Cancer Risk In Women.
Reuters
(7/16, Seaman) reports that, according to a study published in the Annals of
Internal Medicine, long-term use of low-dose aspirin may be linked to a
lower risk of colon cancer in women.
NBC
News (7/16, Carroll) reports on its website, “The new report, based on
data from the Women’s Health Study, followed more than 30,000 women, half
of whom were randomized to take aspirin every other day, while the other
half received placebo treatments.”
On its
website, CBS
News (7/16, Castillo) reports that “after the study, researchers
followed 33,682 participants through March 2012.” The investigators found
that, “after 18 years, women in the aspirin group had a 20 percent lower
colon cancer rate than those who were taking the placebo.” Participants
“who continued to take aspirin on their own after the end of the trial had
the lowest risk for colon cancer.”
The CNN
(7/16) “The Chart” blog reports, however, that “women taking aspirin
were more likely to develop gastrointestinal bleeding and peptic ulcers.”
Meanwhile, the data did not indicate that there were “any cardiovascular
benefit to taking aspirin every other day, contrary to the preventative
properties of aspirin against heart attack and stroke that have been found
in many other studies.” Also covering the story are HealthDay
(7/16, Doheny) and MedPage
Today (7/16, Smith).
Wine May
Help Breast Cancer Patients Boost Their Chances Of Survival.
The Daily
Telegraph (UK) (11/7, Adams) reports that "those who drink a
medium-sized (175ml) glass a day cut their chance of dying within a decade of
[a breast cancer] diagnosis by a fifth - from 20 to 16 per cent, say Cambridge
University doctors." Furthermore, the researchers found that drinking
even half of that amount reduced the chance to 18%. The article adds, "Dr
Paul Pharoah, from the university's department of public health and primary
care, told The Times that their findings suggested women should not deny
themselves the odd drink." Pharoah remarked, "What our study says is
that it is reasonable, if you are diagnosed with breast cancer, to enjoy the
occasional drink of alcohol."
Dr Pharoah was speaking at the National Cancer Research Institute (NCRI)
Cancer Conference in Liverpool, where he was presenting results from a study
conducted with the South Egypt Cancer Institute.
They looked at 13,525 women who had been diagnosed and treated for breast
cancer, who they followed for up to 15 years.
Those who drank seven units a week cut the chance of dying from breast cancer
in a decade from 20 to 18 per cent, and those who drank 14 units weekly reduced
the chance to 16 per cent.
The study did not look at how drinking more than 14 units a week might affect
a women’s chances of survival.
The study found there was a “slightly stronger” benefit for those women
with oestrogen-receptor negative breast cancers. These tend to be more
aggressive but only affect a minority of patients.
The benefit was a little weaker among women with oestrogen-receptor positive
breast cancers, which account for about three-quarters of cases.
Researchers also looked at the link between weight - or more precisely body
mass index (BMI) - and survival.
They found fatter women had slightly poorer survival rates than those who
were thinner.
They warned that women who did opt to drink a little to combat their cancer
should watch their weight as well
High Flavonoid
Consumption May Benefit Patients Diagnosed With Prostate Cancer.
HealthDay
(10/18, Mozes) reports, "Prostate cancer patients who, before their
diagnosis, routinely consumed hefty helpings of the flavonoid compounds found in
plant-based foods and drinks may be at lower risk for the most aggressive form
of the disease," according to a study that was scheduled to be presented at
the annual cancer prevention meeting of the American Association for Cancer
Research. The research, "involving about 1,900 patients newly diagnosed
with prostate cancer, found that those whose diets included the highest amount
of flavonoids were 25 percent less likely to have been diagnosed with the
fastest-moving and harshest form of the disease compared to those who had been
taking in the fewest flavonoids."
Metformin and reduced risk of hepatocellular
carcinoma in diabetic patients: a meta-analysis; Zhang
H, Gao C, Fang L, Zhao HC, Yao SK; Scandinavian Journal of Gastroenterology
(Nov 2012): Scand
J Gastroenterol
Abstract Objectives. Recent epidemiological studies suggest that metformin
treatment may reduce the risks of cancer and overall cancer mortality among
patients with diabetes mellitus (DM). However, data on hepatocellular carcinoma
(HCC) are very limited and inconsistent. This meta-analysis was designed to pool
data currently available to determine the association between metformin use and
HCC among diabetic patients. Methods. The Medline and Embase databases were
searched to identify the relevant studies between January 1966 and December
2011. The overall analysis was derived using a random-effects meta-analysis
model (DerSimonian and Laird method). Subgroup analysis was performed to explore
the source of heterogeneity and validate the results from overall analysis. The
Newcastle-Ottawa Quality assessment scales were adopted for quality assessment;
Begg's funnel plot and Egger's regression asymmetry test were used to detect the
publication bias. Results. A total of seven studies were identified, including
three cohort studies and four case-control studies. Based on the available data,
the overall prevalence of HCC was 3.40% (562/16,549) in DM patients. The overall
analysis showed a significantly reduced risk of HCC in metformin users versus
nonusers in diabetic patients (relative risk (RR) 0.24, 95% confidence interval
(CI) 0.13-0.46, p<0.001). Fifteen subgroup analyses were performed, and most
of them (12/15 = 80%) provided supporting evidence for the results of overall
analysis. Begg's (Z = -0.15, p = 0.8819) and Egger's test (t = -0.79, p = 0.468)
showed no significant risk of having a publication bias. Conclusion. Metformin
treatment was associated with reduced risk of HCC in diabetic patients. To
clarify this relationship, more high-quality studies are required.
Aspirin’s
Ability To Prevent Colon Cancer May Be Driven By Gene Mutation.
Bloomberg
News (6/26, Ostrow) reports that research
(6/26, 250K) published in the Journal of the American Medical Association
suggests that aspirin’s ability to prevent “colon cancer is driven by a
gene mutation that makes tumor cells less sensitive to the drug’s
effects.” Investigators found that “developing colon cancer with a
mutation of the gene BRAF was similar for both regular aspirin users and
non-users.” The study indicated that “regular aspirin users had a 27
percent reduced risk of developing cancer without the mutation compared with
those who didn’t regularly” use the medication.
HealthDay
(6/26, Preidt) reports that “regular aspirin use after a diagnosis...of
colorectal cancer did not improve patients’ survival.”
Medscape
(6/26, Lowry) reports, “In an accompanying
editorial (6/26, 250K), Boris Pasche, MD, PhD, from the University of
Alabama at Birmingham, and a JAMA contributing editor, writes that the results
of this study ‘are likely to help tailor the use of aspirin in the
prevention and treatment of colorectal cancer,’” but “he points out that
the population in this study is predominantly white and includes a large
number of health professionals.” MedPage
Today (6/26, Gever) also covers the story.
Study:
Multivitamins May Lower Cancer Risk, Do Not Reduce Heart Disease In Men.
The AP
(11/6, Marchione) reports on a study
presented at the American Heart Association meeting and published online by the
Journal of the American Medical Association finding that "multivitamins
might help lower the risk for cancer in healthy older men but do not affect
their chances of developing heart disease." Dr. Howard Sesso of Brigham and
Women's Hospital in Boston, who led the study, commented, "They're no
substitute for a heart-healthy diet, exercising, not smoking, keeping your
weight down." The study was based on data over 11 years from "nearly
15,000 healthy male doctors given monthly packets of Centrum Silver or fake
multivitamins." The study found "no differences between the groups in
heart attacks, strokes, chest pain, heart failure or heart-related deaths."
It was funded by the National Institutes of Health
Genes
Determine Aspirin's Effect On Colon Cancer.
HealthDay
(10/25, Reinberg) reports that "for patients suffering from advanced
colorectal cancer, aspirin may prolong their lives if their tumor has a certain
gene mutation." HealthDay quotes lead researcher Dr. Shuji Ogino as saying,
"Aspirin appears to work to increase survival of colorectal cancer patients
if the tumor has PIK3CA mutation but does not work if the tumor does not have
PIK3CA mutation." HealthDay notes, "About 20 percent of colorectal
cancers have PIK3CA mutations," according the study, which "found that
97 percent of the patients with the mutation who were taking aspirin were alive
five years after being diagnosed, compared with 74 percent of similar patients
who weren't taking aspirin." However, aspirin "had no effect on
prolonging life among patients who didn't have the PIK3CA gene mutation."
The study was published in the Oct. 25 issue of the New England Journal of
Medicine.
MedPage
Today (10/25, Walsh) reports that "the investigators also conducted
a number of exploratory analyses and found that aspirin use prior to the
diagnosis of colorectal cancer had no influence on survival. They suggested that
the lack of effect for aspirin pre-diagnosis may be explained by 'tumor
evolution,' with 'interplay among inflammation, aspirin, and tumor molecular
features' contributing to outcome." Researchers also "determined that
aspirin's survival benefit was strongest among patients who had the PIK3CA
mutation and were also PTGS2-positive." And although the numbers were small
in that subanalysis and the results should be interpreted cautiously,
"experimental evidence supports cross-talk between the PI3K and PTGS2
pathways,"
WebMD
(10/25, Boyles) reports that in a commentary published with the study, Boris
Pasche, MD, PhD, says "Even though aspirin was not found to improve
survival in patients in the study without the specific tumor mutation,...it is
too soon to say that aspirin therapy does not benefit these patients. More
research is needed to figure this out. But we can hypothesize that patients with
this mutation are more likely to benefit from aspirin therapy than those who
don't have it."
High Vitamin E
Intake May Protect Against Liver Cancer.
MedPage
Today (7/18, Fiore) reports, "High vitamin E intake seemed to have
a protective effect against liver cancer," according to a study
published online July 17 in the Journal of the National Cancer Institute. In the
132,837-patient study, "among people ages 40-70, higher dietary intakes of
the vitamin were associated with a significantly lower cancer risk (P=0.01 for
trend), and taking vitamin E supplements almost cut the risk in half (HR 0.52,
95% CI 0.30 to 0.90)," researchers reported. MedPage Today adds, "The
study was supported by the National Institutes of Health and the Key State
Project Specialized for Infectious Diseases of China."
Higher
Antioxidant Intake May Be Linked To Reduced Pancreatic Cancer Risk.
Medscape
(7/24, Hand) reports, "Higher intakes of the antioxidants vitamin C,
vitamin E, and selenium could possibly cut the risk of developing pancreatic
cancer by up to 67%, according to a study
published online [July 23] in Gut."
HealthDay
(7/24) reports that investigators "tracked the long-term health of more
than 23,500 people, aged 40 to 74, who entered the study between 1993 and
1997." The investigators "found that people with the highest dietary
intake of selenium were half as likely to develop pancreatic cancer as those
with the lowest intake." Participants "who consumed the highest
dietary intake of three antioxidants -- selenium and vitamins C and E -- were 67
percent less likely to develop pancreatic cancer compared to those with the
lowest intake."
The UK's Telegraph
(7/24) reports, "If further studies prove that the antioxidants were
causing the added protection, the finding could prevent one in 12 cases of
pancreatic cancer, the researchers suggested." The UK's Press
Association (7/24) also covers the story.
Statin use is associated with
a reduction in the incidence of esophageal adenocarcinoma: a case control study;
Beales IL, Vardi I,
Dearman L, Broughton T; Diseases of the Esophagus (Sep 2012)The incidence
of esophageal adenocarcinoma (EAC) is increasing significantly throughout
the developed world. As yet, there are no proven chemopreventive strategies. In
laboratory studies, aspirin, non-steroidal anti-inflammatory drugs and statins
have promising chemopreventive actions. Several observational studies support a
protective effect of aspirin and non-steroidal anti-inflammatory drugs, but
there are only limited clinical data exploring the potential protective effect
of statins. We conducted a case-control study examining aspirin and statin use
in patients with EAC. Cancer cases were compared against age-sex-matched
controls attending for diagnostic upper gastrointestinal endoscopy. Risk factor
and drug exposure were established using standardized interviews. Logistic
regression was used to compare statin exposure and correct for confounding
factors. A total of 112 cases and 448 controls were enrolled. Statin use was
associated with a significantly lower incidence of EAC (odds ratio 0.52, 95%
confidence interval 0.27-0.92). Aspirin use was also associated with apparent
protection against EAC (odds ratio 0.68, 95% confidence interval 0.28-0.92), and
a significantly greater effect was seen with the combination of statin plus
aspirin (odds ratio 0.27, 95% confidence interval 0.05-0.67). There was a
significant trend for greater risk reduction with longer duration and higher
doses of statin use. Simvastatin comprised the majority of statin use, but
similar effects were seen with simvastatin and non-simvastatin agents. In this
observational study, patients regularly using statins or aspirin had a lower
incidence of EAC. Statins may have clinically useful effects in preventing the
development of EAC.
Caffeine
Consumption Associated With Lower Risk For Basal Cell Carcinoma.
ABC World News (7/2, story 8, 0:25, Muir) reported
that the "more coffee you drink, the less likely you are to get the most
common type of skin cancer -- basal cell carcinoma."
For the study,
published July 1 in the journal Cancer Research, "researchers analyzed data
from the famous Nurses' Health Study on more than 112,000 people," the CNN
(7/3, Wadas-Willingham) "Eatocracy" blog reports. "Investigators
found the more someone drank caffeinated coffee, (more than two cups a day) the
lower their risk of developing this form of cancer."
A MyHealthNewsDaily piece posted to the MSNBC
(7/3, Azvolinsky) "Vitals" blog pointed out, "Women who drank
more than three cups of coffee daily were 21 percent less likely to develop
basal cell carcinoma, compared with women who drank less than one cup of
caffeinated coffee per month, the study showed. For men, this risk reduction was
10 percent."
"The study also found that caffeinated tea, cola and
chocolate also appears to reduce risk," HealthDay
(7/3, Gray) reports. In other words, according to the study's lead author,
"it's the caffeine that's most likely responsible for the beneficial
effect."
WebMD
(7/3, Rubin) points out that the investigators "did not find an association
between caffeine intake and risk of squamous cell skin cancer, although animal
studies have suggested such a link." However, "only 1,953 squamous
cell cancers were diagnosed -- compared to 22,786 basal cell cancers -- so there
might not have been enough cases to show a relationship to caffeine
intake," the study's lead author explained. "With another 10 years of
follow-up, though, he and his colleagues might observe a difference in squamous
cell cancer risk between the highest and lowest levels of caffeine
consumption," he said.
According to MedPage
Today (7/3, Bankhead), "Laboratory studies have consistently shown
that oral and topical caffeine prevents" squamous cell carcinoma "in
mice exposed to ultraviolet (UV) light, the authors wrote in their introduction.
Other preclinical studies have suggested a potential mechanistic explanation, as
topical caffeine has been shown to induce apoptosis in UV-damaged keratinocytes
in mice." Also covering the story is the CNN
(7/3, Wadas-Willingham) "The Chart" blog in an entry identical to that
of its "Eatocracy" blog.
Greater Coffee
Consumption Associated With Lower Colon Cancer Risk.
A "Really?" feature posted to the New
York Times (7/3, O'Connor) "Well" blog reports that recently,
investigators "at the National Cancer Institute followed half a million
Americans over 15 years. The researchers looked in detail at their diets, habits
and health, and found that people who drank four or more cups of coffee a day --
regular or decaf -- had a 15 percent lower risk of colon cancer compared with
coffee abstainers." While the study authors "could not prove cause and
effect, they did find that the link was dose-responsive: Greater coffee
consumption was correlated with a lower colon cancer risk." The study
appeared June 13 in the American Journal of Clinical Nutrition
Aspirin May Be
Linked To Reduced Risk Of Prostate Cancer Mortality.
The New
York Times (8/28, D5, Rabin, Subscription Publication) reports,
"Men treated for prostate cancer who took aspirin regularly for other
medical conditions were less likely to die of their cancer than patients who
weren't taking aspirin, according to a new study published on Tuesday in the
Journal of Clinical Oncology." Investigators "used the national
database of a project known as CaPSURE, for Cancer of the Prostate Strategic
Urologic Research Endeavor, to look at nearly 6,000 men who had localized
prostate cancer and were treated with surgery or radiotherapy." The
researchers found that "those taking aspirin were less than half as likely
as those who were not to die of prostate cancer over a 10-year period,
researchers calculated; the prostate cancer death rate for those taking aspirin
was 3 percent, the researchers found, compared with 8 percent for those who did
not."
NSAIDs
May Not Be Linked To Breast Cancer Risk. Reuters
(8/28, Pittman) reports that, according to a study
published online Aug. 27 in the Journal of Clinical Oncology, the use of
nonsteroidal anti-inflammatory drugs (NSAIDs) may not be linked to a reduced
risk of breast cancer.
HealthDay
(8/28, Mozes) reports, "Between 1980 and 2008," researchers
"tracked nearly 85,000 postmenopausal women, all of whom were working as
registered nurses when the study first launched." During "the course
of three decades, more than 4,700 of the women developed some form of invasive
breast cancer." The investigators "found that neither regular aspirin
nor other NSAIDs had any significant impact on overall breast cancer risk,
regardless of how much they were used."
Loosing weight reduces bst cancer risk
The Los
Angeles Times (5/22, Healy) "Booster Shots" blog reports
that "losing as little as 5% of one's body weight -- 10 pounds for a
200-pound woman -- drives down levels of estrogen and other hormones that
raise breast cancer risk," according to a new study published in the
Journal of Clinical Oncology. Researchers found that "the more weight a
woman lost, the greater the reduction in hormones linked to breast cancer
risk." Although "many studies have linked obesity to breast cancer,
this is the first to show that losing weight will drive down that risk."
The Seattle
Post-Intelligencer (5/22, Dawson) reports, "The women with the
best outcome ate more fruits, vegetables and fiber, reduced fat intake and
added regular exercise into their lives. After losing the weight, the women's
estrogen levels were up to 25 percent lower and testosterone levels were 15.6
percent lower."
On its website, ABC
News (5/22) reports, "Dr. Anne McTiernan, director of the
Prevention Center at Fred Hutchinson in Seattle, Wash., and author of the
study, said that postmenopausal women who reduce their weight moderately
through diet and exercise can lower the amount of these hormones circulating
through their bodies, which can in turn decrease their risk of developing
breast cancer."
HealthDay
(5/22, Dotinga) reports that, according to Dr. McTiernan, "Weight loss
represents an additional option for long-term breast cancer risk reduction
without significant or bothersome side effects."
Exposure To
Ultraviolet Radiation May Lower Pancreatic Cancer Risk.
MSNBC
/MyHealthNewsDaily (6/20, Rowan) reports, "Exposure to ultraviolet
radiation may lower the risk of developing pancreatic cancer, according to a new
study from Australia." Investigators "interviewed 704 people with
pancreatic cancer and 713 people without the disease." The
"researchers...found that those born in areas with the highest levels of
ultraviolet (UV) radiation were 24 percent less likely to have pancreatic
cancer, compared with those born in areas with the lowest UV levels."
MedPage
Today (6/20, Bankhead) reports that the researchers also found that
"the risk of pancreatic cancer spanned the spectrum of skin types. However,
participants with the most sun-sensitive skin had almost a 50% lower risk of
pancreatic cancer than those with the least sun sensitivity (OR 0.51, 95% CI
0.36 to 0.73)." Additionally, the investigators reported that "a
history of skin cancer conferred a 40% lower risk of pancreatic cancer, as
compared with individuals who had no history of treated skin lesions (OR 0.60,
95% CI 0.48 to 0.75)."
HealthDay
(6/20, Salamon) reports, however, that "US cancer experts cautioned against
making any lifestyle changes -- including tanning or altering vitamin D intake
-- in response to the study, which is preliminary and does not prove these
factors can prevent pancreatic cancer." The study was "scheduled to be
presented Tuesday at an American Association for Cancer Research
conference."
Coffee
Consumption May Be Linked To Reduced Mortality Risk.
NBC Nightly News (5/16, story 11, 0:20, Williams)
reported that a new study suggests that "coffee drinkers are slightly more
likely to live longer than non-coffee" drinkers.
The Los
Angeles Times (5/17) reports that for the study,
published in the New England Journal of Medicine, "the National Cancer
Institute researchers turned to data on 402,260 adults who were between the ages
of 50 and 71 when they joined the NIH-AARP Diet and Health Study in 1995 and
1996. The volunteers were followed through December 2008 or until they died --
whichever came first." The researchers found that, "compared with men
who didn't drink any coffee at all, those who drank just one cup per day had a
6% lower risk of death during the course of the study; those who drank two to
three cups per day had a 10% lower risk, and those who had four to five cups had
a 12% lower risk."
The Wall
Street Journal (5/17, Mathews) "Health Blog" reports that Neal
D. Freedman, a National Cancer Institute researcher and the study's lead author,
said, "It offers some reassurance for coffee drinkers," but "we
shouldn't say coffee is a fountain of youth or anything like that."
The New
York Times (5/17, Parker-Pope) "Well" blog reports that
according to Freedman, "the biggest concern for a long time has been that
drinking coffee is a risky thing to do. Our results, and some of those of more
recent studies, provide reassurance for coffee drinkers that this isn't the
case." Individuals "who are regularly drinking coffee have a similar
risk of death as nondrinkers, and there might be a modest benefit."
USA
Today (5/17, Szabo) reports, "Coffee drinkers also were a little
less likely to die from specific causes: heart disease, respiratory problems,
strokes, injuries and accidents, diabetes and infections."
The AP
(5/17) reports, "About two-thirds of study participants drank regular
coffee, and the rest, decaf. The type of coffee made no difference in the
results."
Bloomberg
News (5/17, Ostrow) reports that "coffee wasn't associated with a
lower risk of dying from cancer in women. In men who drank the most coffee,
there was a slightly higher chance of dying from cancer, the research
reported."
Coffee drinkers better mortality
Association of coffee drinking with total and cause-specific mortality. Freedman
ND, Park
Y, Abnet
CC, Hollenbeck
AR, Sinha
RN
Engl J Med. 2012 May 17;366(20):1891-904.
During 5,148,760 person-years of follow-up between 1995 and 2008, a total of
33,731 men and 18,784 women died. In age-adjusted models, the risk of death was
increased among coffee drinkers. However, coffee drinkers were also more likely
to smoke, and, after adjustment for tobacco-smoking status and other potential
confounders, there was a significant inverse association between coffee
consumption and mortality. Adjusted hazard ratios for death among men who drank
coffee as compared with those who did not were as follows: 0.99 (95% confidence
interval [CI], 0.95 to 1.04) for drinking less than 1 cup per day, 0.94 (95% CI,
0.90 to 0.99) for 1 cup, 0.90 (95% CI, 0.86 to 0.93) for 2 or 3 cups, 0.88 (95%
CI, 0.84 to 0.93) for 4 or 5 cups, and 0.90 (95% CI, 0.85 to 0.96) for 6 or more
cups of coffee per day (P<0.001 for trend); the respective hazard ratios
among women were 1.01 (95% CI, 0.96 to 1.07), 0.95 (95% CI, 0.90 to 1.01), 0.87
(95% CI, 0.83 to 0.92), 0.84 (95% CI, 0.79 to 0.90), and 0.85 (95% CI, 0.78 to
0.93) (P<0.001 for trend). Inverse associations were observed for deaths due
to heart disease, respiratory disease, stroke, injuries and accidents, diabetes,
and infections, but not for deaths due to cancer. Results were similar in
subgroups, including persons who had never smoked and persons who reported very
good to excellent health at baseline.In this large prospective study, coffee
consumption was inversely associated with total and cause-specific mortality.
Whether this was a causal or associational finding cannot be determined from our
data. (Funded by the Intramural Research Program of the National Institutes of
Health, National Cancer Institute, Division of Cancer Epidemiology and
Genetics.).
Study: NSAIDs
May Reduce Risk For Certain Skin Cancers.
In continuing coverage, ABC World News (5/29,
story 3, 1:40, Sawyer) reported, "A big new study
out today says common pain relievers like aspirin and ibuprofen can cut the risk
of skin cancer, including melanoma."
On NBC Nightly News (5/29, story 8, 0:45,
Williams), chief medical editor Nancy Snyderman, MD, explained, "In a
Danish study published" online May 29 "in 'Cancer,' over 18,000 people
who took these drugs for several years had decreased cancer rates of malignant
melanoma."
Investigators found that people taking nonsteroidal
anti-inflammatory drugs (NSAIDs) "were less likely to develop skin cancer
-- including squamous cell carcinoma and malignant melanoma -- especially when
they took the drugs for at least seven years or used them at least twice a
week," the Time
(5/30, Park) "Healthland" blog reports.
HealthDay
(5/30, Mozes) points out, however, that "the same dynamic was generally not
seen with regards to basal cell carcinoma." However, "taking NSAIDs
for long periods of time, and at relatively high doses, was associated with a
reduced risk (between 15 and 21 percent), specifically for basal cell cases that
manifested in skin regions that typically experience relatively little sun
exposure (areas other than the neck or head)."
Acetaminophen
Use Also Linked To Reduction In Certain Skin Cancers. Focusing not just
on NSAIDs, the Los
Angeles Times (5/30, Mestel) "Booster Shots" blog explains
that "acetaminophen use was also linked" by the study "to a
reduction in basal cell carcinomas and malignant melanoma use. If the
cancer-protection effect is not (or not only) caused by inhibiting Cox-1 and
Cox-2, that would" fit with the theory that "cancer reduction could be
linked to...suppression of Cox-enzyme activity."
Regular Fish
Consumption May Be Linked To Reduced Risk Of Colon, Rectal Cancer.
Reuters
(5/11, Narayanan) reports that, according to a study
published online April 18 in the American Journal of Medicine, regular fish
consumption may be linked to a reduced risk of colon and rectal cancer.
Investigators came to this conclusion after looking at data from 41 different
studies.
Substances In
Red Wine May Act As Aromatase Inhibitors.
The Los
Angeles Times (1/7, Healy) "Booster Shots" blog reported,
"In a study suggesting that red wine might be the next big thing in breast
cancer prevention, a study
has found that women who drank just under two servings of red wine daily
experienced hormonal changes that mimic the effects of a drug used to prevent
malignant breast tumors from coming back." The research, "published
Friday in the Journal of Women's Health, found that consuming the same amount of
white wine did not have the same effect in premenopausal women participating in
the study."
MedPage
Today (1/7, Smith) reported that the "study...suggests that
substances in red wine act as aromatase inhibitors, compounds that are used to
treat breast cancer in post-menopausal women, according to" the researchers
Whole Grain
Consumption May Be Linked To Reduced Colorectal Cancer Risk.
MedPage
Today (11/11, Gever) reports, "Individuals eating three daily
servings of whole grains had a significantly, though modestly, lower risk of
colorectal cancer, according to pooled data from nearly 800,000 individuals --
perhaps the largest and strongest analysis ever conducted." Researchers
found that "a 90-gram per day increase in dietary fiber from whole grains
-- the amount a person would consume from three servings -- was associated with
a risk reduction of 17% (95% CI 11% to 22%) for colorectal cancer." The
study, published online in BMJ, "also found that 'high' versus 'low' intake
of total dietary fiber was associated with a significant reduction in risk (12%,
95% CI 6% to 18%)."
The UK's Telegraph
(11/11, Adams) points out that "bowel cancer kills about 16,000 people in
Britain a year, more than breast or prostate cancer."
Aspirin May
Potentially Help Prevent Cervical Cancer In Women With HIV.
The New
York Times (2/21, D6, McNeil, Subscription Publication) reports,
"Aspirin should be evaluated for its potential to prevent cervical cancer
in women infected with H.I.V., say scientists who recently reported a
connection between the virus and inflammation of cervical tissue." The
research, "published last month in the journal Cancer Prevention
Research, found that the virus that causes AIDS also drives up production of a
prostaglandin called PGE2 in cervical tissue." The researchers
"suggested that a large study be carried out to see if low-dose aspirin
could prevent cervical cancer in women at high risk of getting it."
Two Forms Of
Vitamin E May Have Cancer-Fighting Properties.
The Huffington
Post (4/29) reported that "a new study in the journal Cancer
Prevention Research shows that two forms of vitamin E -- found in corn, soybean
and canola oils -- may have cancer-fighting properties." Researchers
"fed animals the vitamin E form that is found in the vegetable oils, and
found that the gamma and delta-tocopherol forms of vitamin E worked to stop
cancer from developing and growing."
Fair-Skinned
People May Require Vitamin D Supplements.
BBC
News (10/4, Roberts) reports, "Fair-skinned people who are prone to
sunburn may need to take supplements to ensure they get enough vitamin D,"
according to research
(pdf) published in Cancer Causes and Control. The study of 1,200 people revealed
that "those with pale skin, while not deficient, may still be lacking in
the essential vitamin that the body makes from sunlight," and that
"even with a lot of sun exposure, those with fair skin may not be able to
make enough vitamin D."
The study
"suggests the optimal amount of vitamin D required by the body is at least
60nmol/L," the UK's Telegraph
(10/4) reports. "In the new study, people with fair skin did not, on
average, reach 60nmol/L unless they were taking supplements." In addition,
the investigators "found that patients with melanoma skin cancer may need
vitamin D supplements."
Research
Suggests Statins May One Day Be Used To Fight Breast Cancer.
HealthDay
(1/20, Mann) reports, "Amid hints that statins...might also play a role in
preventing or treating certain types of cancer, new research" published in
the journal Cell "sheds some light on how these drugs may help stop breast
cancer in its tracks among certain women." According to HealthDay,
"the p53 tumor suppressor gene stops the uncontrolled growth of cancer
cells, but some women with breast cancer have mutant forms of this gene."
Researchers "in the new study" found that "when the mutant p53
cells were treated in the laboratory with statins, the cells stopped their
erratic growth, and even died in some cases."
According to
the UK's Press
Association (1/20), "Study leader Dr Carol Prives, from Columbia
University in New York, said: 'The data raises the possibility that we might
identify subsets of patients whose tumours may respond to statins.'"
The UK's Telegraph
(1/20, Adams) points out that "Seperate studies have indicated statins
could help fight cancer." For instance, research "published in the
journal Cancer" in 2011 "indicated that men taking them might be 30
per cent less likely to see prostate cancer return after surgery."
Coffee
Consumption May Be Linked To Reduced Risk Of Endometrial Cancer.
The Los
Angeles Times (11/23, Stein) "Booster Shots" blog reports that
research
published in Cancer Epidemiology, Biomarkers & Prevention suggests that
"drinking four or more cups of caffeinated coffee may protect against
endometrial cancer."
Reuters
(11/23) reports that for the study, published in Cancer Epidemiology, Biomarkers
& Prevention, investigators analyzed data on approximately 67,000 women.
Time
(11/23, Park) reports in "Healthland" that the researchers found
"that women who drank four or more cups of coffee a day over 26 years had a
25% lower risk of endometrial cancer, compared with those consuming less than a
cup a day." Meanwhile, "women who drank two or three cups a day had a
7% lower risk."
CNN
/Health.com (11/23, Gardner) reports, "Although the study, which was funded
by the National Institutes of Health, doesn't prove that drinking coffee was
directly responsible for reducing cancer risk, the researchers say a
cause-and-effect relationship is plausible."
WebMD
(11/23, Doheny) reports that the study also found that "the link between
four or more cups of coffee and reduced risk of endometrial cancer
was...stronger" among "past or current smokers."
HealthDay
(11/23, Mozes) reports, "Drinking fewer than four cups a day did not appear
to offer any preventative benefit, however. Nor did drinking tea." Also
covering the story are the UK's Press
Association (11/23) and Medscape
(11/23, Hitt, Subscription Publication).
Long-Term
NSAID Use May Reduce Colorectal-Cancer-Specific Mortality.
Medscape
(10/28, Nelson) reports, "Randomized trials have shown that nonsteroidal
anti-inflammatory drugs (NSAIDs) reduce precancerous polyps, but a new study
suggests that long-term use can reduce colorectal-cancer-specific
mortality." Investigators found that "postmenopausal women who
participated in the Women's Health Initiative (WHI) and who used NSAIDs for an
extended period of time had a lower risk for death from colorectal cancer than
those who did not use NSAIDs at enrollment." The findings "of this
analysis were presented during a poster session...at the Tenth Annual American
Association for Cancer Research International Conference on Frontiers in Cancer
Prevention Research."
Slow Walking
May Relate To Risk For Post-Surgery Complications, Disability.
HealthDay
(10/28, Dallas) reports, "Older people who walk more slowly than their
peers may be at greater risk for complications and disability following surgery,
according to a new study" presented at the 2011 Annual Clinical Congress of
the American College of Surgeons. The study included nearly 200 older patients
who were having either cardiac or colorectal surgery. All participants took a
brief walking test that was timed. Among those undergoing heart surgery, just
"13 percent of" those classified as "fast walkers had more than
one complication following surgery, compared with 37 percent of the slow
group." The researchers also found that "nearly 60 percent of slow
walkers who had a colorectal operation needed institutional care after surgery,
compared with 5 percent of the fast group."
Aspirin May
Reduce Colon Cancer Risk In Patients With Lynch Syndrome.
NBC Nightly News (10/27, lead story, 2:40,
Williams) reported that research suggest that aspirin may help reduce the risk
for colon cancer in individuals with a specific genetic mutation.
USA
Today (10/28, Hellmich) reports, "Observational studies have shown
that aspirin lowers the risk of developing colorectal cancer, but this is the
first randomized controlled trial to find the effect." Investigators
"from the Universities of Newcastle and Leeds in England followed almost
1,000 patients from 43 medical centers in 16 countries." Participants
"all had Lynch syndrome, a genetic condition that predisposes people to
develop colorectal cancer and other types of cancer."
The Los
Angeles Times (10/28, Brown) "Booster Shots" blog reports,
"Some of the patients took two 600 mg aspirins every day, others took a
placebo."
Bloomberg
News (10/28, Kitamura) reports, "People who took" aspirin
"for at least two years had a 63 percent lower rate of colorectal cancer
than those who took a placebo."
The AP
(10/28) points out that "rates of side effects like bleeding and ulcers in
the stomach were similar in both groups." The research is published in the
Lancet.
MedPage
Today (10/28, Gever) reports, "For participants who took aspirin
for less than two years there was no apparent benefit (HR 1.07, 95% CI 0.47 to
2.41) relative to placebo." HealthDay
(10/28, Gardner) also covers the story.
Aspirin and breast cancer
Animal and in vitro studies suggest that the use of aspirin may be
associated with reduced risk for breast cancer, but results from these
studies of the association have been inconsistent. The objective of this
meta-analysis was to quantitatively summarize the current evidence for
such a relationship. We searched MEDLINE for studies of aspirin use and
breast cancer risk that were published in any language, from January 1,
1966, to July 1, 2011. A total of 33 studies (19 cohort studies, 13
case–control studies, and 1 randomized controlled trial [RCT]) that
included 1,916,448 subjects were identified. We pooled the relative
risks from individual studies using a random-effects model,
heterogeneity, and publication bias analyses. In a pooled analysis of
all studies, aspirin use was associated with reduced risk for breast
cancer (odds ratio [OR] = 0.86, 95% confidence interval [CI] = 0.81,
0.92). In the subgroup analysis by study design, results were similar
except for RCT (OR = 0.98, 95% CI = 0.87, 1.09). In
conclusion, this meta-analysis indicated that regular use of aspirin may
be associated with reduced risk of breast cancer. More RCT were needed
to confirm this association in the future.
Lou et al 2012
Breast
Cancer Research and Treatment Volume
131, Number 2,
,
DOI: 10.1007/s10549-011-1747-0
Drinking
Coffee Associated With Decreased BCC Risk.
The Los
Angeles Times (10/25, Brown) reports that according to research
presented yesterday at the American Association for Cancer Research
International Conference on Frontiers in Cancer Prevention Research,
"drinking coffee was associated with decreased risk of a common and
slow-growing form of skin cancer called basal cell carcinoma (BCC)." After
"examining data from the Nurses' Health Study, which followed 72,921 people
between 1984 and 2008, and the Health Professionals Follow-Up Study, which
followed 39,976 people between 1986 and 2008," researchers found that
"women who drank more than three cups of coffee had a 20% reduction in risk
for basal cell carcinoma."
"Men who
drank more than three cups of coffee benefited from a 9% reduction in risk of
this type of skin cancer," WebMD
(10/25, Warner) reports. However, "drinking decaffeinated coffee did not
have any effect on skin cancer risk, which leads researchers to suspect caffeine
is the key ingredient." Researchers are now "also looking into whether
caffeine should be added to sunscreen to increase its effectiveness against skin
cancer."
HealthDay
(10/25, Reinberg) noted, "The amount of caffeine consumption was inversely
associated with risk," the study's lead author pointed out, "meaning
the more coffee consumed, the lower the risk of skin cancer." Still,
"the study could not prove cause-and-effect...and at this point the finding
remains an association only."
Exercise May
Reduce Cancer Risk Through Influencing Hormones, Inflammation.
In continuing coverage, ABC World News (10/3,
story 6, 1:50, Sawyer) reports, "Physical activity has previously been
linked with a lower risk of breast and colon cancer, but now scientists are
beginning to understand why. For starters, the more fat cells you have in your
body, the more insulin and estrogen which can both help cancer cells grow."
In addition, exercise may "reduce stress and inflammation, both of which
can help cancer cells grow. A study of 4,000 women found those with the highest
level of physical activity had half the risk of dying compared to those without
exercise."
Celecoxib May
Curb Colon Cancer, But Increase Risk Of Heart Problems.
Reuters
(5/12, McCook) reports that, according to a study
published in the American Journal of Gastroenterology, patients taking the pain
medication Celebrex (celecoxib) over a three-year period were less likely to
develop polyps that could lead to colorectal cancer, but at the expense of a
higher risk of cardiovascular problems. For the study, 1,561 patients with
diagnosed colorectal adenomas removed within three months of the study's
initiation were assessed after three years on the drug followed by two years off
the treatment. New polyps were found in 58 percent of the patients on placebo,
compared to 51 percent on celecoxib. However, celecoxib users were more likely
to develop heart problems, including a 66-percent greater risk of serious
cardiac disorders.
Daily NSAID
Use May Lower Colon, Rectal Cancer Risk.
Reuters
(4/8, Grens) reported that people who use non-steroidal anti-inflammatory (NSAID)
painkillers regularly, may have a 50% reduced risk of developing colon or
rectal cancer, according to a study in the American Journal of
Gastroenterology. The researchers reviewed survey data from 300,000 adults,
who indicated how often they took any of 19 NSAIDs. They found that daily
NSAID use was associated with a 28% decreased risk of colon cancer risk, while
monthly NSAID use was linked to a 14% reduced risk. Among people with
immediate family members diagnosed with colon cancer, daily NSAID users had a
28% reduced risk of colon or rectal cancer, and there was an 11% risk among
weekly NSAID users.
Aspirin reduces the risk of developing precancerous colorectal
polyps: The Washington Post
Additional coverage of a JNCI study finding that prolonged use of
low-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) reduces
the risk of precancerous colorectal polyps in people at high risk for the
disease. The article notes that study participants who took aspirin more
than four days a week were 17 percent less likely to develop colorectal polyps
than people who took aspirin less than two days a week, and were 28 percent less
likely to develop polyps compared with those who did not take aspirin.
Article: The
Washington Post
Marriage May
Be Linked To Increased Survival Among Colon Cancer Patients.
HealthDay
(6/23, Preidt) reported that "being married improves the likelihood of
survival for colon cancer patients," according to a study published in the
journal Cancer Epidemiology. Investigators "analyzed 127,753 patient
records." They found that "married men and women with colon cancer
were 14 percent less likely to die than other colon cancer patients."
Long-Term Use Of Daily Aspirin May Prevent Melanoma.
An aspirin a day may keep melanoma at
bay," according to a new study. "After scrutinizing the medical
records of 1,000 people, an international team of researchers have determined
that the risk of melanoma was cut by almost half when people took a daily dose
of aspirin for at least five years." Interestingly, "there was also
a hint that other NSAIDs, such as ibuprofen (marketed as Advil and Motrin) and
naproxen (Aleve), might reduce melanoma risk if taken regularly over a long
period of time."
Research
Suggests Folate May Lower Colorectal Cancer Risk.
In "The Checkup" blog, the Washington
Post (7/7, Huget) reported new research published in the July issue of
Gastroenterology "suggests that consuming folate in any form may reduce
risk of colorectal cancer." The same "research also finds that folic
acid - the man-made form of this vitamin that's used to fortify foods and in
dietary supplements - does not, as had been worried, increase risk of developing
that cancer." The Post added that the study "analyzed data for 99,523
participants in the Cancer Prevention Study II Nutrition Cohort," 1,023 of
which "were diagnosed with colorectal cancer between 1999 and 2007."
Certain
Allergies May Reduce Risk Of Skin, Breast Cancers.
Bloomberg
News (7/11, Mead) reports that a study
in BMJ Open suggests that "people with adverse reactions to common metals
and chemicals were less likely to get skin and breast cancers," a result
that "backs up a theory known as immunosurveillance hypothesis, which
says people with allergies have immune systems that are more vigilant at
patrolling the body and eliminating transformed cells, reducing the risk of
cancer." However, "the scientists also observed a higher incidence
of bladder cancer in those with allergies, possibly because more chemical
remains accumulated in their blood."
Study Links
Low Daily Dose Of Aspirin To Reduced Bowel Cancer.
Bloomberg
News (9/16, von Schaper) reports that a study in the medical journal Gut
found that "people who take even a very low dose of aspirin every day for
five years can cut the risk of developing colon cancer by almost a third."
According to researchers, "as little as 75 milligrams of aspirin a
day...lowered the risk of colon cancer by 22 percent after just a year."
While it was already know that aspirin can protect the colon, the "study
showed for the first time that a low dose of aspirin is sufficient to ward off
cancer, and that the drug needs to be taken for at least five years to get the
full benefit."
According to MedPage
Today (9/15, Walsh), "Aspirin has not as yet been recommended for
primary chemoprevention of colorectal cancer...because of unanswered questions
on dose, duration, and effects on survival." WebMD
(9/15, Hendrick), the UK's Press
Association (9/15) also covered this study.
History of
migraine may be linked to reduced risk of breast cancer, study suggests.
Medscape
(7/30, Gandey) reported that, according to a study published in the July issue
of Cancer Epidemiology: Biomarkers & Prevention, "Women with a history
of migraine had a 26 percent reduced risk for breast cancer." For the
study, researchers examined "more than 4,500 cases and another 4,500
controls" from the Women's Contraceptive and Reproductive Experiences
Study, which included women aged 35 to 64 who "had been diagnosed with
invasive breast cancer." Their analysis revealed that the reduced risk for
breast cancer "did not differ by menopausal status, age at migraine
diagnosis, or use of prescription medications." In fact, "the risk was
the same even when researchers restricted the analysis to women who avoided
various migraine triggers, such as alcohol, exogenous hormones, and
smoking." The researchers noted, however, that "it is also possible
that medications used to treat or prevent migraine, rather than the occurrence
of migraines, may be responsible for the reductions in risk."
Statins May
Reduce Prostate Cancer Risk.
Reuters
(6/1, Pittman) reported that taking cholesterol-lowering statins are less likely
to develop prostate cancer than many not on the medication, according to a study
in the Journal of Urology. Researchers reviewed medical data on more than 4,000
men who had a biopsy to test for prostate cancer between 2000 and 2007. About
1,000 of the men were taking statins, and after their biopsies, 55 percent of
them were diagnosed with prostate cancer compared to 58 percent of the 3,000 who
were not taking statins.
Vegetables may alter cancer
genes: Reuters
This article reports on
research published in the journal PLoS One
finding that men with pre-cancerous prostate
lesions who eat extra servings of broccoli
each week for a year have hundreds of
positive genetic changes, including
alterations that activate genes known to
fight cancer and switch off genes known to
contribute to tumors. The article
notes that researchers did not track men
long enough to see who developed cancer, but
that men with a gene called GSTM1 had the
most genetic changes. Article:
Reuters
Experts
Provide Caveat To Sunscreen-Melanoma Study Findings.
Medscape
(5/4, Mulcahy, Subscription Publication) reported, "In the past year,
sunscreen was shown -- for the first time -- to prevent melanoma in one of the
only randomized controlled trials ever conducted on this subject."
However, "there is a caveat about the results that has important public
health implications and was not highlighted in the original study, according
to a letter
published online April 4 in the Journal of Clinical Oncology." People who
participated in the trial were middle-aged Australians whose sun exposure
occurred during the course of their daily activities. In other words, their
sun exposure was incidental, not intentional, as would be the sun exposure of
dedicated beachgoers. Therefore, the authors of the letter say that
"white people in other parts of the world should not interpret the study
results as a 'green light' to tan on the beach."
Consumer Group
Says Chemical Dyes Used For Food Coloring Should Be Banned.
WebMD
(6/29, DeNoon) reported that "chemical dyes used for food coloring carry
serious health risks and should be banned, says a new report from a consumer
group," the Center for Science in the Public Interest (CSPI). CSPI
"notes that none of the nine artificial food dyes approved for US use have
been proven safe." CSPI also "points to animal studies suggesting that
the dyes -- and other chemicals bound to them -- can cause cancer."
Drinking wine
with lower alcohol content may reduce the risk of some cancers.
BBC
News (1/18) reported that drinking "wine with an alcohol content of
10 percent rather than 14 percent might" lower the risk of some cancers,
according to research conducted by the World Cancer Research Fund. An analysis
of "figures in a 2007 report which looked at the evidence for a link
between alcohol consumption and cancer" revealed "the likely extra
risk posed by each extra 10 grams of alcohol...regularly consumed."
The UK's Telegraph
(1/18, Smith) reported that people who switch "from a 14 percent wine to a
10 percent wine" could "reduce their risk of developing bowel cancer
or breast cancer by seven percent." In fact, researchers found that
"for every 100 people who switched, five would develop bowel cancer at some
point in their lives, instead of six."
The UK's Daily
Mail (1/18, Hope) reported, "As well as cutting" the number of
bowel cancer diagnoses, "switching to a lower-alcohol wine would reduce
breast cancer, liver cancer, oesophageal cancer, and cancers of the mouth,
pharynx, and larynx." The study showed that "the reduction in risk for
each type of these cancers is similar to that for bowel cancer."
The UK's Press
Association (1/18) reported that Dr. Rachel Thompson, science program
manager at the charity, said, "If you drink quite a lot at the moment, the
best advice is to reduce the number of drinks you have." The World Cancer
Research Fund recommends that men "should limit consumption to two drinks a
day...and one for a woman," the UK's Independent
(1/18, Laurance) reported.
More Vitamin D
Intake May Be Needed To Cut Cancer Risk.
HealthDay
(2/27, Dotinga) reported that it "takes far more vitamin D than initially
thought to dramatically cut the risk of several major diseases, including breast
cancer," according to a study in the in the journal Anticancer Research.
The study was based on a survey of "several thousand people who took
supplements ranging from 1,000 to 10,000 IU per day. ... 'We found that daily
intakes of vitamin D by adults in the range of 4,000-8,000 IU are needed to
maintain blood levels of vitamin D metabolites in the range needed to reduce by
about half the risk of several diseases -- breast cancer, colon cancer, multiple
sclerosis and type 1 diabetes,'" said study co-author Dr. Cedric Garland
from the University of California in a news release. The Institute of Medicine's
recommended daily level is only "600 IU."
Cost-Effectiveness of Aspirin, Celecoxib, and
Calcium Chemoprevention for Colorectal Cancer;
Studies have indicated that aspirin chemoprevention may be effective in
preventing colorectal cancer within the general population, and aspirin,
celecoxib, and calcium may be effective in preventing adenomas within those
people who have previously undergone polypectomy. Celecoxib
chemoprevention is unlikely to be considered to be cost-effective. Calcium
chemoprevention is likely to be a cost-effective option for individuals who have
undergone polypectomy. Further research is required to assess the long-term
benefits and harms of calcium compared with aspirin chemoprevention.
Chemoprevention appears less economically attractive within the general
population.
Antioxidants
in wine may help ward off radiation-linked skin toxicity in breast cancer
patients, research suggests.
HealthDay
(8/14, Mundell) reported that, according to a study published in the August
issue of the International Journal of Radiation Oncology Biology Physics,
"a glass of wine a day" may "cut the risk of treatment-linked
skin toxicity by two-thirds in women undergoing radiation therapy for breast
cancer." To see "if the natural antioxidants found in wine might work
to ward off radiation-linked damage," researchers from Catholic University
and the National Research Council in Italy divided "348 women with breast
cancer...into three groups, depending on the dose of radiation received."
The team found that "patients who drank wine on the days they had their
treatment had lower rates of Grade 2, or higher acute toxicity, than those who
did not. In fact, women who drank one glass of wine a day had a 13.6 percent
rate of skin toxicity compared to a 38.4 percent incidence among patients who
did not consume wine," the authors said
Green tea
may help reduce levels of some compounds associated with prostate cancer
progression, investigators say.
Following a BBC
News story, Shari Roan pointed out in the Los
Angeles Times (6/22) Booster Shots blog that "men with prostate
cancer might want to include green tea with their meals," because
Louisiana State University researchers have found that it may actually
"reduce the levels of some compounds linked to prostate cancer
progression." Through their study
of 26 prostate patients, who were given "a concentrated extract of tea
polyphenols for an average of 34 days," the team was able to see "a
significant reduction in the levels of several growth factors that promote
cancer as well as reductions in prostate specific antigen." In fact,
"some men had reductions in growth factors of up to 30 percent."
But, according to the paper detailed Cancer Prevention Research, "the
response varied among the men for reasons that researchers don't yet
understand."
New study to
test effect vitamin D, fish oil may have on cancer, heart disease, stroke.
The AP
(6/23, Marchione) reports that in a "$20 million study" that
"will be sponsored by the National Cancer Institute, with the National
Heart, Lung and Blood Institute, and other federal agencies," both
vitamin D and fish oil "will be tested...to see whether either nutrient
can lower a healthy person's risk of getting cancer, heart disease, or having
a stroke." The study will also "be one of the first big nutrition
studies ever to target a specific racial group -- blacks, who will comprise
one quarter of the participants." The study, which starts "later
this year, will enroll 20,000 people with no history of heart attacks, stroke
or a major cancer -- women 65 or older and men 60 or older," who
"will be randomly assigned to take vitamin D, fish oil, both nutrients,
or dummy pills for five years." Participants will receive a "daily
dose of vitamin D" that "will be about 2,000 international units of
D-3," and a "daily dose" of approximately one gram of fish oil,
an amount "five to 10 times what the average American gets."
According to
the Boston
Globe (6/23, Cooney), "The researchers believe higher rates of
cancer, heart disease, and stroke among blacks, compared with whites, might be
related to dark skin's lower ability to make vitamin D from absorbing
sunlight, and they want to establish whether taking vitamin D supplements
could reduce or eliminate these disparities." In addition, the
researchers hope to establish the safety and efficacy of taking large doses of
fish oil. In the past, "vitamin E, vitamin C, beta-carotene, folic acid,
selenium, and other supplements have looked promising for disease prevention,
but their benefits have not been borne out in large trials, and some risk has
been found with high levels." The new study will start recruiting
participants in January. More details can be found on the study's website.
Coffee May
Prevent Non-Melanoma Skin Cancer.
AFP
(8/16, Sheridan) reports that according to a study published in Proceedings of
the National Academy of Sciences, "moderate caffeine drinking, or perhaps
even applying coffee to the skin, could be useful in warding off non-melanoma
cancer." Researchers found that mice with suppressed levels of ATR enzyme
were able to ward off UV-induced skin cancer longer than normal mice, and also
showed that "caffeine -- when consumed or applied to the skin -- works by
inhibiting ATR." Researchers called for the study to be extended to humans.
The UK's Daily
Mail (8/16) reports, "Despite their results, the researchers say
that people shouldn't start consuming vast amounts of tea or coffee just so that
they can lie out in the sun. But they say their finding could be used to create
a caffeine-based sun cream. As an added bonus, caffeine absorbs UV light --
stopping it from damaging and wrinkling the skin." The Voice
of America (8/16) also covers the story.
The health
impact of
coffee: The New York Times
This article
discusses myths and
scientific research on the health impact of
coffee consumption. The article cites
multiple studies suggesting that coffee
consumption does not increase the risk of
developing cancer and that coffee drinkers
may actually have a 50 percent decreased
risk of developing liver cancer. Article:
The New York Times
GENERAL
LIFESTYLE ISSUES
Nearly
Half Of Breast Cancer Cases Could Be Prevented By Healthy Lifestyles.
The UK's Telegraph
(5/6, Beckford) reported that as "many as 20,000 British women could avoid
developing" breast cancer "each year, if they took more exercise,
drank less and ate better." Latest figures "suggest that 47,600 women
developed breast cancer in 2008," and the World Cancer Research Fund
estimates that estimates that "42 per cent of these cases...would be
preventable if women developed healthier lifestyles." The WCRF's "10
Recommendations for Cancer Prevention include being 'as lean as possible without
becoming underweight'; keeping fit; limiting consumption of fatty, salty and
sugary food and drink; eating fruit, vegetables and pulses; eating less red meat
and processed meat; drinking less and choosing a balanced diet rather than
vitamin supplements.
Study Suggests
Spirituality May Boost Ovarian Cancer Outcomes.
MedPage
Today (3/11, Petrochko) reports, "Ovarian cancer patients who reported
high levels of spirituality presurgery had better outcomes for stress and
depression [P<0.001], as well as factors known to regulate tumor angiogenesis
and inflammation," according to data presented at the annual meeting of the
Society of Gynecologic Oncology in Los Angeles. "These same patients also
had significantly lower levels of IL-6, both in peripheral blood (P=0.001) and
in ascites (P=0.013) after adjusting for stress and depression," Premal
Thaker, MD, of the Washington University School of Medicine in St. Louis,
reported at the meeting
Breastfeeding
May Lower Receptor-Negative Breast Cancer Risk.
The Los
Angeles Times (8/17, Healy) "Booster Shots" blog reports a
study published in Cancer Epidemiology, Biomarkers & Prevention showing
"that African American women who had given birth to more children were more
likely to develop estrogen or progesterone-negative" breast "cancer
than their peers who had not given birth or who had given birth to only one
child," but breastfeeding lowered that risk. The study authors hypothesized
that "given the prevalence of infectious diseases in Africa, women of
African origins may respond to pregnancy with a particularly strong immune
response, which in turn can allow cancers to gain a foothold," but
lactation lowers the effect. They also noted that receptor-negative breast
cancers are more aggressive. The researchers suggested that efforts to promote
breastfeeding, which is less common in African American than white women, should
include the information that breastfeeding may lower their risk of this cancer.
The CNN
(8/17, Curley) "Chart" blog reports, "Women who gave birth to two
or more children had a 50% associated increase in aggressive ER-/PR- cancer, but
the association was not found when the women had breastfed. ... The results were
'strikingly different' when researchers compared the number of births and
breastfeeding among women with hormone receptor positive cancers. Women who had
two or more children had lower associations of ER+/PR+ cancers, and
breastfeeding didn't change that association." Researchers said that
African American women tend to have more children than white women, and lower
breastfeeding rates, which given the data may explain why they are at higher
risk for developing receptor negative cancer.
WebMD
(8/17, Doheny) reports the researchers noted that "if a woman does not
breastfeed, the breast goes through a process called involution...marked by
increasing inflammation in the breast tissue. This inflammation may be
associated with breast cancer." Breastfeeding is believed to reduce the
inflammation in the tissue. HealthDay
(8/17, Dallas) also covers this story.
Breast Cancer
With Other Health Issues Associated With Worse Outcomes.
HealthDay
(6/30, Dallas) reported, "Women diagnosed with breast cancer who also
suffer from other health problems have higher death rates than women who just
have breast cancer," according to a study published in the June 30 online
edition of the Journal of the National Cancer Institute. To reach this
conclusion, Jennifer Patnaik, of the University of Colorado Denver, Aurora, and
colleagues, "identified more than 64,000 women aged 66 years and older with
breast cancer. Forty-two percent had a history of one or more of the following
13 health conditions: stroke, chronic obstructive pulmonary disease, chronic
kidney failure, congestive heart failure, dementia, diabetes, liver disease,
heart attack, paralysis, peripheral vascular disease, previous cancer,
rheumatoid arthritis, and ulcers." The researchers found "that each of
these conditions was associated with increased risk of death from any cause,
including cancer."
The Huffington
Post (6/30, Pearson) reported, "In an editorial accompanying the
study, Dr. Worta McCaskill-Stevens and Dr. Jeff Abrams of the National Cancer
Institute, said the study has significant implications for clinical care of
breast cancer patients over the age of 65, who comprise of over half of the
200,000 some women diagnosed with breast cancer in the US each year." Drs.
McCaskill-Stevens and Abrams "said that physicians may reduce treatment or
diminish its intensity in patients with multiple conditions. They also pointed
out that there could be a biological interplay between cancer and other diseases
that impacts the efficacy of certain treatments."
Experts
Attribute UK's High Breast Cancer Rates To Obesity, Excessive Alcohol Intake.
The UK's Press
Association (1/24) reports that the UK ranks "11th out of 50
countries for rates of breast cancer." Overall, the UK ranked "22nd
for cancers in both sexes while Denmark is the cancer capital of the
world," according to the most recent estimates from the World Health
Organisation, for 2008.
According to
the UK's Independent
(1/24), the UK overall ranks "33rd for male cancers and 12th highest for
female cancers." On breast cancer, more women "per 100,000 develop
the disease in the UK (260.5) than in France (254.9), Italy (251.6), Germany
(245.7), Sweden (241.2), Switzerland (236) or Spain (187)." The highest
rates are in "Denmark (325.3), New Zealand (287.1) and Ireland
(285.1)."
The UK's Daily
Telegraph (1/24, Beckford) adds that experts "said that many of
the 46,000 breast cancer cases in the UK each year could be avoided if British
women drank less, ate more healthily or took more exercise." Notably,
more than 25 percent of "women who develop the disease in Britain die
from it, as survival rates have remained low despite record investment in the
NHS under Labour."
Study
indicates obesity may increase risk of developing endometrial cancer.
HealthDay
(6/22, Gordon) reported, "Obesity is already linked to heart disease,
diabetes and high blood pressure, but new research finds those extra pounds
can also significantly increase a woman's risk of developing endometrial
cancer," according to a study appearing in the July issue of Obstetrics
& Gynecology. For the study, investigators "reviewed data from the
CDC's Cancer and Steroid Hormone Study," finding "421 women between
the ages of 20 and 54 who had been diagnosed with endometrial cancer."
Meanwhile, the control group consisted of "3,159 women" who were
"randomly selected...from the same areas of the country." The study
showed that "women who were younger than 45 when they had their last
period and had a BMI above 35 had a 21.7 times greater risk of developing
endometrial cancer than a woman of normal weight." The investigators also
found, however, that "in women older than 45 at their last menstrual
period, those with BMIs above 35 had 3.7 times greater odds of developing
endometrial cancer than their normal-weight peers."
Three
Lifestyle Changes May Significantly Reduce Cancer Rates.
reported that approximately "340,000 cancer cases" in
the US could be prevented "each year if more Americans ate a healthy diet,
got regular exercise and limited their alcohol intake," according to the
World Cancer Research Fund. The WCRF said such lifestyle changes could lead to
"significant reductions in particularly common cancers such as breast (38%
fewer cases per year), stomach (47% fewer) and colon (45% fewer). ... 'Physical
activity is recommended for people of all ages as a means to reduce risks for
certain types of cancers and other non-communicable diseases,'" said Dr.
Tim Armstrong of World Health Organization. The research "was released Feb.
3 to mark World Cancer Day."
Reuters
(2/4, Kelland) notes that the WCRF recommendations are supported by WHO's
suggestions for the prevention cancer, which is a leading cause of death
worldwide. WebMD
(2/3, Hendrick) added that the World Cancer Declaration "outlines 11
targets it says could be achieved by 2020" to fight cancer. These goals
include "significant drops in global tobacco use, obesity, and alcohol
intake; universal vaccination programs for hepatitis B and human papilloma virus
(HPV); universal availability of effective pain medication; and efforts to
dispel misconceptions about cancer." The CNN
(2/3, Bixler) "The Chart" blog also covered the WCRF recommendations
Overall Health
May Impact Likelihood For Surviving Breast Cancer.
HealthDay
(4/6, Preidt) reported, "Poor overall health seems to be associated with
worse outcomes for breast cancer survivors," according to findings
presented at the American Association for Cancer Research meeting. Researchers
analyzed data from almost "9,400 early stage breast cancer survivors
participating in the After Breast Cancer Pooling Project," and found that a
health assessment survey "shortly after diagnosis" and a survey seven
years after diagnosis showed that "about half the women were in poor
physical health." Women with poor physical health scores had a
"27-percent increased risk of experiencing either a recurrence of their
breast cancer or a new breast cancer, and a 65-percent increased risk of death
from any cause," the researchers said. They also found that breast cancer
survivors with low health scores were "less physically active, more likely
to have sleep problems, had 50-percent higher rates of high blood pressure and
diabetes, and were twice as likely to have arthritis."
Study suggests
vegetarians may be less likely than meat eaters to develop cancer.
BBC
News (6/30) reported, "Vegetarians are generally less likely than
meat eaters to develop cancer," according to a study appearing in the
British Journal of Cancer. The study included "61,566 British men and
women" who were "meat eaters, those who ate fish but not meat, and
those who ate neither meat nor fish." Researchers found that "while in
the general population about 33 people in 100 will develop cancer during their
lifetime, for those who do not eat meat that risk is reduced to about 29 in
100." In particular, "they found marked differences between meat
eaters and vegetarians in the propensity to cancers of the lymph and the blood,
with vegetarians just over half as likely to develop these forms of the
disease." Data indicated that "vegetarians were 75 percent less likely
to develop" multiple myeloma "than meat eaters." But, the
researchers said that "the reasons...were unclear," noting that
"potential mechanisms could include viruses and mutation-causing compounds
in meat -- or alternatively that vegetables confer special protection."
Dermatologists
Recommend "Broad Spectrum" Sunscreens With SPF Of At Least 30.
In continuing coverage, the New
York Times (6/21, D7, Brody, Subscription Publication) reported in
"Personal Health" that "the Food and Drug Administration has
finally issued new rules that should help reduce the confusion that currently
prevails when consumers confront the aisle-long array of products in most
pharmacies." Until the new rules take effect, "dermatologists suggest
choosing only products that are labeled 'broad spectrum' and have an SPF rating
of 30 to 50." Consumers need to remember to "apply the sunscreen just
before exposure, and reapply it two hours later -- it loses effectiveness over
time. And, even if the label claims the sunscreen is water resistant, be sure to
reapply it after swimming or sweating heavily."
Statin Use May
Reduce Prostate Cancer Risk.
The Orlando
Sentinel (3/12, Shrieves) reported, "Men who take statins -- one
type of cholesterol-lowering drugs -- may be 60 percent less likely to be
diagnosed with high-grade prostate cancer, according to a" study of
"patient files from the Veteran Affairs New England Healthcare
System." Investigators identified 55,875 patients using either a statin or
a blood pressure drug. Investigators found that "men taking statins were 30
percent less likely to be diagnosed with prostate cancer than those on anti-hypertensive
medication" and that "statin users also were 60 percent less likely to
be diagnosed with high-grade prostate cancer."
Low-dose aspirin (100 mg) taken every other day may reduce a woman’s risk
of developing colon cancer, according to an observational study published in the
Annals
of Internal Medicine. The findings are based on a large long-term study
of 38,876 healthy women enrolled in the Women’s
Health Study looking at the benefits and risks of taking aspirin and vitamin
E for the prevention of cardiovascular disease and cancer.
Study Details
The women, aged 45 or older, were randomly assigned to take 100 mg of aspirin
or a placebo every other day starting between 1993 and 1996 and were followed
through 2004. The study participants completed regular questionnaires about
their cancer status, how often they took medication, any negative effects, any
additional aspirin use, and other risk factors.
After the initial study, researchers followed 33,682 participants through
March 2012, although the women were not given additional aspirin or placebos
during this time. The researchers found that after 18 years, women in the
aspirin arm of the study had a 20% lower colon cancer rate than those taking the
placebo. There were no differences between the aspirin group and the placebo
group for other cancer types.
Taking the aspirin, however, resulted in some intestinal problems. Women who
took aspirin were more likely to have gastrointestinal bleeding (8.3% vs 7.3%)
and peptic ulcers (7.3% vs 6.2%).
The study was funded by the National Cancer Institute and the U.S. National
Heart, Lung, and Blood Cancer Institute.
"Chemo
Brain" May Be Caused By More Than Chemotherapy.
The Huffington
Post (4/13, Chan) reports, "There may be more than one factor
responsible for 'chemo brain' -- the term used for memory and attention
impairments often experienced after undergoing chemotherapy for cancer,
according to a small new study" published in the Journal for Clinical
Psychology in Medical Settings. Investigators "found that women who had
breast cancer surgery but had not yet undergone chemotherapy also experienced
similar memory problems." The researchers also found that "the women
who were most likely to experience these problems were also the ones who were
more stressed or didn't cope with their stress in a direct way."
SYMPTOMS
AND SIDE EFFECTS
Prehabilitation
Linked To Improves Outcomes In Cancer Patients.
Medscape
(8/2, Lowry) reports that research published in the American Journal of
Physical Medicine & Rehabilitation suggests that, “for patients newly
diagnosed with cancer, getting in better physical and mental shape before
starting treatment” may be linked to better outcomes and fewer
complications. Investigators looked at data on studies involving
prehabilitation in patients with cancer. Investigators found that
prehabilitation may improve both physical and “psychologic outcomes.”
Additionally, prehabilitation reduced “hospital readmissions and reduces
cancer-related healthcare costs.”
Cancer Prehabilitation: An Opportunity to Decrease Treatment-Related
Morbidity, Increase Cancer Treatment Options, and Improve Physical and
Psychological Health Outcomes
Silver, Julie K. MD; Baima, Jennifer MD
American Journal of Physical Medicine & Rehabilitation:
doi: 10.1097/PHM.0b013e31829b4afe
ABSTRACT: Cancer prehabilitation, a process on the continuum of care that
occurs between the time of cancer diagnosis and the beginning of acute
treatment, includes physical and psychological assessments that establish a
baseline functional level, identifies impairments, and provides targeted
interventions that improve a patient’s health to reduce the incidence and the
severity of current and future impairments. There is a growing body of
scientific evidence that supports preparing newly diagnosed cancer patients for
and optimizing their health before starting acute treatments. This is the first
review of cancer prehabilitation, and the purpose was to describe early studies
in the noncancer population and then the historical focus in cancer patients on
aerobic conditioning and building strength and stamina through an appropriate
exercise regimen. More recent research shows that opportunities exist to use
other unimodal or multimodal prehabilitation interventions to decrease
morbidity, improve physical and psychological health outcomes, increase the
number of potential treatment options, decrease hospital readmissions, and
reduce both direct and indirect healthcare costs attributed to cancer. Future
research may demonstrate increased compliance with acute cancer treatment
protocols and, therefore, improved survival outcomes. New studies suggest that a
multimodal approach that incorporates both physical and psychological
prehabilitation interventions may be more effective than a unimodal approach
that addresses just one or the other. In an impairment-driven cancer
rehabilitation model, identifying current and anticipating future impairments
are the critical first steps in improving healthcare outcomes and decreasing
costs. More research is urgently needed to evaluate the most effective
prehabilitation interventions, and combinations thereof, for survivors of all
types of cancer.
ADT For
Prostate Cancer Linked To Increased Risk Of Acute Kidney Injury.
The Los
Angeles Times (7/17, Morin, 692K) reports that, according to research
published in the Journal of the American Medical Association, current use of
androgen deprivation therapy (ADT) for prostate cancer may be associated with
“an increased risk of acute kidney injury.” Investigators “examined the
medical records of more than 10,000 men with nonmetastatic prostate cancer and
found that” the treatment “was associated with a 2.5 times greater risk of
acute kidney injury.”
Reuters
(7/17, Pittman) reports, however, that past use of the treatment was not
associated with an increased risk of kidney injury. Also covering the story are HealthDay
(7/17, Thompson), Medscape
(7/17, Mulcahy), and MedPage
Today (7/17, Bankhead).
Pain in long-term breast cancer
survivors: the role of body mass index, physical activity, and
sedentary behavior
Although pain is common among post-treatment
breast cancer survivors, studies that are longitudinal, identify a
case definition of clinically meaningful pain, or examine factors
contributing to pain in survivors are limited. This study describes
longitudinal patterns of pain in long-term breast cancer survivors,
evaluating associations of body mass index (BMI), physical activity,
sedentary behavior with mean pain severity and above-average pain.
Women newly diagnosed with stages 0–IIIA breast cancer (N
= 1183) were assessed, on average, 6 months (demographic/clinical
characteristics), 30 months (demographics), 40 months (demographics,
pain), 5 years (BMI, physical activity, and sedentary behavior), and
10 years (demographics, pain, BMI, physical activity, and sedentary
behavior) post-diagnosis. This analysis includes survivors who
completed pain assessments 40 months post-diagnosis (N
= 801), 10 years post-diagnosis (N =
563), or both (N = 522). Above-average
pain was defined by SF-36 bodily pain scores ≥1/2 standard
deviation worse than age-specific population norms. We used multiple
regression models to test unique associations of BMI, physical
activity, and sedentary behavior with pain adjusting for demographic
and clinical factors. The proportion of survivors reporting
above-average pain was higher at 10 years than at 40 months (32.3
vs. 27.8 %, p < 0.05). Approximately
one-quarter of survivors reported improved pain, while 9.0 %
maintained above-average pain and 33.1 % reported worsened pain.
Cross-sectionally at 10 years, overweight and obese survivors
reported higher pain than normal-weight survivors and women meeting
physical activity guidelines were less likely to report
above-average pain than survivors not meeting these guidelines (p
< 0.05). Longitudinally, weight gain (>5 %) was positively
associated, while meeting physical activity guidelines was inversely
associated, with above-average pain (OR, 95 % CI = 1.76, 1.03–3.01
and 0.40, 0.20–0.84, respectively) (p
< 0.05). Weight gain and lack of physical activity place breast
cancer survivors at risk for pain long after treatment ends. Weight
control and exercise interventions should be tested for effects on
long-term pain in these women.
Anesthesia and analgesia Published
online before print January 9, 2013,
doi: 10.1213/ANE.0b013e318274e4a0 A
& A February
2013 vol. 116 no.
2 482-490 Physical Exercise
Induces Excess Hsp72 Expression and Delays the Development of Hyperalgesia and
Allodynia in Painful Diabetic Neuropathy Rats
- Yu-Wen
Chen, PhD*,
- Pei-Ling
Hsieh, MS†,
- Yu-Chung
Chen, MS†,
- Ching-Hsia
Hung, PhD†
and
- Juei-Tang
Cheng, PhD§║
+ Author
Affiliations
-
From the *Department of Physical Therapy, China Medical
University, Taichung; †Institute & Department of
Physical Therapy, National Cheng Kung University, Tainan; ‡Division
of Physical Therapy, Department of Physical Medicine and Rehabilitation,
Cheng Hsin General Hospital, Taipei; §Department of Medical
Research, Chi-Mei Medical Center, Tainan; and ║Department
of Pharmacology, College of Medicine, National Cheng Kung University,
Tainan, Taiwan.
- Address correspondence to Yu-Wen Chen,
PhD, Department of Physical Therapy, China Medical University, No. 91
Hsueh-Shih Rd., Taichung 40402, Taiwan. Address e-mail to cywhwok@mail.cmu.edu.tw.
Abstract
BACKGROUND: The underlying mechanism of
exercise on the development of diabetes-associated neuropathic pain is not
well understood. We investigated in rats whether exercise regulates the
functional recovery and heat shock protein 72 (Hsp72), tumor necrosis factor
(TNF)-α, and interleukin (IL)-6 expression in streptozotocin (STZ)-induced
diabetes.
METHODS: Male Wistar rats were divided into 4
groups: normal sedentary rats, normal rats with exercise, sedentary STZ-diabetic
(SS) rats, and STZ-diabetic rats with exercise. Diabetes was induced with
STZ (65 mg/kg IV). The trained rats ran daily on a treadmill 30 to 60 min/d
with an intensity of 20 to 25 m/min. We monitored thermal withdrawal latency
and mechanical withdrawal threshold as well as Hsp72, TNF-α, and IL-6
expression in the spinal cord and peripheral nerves.
RESULTS: Two weeks after STZ injection,
sedentary rats exhibited a marked and sustained hypersensitivity to von Frey
tactile and heat stimuli. In contrast, diabetic rats undergoing exercise
demonstrated delayed progress of tactile and thermal hypersensitivity.
Exercise significantly suppressed diabetes-induced blood glucose levels and
body weight loss, although they were not restored to control levels.
Compared with normal sedentary rats, SS rats displayed significantly higher
TNF-α and IL-6 levels in the spinal cord and peripheral nerves. The STZ-diabetic
rats with exercise group showed greater Hsp72 expression and similar TNF-α
or IL-6 level compared with the SS group in the spinal cord and peripheral
nerves on day 14 after STZ treatment.
CONCLUSIONS: These results suggest that
progressive exercise training markedly decreases diabetes-associated
neuropathic pain, including thermal hyperalgesia and mechanical allodynia.
In rats, this protective effect is related to the increase of Hsp72, but not
TNF-α and IL-6, expression in the spinal cord and peripheral nerves of
STZ-induced diabetes.
Ginseng helps cancer related fatigue.
In a double-blind multi-institution study conducted by the North Central
Cancer Treatment Group and Mayo Clinic, 341 patients with cancer-related
fatigue received 2,000 mg of Wisconsin ginseng twice a day for 8 weeks or an
identical placebo. By 4 weeks the primary endpoint fatigue, measured
by a change from baseline in the general subscale of the Multidimensional
Fatigue Symptom Inventory–Short Form (MFSI-SF) was significantly lower in
the Ginseng group. The same effect was seen across all ages, sexes, race,
menopausal status, cancer type and treatment type. The benefit was
maintained at 8 weeks and there were no significant side effects ( Journal
of the National Cancer Institute by DL. Barton
Mayo Clinic,)
Prevalence of Excessive Tearing in
Women With Early Breast Cancer Receiving Adjuvant Docetaxel-Based Chemotherapy
Abstract May 6, 2013, doi: 10.1200/JCO.2012.45.6574
Purpose To define the incidence and impact of
tearing in patients receiving adjuvant docetaxel-based chemotherapy and
assess for lacrimal duct obstruction (LDO) as a causative factor.
Patients and Methods Consecutive patients with
early breast cancer recommended for docetaxel-based chemotherapy with no
prior ocular symptoms were included. Before and after completion of
chemotherapy, patients underwent lacrimal drainage evaluation by computed
tomographic dacrocystography (CT-DCG) and ophthalmic assessment. Eye
symptoms were assessed at baseline, during, and after completion of
chemotherapy.
Results Over a 22-month period, 100 patients
were recruited. Asymptomatic LDO was present at baseline in 17% and 18% of
patients, as assessed by ophthalmic review and CT-DCG, respectively.
Overall, 86% of patients developed tearing, with no significant difference
between those who did and did not have LDO (94% v 84%; P =
.45). Blepharitis occurred in 37% and minor corneal epitheliopathy in 22% of
patients, with neither condition predicting for the development of tearing.
Impairment of visual activities was greatest after cycle one (70% of
patients) but had decreased to < 5% by 4 months after treatment.
Conclusion Tearing occurs in the majority of
patients receiving adjuvant docetaxel-based chemotherapy regimens and
occurred similarly in patients with and without LDO. There was poor
concordance between CT-DCG and ophthalmic examination in the detection of
LDO. Tearing and other eye symptoms impaired visual activities, but in
nearly all patients, both symptoms and functional impairment were mild and
had resolved by 4 months after chemotherapy. Our study demonstrates
docetaxel-related tearing is not caused by LDO, and as such, evaluation or
stenting of the duct is not considered necessary.
editaorial http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2012.47.5897
Fatigue-Reduction
Programs May Benefit Patients With Advanced Cancer.
Medscape
(1/5, Mulcahy) reported, "Fatigue-busting programs work, even in patients
with advanced cancer, according to a rare randomized controlled trial in this
setting, which was published
January 2nd in the Journal of Clinical Oncology." Investigators
"assigned 152 fatigued cancer patients to either a special protocol of
patient-tailored treatment (n = 76) or usual care (n = 76)." The
researchers "found significant improvements during the study period with
the patient-tailored treatment for the primary outcome of general fatigue ( P
< .01)."
Creative Arts
May Reduce Depression, Anxiety In Cancer Patients.
HealthDay
(5/14, Doheny) reports, "Cancer patients who participate in the creative
arts - such as music therapy, dance, art therapy and writing - may be helping to
reduce the anxiety, depression and pain that can be associated with their
diagnosis, according to" research published in JAMA Internal Medicine. The
researchers came to this conclusion after looking at data from 27 studies which
included approximately 1,500 participants. HealthDay adds, "Taking part in
these creative arts 'is an opportunity for these patients to complement the
healing process above and beyond the physical,' said Timothy Puetz, presidential
management fellow at the U.S. National Institutes of Health's Office of the
Director."
Aerobic
Exercise Could Ease Cancer Fatigue.
The Huffington
Post (11/25, Chan) reported, "Running, walking and bicycling
could help people with cancer to beat a common side effect of both the disease
and its treatment, according to a new review of studies." The review
included "56 studies, half of which were included in a previous review
published in the Cochrane Library, that analyzed the impacts different kinds
of exercise had on cancer-related fatigue (half of the studies dealt
specifically with breast cancer-related fatigue)." But exercise
"isn't the only thing that could beat fatigue - research presented at the
annual meeting of the American Society of Clinical Oncology showed that taking
high doses of ginseng could help cancer patients be less fatigued over a
two-month period, compared to taking a placebo."
Stress,
Fatigue May Be Cause Of "Chemo Brain."
USA
Today (12/8, Szabo) reported, "A small study presented"
recently "at the annual San Antonio Breast Cancer Symposium...suggests that
chemo may not be to blame for" so-called "chemo brain."
The Time
(12/8, Park) "Healthland" blog reported that instead, "stress and
fatigue related to receiving a cancer diagnosis and anticipating chemotherapy
may be responsible for triggering muddled thinking." Investigators
"studied 28 women who received chemotherapy, 37 who received radiation, and
32 healthy controls without cancer." At the beginning "of the study,
all the participants completed verbal working memory tasks while their brains
were scanned using functional MRI." Participants then completed the same
tasks a month after initiation of their treatment.
The Huffington
Post (12/7) reported, "Researchers found that fatigue levels were
higher and accuracy on the memory task was lower among the women who underwent
chemotherapy - both before they started the chemotherapy and after - compared
with the women who underwent radiotherapy and the healthy women."
Bloomberg
News (12/7, Ostrow) reported that the study "was funded by the U.S.
National Institutes of Health."
The Boston
Globe (12/8, Kotz) "Daily Dose" blog quoted study leader
Bernadine Cimprich as saying, "What we're suggesting is that we really need
to be more aware that a woman facing breast cancer may have cognitive problems
ahead of her treatment."
MedPage
Today (12/9, Smith) reported that the research suggests "that
'chemo brain' is not the best way of thinking about what Cimprich called
'cancer-related cognitive dysfunction.'"
HealthDay
(12/8, Gray) reported that "Cimprich said the research is encouraging
because it suggests that early intervention may reduce or even prevent
thought-process problems in women who will be getting chemotherapy."
Chemo For
Breast Cancer May Confer Significant Risk Of Secondary Leukemia.
MedPage
Today (12/8, Bankhead) reported, "Chemotherapy for breast cancer
conferred a small but statistically significant risk of secondary leukemia,
according to a study reported" at the San Antonio Breast Cancer Symposium.
Investigators found that, "ten years after treatment for breast cancer,
about 0.5% of women had developed some form of leukemia." Additionally,
"radiation therapy alone...appeared to increase the risk of secondary
leukemia but not substantially beyond the risk associated with
chemotherapy."
Statins May Be
Linked To Reduced Cardiotoxicity In Breast Cancer Patients Receiving Chemo.
MedPage
Today (11/10, Walsh) reported, "Women being treated for breast
cancer with anthracycline chemotherapy experienced less cardiotoxicity if they
also were receiving statins," according to a study
published online in the Journal of the American College of Cardiology.
Investigators found that "a significantly lower risk for new-onset heart
failure was seen among women receiving a statin throughout their chemotherapy,
with a hazard ratio of 0.3 (95% CI 0.1 to 0.9, P=0.03)."
Depressive
Symptoms, Shortened Telomeres Linked To Higher Bladder Cancer Mortality.
HealthDay
(10/19) reports, "People with significant symptoms of depression and
shortened telomeres - pieces of DNA that protect the ends of chromosomes from
deterioration - are at greater risk of death from bladder cancer,"
according to research scheduled to be presented at an American Association for
Cancer Research meeting. Investigators found that "patients with
depression symptoms and short telomeres had more than a three times higher
risk for death and a much shorter period of disease-free survival."
Talk
Therapy, Exercise May Benefit Women With Chemotherapy-Related Menopause.
Reuters
(10/12, Pittman) reports that, according to research published in the Journal
of Clinical Oncology, talk therapy and exercise may benefit women with
chemotherapy-related menopause. In a study involving more than 420 women,
researchers found that women assigned to exercise, talk therapy, or both
reported that the symptoms related to their treatment had improved.
Exercise, Behavioral Therapy Reduce Menopausal Symptoms Caused by
Breast Cancer Treatment
Women with breast
cancer who were suffering from treatment-related menopausal symptoms
experienced symptom relief with cognitive
behavioral therapy, physical exercise, or both, according to a Dutch study.
The findings were
published October 8 in the Journal of Clinical Oncology.
Dr. Neil K. Aaronson of the Netherlands Cancer Institute and his colleagues
randomly assigned 422 patients to behavioral therapy, physical activity, an
intervention combining the two, or a control
group that received usual care. The purpose of the study was to evaluate the
effects of psychosocial interventions and exercise on menopausal symptoms, such
as hot flashes and night sweats, as well as on sexual functioning, psychological
well-being, and health-related quality
of life. The patients reported their symptoms at the start of the study and
12 weeks and 6 months later.
Compared with the control group, women who received the interventions had statistically
significantly lower levels of endocrine and urinary symptoms, and
behavioral therapy and physical activity had a positive effect on physical
functioning. The researchers noted, however, that physical activity “affects
primarily the frequency with which endocrine symptoms are experienced, but not
the frequency of hot flashes and night sweats specifically.” Cognitive
behavioral therapy, in contrast, “seems to not only affect symptom frequency,
but also the perceived burden of hot flashes and night sweats.”
In a related editorial,
Mayo Clinic researchers Drs. Debra Barton and Charles Loprinzi commented that,
despite its limitations, the study demonstrated that “it is not sufficient to
consider only biomedical influences [on symptoms]. …For complete symptom
resolution, it may be necessary to address both the physiological expression and
psychosocial context of the symptom.”
Ginseng May
Help Fight Cancer-Related Fatigue.
The ABC
News (6/5, Gann) "Medical Unit" blog reports that research
presented at the American Society of Clinical Oncology suggests "that
ginseng may be a tool for fighting cancer-related fatigue."
The Huffington
Post (6/5) reports, "The study...included 340 people who were
either currently undergoing cancer treatments, or who had just completed cancer
treatments." Each day, participants were "given either a placebo pill
or a pill that contained 2,000 milligrams of American ginseng root."
HealthDay
(6/5, Dotinga) reports that participants "who took the ginseng capsules
didn't report much improvement at four weeks, but at eight weeks they reported
they felt less 'worn out,' 'fatigued,' 'sluggish' or 'tired,' compared to those
who took the placebo, the investigators found."
Chewing Gum
May Hasten Bowel Function Recovery After Liver Resection.
Medscape
(6/8, Boughton) reports, "Results of a Korean study
support the use of a relatively inexpensive intervention to hasten bowel
function recovery after liver resection for hepatocellular cancer: gum
chewing. In the study of 42 patients published online June 2 in the Journal of
Clinical Nursing, patients who chewed gum three times per day showed faster
recovery in postoperative bowel function than those in a control group."
In addition, "those in the gum-chewing group...had a reduction in
xerostomia grade."
Novel
Procedure May Cure Lymphedema By Transplanting Healthy Nodes.
The New
York Times (6/21, D5, Rabin, Subscription Publication) reports,
"Top plastic surgeons from around the country met in Manhattan last month
to observe an experimental surgery that may cure lymphedema, a serious
complication of breast cancer treatment." As some surgeons "crowded
into an operating room at New York Eye and Ear Infirmary and others watched a
live video broadcast," Dr. Corinne Becker, who "pioneered the
procedure, harvested lymph nodes from a patient's groin to transplant to her
underarm, where nodes had been removed earlier during cancer treatment."
This innovative procedure, called "an autologous vascularized lymph node
transfer, is used to treat lymphedema." In the surgery, the missing lymph
nodes are "replaced with a handful of healthy nodes transplanted from
elsewhere" in the patient.
Omega-3 Fat
Consumption May Reduce Fatigue In Breast Cancer Survivors.
Reuters
(3/21, Norton) reports that, according to research published online in the
Journal of Clinical Oncology, consumption of omega-3 fats may benefit breast
cancer survivors. Researchers found that the omega-3 fats may reduce fatigue
in these patients.
Feelings Of
Loneliness May Impact A Person's Physical Health.
HealthDay
(1/22) reports, "Being lonely does more than just make a person feel sad
- loneliness can affect a person's physical health," according to a study
that was scheduled to be presented at the annual meeting of the Society for
Personality and Social Psychology. Researchers found, "in a study of 200
breast cancer survivors, average age 51," that "compared to study
participants with more social connections, people who said they felt lonely
showed more inflammation in response to stress, and higher levels of
reactivation of a latent herpes virus, which is a sign of poor immunity."
The researchers "also noted that the reactivation of a latent herpes
virus is known to be linked with stress, and said these findings suggest that
loneliness acts as a chronic source of stress that triggers a poorly
controlled immune response."
Chemotherapy
May Have Long-Term Impact On Cognition.
The Los
Angeles Times (2/28, Roan) "Booster Shots" blog reports,
"Chemotherapy patients have long complained of the mental fog that tends to
accompany treatment, but a new study"
published in the Journal of Clinical Oncology "suggests that certain
combinations of chemo drugs may have long-term effects on cognition."
HealthDay
(2/28, Mann) reports, "In the new study, 196 women with breast cancer who
were treated with chemotherapy roughly 21 years earlier performed worse on tests
of their memory, processing speed and other thinking...skills when compared to
their counterparts who had never been diagnosed with cancer." The patients
"had all been treated for breast cancer with a chemotherapy combination
that included the drugs cyclophosphamide, methotrexate and 5-fluorouracil
between 1976 and 1995." Study author Sanne Schagen, in an American Society
of Clinical Oncology news release, said, "To our knowledge, this is the
first study to suggest that subtle cognitive deficits may be among the long-term
effects of chemotherapy, especially of the earlier regimens."
Music May
Improve Cancer Patients' Quality Of Life.
MedPage
Today (8/11, Walker) reports a study published in the Cochrane Database
of Systematic Reviews reviewing "30 trials with a total of 1,891 cancer
patients who underwent music therapy interventions as part of their
treatment." The study "found that both music interventions appeared to
be more effective at reducing anxiety than no music or white noise or nature
sounds delivered through headphones." One exception was that "patients
didn't like listening to music via headphones during a procedure, because they
couldn't hear what the doctor was saying, which causes anxiety and could
actually increase the perception of pain."
WebMD
(8/11, Hendrick) reports, "Music also seemed to help with the mood and pain
levels of patients, though not depression. And smaller beneficial effects were
seen on heart rate, breathing rate, and blood pressure."
Insomnia,
Fatigue May Afflict Cancer Patients.
Reuters
(8/11, Pittman) reports on two papers published in the Journal of Clinical
Oncology showing that persistent insomnia and fatigue can afflict cancer
patients. In one of the studies, Julienne Bower of the University of California,
Los Angeles, and co-authors, discovered that almost 66% of participants had
problems with insomnia and fatigue. Bower noted that it is just recently that
the medical community is becoming aware of such issues. Meanwhile, researchers
are looking into cognitive behavior therapy and tai chi for insomnia, and yoga
for fatigue
Plant may protect cancer
patients' skin during radiation therapy:
Research indicating that ointment
containing Calendula plant extracts may
reduce dermatitis in cancer patients who
apply the ointment before radiation
therapy. Researchers found that 41
percent of patients using the ointment
suffered moderate-to-severe dermatitis,
compared with 63 percent of those using
trolamine, a standard cream used in Europe
to prevent dermatitis.
Researchers
say chemotherapy may disrupt sleep-wake cycles in patients with breast cancer.
HealthDay
(9/1, Dotinga) reported that "chemotherapy in breast cancer patients
disrupts cycles of sleep and wakefulness, and continued treatment leads to worse
and more lasting problems," according to findings appearing in the Sept. 1
issue of Sleep. Investigators examined "95 women with breast cancer who
were scheduled to receive chemotherapy," finding that "during the
first week of" treatment, they "took longer to get to high activity
levels after waking." The women "also decreased their activity levels
earlier at night," which "continued in the first week of the fourth
cycle of chemotherapy." The researchers concluded that "during
chemotherapy, our biological clock gets out of sync, especially after the first
cycle of treatment. The clock seems to regulate itself after only one cycle, but
with repeated administration of chemotherapy, it becomes more difficult for the
biological clock to readjust."
Breast-Cancer
Survival Fatigue May Be Linked To Autonomic Nervous System Alterations.
Medscape
(5/16, Nelson, Subscription Publication) reported that fatigue is a "common
problem in breast cancer survivors," and a study in
Psychoneuroendocrinology suggests that it "might be the result of
alterations in the autonomic nervous system." The researchers analyzed a
cohort of "109 women who had completed treatment for stage 0 to IIIA breast
cancer in the previous two years, and who were at least two months past surgery,
radiation, or chemotherapy." They found that women who "reported
higher levels of fatigue also had significantly higher norepinephrine levels and
lower heart rate variability (HRV) before and after stress was induced than
those who reported less fatigue."
Psychiatric
Treatment, Psychosocial Support May Benefit Women With Cancer.
Medscape
(5/27, Brauser, Subscription Publication) reported that, according to two
studies presented recently at the American Psychiatric Association's annual
meeting, "psychiatric treatment and psychosocial support may make a
significant difference to survival and quality of life in women with
cancer." In the first study,
which was recently published in the Journal of Clinical Oncology, "a
secondary analysis of a randomized controlled trial (RCT) of 125 women with
metastatic breast cancer, investigators found that the median survival time
for those who had decreasing depression symptom scores during a one-year
period was double that of those with increasing scores (53.6 vs. 25.1
months)." And, in a second study,
which was also "published online March 2 in Psycho-Oncology, researchers
found that women who receive a cancer diagnosis during pregnancy were at
particular risk of experiencing high levels of distress."
Study:
Flaxseed Does Not Help Reduce Hot Flashes.
In continuing coverage, MedPage
Today (6/8, Phend) reported that flaxseed "will not ease hot
flashes for women with menopausal symptoms or breast cancer survivors taking
anti-estrogen drugs," according to findings presented at the American
Society of Clinical Oncology meeting. Researchers randomized "188
postmenopausal women" to eat a "fiber bar daily that contained either
410 mg of the active flaxseed lignans or 2 g protein as a placebo for six
weeks." According to results, mean "vasomotor symptom scores dropped
33% with flaxseed-spiked fiber bars, but also fell 29% with placebo fiber bars
without a significant difference between groups. ... The 'disappointing'
randomized trial results showed why clinical trials are necessary, noted Mark G.
Kris, MD, of Memorial Sloan-Kettering Cancer Center in New York City, who
chaired" the ASCO Cancer Communications Committee
Experts
Caution Cancer Patients' Skin Vulnerable To Sun Damage.
HealthDay
(8/2, Dallas) reports that the skin of cancer patients who have received
radiation therapy have increased risk for sun damage, so patients need to be
careful about sun damage, according to researchers at the University of
Alabama-Birmingham. The experts also said that children with cancer are at the
greatest risk. HealthDay Added, "Skin cancer patients should pay
particular attention to the areas of skin being treated, advised the American
Society of Clinical Oncologists. Dark, tightly woven fabrics are best for
guarding against sun exposure, the group noted."
Obesity May
Contribute To Lymphedema In The Legs.
MedPage
Today (5/31, Neale) reports that a recent study
published in the New England Journal of Medicine observes that "obesity
may contribute to the development of lymphedema." Dr. Arin Greene of
Children's Hospital Boston and his colleagues authored the study, writing that
"as the amount of adipose tissue increases in the lower extremity,
lymphatic vessels may become dysfunctional (possibly because of compression or
inflammation), thereby reducing proximal lymphatic flow."
HealthDay
(5/31, Mann) notes that the researchers examined 15 obese individuals with
pain and swelling in the legs, and they diagnosed five of these individuals
with leg lymphedema, labeling obesity as a risk factor for lymphedema in the
legs. The researchers have not yet investigated whether there is a link
between obesity and lymphedema of the arms.
Mind and body
Anxiety,
Depression May Persist Following Cancer Diagnosis.
MedPage
Today (6/19, Wickline) reports that, according to research
published online in the Journal of Clinical Oncology, “in the year following a
cancer diagnosis, some patients showed lingering or late-onset anxiety and/or
depression, although most appeared to cope relatively well.” Researchers found
that “among 1,154 patients followed from initial cancer diagnosis,”
approximately “20% met criteria for clinically relevant anxiety and roughly
10% were found to have depression 6 and 12 months later.” The investigators
found that “significant predictors of development of late-onset or persistent
mood disorders in the prospective study included high levels of such disorders 6
months after diagnosis, but also such factors as gender, type of cancer, and
certain coping styles.”
Hormones cause chemo brain (Rugo H, et al "Prospective study of
cognitive function in women with early-stage breast cancer: Predictors of
cognitive decline" BSC 2013). The study population consisted of 69
patients: 33 in the chemotherapy-hormone therapy group, 22 in the hormone
therapy-only group, and 14 in the chemotherapy-only group. Additionally, 12 age-
and education-matched women not receiving chemotherapy or hormonal treatment
served as a control group.
Patients completed a neuropsychological test battery comprising more than a
dozen individual tests that assessed mood and fatigue, as well as cognitive
function. The battery was administered at baseline and at follow-up visits at
months 1, 9, and 18.
At the 1-month follow-up visit, about 25% of the patients had lower scores on
the neuropsychological battery as compared with baseline. The proportion
increased to about 35% at 9 months, and 30% of patients had scores indicative of
cognitive decline at 18 months. Scores on tests of executive function and verbal
memory were affected most often.
By univariate conditional logistic regression analysis, hormone therapy was
the only independent predictor of cognitive decline at any point in time (OR
4.95, 95% CI 1.68-14.49, P=0.004). Chemotherapy, radiation therapy,
fatigue, and depression did not contribute significantly to cognitive decline.
The longitudinal effect of hormone therapy on cognitive function was
evaluated by multivariate conditional logistic regression analysis controlling
for age, education, estimated baseline IQ, and average estradiol level. The
analysis yielded an odds ratio of 7.69 (95% CI 2.20-27.03, P=0.002).
The study is notable for its objective evaluation of the relationship between
hormonal therapy and cognitive function, which has been examined less
extensively than has chemotherapy, said invited discussant Julia
White, MD, of Ohio State University in Columbus.
"Cognitive changes associated with hormone therapy for breast cancer
[have] proven to be somewhat complex," said White. "Chemotherapy is a
confounding effect. Some reports have suggested the type of hormonal agent makes
a difference -- selective estrogen receptor modulator versus aromatase
inhibitor.
"Menopausal status, prior oophorectomy, and hormone replacement therapy
all can impact cognitive changes in women."
The issues have been particularly difficult to sort out in postmenopausal
breast cancer patients, she added. Cognitive function substudies of several
large randomized clinical trials have yielded disparate results in terms of the
severity, affected domains, and agents implicated in cognitive dysfunction
Positive
Outlook On Life May Help People Live Longer.
The CBS Evening News (5/30, story 8, 2:50,
Pelley) reported, "If you hope to live to be 100, a new study out today
in the journal 'Aging' says a positive outlook on life will help." Dr.
Jon LaPook explains that "Ashkenazi Jews, those who are from Eastern
Europe...live unusually long, healthy lives. ... They caught the attention of
researchers who dubbed them super-agers. Dr. Nir Barzilai of the Albert
Einstein College of Medicine studies them." Dr. Nir Barzilai, Albert
Einstein College of Medicine: "We were trying to find out what are those
biological complements that make us age at different rates?" LaPook:
"Barzilai and his team discovered people who live to be 100 are more than
twice as likely to have a certain variant of a gene called CETP. It helps
control cholesterol and protects against heart disease and dementia."
Feelings Of
Loneliness May Impact A Person's Physical Health.
HealthDay
(1/22) reports, "Being lonely does more than just make a person feel sad
- loneliness can affect a person's physical health," according to a study
that was scheduled to be presented at the annual meeting of the Society for
Personality and Social Psychology. Researchers found, "in a study of 200
breast cancer survivors, average age 51," that "compared to study
participants with more social connections, people who said they felt lonely
showed more inflammation in response to stress, and higher levels of
reactivation of a latent herpes virus, which is a sign of poor immunity."
The researchers "also noted that the reactivation of a latent herpes
virus is known to be linked with stress, and said these findings suggest that
loneliness acts as a chronic source of stress that triggers a poorly
controlled immune response."
Adolescent
Risk Of Self-Harm Greater If Parent Dies Of Cancer.
Reuters
(12/5, Seaman) reports that according to a study
published online Dec. 3 in the Archives of Pediatrics and Adolescent Medicine,
one in five adolescents whose parent has died of cancer may self-harm either
by burning or cutting themselves. In contrast, only one in 10 adolescents with
both parents living will engage in such behavior.
MedPage
Today (12/5, Bankhead) reports that the study "authors identified
several factors that had statistically significant associations with
self-injury in both groups: female sex -- OR 3.2; bullying before age 13 -- OR
2.8; physical/sexual abuse -- OR 6.5; low family cohesion -- OR 3.2; no one to
share joys/sorrows -- OR 1.8; any childhood psychiatric morbidity -- OR 9.0;
deliberately harming others during a menstrual period -- OR 2.9; attempted
suicide/endangering own life -- OR 6.0; [and] self-injury prior to 2000 -- OR
11.7." Researchers arrived at these conclusions after reviewing
"government records of individuals born in Sweden from 1936 to 1973 and
who died of cancer during 2000 through 2003."
Quality Of
Breast Cancer Patients' Personal Relationships May Be Linked To Survival.
HealthDay
(11/16) reports, "The quality of a breast cancer patient's personal
relationships may be as important as the size of her social networks in
predicting survival," according to a study published in Breast Cancer
Research and Treatment. The study of more than 2,200 breast cancer patients
found that "women who were socially isolated were 34 percent more likely
to die from breast cancer or other causes than women who were socially
integrated." The researchers "also discovered that levels of support
within personal relationships were important risk factors for breast cancer
death."
Cancer
Survivors May Have Poorer Quality Of Physical, Mental Health.
MedPage
Today (11/1, Petrochko) reports, "Cancer survivors may be cured of
their disease, but they are still more likely to report a poorer quality of
physical and mental health than adults who have not had cancer," according
to a study
published in Cancer Epidemiology, Biomarkers, & Prevention. Investigators
found, "in a national survey on health-related quality of life, 24.5% of
cancer survivors reported poor physical quality of life and 10.2% said they had
poor mental quality of life." This "compared with 10.2% and 5.9%,
respectively, among adults with no history of cancer, a significant difference (P<0.0001)."
"Cancer-Free"
May Mean Different Things To Some Physicians, Patients.
The Chicago
Tribune (9/26, Sadick) reports on the ambiguity, among cancer survivors
and physicians, surrounding the phrase "cancer-free." Most
"experts agree that there is no magic number of years for a survivor's risk
of recurrence to disappear completely." The Tribune adds, "For studies
run by Cancer Cooperative Groups, which include researchers, cancer centers, and
physicians working together to run clinical trials sponsored by the National
Cancer Institute, patients are usually followed for 15 years after
diagnosis." Meanwhile, "Dr. Catherine Alfano, deputy director of the
Office of Cancer Survivorship at the National Cancer Institute, says that of the
women diagnosed with breast cancer today, 90 percent will be alive in five
years, compared with 63 percent in the 1960s."
Stress,
Depression May Have Adverse Impact On Renal Cell Carcinoma Outcomes.
The CNN
(9/15, Enayati,) reports that "several recent studies underscore how
critically important it is for those fighting" cancer "to learn how to
combat stress." For instance, in a study recently published in PLOS ONE,
"a team of researchers led by Lorenzo Cohen, professor of general oncology
and director of the Integrative Medicine Program at The University of Texas MD
Anderson Cancer Center, found that symptoms of depression among a group of
patients with late-stage renal cell carcinoma were associated with an increased
risk of death." The primary "suspects in Cohen's study: cortisol -
also known as the 'stress hormone' - and inflammatory pathways."
Having fun helps fight cancer
Prof Matthew During from Ohio State University conducted
an experiment in mice with implanted cancers which was reported in the journal
cell. Those living in a stimulating healthy environment had a slower rate of
progression compared to those in a more confined environment. Levels of leptin
were lower in the more stimulated mice
Women With
Breast Cancer May Often Struggle With Depression.
In the "First Person" column in the Miami
Herald (1/3), Miami Herald editor Andrea Torres, a breast cancer
patient, wrote, "Experts in psychosocial oncology say that women with
breast cancer have the third highest rate of depression among cancer
diagnostic groups, and that major depression is an under-recognized and
under-treated problem." Torres goes on to describe her particular battle
with depression. Currently, she is being treated with antidepressants and
"staying connected to others with the help of social media" to
improve her outlook on matters. She is also "set to begin behavioral
therapy soon."
Mindfulness
Training May Benefit Patients Undergoing HSCT.
Medscape
(11/15, Nelson) reports that "Mindfulness training might prove beneficial
for patients who are undergoing hematopoietic stem cell transplantation (HSCT),
according to researchers who conducted a randomized trial of the
intervention." The investigators "evaluated the longitudinal and
short-term effects of mindfulness meditation training in 241 cancer patients who
were hospitalized for HSCT." The researchers found that "although an
intent-to-treat analysis did not reveal long-term group differences, there were
significant immediate improvements in symptoms and mood in patients who
underwent the training, compared with those who didn't." The research was
presented at a Society for Integrative Oncology conference.
Chemotherapy
May Lead To White Matter Alterations.
Medscape
(12/23, Lowry, Subscription Publication) reports, "Cerebral white matter
is altered and cognitive function declines after chemotherapy," according
to a study
published online Dec. 19 in the Journal of Clinical Oncology. The study, which
used magnetic resonance diffusion tensor imaging "to document actual
physical changes in the brain, along with a detailed cognitive assessment
before and after a course of chemotherapy for breast cancer, adds to the
emerging body of literature attesting to the effects of chemotherapy on brain
structure and function, comments the author of an accompanying editorial."
Researchers found that "patients who had received chemotherapy performed
significantly worse on attention and concentration tests, psychomotor speed,
and memory compared with baseline," which correlated with
"significant decreases in fractional anisotropy in the frontal, parietal,
and occipital white matter tracts after chemotherapy."
Chemotherapy Can Impair Cognition More than Two Decades Later
More than 20 years after treatment, breast
cancer patients who received adjuvant
chemotherapy exhibited cognitive deficits compared with women who were never
diagnosed with cancer. The results,
which appeared online February 27 in the Journal of Clinical Oncology,
suggest that the phenomenon known as chemobrain can persist for decades after
cancer treatment ends and may become more common as the number of cancer
survivors grows.
To investigate chemotherapy’s long-term effects on cognition,
Dr. Vincent Koppelmans of Erasmus MC University Medical Center in Rotterdam, the
Netherlands, and his colleagues identified 196 eligible breast cancer patients
from two Dutch hospital registries and invited them to participate in tests that
measured learning, memory, information processing, and psychomotor abilities.
All of the patients had received six cycles of adjuvant chemotherapy with cyclophosphamide,
methotrexate,
and fluorouracil
(CMF) on average 21
years earlier and were between 50 and 80 years old when recruited to the trial.
Women who had experienced a relapse,
second primary tumor,
or distant metastases,
and those who used adjuvant endocrine
therapy were excluded from the study.
The 1,509 women in the reference group were selected from the Rotterdam
Study, a population-based study also being conducted in the Netherlands. These
women had no history of cancer and were also between 50 and 80 years old when
they were tested.
Although the researchers observed no difference between the two groups in a
dementia screening test, the breast cancer survivors performed worse on some
tests of delayed verbal memory, processing speed, and psychomotor speed. The
survivors also had more memory complaints but fewer symptoms of depression.
This pattern of deficits is similar to those from other trials conducted
closer to the time patients finished chemotherapy. But it is unclear whether the
results of this study are representative of the long-term effects of other
chemotherapy regimens.
Although newer regimens are now available for women with early-stage breast
cancer, the authors noted, “[CMF] was the standard regimen up to the 1990s...
[and] cyclophosphamide and fluorouracil continue to be incorporated into
currently used regimens.”
“This work is an important reminder that it is not enough to focus on the
cure and control of cancer,” commented Dr. Julia Rowland, director of NCI’s Office
of Cancer Survivorship. “We must also attend to the impact of therapy on
the long-term health and function of our growing population of survivors.”
See also: “Delving
Into Possible Mechanisms for Chemobrain”
Breast Cancer
May Be Linked To Memory Problems.
The Los
Angeles Times (11/15, Kaplan) "Booster Shots" blog reports,
"A study of breast cancer patients finds that women who had chemotherapy
along with surgery to treat their disease had more trouble kicking their brains
into high gear than women who were treated with surgery alone." The breast
cancer patients "also performed much worse on tests of mental function than
a group of healthy women who served as controls." The research
was published in Archives of Neurology.
MedPage
Today (11/15, Gever) reports that investigators "recruited 44
breast cancer survivors and 18 healthy controls matched for age, menopausal
status, and education level." All "participants underwent functional
MRI scans while performing a card-sorting task in order to measure brain
activation in specific regions." Participants "also were evaluated
with a series of other neurocognitive tests, including one to identify
potentially confounding psychiatric symptoms such as depression."
HealthDay
(11/15, Gardner) reports that the participants "with breast cancer, whether
or not they had had chemotherapy, showed reduced activity in two areas of the
prefrontal cortex, including one heavily involved in memory, the investigators
found." Individuals who "had undergone chemotherapy also had reduced
activity in the prefrontal cortex and tended to repeat errors and complete tasks
more slowly compared to both other groups." Reuters
(11/15, Steenhuysen) also covers the story.
Meditation
Significantly Improves Cancer Survivors' Overall Well Being.
Medscape
(5/24, Harrison, Subscription Publication) reported that group sessions
"during which cancer survivors are taught meditation, mindful yoga, and
communication techniques significantly improve psychological symptoms and
quality of life (QoL)," according to findings presented at the American
Society of Breast Surgeons meeting. Researchers randomly assigned 77 female
cancer survivors to either attend "weekly two-hour classes for eight weeks
plus a single for-hour weekend retreat" or be on a waiting list (control
group). Patients in the intervention group "showed a significant
improvement on the SCL-90-R," with an effect size of 0.373 and a QoL of
"P=.005 in terms of significance." All domains in "symptoms of
stress improved in the intervention group" achieved significance. In
contrast, the control group "did not achieve statistical significance"
on any of the parameters.
Group therapy may prolong
survival for women with breast cancer
This article describes a Cancer
study indicating that women with breast
cancer who participate in group therapy
sessions - consisting of a year of
small-group meetings led by clinical
psychologists - may live longer and have a
lower risk of cancer recurrence.
Researchers found that after 11 years, women
who participated in the one-year group
sessions were 56 percent less likely to die
of breast cancer and 45 percent less likely
to experience cancer recurrence, compared to
women who did not participate
Researchers
to examine cognitive rehabilitation program for women with breast cancer. Chemo
brain is a common, and disconcerting, side effect of chemotherapy" that
is "generally described as changes in cognitive abilities that occur
during" treatment. Patients who suffer from chemo brain typically
"complain that they are mentally tired, can't think clearly, or can't
think as fast as they used to." Now, researchers are "evaluating a
cognitive rehabilitation program for women with breast cancer who may be
experiencing cognitive difficulties." They speculate that variations
"in genes that regulate the immune system render some patients more
vulnerable to" these symptoms. The researchers aim "to develop and
evaluate a rehabilitation program for breast cancer survivors who believe they
are having trouble thinking and concentrating after receiving treatment."
Breast
Cancer-Recurrence Worry Level May Vary By Race, Ethnicity.
MedPage
Today (4/1, Smith) reported, "Worry about a recurrence of breast
cancer varies markedly according to racial and ethnic background,"
according to a study
in the journal Cancer. The researchers analyzed data from Surveillance,
Epidemiology, and End Results registries of women whose "nonmetastatic
breast cancer was diagnosed from June 2005 to February 2007." They found
that "46% of Latinas" who spoke primarily Spanish "reported they
worry 'very much' about recurrence, compared with 25% for Latinas who mainly
spoke English." In contrast, only "14% of white women and 13% of
African Americans said they worried 'very much.'" High levels of worry were
also "significantly associated with younger age, having a job, frequency of
pain and fatigue, and receipt of radiation therapy."
Marital
distress may slow breast cancer recovery:
This article reports on
a Cancer study finding that breast
cancer survivors who report marital distress
have greater difficulty recovering
from treatment, compared to women who said
they were in a non-distressed
relationship. The article notes that
participants who reported marital distress
were more likely to experience slower
recovery of physical functioning, more
severe side effects, an increase in
depressive symptoms and unwanted thoughts
and fear about cancer recurrence.
Researchers suggested women in this group
may benefit from psychosocial
referrals. Article: Reuters
Beta-Blockers
May Boost Breast Cancer Survival.
Reuters
(5/31, Joelving) reported that findings from two preliminary studies suggest
that women with breast cancer who take blood pressure drugs known as
beta-blockers may have a better chance for surviving the disease. The results
are published in the Journal of Clinical Oncology. In one study, women taking
beta-blockers who survived longer were less likely to be diagnosed with
aggressive breast cancer. In the other study, after five years, women taking
propranolol had an average, estimated 9% risk for dying of breast cancer,
compared with 27% of the control group
Multidisciplinary
Interventions Help Cancer Survivors Return To Work.
Medscape
(2/23, Nelson) reported, "Cancer survivors who received multidisciplinary
interventions, which included physical, psychological, and vocational
components, were nearly twice as likely to overcome challenges and
successfully return to work as those who received usual care," according
to a meta-analysis
published online in the Cochrane Database of Systematic Reviews. Included in
the analysis were "14 randomized controlled trials and four controlled
before/after studies, for a total of 1,652" subjects. The researchers
found that "there was moderate-quality evidence that showed that
multidisciplinary interventions led to higher return-to-work rates than care
as usual (OR, 1.87)."
New Research
Suggests Obese People Can Be Fit.
Bloomberg
News (9/5, Hallam) reports that "obese people who are otherwise
physically fit had no greater risk of dying prematurely than those whose
weight is normal, according to research partially funded by Coca-Cola Co.
(KO), the world's biggest soft-drink maker." Additionally, it points to a
separate study, which "found that obese people with heart disease have a
lower risk of dying early than underweight or normal-weight heart
patients." Bloomberg News says that "the findings undermine decades
of public health messages, also supported by research, that obesity can
accelerate the development of heart disease, diabetes and cancer and shrink
lifespans, three European researchers who weren't involved in the two studies
wrote in an editorial that accompanied the results in the European Heart
Journal today."
CNN
(9/5) "The Chart" blog also reports on the study published this week
in the European Heart Journal that "shows it is possible to be both obese
and healthy." According to the blog, "the researchers found that the
metabolically healthy but obese participants had a 38% lower risk of dying
than their metabolically unhealthy peers." Additionally, the article says
that the study found that "there was also no risk difference between the
metabolically healthy obese and the metabolically healthy normal weight
participants."
Study:
Smokers More Likely To Quit Using Nicotine Patches, Medications.
Reuters
(9/5) reports on an international study published in the journal Addiction,
which found that smokers are more successful in quitting when they use
nicotine patches or prescription medications, rather than going it alone.
Study leader Karin Kasza, a statistician at Roswell Park Cancer Institute in
Buffalo, New York, and colleagues wrote, "Smokers in the United Kingdom,
Canada, Australia and the United States are more likely to succeed in quit
attempts when they use (drugs) or nicotine patch." They added, "The
disappointing reality is that even when people use these medications to help
them quit, relapse is still the norm. It's better than nothing, but it's by no
means a magic bullet."
Reducing stress before prostate surgery helps outcome.
Research from the integrative medicine group at
M.D. Anderson Cancer Center in Houston has shown that helping men cope with the stress of prostate cancer surgery before the
operation speeds up both their physical and psychological
recovery. In this study of 159 men with early-stage prostate cancer, scheduled for radical
prostatectomy, a third of the men in the study received routine care, a
third “supportive care,” meaning they had access to psychologists one to
two weeks before surgery as well as right before the operation and in the
days after the procedure and a third group received stress management
training. These men met with a psychologist for support but also learned
deep breathing and guided-imagery techniques to help cope with the stress of
surgery. They were led through a mental imagery exercise so they understood
everything that would be happening to them as they were taken into surgery
and recovery. Two days after surgery, the men who had received stress management had a
measurably stronger immune response, based on higher levels of natural
killer cell function and circulating pro-inflammatory cytokines, which
affect the healing process.
BMI,
Waist-To-Hip Ratio May Impact Breast Cancer Survival.
HealthDay
(10/30, Preidt) reports, "Having a very high or low body-mass index or high
waist-to-hip ratio raises the risk of death among breast cancer patients, but
this association varies some by race and ethnicity," according to a study
that was scheduled to be presented at a meeting of the American Association for
Cancer Research. Investigators looked at data on approximately 12,000 breast
cancer patients. Researchers found that, "compared to normal-weight women,
underweight women had a 47 percent increased overall risk of death and extremely
obese women had a 43 percent increased risk." The investigators also found
that, "compared to those with the lowest waist-to-hip ratio, women with the
highest waist-to-hip ratio (highest level of abdominal fat) had a 30 percent
increased overall risk of death and a 36 percent increased risk for
breast-cancer-related death."
Higher
Levels Of Emotional Support May Be Linked To Better Survival In Ovarian
Cancer.
Reuters
(7/24, Norton) reports that, according to a 168-patient study
published online July 16 in the Journal of Clinical Oncology, ovarian cancer
patients may have a higher chance of survival if they feel that they are
receiving emotional support from friends and family. Researchers reported that
after nearly five years, a higher percentage of study patients who were
classified as having strong emotional support were alive, compared to those
with lower levels of emotional support.
COMPLEMENTARY
THERAPIES
Reflexology
May Benefit Cancer Patients.
The Detroit
Free Press (11/13, Spratling) reports on a study conducted by Michigan
State University Professor in the College of Nursing Gwen Wyatt and funded by
the National Cancer Institute that found, "Reflexology - the method of
massaging the feet to stimulate parts of the body - can help cancer patients
perform daily tasks better." It is "believed to be the first
large-scale study to put hard science behind the benefits of reflexology as a
complement to standard cancer care." The study found that "people
who received the reflexology treatment had significantly less shortness of
breath and were able to more easily perform such tasks as climbing stairs,
getting dressed and going grocery shopping." It "involved 385 women
undergoing chemotherapy or hormonal therapy for advanced-stage breast cancer
that had spread beyond the breast."
Acupuncture
May Relieve Hot Flashes Associated With Prostate Cancer Treatment.
HealthDay
(4/25, Dotinga) reported that acupuncture might help "reduce the hot
flashes that frequently affect prostate cancer patients while they're on
hormone therapy," a small study suggests. The findings "don't
confirm that the ancient Chinese discipline relieves hot flashes, and only 14
men participated in the study," which was conducted by researchers at New
York Methodist Hospital and Weill Cornell Medical College of Cornell
University. Still, "our study shows that physicians and patients have an
additional treatment for something that affects many men undergoing prostate
cancer treatment and actually has long-term benefits, as opposed to more side
effects," said lead author Dr. Hani Ashamalla in a news release from the
American Society for Radiation Oncology.
Acupuncture
May Help To Reduce Cancer-Related Fatigue In Female Patients.
Reuters
(10/30, Pittman) reports that, according to research published online Oct. 29 in
the Journal of Clinical Oncology, acupuncture may help to reduce fatigue in
female patients who have had breast cancer. Investigators reported that
participants who underwent a series of acupuncture sessions reported more
improvements in fatigue, anxiety, depression, and quality of life, compared to
patients who had been given only educational materials
38
Million US Adults Turning To Alternative Therapies.
WebMD
(7/22, Hendrick) reported, "Most Americans believe that prescription
medications are the most effective treatments for many common illnesses, but a
Consumer Reports survey of more than 45,000 people finds that three-fourths of
us are turning to alternative therapies like yoga and acupuncture."
Specifically, "38 million adults make more than 300 million visits per
year to acupuncturists, chiropractors, massage therapists, and other
practitioners of alternative and complementary techniques," the report
found. The report appears in the September issue of Consumer Reports Health,
an online publication.
Study Finds
Medicine From Chinese "Thunder God Vine" Destroys Pancreatic Tumors
In Mice.
Bloomberg
News (10/18, Armstrong) reports that medicine "made from a plant
known as 'thunder god vine,' or lei gong teng, that has been used in
traditional Chinese medicine, wiped out pancreatic tumors in mice, researchers
said, and may soon be tested in humans." The study, which was published
in the journal Science Translational Medicine, found that "mice treated
with the compound showed no signs of tumors after 40 days or after
discontinuing the treatment." Study leader Ashok Saluja was quoted as
stating that the medicine "is just unbelievably potent in killing tumor
cells." Researchers said that these findings will lead the way for
clinical trials of the medicine dubbed "Minnelide" in people with
pancreatic cancer. The research was funded by the University of Minnesota and
the National Institutes Of Health.
Red Wine
Compound May Double Effect Of Breast Cancer Immunosuppressant.
The UK's Telegraph
(2/15, Adams) reported that an "organic compound in the wine called
resveratrol can double the effect of the chemotherapy drug rapamycin,"
according to an analysis published in the journal Cancer Letters. Cancer cells
"often develop resistance to rapamycin, an immunosuppressant. ... 'Our
findings show that resveratrol seems to mitigate rapamycin-induced drug
resistance in breast cancers, at least in the laboratory,'" said lead
researcher Dr. Charis Eng of the Cleveland Clinic, Ohio. She added that their
"lab study on human breast cancer cell lines found that when rapamycin was
used in conjunction with resveratrol, it was twice as effective at killing those
cells than using rapamycin alone.
Herbal supplement may help treat
cancer: Los Angeles Times
This article describes claims
that the herb curcumin, derived from
turmeric, has anti-inflammatory benefits and
may be a treatment for various
cancers. Experts note the lack of
research on the effects of the herb in
humans, but note data suggesting that
curcumin can block inflammation, eliminate
free radicals and kill cancer cells in the
laboratory.
Article:
Los Angeles Times
Depression May
Be Linked To Reduced Survival Times In Kidney Cancer Patients.
HealthDay
(8/2, Dallas) reports, "Symptoms of depression are linked to shorter
survival times among cancer patients, according to a new study" published
in PLoS ONE. Investigators "analyzed surveys completed over a five-year
period by 217 patients newly diagnosed with kidney cancer that had spread."
The participants also provided several saliva samples that were used to gauge
levels of the stress hormone cortisol. The researchers found that depression was
linked to a shorter period of survival. The investigators also found "that
higher than usual cortisol levels throughout the day were...linked to shorter
survival among the cancer patients."
EXERCISE
Research Links
Fitness In Men To Reduced Risk Of Certain Cancers.
Bloomberg
News (5/16, Armstrong) reports, "Middle-aged men who stayed fit were
less likely to die from three common cancers after being diagnosed than those
who were out of shape," according to research released by the American
Society of Clinical Oncology, in advance of the group's upcoming conference.
Researchers found, "in a study of 17,049 men, those with good respiratory
and cardiovascular fitness were more likely to survive prostate, lung or
colorectal cancer, and avoid developing lung or colorectal cancers." In an
interview, ASCO President Sandra Swain said, "It really does lead to
telling patients that they can do something to control their outcome."
In an
interview on the PBS
NewsHour (5/16, Clune) "The Rundown" blog, Dr. Susan Lakoski, the
study's primary author, said, "This is the first study that really
addresses the issue of fitness being a prognostic marker of cancer risk in men,
and then a marker of prognosis after a cancer diagnosis."
MedPage
Today (5/16, Smith) reports that the study also indicated that "the
risks of all-cause mortality and cardiovascular death were lower for the fittest
men, compared with the least fit."
Exercise loweres oestrogen levels in post menopausal women
This trial evaluated 540 Polish women, aged 40 to 74, who were enrolled
as healthy control patients in the NCI Polish Breast Cancer Study. None of the
patients was on hormone therapy.
The women engaged in a range of physical activity. For seven days, they wore
a device called an accelerometer on their waist while awake, which measured
overall activity. The women also collected 12-hour urine samples.
Dallal measured the hormones estradiol and estrone, along with different
estrogen breakdown products, or metabolites, in the urine. "Physical
activity was associated with lower levels of the main estrogens," she said.
Activity also was associated with increased metabolism of some of the breakdown
products, she found.
"Increased overall activity appears to increase the metabolism of
estrogen," she said. "This is the first time we have been able to
assess these 15 metabolites."
Using the accelerometers gives a much more accurate picture of activity
during the day than other methods, such as having women recall their exercise
activity, said Leslie Bernstein, a professor and director of cancer etiology at
the City of Hope Comprehensive Cancer Center, in Duarte, Calif.
Exercise prevents breast cancer and lowers oestrogen
But the principal strength of the latest study, published Tuesday in the
journal Cancer Epidemiology, Biomarkers & Prevention, is that it uses new
techniques and measurements to provide "the most comprehensive analysis on
the effects of exercise on estrogen metabolism to date." Among exercising
women, it finds an increase in "good" estrogen metabolites, which in
other studies have been closely linked to decreases in breast cancer risk.
Mindy Kurzer, a University of Minnesota professor of food science and
nutrition and lead author of the study, said there's still more work to be done
to understand the mechanisms that link aerobic exercise and breast cancer. But
there's no shortage of evidence already that it can drive down the risk of heart
disease--a far more probable threat to a woman as she ages.
Exercise May
Reduce Risk Of Prostate Cancer In Caucasian Men.
MedPage
Today (2/11, Smith) reports, "Another benefit of exercise – at
least for Caucasian men – is that it may cut the risk both of developing
prostate cancer and having high-grade disease," according to a study
published online in Cancer. Investigators found, "in a prospective study,
Caucasian men suspected of prostate cancer and scheduled for biopsy were less
likely to have the disease if they were at least moderately active."
Among those who "did have cancer, they were significantly less likely to
have high-grade disease if they had been working out regularly." The
researchers, however, did not see these associations in black men.
Prolonged
Sitting May Contribute To Diabetes, Certain Cancers.
The Arizona
Republic (3/9, Midey) reports, "Medical experts long have preached
that lack of exercise contributes to heart disease, diabetes and certain
cancers. Now they point to prolonged sitting as a villain, too." At last
year's American Institute for Cancer Research conference, researchers reported
that "the combination of too much sitting and too little exercise may be
connected to as many as 49,000 cases of breast cancer and 43,000 cases of colon
cancer in the United States each year."
Study:
Sitting For Extended Periods Can Lead To Diabetes, Cancer, Heart Disease.
The Daily
Telegraph (UK) (2/21, 871K) reports that, according to research conducted
by Richard Rosenkranz of Kansas State University, "People who sit down
for long amounts of time are more likely to get chronic diseases such as
cancer, diabetes, heart disease and high blood pressure." Rosenkranz's
study "involved around 60,000 men aged between 45 and 65 who were asked
how long they spent sat down each day," and found that "those
sitting for at least six hours per day were significantly more likely to
report having diabetes." Rosenkranz said that "It's not just that
people aren't getting enough physical activity, but it's that they're also
sitting too much. And on top of that, the more you sit, the less time you have
for physical activity."
Associations of Recreational
Physical Activity and Leisure Time Spent Sitting With Colorectal Cancer Survival
- Campbell
p et a JCO 22, 2013, doi: 10.1200/JCO.2012.45.9735
Purpose Little is known about the association
of recreational physical activity or leisure time spent sitting with
survival after colorectal cancer diagnosis. This study examined the
associations of prediagnosis and postdiagnosis recreational physical
activity and leisure time spent sitting with mortality among patients with
colorectal cancer.
Patients and Methods From a cohort of adults
without colorectal cancer at baseline in 1992-1993, we identified 2,293
participants who were diagnosed with invasive, nonmetastatic colorectal
cancer up to mid-2007. At baseline, before their cancer diagnosis, and again
after their cancer diagnosis, participants completed detailed questionnaires
that included information concerning recreational physical activity and
leisure time spent sitting.
Results During a maximum follow-up of 16.1
years after colorectal cancer diagnosis, 846 patients with colorectal cancer
died, 379 of them from colorectal cancer. Engaging in 8.75 or more metabolic
equivalent (MET) hours per week of recreational physical activity
(equivalent to approximately 150 minutes per week of walking) compared with
fewer than 3.5 MET hours per week was associated with lower all-cause
mortality (prediagnosis physical activity: relative risk [RR], 0.72; 95% CI,
0.58 to 0.89; postdiagnosis physical activity: RR, 0.58; 95% CI, 0.47 to
0.71). Spending 6 or more hours per day of leisure time sitting compared
with fewer than 3 hours per day was associated with higher all-cause
mortality (prediagnosis sitting time: RR, 1.36; 95% CI, 1.10 to 1.68;
postdiagnosis sitting time: RR, 1.27; 95% CI, 0.99 to 1.64).
Conclusion More recreational physical activity
before and after colorectal cancer diagnosis was associated with lower
mortality, whereas longer leisure time spent sitting was associated with
higher risk of death.
Physical activity and risk of breast cancer:
a meta-analysis of prospective studies
A meta-analysis to summarize the evidence from
prospective studies regarding the association between physical activity and
breast cancer risk. A comprehensive search was conducted to identify eligible
studies. The fixed or random effect model was used based on heterogeneity
test. The dose–response relationship was assessed by restricted cubic spline
model and multivariate random-effect meta-regression. Overall, 31 studies with
63,786 cases were included, and the combined relative risk (RR) with 95 % CI
of breast cancer was 0.88 (0.85–0.91). In subgroup analysis by activity
type, data from 27 studies including 37,568 cases for non-occupational
activity (including recreational activity and household activity) and seven
studies including 28,268 cases for occupational activity were used, and the RR
(95 % CI) of breast cancer was 0.87 (0.83–0.91) and 0.90 (0.83–0.97),
respectively. The inverse association was consistent among all subgroups
analyses. Stronger association was found for subjects with BMI <25 kg/m2
[0.72 (0.65–0.81)], premenopausal women [0.77 (0.72–0.84)], and estrogen
and progesterone receptor-negative breast cancer [0.80 (0.73–0.87)].
Dose–response analysis suggested that the risk of breast cancer decreased by
2 % (P < 0.00) for every 25 metabolic
equivalent (MET)-h/week increment in non-occupational physical activity, 3 % (P
< 0.00) for every 10 MET-h/week (roughly equivalent to 4 h/week of walking
in 2 miles/h or 1 h/week of running in 6 miles/h) increment in recreational
activity, and 5 % (P < 0.00) for every 2
h/week increment in moderate plus vigorous recreational activity,
respectively. Physical activity could significantly reduce the risk of breast
cancer.
Walking,
Cycling May Help Increase Energy In Patients Treated For Cancer.
Reuters
(11/16) reports that, according to a study published in The Cochrane Library,
walking or cycling may help to increase energy in individuals who have been
treated for cancer. Researchers analyzed data from 38 studies that included more
than 2,600 patients. The investigators found that physical activity after
treatment for cancer, as well as during treatment, was linked to higher levels
of energy. The researchers found that walking and cycling generally led to
greater reductions in fatigue than resistance training.
Cancer
Survivors Who Believe In Ability To Exercise More Likely To Continue.
HealthDay
(10/13, Dallas) reports that a study
published in the October issue of Supportive Care in Cancer conducted by
Oregon State University researchers found that "breast cancer survivors
who believe in their ability to follow through with an exercise program are
more likely to continue working out after their treatment ends," and
"physical activity can reduce the risk of breast cancer recurrence."
The researchers also said that "We can teach breast cancer survivors how
to enlist the support of others and how to identify exercise-related
barriers."
New Research
Suggests Obese People Can Be Fit.
Bloomberg
News (9/5, Hallam) reports that "obese people who are otherwise
physically fit had no greater risk of dying prematurely than those whose
weight is normal, according to research partially funded by Coca-Cola Co.
(KO), the world's biggest soft-drink maker." Additionally, it points to a
separate study, which "found that obese people with heart disease have a
lower risk of dying early than underweight or normal-weight heart
patients." Bloomberg News says that "the findings undermine decades
of public health messages, also supported by research, that obesity can
accelerate the development of heart disease, diabetes and cancer and shrink
lifespans, three European researchers who weren't involved in the two studies
wrote in an editorial that accompanied the results in the European Heart
Journal today."
CNN
(9/5) "The Chart" blog also reports on the study published this week
in the European Heart Journal that "shows it is possible to be both obese
and healthy." According to the blog, "the researchers found that the
metabolically healthy but obese participants had a 38% lower risk of dying
than their metabolically unhealthy peers." Additionally, the article says
that the study found that "there was also no risk difference between the
metabolically healthy obese and the metabolically healthy normal weight
participants."
Exercise,
Balanced Diet May Be Linked To Better Survival In Older Women With Cancer.
HealthDay
(10/18, Dallas) reports, "Older women diagnosed with cancer who stay
physically active, maintain a healthy weight and eat a well-balanced diet are
much more likely to survive than those who don't, according to a new study"
that was scheduled to be presented at the annual cancer prevention conference of
the American Association for Cancer Research. Investigators "found that of
the three factors, getting regular exercise had the most significant effect on
the women's cancer survival."
Study: Six
Hours Of Housework Per Day May Reduce Women's Cancer Risk By 13%.
The Daily
Telegraph (UK) (9/4, Smith, Editor) reports on a new study that finds
that "those who are extremely physically active can reduce their risk of
breast cancer by 13 per cent - but they have to do six hours of housework per
day." Additionally, the findings suggest that even women who do three
hours of gardening or two-and-a-half hours of housework or walking a day can
reduce their risk by about six percent. The Telegraph details that "the
findings were based on 257,805 women, across Europe who are part of the
massive European Prospective Investigation of Cancer (EPIC) study, funded by
Cancer Research UK." The article says that "when the other factors
were taken into account it was found that the more exercise women did the
bigger the reduction in their cancer risk."
Study: Fit
50-Year Olds Less Likely To Face Chronic Disease.
Reuters
(8/28, Joelving) reports that a new study published in the Archives of Internal
Medicine found that fit 50-year-olds are less likely to be afflicted with
chronic disease as they get older than those who are sedentary. Dr. Jarett Berry
at the University of Texas Southwestern Medical Center led the study. Berry
explained the findings of the research, "We see truly reduced chronic
disease, rather than just delaying the inevitable." He added that the study
also makes the case for more vigorous exercise. Berry states, "We know from
prior literature that higher-intensity exercise tends to translate into more
fitness."
The Washington
Post (8/28, Huget) reports in "The Checkup" blog that
"the strongest connection between fitness and chronic disease burden was
found among those with the lowest levels of midlife fitness (i.e. those in the
bottom fifth of the group, fitness-wise, had the heaviest load of chronic
disease near the end of their lives)." From that finding, the researchers
"found promise, suggesting that those with low fitness levels who make
modest improvements (the equivalent of six months of moderate-intensity
exercise, 150 minutes per week) might lighten their future burden of chronic
conditions by 20 percent," according to the article. However, the blog also
notes that "the authors acknowledge several limitations in their work,
including the fact that the participants in the Cooper Center Longitudinal Study
were in a socioeconomic group - with higher income and better education - that
generally enjoys better fitness and health than the general population."
HealthDay
(8/28, Goodwin) also quoted Dr. Jarett Berry, who said, "not only do the
people with higher fitness live a little bit longer, the onset of chronic
disease occurs even later, so that the amount of time you spend in your life
with chronic diseases is compressed into a smaller period of time."
MedPage
Today (8/28, Walsh) notes that "limitations of the study included
its reliance on administrative data and the relatively healthy participants
included in the cohort, and the lack of other information such as dietary
habits." The article also stated that "in an invited commentary, Diane
Bild, MD, of the National Heart, Lung and Blood Institute in Bethesda, Md.,
pointed out that genetics also plays a role in successful aging and
longevity."
Also covering the story are the Los
Angeles Times (8/28, Healy, Times) "Booster Shots" blog, the ABC
(8/28, Barnett and Shroff) "Medical Unit" blog, and the CNN
(8/28) "The Chart" blog.
CDC: More
People In US Walking Regularly.
A Centers for Disease Control and Prevention report on
walking trends in the US population received moderate coverage, mostly online.
The report is portrayed as a step in the right direction, although a large
swath of the population is still getting little or no exercise. Thomas Frieden,
MD, MPH, director of the CDC, is quoted in several articles, as is Joan Dorn,
chief of CDC's Physical Activity and Health Branch.
USA
Today (8/8, Hellmich) reports, "More people in this country say
they're walking regularly, a new government survey shows." However,
"less than half of people say they are meeting the federal government's
physical activity guidelines." According to Frieden, "The basic news
today is that physical activity is the wonder drug, and more Americans are
making a great first step in getting more physical activity." Meanwhile,
Dorn says, "We hypothesize that new walkers appear to be starting with
short bouts of walking, so overall the average time people spent walking has
gone down slightly."
On its website, Fox
News (8/8, Serrie) reports, "Sixty-two percent of adults surveyed
in 2010 said they walked 10 minutes or more at least once during the preceding
week, compared to 56 percent in 2005. However, the National Health Interview
Survey determined only 48 percent of adults are getting enough physical
activity to see health benefits."
The Time
(8/8, Sifferlin) "Healthland" blog reports, "Increases in
walking were seen among nearly all subgroups of participants surveyed,
regardless of age, gender, weight, race, geography or overall health. Even
among adults who needed walking assistance, one in four reported
walking."
CQ
(8/8, Norman, Subscription Publication) reports that during a news conference,
Frieden told reporters, "Physical activity is the wonder drug," and
added, "Even if you don't lose any weight, regular physical activity will
reduce your risk of getting sick...and a host of many other conditions."
Still, CQ added, "About a third of all adults reported no physical
activity at all, and half don't meet the 150-minute standard, said the CDC."
a lipid transporter gene," according to a study
published in Cancer Research. Investigators found that "deletion or
down-regulation of LDL receptor-related protein 1B (LRP1B) correlated with
resistance to liposomal doxorubicin (Doxil), a common choice for second-line
chemotherapy in ovarian cancer." The researchers reported that "all
tumor specimens with LRP1B deletion came from patients who had received
liposomal doxorubicin, and none of the patients had objective responses."
Exercise May
Improve QoL For Cancer Survivors, Patients Receiving Treatment.
MedPage
Today (8/17, Fiore) reports, "Exercise improves quality of life for
both cancer survivors and patients currently undergoing treatment,"
according to research published in Cochrane Reviews. "In two separate
studies, 12 weeks of exercise was associated with significant improvement in
overall health-related quality of life for cancer patients and survivors
(standard mean difference [SMD] 0.33, 95% CI 0.12 to 0.55, and SMD 0.48, 95% CI
0.16 to 0.81), Shiraz Mishra, PhD, of the University of New Mexico, and
colleagues wrote." The studies are available here
and here.
Exercise May
Help Reduce Fatigue, Depression In Breast Cancer Patients.
The Huffington
Post (4/14, Chan) reported, "Exercise could be the secret weapon to
help breast cancer patients combat common side effects of cancer and cancer
treatments," according to research presented at a Society of Behavioral
Medicine meeting.
HealthDay
(4/14, Preidt) reported, "University of Miami researchers examined the
physical activity levels and mental/physical health of 240 women with non-metastatic
breast cancer...who were recruited for the study four to 10 weeks after
surgery."
WebMD
(4/14, Boyles) reported, "Half the women took part in a 10-week,
group-based behavioral therapy program aimed at reducing stress, while the other
half participated in a much less intensive, single-day educational
session." The investigators "found that women who increased the time
they spent engaged in physical activity between the time of surgery and other
treatments had less fatigue-related disruptions in everyday activities."
The researchers reported that "women in both groups who exercised more also
experienced less depression and scored higher on tests measuring quality of
life."
Vigorous
Exercise May Cause Changes In 180 Prostate Genes.
HealthDay
(2/1, Reinberg) reports, "Vigorous exercise causes changes in some 180
prostate genes among men with early stage prostate cancer," according to
a study scheduled to be presented at an American Society of Clinical Oncology
meeting. Investigators "found 184 genes that were differently expressed
in men" with low-risk prostate cancer "who did activities such as
jogging, tennis or swimming for at least three hours a week, compared with
genes in men who did less exercise." The same researchers, in a study
published in the "Journal of Clinical Oncology," found that
"men with prostate cancer who participated in three or more hours a week
of vigorous activity had about a 50 percent lower risk of death from all
illnesses, and a 60 percent lower risk of death from prostate cancer, compared
to men who participated in less than one hour per week of vigorous physical
activity," one of the researchers "said."
BMJ 2012
Meta analysis of 30 RCT trials 0 regular exercise
reduced fatigue, obeseity
A study from Seattle demonstrate the importance of
exercise guidelines after cancer
The 2008 Physical Activity (PA) Guidelines recommend engaging in at least 2.5 h
(10 MET-hours/week) of moderate intensity PA per week (defined as 4 METs) to
reduce risk of morbidity and mortality. This analysis was conducted to
investigate whether this recommendation can be extended to breast cancer
survivors. Data from four studies of breast cancer survivors measuring
recreational PA from semi-quantitative questionnaires a median of 23 months
post-diagnosis (interquartile range 18–32 months) were pooled in the
After Breast Cancer Pooling Project (n = 13,302). Delayed
entry Cox proportional hazards models were applied in data analysis with
adjustment for age, post-diagnosis body mass index, race/ethnicity, menopausal
status, TNM stage, cancer treatment, and smoking history. Engaging in at least
10 MET-hours/week of PA was associated with a 27% reduction in all-cause
mortality (n = 1,468 events, Hazard Ratio (HR) = 0.73,
95% CI, 0.66–0.82) and a 25% reduction in breast cancer mortality (n = 971
events, HR = 0.75, 95% CI 0.65–0.85) compared with women who did
not meet the PA Guidelines (<10 MET-hours/week). Risk of breast cancer
recurrence (n = 1,421 events) was not associated with meeting
the PA Guidelines (HR = 0.96, 95% CI, 0.86–1.06). These data
suggest that adhering to the PA guidelines may be an important intervention
target for reducing mortality among breast cancer survivors Jeannette
M. Beasley et al .
Volume
131, Number 2,
,
DOI: 10.1007/s10549-011-1770-1
Further evidence for the mechanism of the benefit of exercise
There is convincing evidence from numerous clinical and epidemiological
studies that physical activity can reduce the risk for breast and prostate
cancer. The biological mechanisms underlying this phenomenon remain
elusive. Herein we suggest a role for naturally produced antibodies
reactive with the vasoactive intestinal peptide (VIP) in the suppression
of breast and prostate cancer, which we believe could offer a possible
molecular mechanism underlying control of these cancers by physical
exercise. METHODOLOGY AND RESULTSWe found that sera from individuals
having breast and prostate cancers have decreased titers of VIP natural
antibodies as demonstrated by a lower reactivity against peptide NTM1,
having similar informational and structural properties as VIP. In
contrast, sera collected from elite athletes, exhibited titers of natural
NTM1-reactive antibodies that are significantly increased, suggesting that
physical activity boosts production of these antibodies. SIGNIFICANCE
Presented results suggest that physical exercise stimulates production of
natural anti-VIP antibodies and likely results in suppression of VIP.
This, in turn, may play a protective role against breast and prostate
cancers. Physical exercise should be further investigated as a potential
tool in the treatment of these diseases.Physical
Activity and Natural Anti-VIP Antibodies: Potential Role in Breast and
Prostate Cancer Therapy; Veljkovic
M, Dopsaj et al 2012 pLoS
One. 2011;6(11):e28304. Epub 2011 Nov 30.
Regular
Walking May Improve Fatigue, Ease Pain In Pancreatic Cancer Patients.
HealthDay
(4/11, Preidt) reports, "Regular walking can help reduce fatigue in
some pancreatic cancer patients," according to a study published in
the April issue of the Journal of the American College of Surgeons. After
randomizing "102 white men and women aged 66 or 67 who underwent
pancreatic cancer surgery" to a walking program or to usual
post-operative instructions for care, researchers found that by the
study's end, "improvements in fatigue levels were reported by 27
percent of those in the walking group and 19 percent of those in the
control group. The patients in the walking group also reported less pain
than those in the control group."
Factors which predict reduced physical activity after Breast Cancer
Physical activity offers many benefits to breast cancer survivors, yet
research on physical activity during the immediate period following a
breast cancer diagnosis is limited. In a prospective cohort study of
1,696 women diagnosed with invasive breast cancer in the Kaiser
Permanente Northern California Medical Care Program from 2006–2009,
we describe change in self-reported physical activity levels from
around diagnosis to 6 months post-diagnosis and determine factors
associated with change. Participants completed a comprehensive
physical activity questionnaire at baseline (2 months
post-diagnosis) and at follow-up (8 months post-diagnosis).
Predictors of physical activity change were determined by
multivariable linear regression. Reductions in all physical activity
levels were observed (
P < 0.0001); mean (SD)
change (h/week) of moderate-vigorous physical activity (MVPA) was
−1.28 (4.48) and sedentary behavior was −0.83 (6.95). In
fully-adjusted models, overweight and obesity were associated with
greater declines in MVPA of −1.58 h/week
(SD = 0.92) and −1.29 h/week
(SD = 0.93), respectively (
P = 0.0079).
Receipt of chemotherapy only was also associated with a greater
decrease in MVPA (−2.12 h/week; SD = 0.92;
P < 0.0001),
specifically for recreational activities (−1.62 h/week;
SD = 0.64;
P = 0.0001). These data suggest
challenges in maintaining physical activity levels during active
treatment among women with breast cancer. Interventions to encourage
physical activity in breast cancer survivors should be pursued.
Marilyn
L. Kwan 2012
Researcher:
Between 8% And 30% Of Cancers Potentially Linked To Inactivity.
Medscape
(11/9, Yin) reports, "Between 8% and 30% of all cancers are potentially
related to physical inactivity, according to a researcher who reports that
exercise can lower the risk." Christine Friedenreich, PhD, a cancer
epidemiologist at the Department of Population Health Research, Alberta Health
Services, "reported the results from the Alberta Physical Activity and
Breast Cancer Prevention (ALPHA) trial, which found that physical activity can
lower the risk for cancer in postmenopausal women...at the American Institute
for Cancer Research 2011 Research Conference on Food, Nutrition, Physical
Activity and Cancer." The results "add to existing evidence that
physical activity reduces the risk for colon, breast, and probably endometrial
cancer, and possibly prostate, lung, and ovarian cancer, by 10% to 30%, said Dr.
Friedenreich."
Physical
Inactivity, Prolonged Sitting Linked To More Than 90,000 New Cancer Cases.
USA
Today (11/3, Hellmich) reports, "More than 90,000 new cancer cases
a year in the United States may be due to physical inactivity and prolonged
periods of sitting," according to an analysis presented at the annual
conference of the American Institute for Cancer Research (AICR). The research
"cites about 49,000 cases of breast cancer and 43,000 of colon
cancer."
Exercising
May Help Reduce Risk Of Dying From Colon Cancer.
Walking for just 30 minutes a day could lower the risk
of dying from colon cancer, new research shows. "Â The Telegraph
added, "Taking on an exercise program could also reduce the risk of heart
disease, diabetes, and other cancers," while "regular physical
activity can...be beneficial after a cancer diagnosis has already been
made."
Exercise May
Benefit Cancer Patients.
BBC
News (8/8) reports that a study called Move
More recommends that "adult cancer patients and cancer survivors
should undertake 150 minutes of moderate intensity physical activity per
week," which can reduce side effects, lower chances of other diseases,
and reduce the chance of cancer recurring. The report also found that
"physical exercise does not increase fatigue during treatment, and can in
fact boost energy after treatment."
Study suggests
exercise during adolescence may cut risk of gliomas in adulthood.
HealthDay
(10/6, Thomas) reported, "Exercising during adolescence may help guard
against" gliomas "in adulthood," according to a study published
Nov. 1 in the journal Cancer Research. Researchers "examined data on nearly
500,000 men and women aged 50 to 71" who responded to "questionnaires
on height and weight at various points during their lives." They found that
participants "who'd reported doing substantial amounts of light, moderate,
and vigorous exercise between the ages 15 and 18 were 36 percent less likely to
develop glioma than those who were sedentary." The study also showed that
"those who were obese during their teen years had a three to four times
greater risk of developing glioma than those of a normal weight." Notably,
"tall people were also at increased risk of glioma," with "each
10 centimeter...increase" linked to "a nearly 20 percent increase in
risk of developing glioma."
Researchers
say moderate-to-vigorous exercise may cut breast cancer risk in postmenopausal
women.
The UK's Daily
Mail (10/1) reports, "A daily dose of housework could cut the risk
of breast cancer," according to a study appearing in BMC Cancer. For the
study, investigators surveyed over "110,000 postmenopausal women to rate
their activity levels at different ages." They found that "women in
the group who had done more than seven hours a week of moderate-to-vigorous
exercise were less likely to develop breast cancer than inactive women." In
fact, data indicated that "women who stay fit and physically active after
the menopause are 17 percent less likely to develop the disease than those who
rarely leave the sofa." But, "light exercise in later life did not
help, nor did exercise at younger ages." The researchers speculated that
"exercise may affect hormones in a way that helped prevent breast
cancer."
Yoga May
Benefit Metastatic Breast Cancer Patients.
Medscape
(12/17, Mulcahy, Subscription Publication) reported, "The practice of
yoga might reduce psychological distress and modulate abnormal cortisol
levels and immune responses in patients with metastatic breast cancer,
according to a study presented...at the 34th Annual San Antonio Breast
Cancer Symposium. ... In a three-month study, 45 patients were randomized to
a daily yoga intervention and 46 to standard supportive counseling. The
subjects, with an average age of 50.5 years, were assessed at baseline and
after the intervention." After the yoga intervention, researchers
reported "a statistically significant decrease in anxiety" and
depression, "as well as cortisol levels, compared to the
controls." Those in the yoga group also had "a significant
increase in the percentage of natural killer cells."
Weight lifting
may ease lymphedema in women with breast cancer, researchers say.
On the front page of the New
York Times (8/18, D1) Science Times section, Tara Parker-Pope writes in
the Well column that women who undergo "surgery for breast cancer" are
typically advised not to "lift anything heavier than 15 pounds" or
"carry a heavy purse or grocery bags" in order to "prevent
lymphedema." The condition is "a painful and unsightly swelling of an
arm or leg that can occur near the site where lymph nodes have been removed or
damaged by radiation." But, "new research," published in The New
England Journal of Medicine, "suggests that much of that advice may be too
restrictive." In the "study
of 141 breast cancer patients who had lymphedema," women who "embarked
on a slow, progressive program of weight lifting" had "significantly
fewer flare-ups than the women who restricted their activity." Still,
Parker-Pope cautions patients not to "disregard everything their doctors
tell them about lymphedema," noting that "some patients never fully
recover."
Fitness
Regimen May Benefit Cancer Survivors.
The Los
Angeles Times (2/1, Stein) "Booster Shots" blog reports that
research published in the British Medical Journal "suggests that a
fitness regimen can enhance the health of" cancer "patients
following treatment." Investigators looked at data from 34 different
studies. Researchers found that "breast cancer patients who exercised
showed improvements in body mass index, weight and blood sugar control, and
had better lower limb strength," in addition to other benefits. Among
"those with other types of cancer, improvements were seen in BMI and body
weight, oxygen consumption and hand-grip strength (fitness measures), as well
as depression and quality of life."
Walking after prostate cancer
BBC
News (5/25, Roberts) reports that men who "power walk for at least
three hours a week can halve how much their cancer will grow and spread over the
next couple of years," according to a study in Cancer Research. Strolling,
however, "does not have the same effect," the study authors cautioned.
WebMD
(5/24, Hendrick) reported that the researchers followed "1,455 men who had
been diagnosed with early-stage prostate cancer." The results showed that
survivors who walk briskly "at a pace of at least three miles per hour for
three hours or more per week were 57% less likely to develop the biochemical
markers of cancer recurrence or to need a second round of treatment for their
disease." Also covering the study were HealthDay
(5/24, Mozes) and the UK's Telegraph
(5/25, Beckford). Author: Erin L. Richman, a research associate in the
department of epidemiology and biostatistics at the University of California,
San Francisco.June 1 issue of Cancer Research.
SMOKING
Smokers Said
To Cost Employers An Extra $5,816 Per Year.
The New
York Times (8/7, 1.68M) reports on its “Well” blog that researchers at
The Ohio State University have analyzed data from earlier studies on the costs
of smoking and concluded that a smoker “costs a private employer in the United
States an extra $5,816 per year compared with a nonsmoker.” The researchers
“estimated that the largest cost, at $3,077 annually, came from taking smoking
breaks” as smokers took, “on average, about five breaks a day, compared with
the three breaks typically sanctioned for most workers.” At $2,056, the second
largest cost “was related to excess health care expenses,” as smokers
“typically have more health problems than nonsmokers, including heart and lung
disease and various cancers.” Additional costs were dues to “increased
absenteeism.”
Study: Smoking
Increases Chance Of Colon Cancer In Women.
HealthDay
(5/1, Reinberg) reports a study published Tuesday in Cancer Epidemiology,
Biomarkers & Prevention states "women who've ever smoked have an almost
20 percent increased risk for colon cancer, compared with women who never
smoked." Lead researcher Dr. Inger Gram, a professor of community medicine
at Norway's University of Tromso, stated that moderate smoking by women can lead
to "many new cases" of colon cancer. The study found the "more
years a woman smoked, the earlier she started smoking, and the more packs of
cigarettes smoked a year, the greater her risk of developing colon cancer. Women
who smoked for 40 years or more increased their risk for colon cancer almost 50
percent, the researchers said." The researchers note the study does show an
association between smoking and colon cancer, it does not firmly link a
cause-and-effect relationship.
MedPage
Today (5/1, Laino) documents the study. "Using four Norwegian Institute
of Public Health surveys, the researchers identified 602,242 adults (ages 19-67)
and followed them from 1972 through 2003. All had a short health exam and
completed questionnaires about smoking habits, physical activity and other
lifestyle factors." It adds, "During a mean follow-up of 14 years,
3,998 participants - 46% of whom were women - developed colon cancer."
BBC
News (4/30, Roberts) reported the study shows "female smokers had a 19%
increased risk of the disease while male smokers had a 9% increased risk."
Furthermore, researched published in the Journal of Clinical Endocrinology &
Metabolism suggest a reason why this might be. A recent study by University of
Western Australian researchers "found teenaged girls exposed to passive
smoking had lower levels of the 'good' form of cholesterol that reduces heart
disease risk." However, the study also revealed "second-hand smoke did
not appear to have the same impact on teenage boys."
HealthDay
(4/30, Preidt) quoted lead author Dr. Chi Le-Ha, of the University of Western
Australia, said in a news release from the Endocrine Society: "In our
study, we found 17-year-old girls raised in households where passive smoking
occurred were more likely to experience declines in HDL cholesterol
levels." She added, "Secondhand smoke did not have the same impact on
teenage boys of the same age, which suggests passive smoking exposure may be
more harmful to girls. Considering cardiovascular disease is the leading cause
of death in women in the western world, this is a serious concern." She
said officials need to "redouble public health efforts" to curb
children's exposure to secondhand smoke.
Study:
Smokers With Colon Cancer More Likely To Have Recurrence.
Reuters
(4/4, Seaman) reports that a study
published online April 1 in the Journal of Clinical Oncology found that among
patients who had colon cancer surgery, 74 percent of non-smokers were
cancer-free three years after surgery, compared to 70 percent of smokers.
Amanda Phipps, the study's lead author from the Fred Hutchinson Cancer
Research Center in Seattle, and colleagues previously concluded smokers with
colon cancer had an increased chance of dying of any cause compared to
non-smokers, but their most recent study examined what it meant for
recurrence.
Cancer
Patients Who Quit Smoking Before Surgery Less Likely To Resume The Habit.
HealthDay
(1/26) reports, "Cancer patients who smoked up until their surgery were
more likely to take up the habit again compared to those who quit earlier,"
according to a "study from the Moffitt Cancer Center in Tampa, Fla."
that "included lung cancer and head and neck cancer patients who quit
smoking before or immediately after surgery." Participants were followed
for 12 months following their surgery. In a Moffitt news release, study
corresponding author Vani Nath Simmons said, "Sixty percent of patients who
smoked during the week prior to surgery resumed smoking afterward, contrasted
with a 13 percent relapse rate for those who had quit smoking prior to
surgery."
Study
Strengthens Link Between Smoking, Breast Cancer.
HealthDay
(3/1, Doheny) reports that a study published online Feb. 28 in the Journal of
the National Cancer Institute suggests that "cigarette smoking appears to
increase the risk of breast cancer, especially when women start smoking early in
life." After analyzing "data from more than 73,000 women,"
researchers found that the "incidence of invasive breast cancer was 24
percent higher in current smokers and 13 percent higher in former smokers,
compared to never smokers."
Quitting
Smoking May Be Linked To Longer Survival In Younger Lung Cancer Patients.
Reuters
(10/12, Grens) reports that, according to a study published online in Cancer,
younger lung cancer patients with advanced disease who abandoned their smoking
habit do better for example, that 45-year-old patients who had stopped smoking
faced a 30 percent lower risk of dying from stage 4 disease within 24 months
compared to patients who had not stopped smoking.
Cancer Risk
Of Nicotine Gum Use Likely Smaller Than With Smoking.
In its "Well" blog, the New
York Times (1/24, O'Connor, 1.68M) reports that "some research has
raised speculation that long-term use of nicotine might also raise the risk of
cancer, though it has mostly involved laboratory and animal research, and
there have not been any long-term randomized studies specifically addressing
this question in people." The article points out that "one recent
report that reviewed the evidence on nicotine replacement therapy and cancer
concluded that, 'the risk, if any, seems small compared with continued
smoking.'" According to the blog, Lauren Indorf, a nurse practitioner
with the Cleveland Clinic's Tobacco Treatment Center, said, "ultimately,
the biggest problem with using nicotine gum for long periods is that the
longer you stay on it, the longer you remain dependent on nicotine, and thus
the greater your odds of a smoking relapse."
CDC Report
Suggests Many Smokers Attempt To Quit.
The Wall
Street Journal (11/11, McKay, Subscription Publication) reports that in
2010, 69% of adult smokers wished to quit, according to a US Centers for Disease
Control and Prevention Morbidity
and Mortality Weekly Report. Of those, 6.2% succeeded. Most smokers did not
utilize advice, counseling, or other assistance to help them quit.
Bloomberg
News (11/11, Lopatto) reports, "Smokers could double or triple their
chances of quitting by getting counseling, medicine or both, said the US Centers
for Disease Control."
The National
Journal (11/11, Quinton, Subscription Publication) reports that "Tim
McAfee, director of the CDC's Office on Smoking and Health," expressed
concern that "many of the states have drastically cut back their efforts,
not only because of tough economic times," but also because "the
Centers for Medicare and Medicaid Services have made it easier to get
quit-smoking services. Until recently, Medicaid did not offer states the
flexibility to help smokers quit with medication or counseling, said McAfee; and
until recently, Medicare only offered such services to seniors who had already
contracted a smoking-related disease."
Reuters
(11/11, Steenhuysen) reports that having health insurance increased the odds of
succeeding in smoking cessation, since insurance increased access to doctors,
counseling, and reimbursements for aids, such as nicotine patches.
HealthDay
(11/11, Reinberg) reports, "Other factors that are equated with quitting
are education, where 11 percent of those with a college degree were able to
quit, compared with three percent of those who did not graduate from high
school. ... In addition, blacks had the highest interest in quitting and the
highest quit attempt rate than any other group, but blacks also had the lowest
rate of successful quitting" and "were also less likely to use
medication or counseling." Based on the report's conclusions, advocates
said that "to help more smokers quit, it is critical that all private and
government health plans provide affordable and accessible coverage for
smoking-cessation medication and counseling, and that states use more of their
tobacco revenues to properly fund tobacco prevention and cessation
programs."
MedPage
Today (11/11) reports, "The findings come from analysis of the National
Health Interview Surveys from 2001 through 2010, and are being released a week
ahead of the annual Great American Smokeout on Nov. 17, according to Tim McAfee,
MD, director of the CDC's Office on Smoking and Health." CQ
(11/11, Bunis, Subscription Publication) also covers the story
tudy: Smokers
More Likely To Quit Using Nicotine Patches, Medications.
Reuters
(9/5) reports on an international study published in the journal Addiction,
which found that smokers are more successful in quitting when they use nicotine
patches or prescription medications, rather than going it alone. Study leader
Karin Kasza, a statistician at Roswell Park Cancer Institute in Buffalo, New
York, and colleagues wrote, "Smokers in the United Kingdom, Canada,
Australia and the United States are more likely to succeed in quit attempts when
they use (drugs) or nicotine patch." They added, "The disappointing
reality is that even when people use these medications to help them quit,
relapse is still the norm. It's better than nothing, but it's by no means a
magic bullet."
Smokers
Diagnosed With Prostate Cancer May Be More Likely To Experience A Recurrence.
CNN
/Health.com (6/22, McMillen) reports, "Men with prostate cancer who are
cigarette smokers at the time of their diagnosis are much more likely to die of
the disease or experience a recurrence than nonsmokers, including former smokers
who kicked the habit at least 10 years before diagnosis," according to a study
in the Journal of the American Medical Association. Researchers followed 5,366
men with prostate cancer "for about eight years" and found that nearly
"10% of the men ultimately died from the disease, and 16% experienced a
recurrence after treatment." Those who were "actively smoking when
their cancer was diagnosed were 61% more likely to die and 61% more likely to
experience a recurrence." Notably, even when the researchers factored in
the severity of the cancer, smokers were still "38% more likely to die and
47% more likely to have a recurrence."
"However,
former smokers who had quit 10 years or more before they were diagnosed saw a
risk of recurrence and death similar to men who never smoked," AFP
(6/21) reported. The story was also covered by Reuters
(6/22, Steenhuysen), MedPage
Today (6/21, Neale), and HealthDay
(6/21, Preidt).
Exposure to
tobacco smoke may promote lung tumor growth.
HealthDay
(1/19, Preidt) reported that a "team at the University of California-San
Diego School of Medicine conducted tests on mice with early lung cancer lesions
and found that those repeatedly exposed to tobacco smoke developed larger tumors
-- and developed tumors more quickly -- than those that weren't exposed to
tobacco smoke." Investigators say their work in Cancer Cell "offers
definitive proof that lung inflammation caused by chronic exposure to tobacco
smoke promotes lung cancer growth."
Patients with
early lung cancer may double their chances of survival by quitting smoking.
The AP
(1/22, Cheng) reports that "there has been little proof that quitting
smoking after developing lung cancer makes any difference to survival."
Now, however, researchers in the UK are saying those who do "could double
their chances of surviving."
In fact,
"63 to 70 percent of" their study participants "who quit
survived" for five years, HealthDay
(1/21, Gardner) reported. Conversely, "only 29 to 33 percent of early stage
lung cancer patients who kept smoking survived" for that long. According to
the paper in the BMJ, the "survival seemed to come from a lower likelihood
of tumor recurrence, not from heart/lung improvements." WebMD
(1/21, Stacy) also covered the study.
Nicotine
Replacement Therapy May Not Lower Risk Of Smoking Relapses.
On the front of its Personal Journal section, the Wall
Street Journal (1/10, D1, Esterl, Subscription Publication) reports that
a study in Tobacco Control suggesting that smokers who quit using aids such as
nicotine patches and gum are as likely to relapse as smokers who do not.
On its front
page, the New
York Times (1/10, A1, Carey, Subscription Publication) reports,
"Doctors who treat smokers said that the study findings were not
unexpected, given the haphazard way many smokers used the products. ... Dr.
Richard Hurt, director of the Nicotine Dependence Center at the Mayo
Clinic," said that "products like nicotine gum and patches 'are
absolutely essential, but we use them in combinations and doses that match
treatment to what the individual patient needs,' unlike smokers who are
self-treating." The Times notes that nicotine replacement therapy
"products have been controversial since at least 2002, when researchers at
the University of California, San Diego, reported from a large survey that they
appeared to offer no benefit. ... A government-appointed panel that included
nicotine replacement as part of federal guidelines for treatment also came under
fire, because panel members had gotten payments from the product
manufacturers."
According to
the Boston
Globe (1/10, Kotz) "Daily Dose" blog, "researchers said
they are surprised and disappointed by their results, which found that
two-thirds of people resumed smoking within four years, even when nicotine
therapies were used in conjunction with behavioral counselig."
Investigators "found that one-third of recent quitters who used nicotine
replacement therapies relapsed within two years after the study began,"
which "was the same relapse rate as among people who used no
smoking-cessation aids." Study co-author Gregory Connolly, head of Harvard
University's Center for Global Tobacco Control, noted that the results
"should give public health officials pause in terms of how much money they
allocate toward smoking cessation programs," since "Medicaid
beneficiaries in Massachusetts can obtain FDA-approved smoking cessation
medications, including nicotine replacement therapies and drugs."
The Los
Angeles Times (1/10, Kaplan) "Booster Shots" blog reports that
GlaxoSmithKline Consumer Healthcare, manufacturer of "Nicorette, Nicoderm
and Commit lozenges, among other smoking cessation products...noted that most of
the adults in the study who used nicotine replacement products didn't use them
for the full eight weeks that are recommended" and suggested that if they
had done so, "they might have had more success." Also reporting the
study are WebMD
(1/10, Doheny) and HealthDay
(1/10, Mozes)
Study Links
Tobacco Use To Increased Skin Cancer Risk In Women.
HealthDay
(12/16, Holohan) reports, "If you're a woman who smokes and you are looking
for another reason to quit, consider this: A new study" published online in
Cancer Causes Control "has found a link between tobacco use and skin
cancer." Researchers "found that women who had squamous cell skin
cancer were more likely to have smoked than those who were free from the
disease." Women "who smoked at least 20 years were twice as likely to
develop squamous cell skin cancer, a less aggressive form of skin cancer than
melanoma."
Kids With
Fathers Who Smoked May Face Greater Risk Of Developing ALL.
Reuters
(12/15, Grens) reports that, according to a study
published online in the American Journal of Epidemiology, kids with fathers who
smoked may face a greater risk of developing acute lymphoblastic leukemia (ALL).
Investigators surveyed families of approximately 400 kids with the disease. The
researchers found that while the mothers' smoking status did not impact the
children's risk of developing ALL, children whose fathers smoked near the time
they were conceived faced a roughly 15 percent higher risk of developing the
condition.
Smoking May
Boost Colon Cancer Risk In Older Women By Causing Genetic Mutations.
HealthDay
(6/29, Dotinga) reported that "smoking may boost the risk of colon cancer
in older women by causing certain genetic mutations," according to the
paper in the Journal of the National Cancer Institute. "Previous research
has indicated that current and former smokers are 18 percent more likely to
develop colorectal cancer than those who never smoked," but it was unclear
"how smoking and tumors are connected, especially at the molecular
level." After examining "statistics from the Iowa Women's Health
Study," Mayo Clinic researchers eventually discovered "a strong link
between smoking and a specific type of colorectal cancer that's connected to
genetic mutations and variations."
Weight May
Impact Smokers' Risk For Developing Breast Cancer.
The AP
(4/4, Marchione) reports, "Smoking raises the risk of breast cancer for
healthy-weight and overweight women but not for those who are obese,"
according to findings presented at the American Association for Cancer Research
meeting. The researchers analyzed data from the Women's Health Initiative, and
found that of the "3,378 breast cancer cases," those who were
"healthy-weight or overweight, with BMIs under 30," had a 16- to
25-percent increased risk to "develop breast cancer if they smoked."
Conversely, the study team saw "no added breast cancer risk in obese"
smokers (BMI 30+) compared to obese nonsmokers. The researchers speculated that
because fat tissue makes estrogen, which fuels many breast cancers, obesity may
be contributing "so much risk" that the risk from smoking "is
less apparent."
According to HealthDay
(4/1, Preidt), Juhua Luo, an assistant professor in the department of community
medicine at West Virginia University, emphasized that previous research has
shown "obesity alone is a risk factor" for breast cancer in
postmenopausal women. Moreover, Luo stressed that because this is the
"first study to examine the interaction between smoking, obesity and breast
cancer risk," more research is needed to confirm the results.
Women Living,
Working In Smoke-Free Environments Have Lower Breast Cancer Rates.
HealthDay
(3/18, Preidt) reported, "Women in smoke-free homes and workplaces are less
likely to develop or die from breast cancer," according to a study in the
journal Tobacco Control. Researchers compared "rates of non-smoking homes
and workplaces with state-specific rates of breast cancer incidence and
death," and found that states with "higher numbers of smoke-free homes
and workplaces had significantly fewer breast cancer deaths, particularly among
younger premenopausal women." The study authors estimated that about
"20 percent of the change in breast-cancer death rates is due to changes in
smoke-free home and workplace policies."
Smoking May
Raise Women's Bladder Cancer Risk.
AFP
(8/17) reports a study
published in the Journal of the American Medical Association showing that
women smokers have a 52% risk of bladder cancer, while men's risk is 50%.
Previous studies reported a lower risk for women, which the research
attributes to "the composition of cigarettes" having changed
"during the past 50 years," specifically a "reduction in tar
and nicotine," but an "increase in the concentration of specific
carcinogens, including beta-napthylamine, a known bladder carcinogen."
Also, more women are smoking now than in the past. AFP notes the study was
conducted by Neal Freedman of the National Cancer Institute and funded by the
National Institutes of Health.
The Canadian
Press (8/17) reports, "Researchers found that former smokers were
twice as likely as people who never used tobacco to develop bladder cancer.
Those who had been smoke-free for at least 10 years had a lower incidence than
those who quit for shorter periods or who still smoked."
WebMD
(8/17, Mann) reports that the National Cancer Institute's Neal D. Freedman,
PhD, MPH, who authored the study, said that "future studies should try to
replicate these findings and analyze the constituents of tobacco smoke and
identify the components that may have led to this increase" in bladder
cancer risk.
HealthDay
(8/17, Gordon) reports, "Although the incidence rates for bladder cancer
appear to be remaining stable, the researchers noted that findings from
several studies suggested that rates for smokers seemed to be rising."
MedPage
Today (8/17, Bankhead) notes, "A limitation of the study included
lack of information on the year smoking started, thereby eliminating
calculation of duration or pack years of smoking. Also, there was a lack of
follow-up data on smoking after the baseline survey to know how many people
may have quit."
Smoking's
Impact On Breast Cancer Risk May Be More Profound Than Previously Thought.
Medscape
(5/24, Nelson, Subscription Publication) reported that the impact of
"smoking on breast cancer might be larger than previously assumed,"
according to findings presented in advance of the American Society of Clinical
Oncology meeting. Researchers found that women between the ages of 15 and 35
"who smoked for had a 34% higher risk for breast cancer than women who
never smoked." Notably, women who smoked for "at least 35 years had a
59% higher risk, whereas those who smoked for less than 15 years had no
increased risk for breast cancer."
Smoking May
Increase Risk For Prostate Cancer Recurrence.
HealthDay
(5/16, Preidt) reported that for men who "had their prostate surgically
removed due to prostate cancer, smoking seems linked to a rise in blood levels
of prostate specific antigen (PSA)," according to findings presented at the
American Urological Association meeting. Among "321 smokers and 309
nonsmokers who underwent radical prostatectomy" between 1989 and 2005, the
study team found that smokers had a "higher volume and a greater volume of
high-grade cancer than nonsmokers." Smokers also tended to "chart a
steeper rise in their blood levels of PSA, signaling a greater risk of
'biochemical recurrence' of prostate cancer."
Smoking
increases colon cancer risk: Reuters
This
article reports on a JAMA study indicating
that regular smokers are 18 percent more
likely to develop colorectal cancer and 25
percent more likely to die of the disease
than people who have never smoked.
Researchers suggest that smokers may need to
undergo colorectal cancer screenings earlier
than people who do not smoke. Article: Reuters
Study Suggests
Stress Of Cancer Makes Smoking Cessation Harder.
The Winston-Salem
(NC) Journal (4/3, Craver) reported, "Researchers at Wake Forest
Baptist Medical Center recently conducted a study of 742 cancer patients and
caregivers to determine why they can't throw the cigarettes away, and whether
there are reasons beyond their addiction to nicotine." The study, which was
supported by grants from the National Cancer Institute, found is that
"having cancer 'creates a very stressful period of time for everyone
involved, and the added stress may make it a difficult time to quit.'" The
researchers found that "18 percent of lung-cancer patients and 12 percent
of colorectal-cancer patients continued to smoke after their diagnosis."
Among caregivers, "25 percent continued to smoke, even though a family
member had been diagnosed with lung cancer, as well as 20 percent" who had
a family member with colorectal cancer.
Tobacco
Companies Sue FDA Alleging Cigarette Warnings Violate Free Speech.
Dow
Jones Newswire (8/17, FitzGerald, Subscription Publication) reports that
four of the largest US tobacco companies sued the federal government Tuesday
over new graphic cigarette label warnings, which they say violate their
constitutional right to free speech.
The AP
(8/17) reports that the companies, led by "R.J. Reynolds Tobacco Co.,
Lorillard Tobacco Co.," also said the labels, which include the
"sewn-up corpse of a smoker and a picture of diseased lungs" will cost
them "millions of dollars to print." The tobacco firms said rather
than simply conveying "facts to allow people to make a decision whether to
smoke," the warnings force them to "put government anti-smoking
advocacy more prominently on their packs than their own brands. ... 'Never
before in the US have producers of a lawful product been required to use their
own packaging and advertising to convey an emotionally-charged government
message urging adult consumers to shun their products,'" the companies
wrote in the lawsuit filed in federal court in the District of Columbia.
Reuters
(8/17) notes that FDA refused to comment on the suit, saying the agency does not
discuss pending litigation. However, Reuters quotes HHS Secretary Kathleen
Sebelius as saying when she announced the new warnings in June that the new
warnings would guarantee that every "person who picks up a pack of
cigarettes is going to know exactly what risks" he or she is
"taking."
Habits That
Promote Heart Health May Also Protect Against Cancer.
HealthDay
(11/17, Gardner) reports that individuals "who are diligent about keeping
their heart healthy have a good chance of staving off cancer as well,"
according to a study scheduled to be presented at the American Heart
Association meeting. In a study of approximately 13,000 healthy participants,
researchers found that "between 1987 and 2006, the participants developed
more than 1,800 new cancers, namely prostate, breast, lung and colon."
The investigators found that "individuals who don't smoke and who
maintain a healthy body-mass index (BMI), normal blood pressure and two to
four other 'ideal' measures of heart health have a 38 percent lower risk of
developing cancer."
Study Finds
Obese Women At Greater Risk For Complications After Breast Surgery.
HealthDay
(11/3, Dalls) reports that according to study
results published in the November issue of Plastic and Reconstructive Surgery,
"Obese women who undergo elective breast surgery, such as a breast
reduction or reconstruction, are nearly 12 times more likely than non-obese
women to have complications following their operation." The study analyzed
"insurance claims of about 8,000 women undergoing elective breast
surgery" and found "30 percent, or 2,400 women, were obese."
Procedures and complications were compared between obese women and non-obese
women. The researchers also noted that "obese women were more than 20 times
as likely to experience inflammation as other women."
Depression May
Be Linked To Reduced Survival Times In Kidney Cancer Patients.
HealthDay
(8/2, Dallas) reports, "Symptoms of depression are linked to shorter
survival times among cancer patients, according to a new study" published
in PLoS ONE. Investigators "analyzed surveys completed over a five-year
period by 217 patients newly diagnosed with kidney cancer that had spread."
The participants also provided several saliva samples that were used to gauge
levels of the stress hormone cortisol. The researchers found that depression was
linked to a shorter period of survival. The investigators also found "that
higher than usual cortisol levels throughout the day were...linked to shorter
survival among the cancer patients."
Vitamin D tests increase after
deficiencies are linked to diseases: USA
Today (July 13, 2008)
This article reports that
testing for vitamin D levels, once uncommon,
has skyrocketed since medical studies linked
deficiencies to a variety of diseases,
including cancer. The article notes
that between 2006 and 2008, vitamin D
testing increased by 74 percent and that
manufacturers of vitamin D diagnostic tests
have seen similar increases in demand. Article:
USA Today
Music
Therapy May Help Cancer Patients.
In continuing coverage, Reuters
(8/16, Pittman) reports a study published in Cochrane Database of Systematic
Reviews showing that cancer patients' anxiety and pain may be improved by
music therapy. However, depression and fatigue did not show improvement.
Drexel University creative arts therapist Joke Bradt, who performed the
analysis, suggests that participating in the therapy may be empowering for the
patient.
Parity
Associated With Risk For Triple-Negative Breast Cancer.
MedPage
Today (2/28) reports, "The risk of triple-negative breast cancer
increased by almost 50% in women who had given birth three times or more,"
according to a study in the Journal of the National Cancer Institute. In
contrast, the analysis found that "nulliparity was associated with a 40%
lower risk of triple-negative breast cancer but a 35% greater risk of estrogen
receptor-positive cancer." The analysis was based on Women's Health
Initiative data, which included "155,723 women, of whom 5,194 developed
invasive breast cancer during a median follow-up of 7.9 years." Although
the findings have implications for individualized care, they require
confirmation, the study authors cautioned.
LA Times Calls
For Improved Testing, Research To Determine Impact Of Chemicals On Health.
The Los
Angeles Times (6/28) editorialized that the President's Cancer Panel,
which published a report in May that "raises alarms about 'grievous harm'
caused by synthetic chemicals and asserts that the number of cancer cases
they're responsible for has been 'grossly underestimated,'" was "right
to broaden the discussion of cancer." The report indicates "just how
little we know, at our possible peril." Even though it is difficult
"to track direct links to cancer, which would not show up for years after
prolonged exposure," the public should "be wary about the long list of
chemicals to which it is exposed." For their part, "the Endocrine
Society...and the American Medical Assn. adopted positions last year calling for
federal policies to reduce public exposure to hormone-disrupting
chemicals." The Times concluded, "We hope the [panel's] report...helps
convince Congress that better testing and research for chemicals are in
everyone's interest."
Men treated
with androgen deprivation therapy for prostate cancer may face increased heart
risks.
HealthDay
(12/7, Edelson) reported that "diabetes, heart attacks, and other
cardiovascular problems appear to be more common in men with prostate cancer who
are treated with androgen deprivation therapy," according to a study
published online Dec. 7 in the Journal of the National Cancer Institute.
Investigators looked at data on "37,000 men treated for prostate cancer at
Veterans Affairs hospitals." The researchers found that "surgical
removal of the testes was associated with a 40 percent increased risk for heart
disease and a more than doubled risk for heart attack. Use of multiple
hormone-blocking agents was associated with a 27 percent increased risk for
heart disease."
Dog Sniffs Out
Colorectal Cancer; Findings May Help Develop VOC-Based Tests.
Bloomberg
News (2/1, Von Schaper) reports that a dog "trained to sniff out
colorectal cancer was almost as accurate as a colonoscopy." According to a study
in the journal Gut, a "Labrador retriever was at least 95 percent as
accurate as colonoscopy when smelling breath samples, and 98-percent accurate
when sniffing stool samples." The dog's sense of smell was "especially
effective in early-stage cancer"; and the canine could "discern polyps
from malignancies, which colonoscopy can't."
The CNN
(1/31, Bonifield) "The Chart" blog noted that the dog "sniffed
out the cancer sample in 33 out of 36 breath tests and in 37 out of 38 stool
tests." In contrast, a "fecal occult blood test to screen for cancer
at early stages" is accurate in "only one in 10 cases," the study
authors noted. According to WebMD
(1/31, Warner), the samples "came from 48 people with confirmed colorectal
cancer and 258 volunteers with no cancer." Half of the comparison samples
"came from people with bowel polyps," which are thought to be a
"precursor of colorectal cancer."
The Los
Angeles Times (1/31, Kaplan) "Booster Shots" blog reported
that the although it is not yet clear whether "each cancer has its own
chemical signature," the dog in the study has "been able to detect
breast, lung, prostate, uterine, ovarian, bladder, gastric, pancreatic and
esophageal cancers from breath samples, along with hepatocellular carcinoma and
cholangiocarcinoma."
Still,
according to Medscape
(1/31, Chustecka), the researchers are "not suggesting using dogs in
clinical practice." Instead, they propose using the findings to
"develop cancer detection tests based on 'odor materials.'" MedPage
Today (1/31, Fiore) and HealthDay
(1/31, Reinberg) also covered the study.
Diabetes May
Increase Risk For Developing, Dying From Cancer.
HealthDay
(4/3, Gordon) reported that the risk of dying from a cancer is "higher in
people with diabetes -- 11 percent greater for women and 17 percent higher in
men," according to findings presented at the American Association for
Cancer Research meeting. The researchers analyzed data on "55,888 men and
26,364 women" with cancer. Notably, lead study author, Gabriel Lai, a
fellow at the National Cancer Institute, said diabetes was associated with an
"8-percent increase in cancer risk in women, and there was a similar
pattern in men, except for prostate cancer." She said that when prostate
cancer rates were included, diabetic men's "odds for cancer generally were
reduced by 4 percent. But, once the statistics on prostate tumors were factored
out," men with diabetes had a "9-percent higher risk for cancer
overall, compared to nondiabetic men."
Experts say
HPV-positive head, neck cancers may respond better to treatment.
Following a MedPage
Today article, Medscape
(7/30, Mulcahy) reported, "HPV-positive cancers of the head and neck have
dramatically better prognoses and are more responsive to chemotherapy and
radiotherapy than HPV-negative cancers, which have a poor prognosis, experts
noted at a press conference organized by the American Association for Cancer
Research." Therefore, they maintain that "clinicians who diagnose
oropharyngeal cancer should now test their patients' tumor tissue for" the
virus. Although the suggestion is not new, the new study, led by researchers at
the University of Maryland "makes an important contribution to the
understanding of this link." What's more, it demonstrates, "for the
first time, that the well-known difference in survival between black and white
patients" is not "racially based. Instead, it is due to the fact that
blacks are much more likely to have difficult-to-treat HPV-negative
oropharyngeal cancer than whites, and thus have greater mortality."
Delving into
the specifics of the study,
which was published online July 29 in Cancer Prevention Research, HealthDay
(7/30, Preidt) reported that the team "found that median overall survival
was 70.6 months for white patients and 20.9 months for black patients treated
with chemotherapy and radiation." Yet, "median survival was 26.6
months for HPV-negative patients, while the survival rate for HPV-positive
patients couldn't be calculated because most were still alive." Notably,
"four percent of black patients and 34 percent of white patients were HPV-positive."
New Data
Show Nearly 12 Million US Adults Are Cancer Survivors.
The CBS Evening News (3/10, story 8, 0:20, Couric)
reported that the Centers for Disease Control and Prevention (CDC) "said
today about one in 20 Americans over the age of 20 is a cancer survivor."
According to
the New
York Times (3/11, A14, Belluck), the study
in the CDC's most recent Morbidity and Mortality Weekly Report indicates that
the "number of cancer survivors increased by about 20 percent in just six
years, to 11.7 million in 2007, the latest year for which figures were analyzed,
from 9.8 million in 2001." CDC Director Dr. Thomas R. Frieden said the
increase was due to many factors. "In some cases of breast cancer and colon
cancer, for example, improved treatment and increased follow-up after treatment
have helped increase survival." He added that in others, such as prostate
cancer, an "explosion in screening has identified many men with the
disease, but the cancer is often so slow-growing that they would be unlikely to
die from it."
The CNN
(3/11, Willingham) "The Chart" says that researchers believe the
increase is due to a "growing aging population, early detection, improved
diagnostic methods, more effective treatment, and improved clinical follow-up
after treatment." Moreover, Dr. Frieden said, "Not smoking, getting
regular physical activity, eating healthy foods, and limiting alcohol use can
reduce the risk of many cancers."
On ABC
World News (3/10, lead story, 2:50, Stephanopoulos), Dr. Frieden was shown
saying, "Life doesn't have to end with cancer. If you get a diagnosis of
cancer, there's a lot you can do to ensure that you lead a long, healthy,
productive life as much as possible."
The AP
(3/11) notes that the data showed "7 million -- 60 percent -- of the cancer
survivors were 65 or older." Women diagnosed with breast cancer "made
up the largest share of cancer survivors, at 22 percent, followed by men with
prostate cancer, at 19 percent."
The Los
Angeles Times (3/11, Maugh) "Booster Shots" blog reports that
trailing "far behind" survivors of breast and prostate cancers were
the "1.1 million survivors of colorectal cancer; in fourth place were the
nearly 800,000 survivors of kidney and renal pelvis cancers." The data come
from the "nine Surveillance, Epidemiology, and End Results programs."
According to
the Fox
News (3/10) Body & Mind column, CDC defines a cancer survivor as
"anyone who has been diagnosed with cancer, from the time of diagnosis
through the balance of his or her life."
The National
Journal (3/11, Fox, subscription required) reports, "Approximately
1.1 million of the 11.7 million cancer survivors had lived with a diagnosis of
cancer for 25 years or more."
In contrast,
notes the NPR
(3/11, Knox) "Shots" blog, in "1971, when cancer was considered
pretty much a death sentence, there were only one-fourth as many survivors, and
they made up less than 2 percent of the population."
Higher
Melanoma Incidence Documented In Girls, Young Women In Higher Socioeconomic
Groups.
MedPage
Today (3/21, Smith) reported, "Girls and young women who live in
wealthier neighborhoods and get more sun-soaked recreation appear to have a
higher risk of melanoma," according to a study
published online March 21 in the Archives of Dermatology. "Data from"
one "state's cancer registry linked greater melanoma incidence among women
and girls ages 15 through 39 with socioeconomic status and the average
ultraviolet-B light exposure in their neighborhoods."
HealthDay
(3/21, Salamon) reported, "In research examining the relationship between
melanoma incidence, ultraviolet (UV) light exposure and socioeconomic status,
scientists studied data from 3,800 white girls and women in California aged 15
to 39 during two periods a decade apart." In these "women, 3,842
melanomas were diagnosed, with diagnoses increasing most significantly over time
in the three highest socioeconomic levels."
WebMD
(3/21, Boyles) reported, "Among women living in neighborhoods with the
highest UV radiation levels, melanoma rates were 70% higher for those living in
the highest income neighborhoods, compared to the lowest."
Reuters
(3/22) also covers the story, pointing out that, according to the National
Cancer Institute, melanoma is the deadliest form of skin cancer.
Higher HDL
Cholesterol May Reduce Risk For Colon Cancer.
(3/8, Reinberg) reported, "High levels of 'good' cholesterol" may
reduce the risk of colon cancer, according to a study published online March 7
in Gut. The researchers compared 1,238 people (779 had colon cancer and 459
had rectal cancer) with 1,238 healthy people, and found that "those with
the highest levels of HDL cholesterol and another blood fat called
apolipoprotein A (apoA) had the least chance of developing colon cancer, but
no impact was seen on rectal cancer." Specifically, for each "16.6
milligrams per deciliter (mg/dL) increase in HDL and 32 mg/dL increase in apoA,
the risk of colon cancer was cut by 22 percent and 18 percent,"
respectively.
WebMD
(3/8, Boyles) noted that in an interview, study co-researcher Bas
Bueno-De-Mesquita, MD, PhD, from the National Institute for Public Health and
the Environment in Bilthoven, the Netherlands, said that if the "findings
are confirmed, HDL levels may be a useful indicator of colon cancer risk,
along with other risk factors that are already known." The UK's Press
Association (3/8) also covered the study results.
Smoking,
Second-Hand Exposure Raise Breast Cancer Risk.
HealthDay
(3/1, Reinberg) reported, "Both smoking and exposure to secondhand smoke
appear to increase the risk for breast cancer among postmenopausal women,"
according to a study in the BMJ. The researchers collected 10 years of follow-up
data on "79,990 women aged 50 to 79 who took part in the Women's Health
Initiative" and found that "3,250 women developed breast cancer."
The women who smoked had a "16-percent increased risk of developing breast
cancer. Among women who quit, the increased risk was 9 percent."
BBC
News (3/2, Roberts) adds that "women who had never smoked but had
lived or worked with smokers for prolonged times also appeared to be at
increased risk for breast cancer." For example, over "10 years'
exposure in childhood, over 20 years' exposure as an adult at home and over 10
years' exposure as an adult at work, increased the risk by 32%," the
researchers concluded. The same trend, however, was not seen "among women
who had been exposed to lesser amounts." AFP
(3/2) also covers the study.
Obesity May
Boost Odds For Developing Triple-Negative Breast Cancers.
Reuters
(3/2, Steenhuysen) notes that research has already shown that being overweight
increases the risk of breast cancers, but excessive body weight may also
increase the risk of triple-negative breast cancers, according to a new study in
the journal Cancer Epidemiology, Biomarkers & Prevention. The researchers
analyzed study data from the 155,723 women and found that women with the highest
BMIs had a 35% increased chance for developing triple-negative breast cancers. HealthDay
(3/1, Doheny) and WebMD
(3/1, Boyles) also covered the study.
Sedentary
Lifestyle Increases Risk Of Developing Bowel Cancer Polyps.
BBC
News (3/2, Hughes) reports, people who engage in regular exercise are
"16% less likely to develop bowel polyps and 30% less likely to develop
large or advanced polyps," according to an analysis of 20 previous studies
published in the British Journal of Cancer. AFP
(3/2) also covers the study; as does the UK's Press
Association (3/2), which notes that bowel cancer is the "third most
common cancer in the UK after breast and lung cancer, with more than 38,000 new
cases each year."
Study Refutes
Cellphone, Brain Cancer Risk.
The Washington
Post (2/21, Huget) "The Checkup" blog reported that a study
published in the journal Bioelectromagnetics in January suggests that cellphones
do not cause cancer. Researchers fanalyzed data for cases of brain cancer
reported by the "UK Office of National Statistics from 1998 to 2007,"
and reasoned that if the radio frequencies cellphones emit caused brain cancer,
there would have been a "notable uptick in the number of such cancers in
cellphone-using societies during the past 20 years as cellphone use has risen.
In short, the paper finds, no such uptick is evident."
According to HealthDay
(2/18), the study did find a "very small increase (0.6 more cases per
100,000 people) in the incidence of cancers of the brain's temporal lobe."
That equates to "31 extra cases per year in England's population of nearly
52 million people," the researchers said.
Data Indicate
Oral Sex Increases Risk Of Oropharynx Cancers.
The CNN
(2/21, Landau) "The Chart" blog reported that experts are saying that
it is crucial for teens to understand that "oral sex carries many of the
same risks as vaginal sex, including human papilloma virus, or HPV. And HPV may
now be overtaking tobacco as the leading cause of oral cancers in America in
people under age 50." During a conference on Sunday, researchers said that
the "latest data suggest that 64% of oropharynx cancers -- growing in the
middle part of the throat -- in the United States are caused by HPV, which is
more than tobacco causes." Notably, the
Melanoma In
Adults May Be Preventable With Regular Sunscreen Use.
Medscape
(1/25, Mulcahy) reported, "Melanoma in adults might be preventable with
the regular use of sunscreen -- that is, with the daily application to the
head, neck, arms, and hands," according to a study
published in the Jan. 20 issue of the Journal of Clinical Oncology. In a study
in which 1,621 adults were randomized "to regular sunscreen use or to
discretionary use, which included no use at all," researchers found that
"regular application of sunscreen with a sun protection factor of 15 or
more during a five-year treatment period reduced the incidence of new primary
melanomas during a subsequent 10-year follow-up period."
"
Dutasteride
May Slow Growth Of Early, Low-Risk Prostate Cancer.
The AP
(2/16, Marchione) reports, "A new study suggests a way to help men with
early, low-risk prostate cancer avoid being overtreated." According to
results "released Tuesday in a telephone news conference sponsored by the
American Society for Clinical Oncology," the study enrolled about 300 men
with low-risk prostate cancer. Biopsies taken 1-1/2 years later showed that
prostate cancer got worse in "38 percent" of men taking Avodart (dutasteride)
and "49 percent of those" on placebo. Final biopsies at three years,
however, "showed no signs of cancer in 36 percent of men on Avodart versus
23 percent of those on dummy pills." The researchers concluded that Avodart,
which is manufactured by GlaxoSmithKline, can "slow the growth of these
tumors in men who opt to be monitored instead of having treatment right
away."
FDA
Panel Rejects Bid To Include Prostate Cancer Prevention In Dutasteride's
Indications. MedPage
Today (2/15, Bankhead) reports that the FDA in January "rejected a
bid to expand dutasteride's indications to include prostate cancer
prevention." The decision followed a "December meeting of an FDA
advisory committee, whose members voted overwhelmingly against the indication
for both dutasteride" and Proscar (finasteride). The advisory committee
"cited evidence of an increased risk of high-grade cancer among" men
treated with 5-alpha reductase inhibitors as the "key factor in their
thumbs-down votes."
Women Exposed
To Second-Hand Smoke May Be More Likely To Have Abnormal Pap Tests.
Reuters
(2/11, Norton) reported that studies have shown that women who smoke have a
higher-than-average cervical cancer risk. Now, a new study
of 4,400 women, in the American Journal of Obstetrics & Gynecology, reveals
that women who are exposed to second-hand smoke have damaged cervical cells.
Although the study did not confirm that the women had an increased cervical
cancer risk, it did show that one out every 14 women, who reported second-hand
smoke exposure, had an abnormal Pap test result. Overall, the researchers found
that 70 percent more women who reported second-hand smoke exposure were likely
have abnormal Pap results, even after the women's own smoking habits and sexual
history were considered.
Obesity May
Influence Molecular Pathogenesis Of Colon Cancer.
MedPage
Today (12/28, Fiore) reports, "Obese patients are less likely to
have a genetic mutation that is associated with better outcomes in colorectal
cancer," according to a study
published in the Journal of Clinical Oncology. Researchers found, "in a
retrospective study," that "obese patients were significantly less
likely to have a tumor with deficient DNA mismatch repair (dMMR) status -- a
phenotype predictive of improved outcomes -- than normal-weight patients
(P<0.001)." According to the investigators, "Obesity may
influence the molecular pathogenesis of colon cancer and reduce the favorable
prognostic dMMR subtype."
Some Scientists Attribute Childhood Leukemia, Brain Cancer Increases To
Environmental Chemicals.
WebMD
(1/27, Mann) reports that the rise in childhood leukemia and brain cancer
rates "may be partially" blamed on exposure to environmental
chemicals such as "chlorinated solvents and the head lice treatment
lindane," according to experts speaking at a conference call sponsored by
Safer Chemicals, Healthy Families. The group is seeking to "overhaul the
1976 Toxic Substances Control Act (TSCA)." Sean Palfrey, MD, of Boston
University, "says that chemical exposures can be passed down, much like
genes. ... 'They may not harm the first organ, but they may harm the blood
cells related to leukemia and brain cells related to brain cancer,'" Dr.
Palfrey said. However, "not everyone in the scientific community
agrees" with the chemical-exposure connection. Some suggest that
"improvements in diagnosing childhood cancers may also have a role."
Meta-Analysis
Shows Having Both Breast Cancer, Diabetes Doubles Mortality Risk.
HealthDay
(1/20, Goodwin) reported, "Having both breast cancer and diabetes greatly
increases the chances of dying," according to a study in the Journal of
Clinical Oncology. Researchers conducted a meta-analysis of seven studies and
determined that six of them "found pre-existing diabetes was associated
with significantly higher long-term, all-cause mortality." Specifically,
the studies showed "breast cancer patients with diabetes were nearly
50-percent more likely to die than those who didn't have diabetes."
Research
Suggests Cigarettes May Cause Genetic Damage Within Minutes.
AFP
(1/18) reports, "Those first few puffs on a cigarette can within minutes
cause genetic damage linked to cancer," according to a study in the journal
Chemical Research in Toxicology. The researchers "said the 'effect is so
fast that it's equivalent to injecting the substance directly into the
bloodstream,' in findings described as a 'stark warning' to those who
smoke."
According to HealthDay
(1/18, Mozes), the investigators "focused on a class of cancer-causing
culprits found in cigarette smoke called polycyclic aromatic hydrocarbons, or
PAHs." They labeled and tracked the PAH phenanthrene "through the
bodies of 12 volunteer smokers" and found that the PAH "began to cause
havoc on the DNA of the smokers within just 15 to 30 minutes after
smoking," suggesting that a smoking habit "causes immediate genetic
damage and quickly raises the short-term risk for cancer." BBC
News (1/15) also covers the study.
FDA Says
Breast Implants May Be Linked To Rare Form Of Lymphomatous Cancer.
ABC World News (1/26, story 7, 2:10, Sawyer)
reported, "An important health warning tonight from the FDA about a
possible link between breast implants and a rare form of cancer." ABC
(Stark) added, "The government says they may be linked to a rare form of
lymphoma. ... There are 60 cases worldwide, in as many 10-million women with
implants."
The Washington
Post (1/27, Stein) reports that the FDA on Wednesday announced
it had "detected a possible association between saline and silicone
gel-filled breast implants and anaplastic large cell lymphoma (ALCL)" The
agency said most women with implants "do not have to have them removed or
take any other steps," but they should "immediately seek medical
care" if they develop "unusual problems," such as "swelling
or pain around the implant."
According to
the AP
(1/27), the FDA based its warning on a review of "scientific literature
going back to 1997 along with information provided by international governments
and manufacturers." Most of the cases were "reported after patients
sought medical care" for problems "around the surgical site."
The Wall
Street Journal (1/27, Dooren, Mundy, subscription required) reports the
FDA has identified 60 ALCL cases in women who had breast implants, of which 34
cases have thus far been verified, according to a statement released by the
agency. HealthDay
(1/26, Reinberg) noted that 24 of the cases were "related to silicone
implants, seven to saline implants and the type of implant in the remaining
three cases are not known," according to the FDA. The agency also said that
"19 of the implants were inserted for cosmetic reasons and 11 were used in
reconstructive procedures. The reasons for the other four procedures are not
known."
The New
York Times (1/27, A18, Grady) reports that in some cases, simply
"removing the implant and scar tissue gets rid of the disease, but some
women might need chemotherapy and radiation," said Center for Devices and
Radiological Health Deputy Director Dr. William Maisel. He noted that although
60 cases is "a tiny number compared" with the number of women who have
implants, it is an excess when "compared with the usual incidence."
ALCL in the breast is "normally found in only three in 100-million women
who do not have implants."
Study Suggests
30 Percent Of Breast Cancers Could Be Prevented By Lifestyle Modifications.
The Boston
Globe (1/19, Kotz) "Daily Dose" blog reports that a study in
the journal Cancer Epidemiology "compared 6,386 healthy women with 3,074
breast cancer patients." The researchers then "calculated the
percentage of cancer cases attributed" to particular risk factors and found
that about "37 percent of all postmenopausal breast cancers are caused by
factors women can't change, such as their family history, their age, or the age
of their first and last menstrual period." However, the researchers also
determined that nearly "30 percent of breast cancers could be prevented by
modifying certain lifestyle habits." The biggest lifestyle habits were
"use of hormone replacement therapy and a lack of physical activity,"
while excess "body weight and alcohol consumption" played minor roles.
Behavioral
Therapy May Help Reduce Incontinence Episodes After Prostate Cancer Surgery.
The Wall
Street Journal (1/11, Hobson, subscription required) "Health Blog"
reported that some 65% of men experience incontinence after undergoing surgery
for prostate cancer. Some patients opt for more surgery to correct the issue.
Now, however, a paper appearing in the Journal of the American Medical
Association suggests that a therapy, often prescribed for women, may help
relieve the problem.
The
"behavioral intervention consisted of four visits scheduled two weeks
apart," WebMD
(1/11, Mann) reported. "Men received education on their pelvic floor
anatomy and learned how to do the pelvic-floor-muscle exercises." They
"were also advised to hold their urine stream during voiding once a day for
two weeks, keep a bladder diary, avoid caffeine, and to distribute their fluid
throughout the day."
The University
of Alabama study participants, 208 men, were "randomly assigned to one of
three groups," HealthDay
(1/11, Gordon) reported. "After eight weeks, the researchers found that the
average number of incontinence episodes dropped from 28 to 13 a week, a 55
percent decline, for the men in the behavioral therapy group, and from 26 to 12
episodes a week, down 51 percent, for men who'd had biofeedback and electrical
stimulation as well as behavioral therapy. The control group had a 24 percent
reduction, on average, in incontinence episodes."
Researchers
May Have Pinpointed Association Between Bedroom Light Intensity, Breast Cancer
Risk.
Medscape
(1/11, Chustecka) reported "that light at night, specifically in the
bedroom, increases the risk for breast cancer," researchers in Israeli
concluded after evaluating 1,679 women. The study detailed in Chronobiology
International, the authors asserted, is the "first...to have identified an
unequivocal positive association between bedroom light intensity and breast
cancer risk." However, two "experts in the field took issue with the
word 'unequivocal.'" Richard Stevens, PhD, of the University of
Connecticut, said "there is a serious potential for recall bias, he
emphasized," while Johnni Hansen, PhD, from the Danish Cancer Society's
Institute of Cancer Epidemiology, "noted that there was a large difference
is the response rates -- only 52% of controls, compared with 86% of cases,
agreed to answer the questions on light in the bedroom."
Vitamin and mineral supplements increase the risk of skin cancer (SU.VI.MAX
study)
A study in France compared supplementation with Vitamin A, C & E with
selenium and zinc against placebo. After 7.5 years the incidence of skin cancers
including melanoma were higher in the supplementation group although only in
women. Fortunately a study published in the EJC (2010, 46, 3316-3322) showed
that stopping the supplements reduced the risk in the normal levels within 5
years. This study did not measure baseline levels of this vitamins an mineral
and confirms the importance of measuring levels before taking supplement with
the aim of correcting specific deficiencies avoiding excess levels which are
clearly carcinogenic.
Vitamin Use
Linked To Reduced Risk For Mortality, Recurrence In Some Cancer Patients.
Medscape
(12/30, Nelson) reported, "The evidence continues to be unclear as to
whether dietary supplements are helpful or harmful during cancer
treatment." Yet, researchers at Vanderbilt University were unable to find
"evidence that the use of vitamins during first six months after a
diagnosis of breast cancer adversely affected outcomes. In fact,"
according to their paper in Cancer Epidemiology, Biomarkers & Prevention,
"vitamin use -- and the use of vitamins C and E in particular -- appeared
to be associated with reduced risk for mortality and recurrence."
Specifically, those "who used antioxidants (vitamin E, vitamin C,
multivitamins) had an 18% reduction in their mortality risk, and the risk for
recurrence was decreased by 22%," an association that "was observed
whether vitamin use was concurrent or nonconcurrent with chemotherapy."
Long-Term Soy
Isoflavone Use May Not Increase Risk For Breast Cancer In Menopausal Women.
According
to a study
published online Dec. 22 in the American Journal of Clinical Nutrition,
long-term use of soy isoflavones does not appear to increase the risk for breast
cancer in menopausal women. In a study of 403 women who were randomized to
placebo or to 80- or 120-milligram tablets of soy hypocotyls isoflavone
supplementation over the course of two years, researchers detected no
differences in screening tests, blood tests, and blood pressure measurements
taken during well-woman examinations.
Replacing
Carbs With Proteins From Plants May Be Better Than Doing So With Meat Proteins.
USA
Today (9/7, Hellmich) reports, "If you're trying to cut carbs, it
may be better for your health to eat more protein and fat from plant sources
than animal sources," according to research published in the Annals of
Internal Medicine. Investigators "followed 85,168 women and 44,548 men for
several decades." The researchers found that "participants who
replaced carbs with protein and fat from animal sources were more likely to die
from all causes, including cancer and heart disease." The Los
Angeles Times (9/6, Stein) "Booster Shots" blog, the CNN
(9/6) "The Chart" blog, and HealthDay
(9/6, Gardner) also covered the story
Obesity May
Increase Risk Of Colon Cancer-Induced Mortality Among Postmenopausal Women.
The Los
Angeles Times (9/9, Khan) "Booster Shots" blog reported,
"Obesity doesn't just increase postmenopausal women's risk of developing
colon cancer, it might even raise their risk of dying from it," according
to a paper published in Cancer Epidemiology, Biomarkers and Prevention.
"That doesn't mean going on a crash diet and emaciating yourself." The
"term 'healthy body weight' is the key here," considering that
"being underweight is also dangerous: Underweight women diagnosed with
colon cancer were 89% more likely to die of any cause than women with a normal
BMI."
Before
reaching those conclusions, the team looked at data on 1,096 women and
eventually discovered that "obese women -- those with a body-mass index
(BMI) of 30 or higher -- had a 45 percent increase in all causes of death
compared to women with a healthy weight," HealthDay
(9/9, Doheny) reported. Investigators also discovered that an "unhealthy
waist-to-hip ratio and large waist...were associated with a higher risk of dying
from colon cancer." Specifically, "women with waists of 37.5 inches or
higher had a higher death risk than those with a healthier waist size."
Consuming
Even Moderate Amounts Of Alcohol May Raise Breast Cancer Recurrence Risk In
Certain Women.
HealthDay
(8/30, Mozes) reported, "Drinking even moderate amounts of alcohol may
raise the risk for breast cancer recurrence in some women," according to
a paper in the Journal of Clinical Oncology. The "association seems
confined to former breast cancer patients who are postmenopausal or overweight
or obese." In fact, Kaiser Permanente researchers found that
"participants who were postmenopausal or overweight/obese raised their
risk for breast cancer recurrence by nearly 1.5 times if they regularly
consumed a minimum of three to four drinks of any type of alcohol a
week."
Oklahoma
Researchers Studying Effects Of Turmeric On Prostate Cancer.
The Oklahoman
(7/27) reports "Oklahoma Medical Research Foundation scientist Biji Kurien
is studying the effects of curcumin, a chemical in the spice turmeric, on
prostate cancer." Turmeric is a "widely used spice in Asia, where the
rate of prostate cancer is much lower" than in the US. So far,
"published studies have shown that curcumin can induce death in some cancer
cells, which absorb more of the chemical than normal cells," he said
Dietary
Nitrites, Nitrates May Be Linked To Bladder Cancer Risk.
MedPage
Today (8/2, Fiore) reported, "High intake of nitrite and nitrate
added to processed meats to aid preservation may be tied to bladder
cancer," NIH researchers found. "In a prospective cohort study that
followed more than 300,000 men and women for seven years, dietary nitrite and
nitrate, and nitrite alone, were associated with an increased risk of bladder
cancer among individuals with the highest consumption of processed meat -- but
it was of borderline statistical significance," according to the paper in
Cancer. "However, consumption of processed meat itself was not associated
with an increased risk of bladder cancer."
Apparently,
during the cooking process, chemicals that are naturally present in meat can
combine with nitrates and nitrites to form N-nitroso compounds, which have been
known to cause cancer, Reuters
(8/3, Peeples) reports. Upon exiting the system, the compounds may come in
contact with the bladder's lining -- hence the potential cancer risk.
Long Ring
Finger Linked To Prostate Cancer Risk.
The UK's Telegraph
(7/21, Jamieson) reports that "hospital patients...whose ring finger on the
right hand was significantly longer than the index finger were more likely
to" develop prostate cancer "than those fingers were roughly same
length," South Korean researchers found after looking at 366 men.
"Blood tests showed that men whose ring fingers were much longer than their
index finger, next to the thumb, had almost double the normal levels of prostate
specific antigen." And, "three times as many of these men went on to
be diagnosed with prostate cancer."
Guidelines
Urge Cancer Survivors To Exercise More Often.
The AP
(6/29, Neergaard) reports that the medical community has "long advised that
being overweight and sedentary increases the risk for various cancers."
Now, new "guidelines issued this month" from a panel commissioned by
the American College of Sports Medicine "advise cancer survivors to aim for
the same amount of exercise as recommended for the average person: about 2 1/2
hours a week." Indeed, "patients still in treatment may not feel up to
that much, the guidelines acknowledge, but should avoid inactivity on their good
days." Notably, "innovative new studies are under way to start
answering" questions regarding exercise type and intensity.
IOM Panel
Investigating Possible Link Between Breast Cancer, Environmental Risk Factors.
NBC Nightly News (7/7, story 7, 2:20, Williams)
reported, "It's long been a fear -- more than that, a belief held by many
people that things in our environment, our daily life that we come in contact
with cause certain kinds of cancer." Specifically, "for breast
cancer," there are concerns about "pesticides and chemicals like BPA
in plastic bottles and can liners that can disrupt hormone function in animal
studies." Yesterday, however, "a panel of experts...in San Francisco
heard so far there is no proof of a connection, but it is critical to
look." Therefore, the "panel from the Institute of Medicine...is
holding studies to determine what further research is needed."
Fish Oil May
Help Lower Risk Of Certain Types Of Breast Cancer.
CNN
/Health.com (7/8, Gardner) reported, "Millions of Americans already take
fish oil to keep their hearts healthy and to treat ailments ranging from
arthritis to depression." Now, a paper appearing in Cancer Epidemiology,
Biomarkers & Prevention indicates that the "supplements may also help
women lower their risk of breast cancer." In fact, "postmenopausal
women between the ages of 50 and 76 who took fish oil were...less likely to
develop certain types of breast cancer than women who didn't," researchers
at the Fred Hutchinson Cancer Research Center found.
Delving into
specifics, the UK's Press
Association (7/8) reports that the "Vitamins and Lifestyle (Vital)
study recruited 35,000 post-menopausal women who had no history of breast
cancer." Each participant was "asked to fill out a 24-page
questionnaire about their use of dietary supplements and monitored for six
years." Eventually, "880 of the women went on to develop breast
cancer."
Yet,
"researchers found a 32-percent reduction in breast cancer risk among women
taking fish oil," Canwest
News Service (7/7, Kirkey) reported. "The results held for ductal
breast cancer, the most common type of the disease, but not for lobular
cancers." Lead investigator Emily White said, "To find that it reduced
a specific type of breast cancer adds a little support to the association."
Still,
according to the UK's Independent
(7/8, Laurance), the findings are "likely to further boost the booming
market for the supplements, worth about $2bn (£1.31bn) globally in 2007,
doubling since 2003." The UK's Daily
Mail (7/8, Borland) also covers the study.
Consuming
Fruit, Vegetables Regularly May Lower Lung Cancer Risk.
The UK's Daily
Mail (7/6) reports, "Eating fruit and vegetables regularly may
lower the risk of lung cancer," according to "research based on 700
people." Meanwhile, "another study...found eating 1½ pieces of fruit
or a large tablespoonful of vegetables every day can protect against emphysema
and chronic bronchitis." In fact, those "who ate the most celery had a
60 percent lower risk than those who ate the least," while those who ate
carrots experienced a 50 percent reduction.
Tea Tree Oil
May Help Treat Some Skin Cancers.
The UK's Daily
Mail (7/5) reported, "Tea tree oil may provide a fast, cheap and
effective treatments for some skin cancers, according to researchers." A
team of researchers from the University of Western Australia found that the
common remedy was able "to shrink non-melanoma skin cancers in mice in just
one day and wiped them out within three days." Study leader Dr. Sara Greay
said, "We are very excited about these results and are hoping to find
funding for a small clinical trial of about 50 people with pre-cancerous
lesions, with the aim of preventing the development of skin cancers."
Women Who
Drink Tea May Be Less Likely To Develop Ovarian Cancer.
The UK's Telegraph
(5/25) reported that "women who drink a single cup every day are ten per
cent less likely to develop" ovarian cancer "than those who never
drink tea," according to a study published in the journal Cancer Causes and
Control. Investigators found that "a single daily cup of black tea appeared
to lower the risk by around ten per cent, two to three cups by 13 per cent and
four or more by 12 per cent." The researchers also found that "those
drinking green tea saw their risks decline by 20 per cent for one cup a day,
eight per cent for two to three cups, and 18 per cent for four cups or
more."
Healthy,
Largely Plant-Based Diet May Reduce Risk For Colorectal Cancer.
WebMD
(6/16, Doheny) reported that, according to a study published in the Journal of
Nutrition, "eating a diet rich in fruits and vegetables, low-fat dairy
foods, and fish may reduce your risk of colorectal cancer." After comparing
the diets of "431 men and women with colorectal cancer and the diets of
726" matched controls without colon cancer, researchers found that
"eating a largely plant-based diet with higher intakes of fruits,
vegetables, whole grains, nuts, seeds, vegetable oils, and low-fat dairy in
women and fish in men" appeared to reduce the risk of colorectal cancer by
62% in men and by 65% in women.
Smoking May
Increase Risk Of Leukemia, Hodgkin's Lymphoma In Women.
Bloomberg
News (8/10, Kitamura) reports, "Female smokers have a higher risk
of developing leukemia and Hodgkin's lymphoma, according to a study published in
the British Journal of Cancer." Investigators found that "the risks of
Hodgkin's lymphoma and some bone marrow cancers were doubled in women who smoked
about 20 cigarettes a day compared with non-smokers in research that looked at
1.3 million middle-aged women."
High blood sugar risk of cancer The UK's Telegraph
(1/3, Alleyne) reported that, according to findings published in the Public
Library of Science journal, "excess blood sugar means someone could be more
likely both to develop cancer and also to die from it." In a study of
"blood sugar levels in 274,126 men and 275,818 women from Norway, Austria,
and Sweden," researchers found that "women were more vulnerable than
men, and high blood sugar is linked to a range of different cancers for each
gender." Notably, "the increased likelihood of cancer occurred
regardless of the participants' body mass index levels."
Folic acid
plus vitamin B12 may increase risk of cancer, death in heart-disease patients.
Canada's Globe
and Mail (11/18, Weeks) reports that, according to research
published Nov. 18 in the Journal of the American Medical Association,
"heart-disease patients treated with a combination of folic acid and
vitamin B12 had an increased risk of cancer and death, compared to patients who
didn't receive the vitamins as treatment." The finding "fuels fears
that mandatory fortification of the food supply with folic acid could yield
unintended consequences."
The Los
Angeles Times (11/17, Dennis) "Booster Shots" blog reported
that the researchers "analyzed data from 6,837 people with ischemic heart
disease treated with folic acid, B6 and B12; folic acid and B12; just B6 or a
placebo," finding that "those treated with folic acid and B12 had
higher rates of cancer, cancer deaths, and deaths in general over the course of
several years."
In fact, 10
percent "of patients getting folic acid and vitamin B12 developed cancer,
compared with 8.4 percent who didn't receive this treatment," Bloomberg
News (11/18, Cortez) reports. Meanwhile, "four percent died from
cancer and 16 percent died from any cause among those getting folic acid and
vitamin B12" compared to "2.9 percent of people who died from cancer
and 13.8 percent who died from any cause among those who didn't get the
combination."
Notably,
"the most common cancers associated with folic acid were colorectal, lung,
prostate, and blood cancer," HealthDay
(11/17, Reinberg) reported. But, "other researchers cautioned that the
results should not turn women away from normal folic acid supplements that can
help prevent birth defects," MedPage
Today (11/17, Walsh) reported. WebMD
(11/17, Boyles) also covered the story.
Heart
Disease Could Potentially Be A Prostate Cancer Risk Factor.
HealthDay
(2/10, Preidt) reports, "Heart disease may be a risk factor for prostate
cancer," according to a study published online in Cancer Epidemiology,
Biomarkers & Prevention. Investigators looked at data on nearly 6,400 men
participating in a clinical trial to see if a medication would cut the risk of
prostate cancer. The investigators "found that men with coronary artery
disease had a 35 percent greater risk of developing prostate cancer over time
and a 24 percent greater risk of being diagnosed with prostate cancer within
the first two years of the study compared to men who did not have heart
disease." Meanwhile, "four years into the clinical trial, men with
coronary artery disease had a 74 percent higher risk of prostate cancer than
those with no heart disease."
Soy foods may
be safe, beneficial for breast cancer survivors.
USA
Today (12/9, Szabo) reports that, according to a study
published Dec. 9 in the Journal of the American Medical Association, "soy
foods may be safe, and possibly even beneficial, for breast cancer
survivors." Until now, "many breast cancer doctors have been cautious
about recommending soy products -- such as soy milk, tofu, edamame, or miso soup
-- because they contain plant estrogens. Most breast cancers are fueled by
estrogen, which can make it risky to take additional hormones, such as for
menopausal symptoms."
The Los
Angeles Times (12/9, Roan) reports that researchers at Vanderbilt
University "analyzed data from the Shanghai Breast Cancer Survival Study of
5,042" Chinese women "ages 20 to 75." The investigators found
that "patients with the highest intake had a 29% lower risk of death during
the study period and a 32% lower risk of breast cancer recurrence compared to
patients with the lowest intake of soy foods," which "was measured by
either soy protein or soy isoflavone intake."
Bloomberg
News (12/9, Ostrow) reports, "The study, which followed women for
an average of about four years, is the largest to examine the influence of soy
intake on breast cancer survival and recurrence, the authors said. More than
192,000 women in the US will be diagnosed with breast cancer this year,
according to the National Cancer Institute."
HealthDay
(12/8, Gordon) reported, "What's more, the association between soy and a
reduced risk of death held true even for women with estrogen receptor-positive
cancers and women taking tamoxifen," the investigators found. In fact, the
research team "found that soy actually reduces the availability of
naturally occurring estrogen by binding to its receptors," having "a
very similar effect to tamoxifen."
MedPage
Today (12/8, Phend) noted that "the study was done in China, where
soy intake tends to be higher than in the US and eaten in less processed
forms." But, "while American women typically eat less than one-tenth
as much soy as their counterparts in China, the results should be reassuring
regardless of consumption, according to an accompanying editorial."
The editorialists also "cautioned that any potential benefits cannot be
extrapolated to dietary supplements containing soy," but said that
"patients with breast cancer can be assured that enjoying a soy latte or
indulging in pad thai with tofu causes no harm and, when consumed in plentiful
amounts, may reduce risk of disease recurrence."
The UK's Telegraph
(12/9, Smith), the UK's Press
Association (12/8), Medscape
(12/8, Barclay), WebMD
(12/8, Doheny),
and Time
(12/8, Park) also covered the study.
Exposure to
aristolochic acid may increase risk for urinary tract cancer.
MedPage
Today (12/21, Woznicki) reported that "exposure to aristolochic
acid, found in some Chinese herbal products such as Mu Tong and Fangchi,
significantly increased the risk for urinary tract cancer, according to a" study
published in the Journal of the National Cancer Institute. Investigators
"found prescription of more than 60 grams of Mu Tong and consumption of
more than 150 mg aristolochic acid were independently associated with an
increased risk for urinary tract cancer." MedPage pointed out, "Once
used in Chinese herbal preparations taken for weight loss or urinary tract
infections, aristolochic acid has been banned in several countries, including in
Taiwan and in the US."
Compound found
in hops might help prevent prostate cancer.
The Time
(12/8, O'Callaghan) "Wellness" blog reported, "Prostate cancer
researchers are enthusiastic about new findings that suggest a natural compound
found in hops plants might help to prevent the disease." Previous research
revealed that xanthohumol "can effectively bind to estrogen receptors,
blocking estrogen and potentially helping to prevent breast cancer." The
new work suggests that it "may work similarly with testosterone,
potentially interrupting the development of prostate cancer."
Coffee
consumption, exercise may lower prostate cancer risk.
Bloomberg
News (12/8, Bennett) reported that Harvard scientists have discovered
that "drinking coffee may lower the risk of developing the deadliest form
of prostate cancer." In fact, "the five percent of" study
participants "who drank six or more cups a day had a 60 percent lower risk
of developing the advanced form of the disease than those who didn't consume
any." The work, Bloomberg notes, "is the first to associate coffee
with prostate cancer, contradicting previous research that's found no
link."
The team is
quick to point out, however, that "it's too early to start recommending
that men start drinking coffee to help prevent prostate cancer, but the results
are encouraging," WebMD
(12/7, Warner) reported. BBC
News (12/8) and the UK's Telegraph
(12/8, Smith) also cover the study.
Research
explores role exercise could play in fight against prostate cancer. A
presentation made "at the Frontiers in Cancer Prevention Research
conference" touched on the "role that exercise...could play in the
fight against prostate cancer," the Time
(12/7, O'Callaghan) "Wellness" blog reported. "An analysis of
activity levels among 2,686 prostate cancer patients showed that men who jogged,
played tennis, or participated in other comparable exercise for an average of
three or more hours per week had 35% lower mortality rates than those who
exercised less frequently or not at all." As for walking, those who did so
"for four or more hours per week" had "overall mortality rates
[that] were 23% lower than those of men who walked for fewer than 20 minutes per
week."
Research
indicates many breast cancer patients may have low levels of vitamin D.
HealthDay
(10/9, Preidt) reported, "Many breast cancer patients have low levels of
vitamin D, which could lead to weaker bones and increased risk of
fractures," according to research presented Oct. 8 at the American Society
of Clinical Oncology's breast cancer symposium. Researchers examined "166
women undergoing treatment for breast cancer," finding that "nearly 70
percent had low levels of vitamin D in their blood." On average, there were
"27 nanograms of vitamin D per milliliter of blood," while
"levels of 32 nanograms per milliliter are adequate, according to the US
Institute of Medicine." Notably, researchers found "the lowest levels
of vitamin D...in non-whites and those with late-stage breast cancer." But,
"weekly supplementation with high doses of vitamin D (50,000 IU or more)
boosted the levels of the vitamin among all women."
Many cases of
cancer may be preventable with healthier lifestyle.
The UK's Daily
Mail (11/16, Hope) reports, "Almost 80,000 patients diagnosed with
cancer each year could have avoided the disease by adopting a healthier
lifestyle," according to data from the World Cancer Research Fund. In fact,
"39 percent of cases of the 12 major cancers are preventable through better
diet, drinking, and exercise habits." For the UK in particular,
"record levels of drinking" have "risen more sharply...than in
any other developed country," which means "the UK has one of the
highest levels of preventable cancers." Research has shown that "bowel
cancer can be cut by eating less red and processed meat, while drinking less
alcohol would reduce the chances of breast cancer." Meanwhile, "eating
more fresh fruit and [vegetables] and keeping a healthy weight reduces cancers
of the stomach and pancreas."
Chronic pain
may be common after breast cancer surgery.
USA
Today (11/11, Szabo) reports, "Nearly half of breast cancer
survivors suffer from persistent pain, even two to three years after
surgery," according to research
published in the Journal of the American Medical Association. The findings
highlight "the need to improve care, both by finding ways to reduce nerve
damage during surgery and by learning why some women have so much pain and
others do not," researchers noted.
The New
York Times (11/10, Rabin) reports in Vital Signs that the study of
"3,253 women who were breast cancer patients" showed that "the
patients most likely to" report chronic pain "were those under 40,
those who had undergone radiation treatment, and those who had surgery to remove
all of the lymph nodes in the armpit rather than...a sentinel node biopsy."
Of those who
reported "severe pain, 77 percent said they had it daily," while 36
percent of patients experienced "light" pain every day, HealthDay
(11/10, Doheny) reported. Patients reported "pain...in the breast area, the
armpit, the arm and the side of the body."
WebMD
(11/10, Boyles) reported that the researchers concluded "that the cause of
most chronic pain following breast cancer treatment is injury to key nerves
during surgery." As a result, they called for "more delicate surgical
techniques to avoid nerve damage." MedPage
Today (11/10, Phend) also covered the story.
Herbal
Supplements May Intensify, Weaken Chemotherapy Effects.
The Toronto
Sun /QMI Agency (8/18) reports, "Patients undergoing chemotherapy
may think they're helping their treatment by taking herbal supplements"
such as "acai berry, herbal teas, cumin, turmeric and...garlic," but
they "can intensify or weaken the effect of chemotherapy drugs, and in some
cases may cause a toxic or even lethal reaction." Some supplements can also
interfere with the metabolism of chemotherapy drugs, while garlic taken over a
long time may increase bleeding risk during surgery. The results were presented
at an American Society of Clinical Oncology meeting. Lead investigator Dr. June
M. McKoy recommended that patients always tell their doctors what supplements
they are taking.
ACS calls for
more effective, efficient screening of carcinogens.
MedPage
Today (10/28, Walsh) reported, "Although many carcinogens have been
removed from working and living environments, many potential hazards remain,
including building materials, additives, or contaminants in food and water, and
pollutants, indoors and out, the American Cancer Society reported" in the
Nov./Dec. issue of CA: A Cancer Journal for Clinicians. The report stated that
"concerns remain because of the vast and increasing number of potentially
risky substances and the involuntary nature of many exposures."
ACS
"calls for new strategies to more effectively and efficiently screen the
chemicals to which the public is exposed," WebMD
(10/28, Wilbert) reported. The authors outlined several goals, including
"new strategies for toxicity testing, for occupational and community
exposures to meet regulatory standards, [and] funding for research to identify
and reduce carcinogenic hazards." The Time
(10/28, Guthrie) "Wellness" blog also covered the story.
Study
indicates heavy cell phone use may increase risk of brain tumors.
The UK's Telegraph
(10/24, Beckford, Winnett) reported that "the World Health Organization
(WHO) will publish evidence that heavy users" of cell phones "face a
higher risk of developing brain tumors later in life." The
"decade-long investigation" was "conducted...in 13
countries" where researchers interviewed "tumor sufferers and people
in good health to see whether their mobile phone use differed." The review
of "12,800 people" showed that "six of eight...studies found some
rise in the risk of glioma (the most common brain tumour), with one finding a 39
percent increase." Meanwhile, "two of seven studies into acoustic
neurinoma (a benign tumor of a nerve between the ear and brain) reported a
higher risk after using mobiles for 10 years." But, the "inquiry has
faced criticism for including people who made just one call a week, and leaving
out children, which some experts said could underplay the risks."
Obesity linked
to 124,050 new cancer cases in Europe last year, researchers say.
Bloomberg
News (9/24, Cortez, Kresge) reported, "Obesity may have caused
124,050 new cases of cancer last year in Europe," according to research
presented at the European Cancer Organization and European Society for Medical
Oncology. That estimate, "based on information from sources including the
World Health Organization and the International Agency for Research on
Cancer," was "77 percent higher...than in 2002, when 70,000 of the 2.2
million cancers diagnosed across Europe could be linked to extra weight."
For the study,
researchers "designed a model to estimate the number of cancers that could
be blamed on being fat in 30 European countries," finding that "being
overweight or obese accounts for up to eight percent of cancers in Europe,"
the AP
(9/25) reports. But, experts said that the "figure is poised to increase
substantially as the obesity epidemic continues, and as major causes of cancer,
such as smoking and hormone replacement therapy for menopausal women, drop
dramatically."
Researchers
found that the "65 percent of all cancers linked to being fat"
included "colorectal cancer, breast cancer in menopausal women, and
endometrial cancer," the UK's Telegraph
(9/24) reported. While researchers remain uncertain "why being fat
boosts...cancer risk," they "suspect it is connected to
hormones," as those who "become fatter...produce more hormones like
oestrogen that helps tumors grow."
The UK's Daily
Mail (9/25) reports that "almost one in ten new cases of the
disease among women in Europe are currently attributed to being overweight or
obese -- almost three times more than men," the study showed. Specifically,
8.6 percent "of new cancers could be attributed to being overweight or
obese" in women, compared to "3.2 percent...in men," the UK's Press
Association (9/24) noted.
Prostate
cancer survivor says he was "ambushed" by depression.
In the New
York Times (9/29) "Well" blog, Dana Jennings discussed how he
has been "ambushed" by depression, despite the fact that he is
"recovering well from an aggressive case of prostate cancer." Jennings
noted that "as many as 25 percent of cancer patients develop depression,
according to the American Cancer Society," compared to "about seven
percent of the general population." Currently, Jennings is "seeing a
psychiatrist who specializes in cancer patients," and has begun "a
course of medication." Even though his physician has assured him that
"depression isn't unusual among those who are on the far side of [cancer]
treatment," Jennings said he is still "grieving for the person"
he was before cancer.
Many People
Continue Unhealthy Habits After Disease Diagnosis.
The Pittsburgh
Tribune-Review (6/27, Gormly) reported, "Even when faced with a
health scare like a heart attack or stroke, or a life-changing diagnosis like
diabetes or cancer, many people continue unhealthy habits with eating,
smoking, exercising and the like." One "study of more than 9,000
cancer survivors, Canadian researchers found that few people had made
significant lifestyle changes." Approximately "80 percent of people
in the study, published in 2008 in the Journal of Clinical Oncology, had quit
smoking, but fewer than 20 percent were consuming five servings of fruits and
vegetables a day, and exercising regularly."
Vitamin D,
Calcium Supplements May Lower Melanoma Risk For Some Women.
Reuters
(6/27, Pittman) reported that taking a vitamin D and calcium supplement may help
some women reduce their risk for developing melanoma, according to a study
in the Journal of Clinical Oncology. Researchers analyzed medical data from
roughly 36,000 women between the age 50 and 79, were randomized to either take
both calcium (1,000 mg) and vitamin D3 (400 IUs) supplements or placebo, daily
for seven years. The study team found that women who previously had non-melanoma
skin cancer were less likely to get melanoma, if they were in the calcium and
vitamin D group.
HealthDay
(6/27, Reinberg) reported that the women taking the supplements who had had
previous non-melanoma skin cancer reduced their risk of developing melanoma
"by 57 percent," compared with women taking the placebo supplements.
Overall, "176 cases of melanoma developed." Lead researcher Dr. Jean
Tang from Stanford University School of Medicine "speculated that cancer
cells lurking in the skin of women who have had a previous skin cancer may be
waiting to develop into melanoma. 'But if they take calcium and vitamin D that
reduces the risk of developing an actual tumor,' she said." Although the US
Institute of Medicine "recommends 600 IU of vitamin D" daily, the
findings indicated that as little as 400 IU "may be protective," Dr.
Tang added.
Excess
weight's influence on prostate cancer risk may vary by ethnicity, research
suggests.
HealthDay
(9/1, Reinberg) reported, "Men who pack on excess pounds as young adults
are at heightened risk of developing prostate cancer, although the risk varies
by ethnic group," according to a University of Hawaii study appearing
online in Cancer Epidemiology, Biomarkers & Prevention. Investigators
reviewed "data on almost 84,000 men" of varying ethnicity. "In
all, more than 5,500 men were diagnosed with prostate cancer." However, it
was important to note the specific timeframe in which the men gained weight. For
instance, "higher weight in older adulthood was associated with increased
risk of prostate cancer among white and Native Hawaiian men," but "a
decreased risk of prostate cancer among Japanese men." And, "excessive
weight gain in young adulthood increased the risk of advanced and high-grade
prostate cancers...for white men," while it "upped risks for less
hazardous, localized, and low-grade forms of the disease" in black men.
Study suggests
married cancer patients may live longer than single ones.
The New
York Times (9/1, D6, Rabin) reports in Vital Signs, "Married cancer
patients live longer than single ones, presumably because they have a built-in
support system, are more likely to stick to their treatment regimens, and may
even be in better health to begin with," according to a study published in
the journal Cancer. Data indicated that 65 percent "of married patients
survived at least five years after a cancer diagnosis, compared with 57 percent
of those who had never been married, 52 percent of the divorced patients and 47
percent of widowed patients."
Researchers
say healthier lifestyles may help prevent breast cancer among women in the UK.
The UK's Daily
Mail (9/1, Hope) reports, "Thousands of women could avoid breast
cancer if they adopted healthier lifestyles," according to experts at the
World Cancer Research Fund. For the report, which "updates the fund's
cancer prevention report in 2007," researchers examined "many
different types of the disease," finding that "over 40 percent of
breast cancer cases in the UK could be prevented just by making...relatively
straightforward changes." In fact, researchers said that "at least
18,000" breast cancers "could be prevented" each year in the UK
if women "drank less, kept healthy weight, and were more active."
Research also showed that "breastfeeding babies is...an important factor in
cutting the risk of the disease." The UK's Telegraph
(9/1, Devlin) also covers the story.
Wine associated with decreased
risk of Barret's esophagus: Reuters Health;
HealthDay News; WebMD
These articles report on a
Gastroenterology study finding that wine may
reduce the risk of developing Barrett's
esophagus, a precursor to esophageal cancer.
The articles note that study participants
who drank one or more glasses of red or
white wine a day were 56 percent less likely
to develop Barrett's esophagus, compared
with those who did not drink wine. They
report beer or liquor did not lower the risk
of developing Barrett's esophagus.
Representative Article: Reuters
Health
Research
suggests cancer survivors may be more likely to suffer psychological distress.
HealthDay
(7/30, Thomas) reported, "Cancer survivors are more likely than their
healthy peers to suffer serious psychological distress, such as anxiety and
depression, even a decade after treatment ends," according to a study
published in the July 27 issue of the Archives of Internal Medicine. Researchers
"analyzed mental health and medical data on 4,636 adults who'd survived
cancer and 122,220 who had never had cancer," finding that "about 5.6
percent of cancer survivors...have experienced severe psychological distress
within the previous month, compared with three percent of those without
cancer." Among those "at the highest risk of psychological
problems" were patients "who were relatively young at the time of
diagnosis, unmarried, had less than a high-school education, were uninsured, had
other illnesses, or had difficulty doing the activities of daily living."
Data indicated that "nine percent of long-term cancer survivors and six
percent of individuals without cancer reported seeing or talking to a
mental-health professional within the previous year."
Scientists say
ovarian tumor growth could be slowed using "suicide genes."
HealthDay
(7/30, Preidt) reported, "Treatment with 'suicide' genes slowed ovarian
tumor growth in mice and may one day offer a way to treat late-stage ovarian
cancer in women." According to the paper, published online in Cancer
Research, investigators "found that nanoparticle delivery of diphtheria
toxin-encoding DNA selectively expressed in ovarian cancer cells significantly
slowed the growth of ovarian tumors." Dr. Edward Sausville, the journal's
associate editor, says the "new treatment, which could be tested on humans
within 18 to 24 months, could prove to be a significant advance in targeted
therapy for cancer."
Study
indicates ALL in children may be linked to exposure to household pesticides.
MedPage
Today (7/30, Bankhead) reported, "Children with acute lymphoblastic
leukemia (ALL) had a significantly greater likelihood of exposure to household
pesticides compared with a control group," according to a study
published in the August issue of Therapeutic Drug Monitoring. The study included
"41 children with ALL and their mothers," who were "matched for
age and area of residence with 41 children without ALL." Researchers
"assessed environmental exposures by means of questionnaires and by
analysis of pesticide metabolites in urine samples." They targeted
"six organophosphate metabolites commonly found in household and garden
insecticides," which "consisted of three dimethyl phosphates and three
diethyl phosphates." The study showed that "33 percent of case mothers
reported use of insecticides in the home, compared with 14 percent of control
mothers." Notably, "children with ALL had significantly higher levels
of diethyldithiophosphate (P<0.05) and diethylthiophosphate."
Lifestyle after cancer - New
self help book launched.
This practical guide book summarises the
lifestyle evidence from across the world,
and is based only on proven facts. It
explains how lifestyle after a cancer
diagnosis can optimise the chances of living
longer and living better, both during
treatments and afterwards. The author Robert
Thomas
is
Director of the Primrose Research Unit,
visiting Professor at Cranfield University
and Oncologist at Addenbrooke’s Hospital
Cambridge University NHS trust. He
specialises in communication and lifestyle
research and was awarded the UK “Hospital
Doctor of the Year” and “Oncologist of
the Year”.
More information and how to order
New Data Show
Nearly 12 Million US Adults Are Cancer Survivors.
The CBS Evening News (3/10, story 8, 0:20, Couric)
reported that the Centers for Disease Control and Prevention (CDC) "said
today about one in 20 Americans over the age of 20 is a cancer survivor."
According to
the New
York Times (3/11, A14, Belluck), the study
in the CDC's most recent Morbidity and Mortality Weekly Report indicates that
the "number of cancer survivors increased by about 20 percent in just six
years, to 11.7 million in 2007, the latest year for which figures were analyzed,
from 9.8 million in 2001." CDC Director Dr. Thomas R. Frieden said the
increase was due to many factors. "In some cases of breast cancer and colon
cancer, for example, improved treatment and increased follow-up after treatment
have helped increase survival." He added that in others, such as prostate
cancer, an "explosion in screening has identified many men with the
disease, but the cancer is often so slow-growing that they would be unlikely to
die from it."
The CNN
(3/11, Willingham) "The Chart" says that researchers believe the
increase is due to a "growing aging population, early detection, improved
diagnostic methods, more effective treatment, and improved clinical follow-up
after treatment." Moreover, Dr. Frieden said, "Not smoking, getting
regular physical activity, eating healthy foods, and limiting alcohol use can
reduce the risk of many cancers."
On ABC
World News (3/10, lead story, 2:50, Stephanopoulos), Dr. Frieden was shown
saying, "Life doesn't have to end with cancer. If you get a diagnosis of
cancer, there's a lot you can do to ensure that you lead a long, healthy,
productive life as much as possible."
The AP
(3/11) notes that the data showed "7 million -- 60 percent -- of the cancer
survivors were 65 or older." Women diagnosed with breast cancer "made
up the largest share of cancer survivors, at 22 percent, followed by men with
prostate cancer, at 19 percent."
Research
Suggests Metformin May Slow Tumor Growth.
The Los
Angeles Times (4/2, Kaplan) "Booster Shots" blog reports,
"Results of a preliminary study presented...at the American Assn. for
Cancer Research's annual meeting," and published in Cancer Prevention
Research, "suggest metformin slowed the growth of prostate cancer
tumors." Investigators looked at 22 prostate cancer patients, "all
of" whom "were scheduled to have their prostates removed." The
researchers found, "after the" participants' "prostates were
excised...that tumors grew more slowly in men who took the diabetes drug than in
men who didn't."
HealthDay
(4/1, Gardner) reported that, in a separate "study, researchers...reviewed
records of 302 patients who had both diabetes and pancreatic cancer, two
conditions that often go hand-in-hand," about 40% of whom were using
metformin. The investigators found that approximately "30 percent of those
who had taken the drug were alive after two years, compared with 15.4 percent of
those who had not taken metformin." The researchers also found that
"patients on metformin lived an average of just over 15 months versus about
11 months for the control group, translating into a 32 percent reduced risk of
dying."
Healthier lifestyles can
reduce cancer cases worldwide: Reuters
This article reports on a World
Cancer Research Fund and American Institute
for Cancer Research study suggesting that
healthier living can prevent one-third of
the most common cancers in developed
countries and a quarter of cancers in
developing countries. Researchers
suggest that diets based on fruits,
vegetables and whole grains, instead of red
meats, dairy and fats, as well as exercise
and weight control, can reduce the risk of
many cancers, including cancers of the
breast, prostate, kidneys
and lungs.
Reuters
Dogs May Be
Able To "Sniff Out" Lung Cancer.
The CNN
(8/18, Rice) "The Chart" blog reports that four dogs were trained on
"test tubes containing breath samples of 220 patients, both those with lung
cancer and those without it," and were able to correctly find 71 out of 100
patients who had lung cancer. The study, published in the European Respiratory
journal, also found that dogs could find cancer in COPD patients as well as
otherwise healthy patients. The theory is that "cancer cells may produce
chemical compounds that circulate throughout the body and can be breathed
out." The blog notes that previous studies have "shown promise in
sniffing out breast cancer, bowel cancer, colon cancer, COPD and lung cancer,
and even type 1 diabetes." Researchers say that while the study is
encouraging, more study is needed to identify what exactly the dogs are
smelling.
WebMD
(8/18, Goodman) reports that Suresh S. Ramalingam, MD, of Emory University's
Winship Cancer Institute, "is developing technology that aims to replicate
the ability of dogs to smell trace amount of chemicals produced by cancerous
tumors." WebMD notes that "doctors have previously reported cases in
which dogs have alerted their owners to undiagnosed skin, breast, and lung
cancers by repeatedly pawing or nosing an affected body part," and that
"in June, researchers in Japan reported that dogs could detect the presence
of colon cancer in human breath and stool samples with nearly 90% accuracy, a
success rate only slightly lower than colonoscopy."
Also covering
the story are BBC
News (8/18, Gallagher), CBC
News (8/18), and the UK's Daily
Mail (8/18, Hope).
Four In 10
People In UK Will Develop Cancer At Some Point.
BBC
News (7/14, Brimelow) reports, "Rising cancer rates mean four in 10
people in the UK get the disease at some point in their lives," Macmillan
Cancer Support, "a health charity, says." The projections "are
drawn from projections published two years ago in the British Journal of Cancer,
which concluded that at the end of 2008 there were two million cancer survivors
in the UK and that the figure was rising every year." The charity
"also looked at recent cancer incidence and mortality statistics for the
UK, indicating that 310,000 people were diagnosed with cancer in 2008."
One
alcoholic drink per day increases women's
cancer risk: The Washington Post; Los
Angeles Times; Associated Press; Reuters;
HealthDay News
These
articles report on a JNCI study finding that
nearly 13 percent of breast, liver, rectum,
upper respiratory and upper gastrointestinal
system cancers in women may be associated
with alcohol use. Researchers noted
that as little as one serving of alcohol per
day increases cancer risk, regardless of the
type of alcohol consumed. Representative
Article: The
Washington Post
Breastfeeding
May Help Reduce Breast Cancer Risk In Certain High-Risk Women.
The UK's Telegraph
(3/17) reports, "Breastfeeding for at least a year can cut the chances of
developing breast cancer by a third in women with a strong family history of
the disease," according to a study published in BioMed Central.
Investigators "found that women carrying the BRCA1 gene were 32 per cent
less likely to develop breast cancer if they breastfed for at least a year
compared with women with the gene who didn't." The study, "conducted
by the Women's Research Institute in Ontario, Canada, calculated that just
five women with the BRCA 1 gene needed to breastfeed for a year to prevent one
developing cancer."
Heart Failure
May Be Associated With Increased Risk For Fatal Cancer.
MedPage
Today (11/11, Petrochko) reports, "Heart failure patients face an
increased risk of cancer along with an increased risk of death, researchers
said" at the American Heart Association meeting. Investigators found that
"a cohort of patients diagnosed with heart failure at baseline were
significantly more likely than participants in a control population without
heart failure to develop cancer at follow-up (HR 1.57, 95% CI 1.13 to
2.50)." The researchers reported that "incident cancer was associated
with a 46% increased risk of death in heart failure patients (hazard ratio 1.46,
95% CI 1.22 to 1.99)."
Lung Cancer
Rates Among Women In UK Rising Rapidly.
BBC
News (11/12) reports that the "number of women living with lung
cancer in the UK is set to rise significantly faster than the number of men
with the disease over the next 30 years," according to new data released
by Macmillan Cancer Support. The group estimates that cases of lung cancer
"in women will rise from about 26,000 in 2010 to 95,000 in 2040,"
and roughly "80% of cases are linked to tobacco." In contrast,
tobacco-related lung cancer cases among men in the UK are expected to
"increase from 39,000 to 42,000" during the same time frame.
The Daily
Mail (UK) (11/12, Borland) adds that lung cancer is the "third
most common form of the illness" among women in the UK "after breast
and bowel" cancer; and it is "also the biggest cause of death in
Britain claiming 35,000 lives annually, more than heart disease or any other
type of cancer." The Daily Mail also points out that tobacco
manufacturers in the UK target women by "saying smoking helps you stay
slim."
Colon Cancer
Prognosis May Be Worse For Obese, Patients With Type 2 Diabetes.
HealthDay
(12/3, Gordon) reported, "People who have been diagnosed with colon cancer
have a poorer prognosis if they're obese or have type 2 diabetes,"
according to two studies published in the Journal of Clinical Oncology. The
first study of 2,303 people found that "the risk of dying from colorectal
cancer was 35 percent higher" in those who were obese vs. those of a normal
weight. The second study of 2,278 people revealed that those "with type 2
diabetes had a 53 percent higher risk of dying from any cause and a 29 percent
higher risk of dying from colorectal cancer, compared to people without type 2
diabetes."
Mobile phones do not increase risk of eye
cancer: Reuters
This article discusses a Journal of the
National Cancer Institute study finding that
regular mobile phone use does not appear to
increase the risk of uveal melanoma.
Article: Reuters
Head of cancer research institute
warns cell phone use causing cancer:
Associated Press
This article reports that the head of the
Pittsburgh Cancer Institute urged his
faculty and staff to limit cell phone use
because of the possible increased risk of
cancer. The article notes that the
warning was based on unpublished data and
that numerous studies have not found a link
between cell phone use and cancer.
Article:
Associated Press
Red wine
may protect against lung cancer: HealthDay
News
This article describes an American
Association for Cancer Research study suggesting that
each glass of red wine
consumed per month is linked to a 2
percent reduced risk of lung
cancer among men. Researchers note
that smokers who drink one to two glasses of
red wine per day reduce their risk of lung
cancer by 60 percent, compared to smokers
who do not consume red wine. Article:
HealthDay
News
Exercise cuts some health risks of
smoking: Los Angeles Times (August 4)
This article discusses the benefits of
smoking cessation for athletes and the
effects of exercise for smokers. The
article cites a Cancer Epidemiology
Biomarkers & Prevention study showing
that women who were current or former
smokers and had high levels of physical
activity were less likely to develop lung
cancer than those who were less
sedentary.
Article:
Los Angeles Times
Manufacturers to reduce amounts of suspected
carcinogen in snacks:
These articles report that after a lawsuit
in California, four snack manufacturers
agreed to reduce levels of a suspected
carcinogen called acrylamide in potato chips
and french fries over the next three
years. The articles note that
acrylamide forms naturally when starchy
foods are baked or fried, and that the FDA
is studying the effects of the compound but
has not yet taken formal action.
Representative Article:
Associated Press
Broccoli
compound may fight cancer: Newsday (October
5)
This article reports on
research finding that sulforaphane
glucosinate, a compound found in broccoli
and other cruciferous vegetables, boosts
tumor-fighting enzymes and may help prevent
breast cancer. The article notes that
despite promising research on anti-cancer
foods, doctors are cautious about sweeping
recommendations that focus on one food
group.
Article: Newsday
Effects of breast cancer
diagnosis on some marriages: Los Angeles
Times (October 5)
This article, written by the
author of a book on breast cancer, discusses
the effects of breast cancer diagnoses on
patients' marriages. The author
describes research suggesting that a breast
cancer diagnosis contributed to divorce
among some couples, but in others, it
strengthened the relationship.
Article: Los
Angeles Times
Cancer patients turn to
complementary therapies: HealthDay News
This article discusses a Cancer study
finding that as many as 61 percent of cancer
patients use alternative therapies like
prayer, relaxation and massage.
Researchers note that women are more likely
to engage in complementary therapies and
that it remains unclear how much benefit
these therapies confer to cancer
patients.
Article:
HealthDay News
Experts
Predict 165 Million Americans Will Be Obese By 2030.
ABC World News (8/25, story 7, 2:00,
Stephanopoulos) reported, "Tonight, sobering new numbers on America's
struggle with obesity." A new series
on obesity published in "the medical journal Lancet says if trends
continue, half of all American men will be obese by 2030."
Bloomberg
News (8/26, Gerlin) reports, "US health-care spending will rise by
as much as $66 billion a year by 2030 because of increased obesity if historic
trends continue," the study suggested. "Almost 100 million Americans
and 15 million Britons are already considered obese, based on body-mass index, a
ratio of weight to height, Y. Claire Wang, an epidemiologist at Columbia
University's Mailman School of Public Health in New York, said yesterday at a
London news conference." Yet "another 65 million American adults and
another 11 million British adults would join them in the next two decades based
on past trends, said Wang."
The Washington
Post (8/26, Huget) "The Checkup" blog reported that a
"four-part series by a number of international public health experts argues
that the global obesity crisis will continue to grow worse and add substantial
burdens to health-care systems and economies unless governments, international
agencies and other major institutions take action to monitor, prevent and
control the problem." The blog adds, "The series, which had support
from the federal government and foundations, is published in advance of the
first High-Level Meeting of the United Nations General Assembly focused on
non-communicable disease prevention and control, which will take place in New
York City Sept. 19 and 20."
WebMD
(8/26, Boyles) reports that should164 million Americans become obese by 2030,
"Wang says the health care burden will include an additional eight million
cases of diabetes, 6.8 million additional cases of heart disease and
stroke," and "over 0.5 million cases of cancer." But, "the
researchers calculate that just a 1% reduction in body mass index (BMI) at the
population level would prevent as many as 2.4 million cases of diabetes and 1.7
million cases of heart disease and stroke."
Researchers
See No Increased Cancer Risk Among Statin Users.
HealthDay
(7/18, Mann) reported that "a large, new study" published in the
Journal of the American College of Cardiology "appears to quell concerns
that taking statins might raise the risk of cancer." For roughly
"91,000 adults whose full medical records were available via an electronic
database, researchers report there was no significant difference in cancer risk
among those who took statins and those who didn't." The investigators found
that, "after an average of five years of follow-up among nearly 46,000
pairs of people who either used the cholesterol-lowering drugs or did not use
them, 11.37 percent of participants taking a statin developed cancer, compared
to 11.11 percent of those individuals not taking a statin."
Women Who
Drink, Smoke Less Likely To Stick With Tamoxifen Regimen.
HealthDay
(8/24) reports, "Women at high risk for breast cancer who smoke and drink
are less likely to stick with a drug regimen meant to prevent cancer,"
according to a new study
published online Aug. 23 in the journal Cancer Prevention Research.
"Researchers analyzed adherence to the drug tamoxifen by 11,000 women with
a high risk of breast cancer," and found that "heavy drinkers"
and smokers were both less likely to "stick with the drug regimen."
However, the researchers found that "physical activity levels and obesity
were not associated with adherence," which according to the researchers
could indicate that "poor adherence is not simply based on a pattern of
unhealthy behavior in general, but could be related to common sociological,
psychological, biological or genetic mechanisms that impact both substance use
and medication adherence."
Medscape
(8/24, Hitt, Subscription Publication) reports Stephanie R. Land, PhD, from the
Division of Cancer Control and Population Sciences at the National Cancer
Institute, and colleagues, said that the "lack of adherence represents a
significant barrier to the efficacy of chemopreventive therapies, " and
that "there have been calls for research to identify patients most at risk
of poor utilization."
Therapy
Program May Improve QoL In Some Advanced Cancer Patients.
Reuters
(9/15, Pittman) reports that, according to a study published online in Cancer, a
therapy program designed to improve quality of life in cancer patients may be
beneficial. The study included more than 130 patients with advanced cancers of
the colon, brain, or lung. Participants had all been diagnosed within the
previous 12 months and were undergoing radiation therapy. Patients were randomly
assigned to either receive usual medical care or to the therapy, which combines
physical and talk therapy, relaxation techniques, and discussions of spiritual
matters. Participants who were assigned to the program reported higher quality
of life than other participants.
Obesity Costs
Some States $15B Annually.
MSNBC
/MyHealthNewsDaily (8/24, Rettner) reports, "Obesity costs some states as
much as $15 billion a year," according to a study recently published in the
journal Obesity. Using "medical expenditure information from 2006,"
the study authors "estimated how much each state spends on obesity-related
medical costs each year." They found that "the estimated costs range
from $203 million in Wyoming to $15.2 billion in California. (Estimates are in
2009 dollars.)"
Active lifestyle may help prevent
cancer: Reuters
This article describes an American Journal
of Epidemiology study that found individuals
who are physically active, including those
who exercise and are active in daily
routines, are less likely to develop cancer
than sedentary people. Researchers
note that the most active groups of men and
women surveyed had a 13 percent and 16
percent lower risk of developing cancer,
respectively, compared to the least active
groups.
Women Who
Drink, Smoke Less Likely To Stick With Tamoxifen Regimen.
HealthDay
(8/24) reports, "Women at high risk for breast cancer who smoke and drink
are less likely to stick with a drug regimen meant to prevent cancer,"
according to a new study
published online Aug. 23 in the journal Cancer Prevention Research.
"Researchers analyzed adherence to the drug tamoxifen by 11,000 women
with a high risk of breast cancer," and found that "heavy
drinkers" and smokers were both less likely to "stick with the drug
regimen." However, the researchers found that "physical activity
levels and obesity were not associated with adherence," which according
to the researchers could indicate that "poor adherence is not simply
based on a pattern of unhealthy behavior in general, but could be related to
common sociological, psychological, biological or genetic mechanisms that
impact both substance use and medication adherence."
Medscape
(8/24, Hitt, Subscription Publication) reports Stephanie R. Land, PhD, from
the Division of Cancer Control and Population Sciences at the National Cancer
Institute, and colleagues, said that the "lack of adherence represents a
significant barrier to the efficacy of chemopreventive therapies, " and
that "there have been calls for research to identify patients most at
risk of poor utilization."
Fish Oil May
Block Some Chemo Effects.
AFP
(9/13) reports a study in Cancer Cell showing that "cisplatin, often used
to treat lung, bladder, ovarian and testicular cancer, was rendered impotent
by" platinum-induced fatty acids (PIFAs), "which are made by stem
cells in the blood and are also present in fish oil supplements." In mice
tumors, animals injected with "'normal amounts of fish oil,' became
insensitive to chemotherapy." Medical oncologist Emile Voest said "we
currently recommend that these products should not be used whilst people are
undergoing chemotherapy" and that "the body itself secretes protective
substances into the blood that are powerful enough to block the effect of
chemotherapy."
BBC
News (9/13, Gallagher) reports, "Using drugs to block the
production of the fatty acids prevented this form of resistance which
"significantly enhances the chemotherapy," the study says." The Daily
Telegraph (UK) (9/13, Adams) also covered this story.
Breast Cancer
Statistic Cited By Mitchell Refuted.
The New
York Times (9/16, Parker-Pope) "Well" blog reports,
"Andrea Mitchell of NBC recently announced she had been treated for breast
cancer this summer." Mitchell said that she is "now among the 1 in 8
women in this country -- incredibly 1 in 8 -- who have had breast cancer."
But, Gary Schwitzer, publisher of HealthNewsReview.org, points out that
"Mitchell misused" the statistic. The National Cancer Institute says
that "there are 2,632,005 women alive in the United States who have ever
been given a breast cancer diagnosis," which "translates to about 2.2
percent, or 1 in 45 adult women, who are undergoing active treatment or have in
the past had a diagnosis of breast cancer."
Cancer
Survivors May Have Increased Risk Of Heart Damage.
ABC World News (9/21, story 6, 2:00, Sawyer)
reported, "Beating back cancer cells with toxic chemicals and beams of
radiation takes a toll on the healthy cells, as well. When radiation is targeted
at the breast or lung, especially on the left side of the body, the heart can be
accidentally damaged." Chemotherapy can also weaken the heart. These
concerns have "given rise" to the field of cardiooncology, focusing on
"at-risk cancer survivors." ABC's Besser said that doctors
"recommend a stress test or heart ultrasound to check for damage." On
a more positive note, there is now "more precise equipment that allows
radiologists to do a better job at avoiding the heart and the drugs are
monitored more closely to reduce their damaging effects on the heart
itself."
Lung Cancer
Patients May Be At Elevated Stroke Risk.
Reuters
(9/22, Thrasybule) reports that a study
of more than 150,000 adults published Sept. 13 in the journal Stroke found that
26 out of every 1000 lung cancer patients had a stroke every year, but for those
without cancer, the incidence was 17 out of 1000. The risk was highest in the
first three months after diagnosis for men, and between months four and six for
women. Moreover, hemorrhagic stroke was more common than ischemic stroke in lung
patients, even though it is less common overall. Researchers suggested that
tumors and chemotherapy may both lead to bleeding and blood clots that cause
strokes. However, factors such as smoking, alcohol, or diet were not accounted
for in the study.
Study: Male
Partners Of Breast Cancer Patients Not Fans Of Spousal Support Groups.
HealthDay
(8/10, Dotinga) reports that "male partners of women with breast cancer
aren't big fans of spousal support groups and instead choose to de-stress by
exercising or hanging out with friends," according to a study published in
Oncology Nursing Forum. Researchers "also found that men had difficulty
going to medical appointments with their partners due to work schedules."
Investigators came to these conclusions after looking at surveys from "men
in Edmonton and Saskatoon" who "answered questions about how they
dealt with their partners' breast cancer."
Cancer
Patients May Not Be Getting Needed Rehab.
USA
Today (10/24, Szabo) reports on the end of cancer treatment, which can
be difficult for patients. "Two-thirds of cancer survivors have trouble
sleeping, even two years after treatment, found a study presented last year at a
meeting of the American Society of Clinical Oncology. Up to 30% of breast cancer
survivors suffer from persistent fatigue," and many "suffer from
'chemo brain,' a common term for post-cancer memory problems." In addition,
"a 2008 study in the Journal of Clinical Oncology found that 90% of women
with metastatic breast cancer could benefit from rehab, but only 30% got
it." Some groups, such as the American College of Surgeons, are now
requiring "accredited hospitals to provide follow-up care plans and make
rehab available."
Number Of
New Cancer Cases In The UK Could Rise By 45% By 2030.
BBC
News (10/28, Brimelow) reports, "The number of new cancer cases
in the UK could rise by 45% by 2030 to more than 430,000 a year, research
suggests." The increase "is explained almost entirely by the
expected increase in the number of people living in the UK and the ageing
population." BBC News adds that "Cancer Research UK, which funded
the study published in the British Journal of Cancer, says the NHS must act
now to avoid being 'overwhelmed.'"
Rehabilitation
After Cancer Presents Challenges For Patients, Doctors.
On the front of its Personal Journal section, the Wall
Street Journal (10/11, D1, Beck, Subscription Publication) reports on
the issues facing survivors of breast cancer. Side effects of treatment include
heart damage, nerve damage, fatigue, secondary cancers due to treatment, sleep
problems, sexual problems, or osteoporosis. One highlighted issue is various
estrogen-blocking drugs, which can keep certain breast cancers at bay but bring
side effects of menopause, blood clots, uterine cancer, or osteoporosis.
Notably, a study in the Journal of Clinical Oncology found that only about 50%
of patients keep taking such drugs for five years, even though the drugs can
increase survival.
The Washington
Post /Kaiser Health News (10/11, Graham) reports on the
"'prospective surveillance model' of cancer rehabilitation," which
"involves evaluating patients soon after diagnosis and then at regular
intervals -- typically every three months, for up to a year -- once treatment is
complete. If emerging problems are identified, they can be addressed
promptly." Notably, "researchers estimated that treatment for
breast-cancer-related lymphedema cost $636.19 a year when the prospective
surveillance model was used vs. $3,125 for traditional treatment. ... In
February, officials from" groups, including the American Society of
Clinical Oncology, "met to review evidence supporting the prospective
surveillance model and to consider promoting its widespread adoption.
Proceedings from that meeting will be published early next year."
In a related
piece, Kaiser
Health News (10/11, Graham) discusses a number of examples of
rehabilitation from cancer treatment. "'We need to raise awareness of the
functional problems that cancer patients experience, and our obligation to
address them,' said Julia Rowland, director of the Office of Cancer Survivorship
at the National Cancer Institute, noting that there are now 12 million cancer
survivors in the United States." Kaiser adds that "what constitutes
cancer rehabilitation and what best practices consist of are not yet clear.
There are no generally accepted standards for programs and no clinical
guidelines that medical professionals are expected to follow," and as a
result, institutions vary widely in the services offered
Many Baby
Boomers Do Not Have Living Will, Healthcare Proxy.
The AP
(11/17) reports, "An Associated Press-LifeGoesStrong.com poll found that 64
percent of boomers - those born between 1946 and 1964 - say they don't have a
health care proxy or living will." The "documents would guide medical
decisions should a patient be unable to communicate with doctors."
Vitamin D,
Calcium Pills May Not Reduce Risk Of Dying From Cancer Or Heart Disease.
Reuters
(12/9, Grens) reports that, according to a study published in the Journal of
Clinical Endocrinology and Metabolism, vitamin D or calcium pills may not reduce
the risk of dying from cancer or heart disease in older patients who already
face an increased risk of bone fractures.
(Reuters Health) - Among seniors with a high risk of bone fractures, taking
vitamin D or calcium pills has no impact on their chances of dying from cancer
or vascular disease, researchers say in a new study.
Vitamin D is considered beneficial for bone health, and earlier studies have
found that having low vitamin D levels in the blood is tied to a greater chance
of dying from heart problems (see Reuters Health reports of November 25, 2011
and June 24, 2011).
The thinking, therefore, has been that taking extra vitamin D might cut that
risk.
"There's a lot of interest in vitamin D preventing heart disease and
cancer, but the evidence from randomized trials is weak," said Dr. Alison
Avenell, the lead author of the study and a researcher at the University of
Aberdeen in England.
In the latest study, published in the Journal of Clinical Endocrinology and
Metabolism, the researchers tracked the health of nearly 5,300 people over age
70 who had had a bone fracture.
The participants were randomly divided into four groups: one took 800 IU
(International Units) of vitamin D daily, the second group took 1000 milligrams
of calcium each day, a third group took both supplements, and a fourth group
took fake pills that looked like the supplements.
People in the study took the pills for two to five years, and were followed
for up to three years afterward.
Among people who took vitamin D, 32 out of every 100 died during the study,
while 33 out of every 100 people who did not get the supplement died. That small
difference could easily have been due to chance, the researchers found.
There were no differences in deaths from cancer or heart disease either.
Calcium also proved unhelpful.
A recent analysis of 50 studies on vitamin D and heart health found no impact
from taking the vitamin (see Reuters Health report of July 11, 2011).
Still, Avenell said her study doesn't provide the final answer on whether
vitamin D can help stop heart disease or cancer.
"People often stopped taking their tablets, so we might not have had
enough people taking tablets to find effects," Avenell wrote in an email to
Reuters Health. "The dose of vitamin D might not have been high
enough."
Peggy Cawthon, a researcher with the California Pacific Medical Center
Research Institute who was not involved in the new work, said people should be
cautious regarding information on vitamin D's alleged heart and cancer benefits.
"A supplement or vitamin might not have the magic bullet to prevent the
next disease," Cawthon told Reuters Health. "We've had a lot of
examples, and vitamin D is just the latest showing it has no effect on these
health issues."
Vitamin D is formed in the skin when it is exposed to sunlight. Though higher
levels of the molecule are linked to better heart health, it could be that the
vitamin D is only a sign of general health, and not something that actually
improves the heart's function.
"My thought is that people who are healthier get out more and would
produce more vitamin D," speculated Cawthon.
Avenell said she is looking forward to two other studies in the Unites States
and the UK that will help confirm whether vitamin D has benefits beyond boosting
bone strength.
SOURCE: bit.ly/s4fs1g Journal of Clinical
Endocrinology and Metabolism, online November 23, 2011.
More
Research Challenges Benefits Of Axillary Dissection.
Medscape
(12/9, Mulcahy, Subscription Publication) reports, "More evidence
suggests that there is no price to pay for forgoing axillary dissection (AD)
in patients with breast cancer who have minimal lymph node involvement."
A study presented at the 34th Annual San Antonio Breast Cancer Symposium (SABCS)
found that "the 5-year rate of disease-free survival was 87.3% for AD and
88.4% for no AD (P = .48), with a median follow-up of 57 months," while
"the 5-year overall survival rate was 97.6% for AD and 98% for no AD (P =
.35)." Medscape adds that "at the American Society of Clinical
Oncology meeting in 2010, the lead investigator of the Z0011 trial,"
whose findings were similar to this study, "admitted that leaving behind
some cancer in the axilla was 'counterintuitive.'"
Experts Say
Cancer Survivors Need More Customized Help.
Bloomberg
News (12/17, Tozzi) reported, "The medical world is recognizing
that the 12 million cancer survivors in the US can benefit from more
comprehensive rehab. Six years ago the Institute of Medicine called for giving
every survivor a 'care plan' to manage the lasting consequences of treatment,
and this year the American College of Surgeons made such post-treatment
attention to quality of life a requirement for its 1,500 accredited
hospitals." However, experts say that "many survivors need more
customized help, including physical, occupational and speech therapy, to regain
their abilities and transition back into work and family life."
Hypertension
May Be Linked To Certain Brain Cancers.
The UK's Press
Association (12/21) reports a study in the Journal of Hypertension
suggesting a link between high blood pressure and certain brain tumors.
Researchers "analysed data for almost 580,000 people from Sweden, Austria
and Norway, who were followed for around 10 years" and found that "20%
of participants with the highest blood pressure readings were more than twice as
likely to later be diagnosed with meningioma or malignant glioma compared with
the 20% with the lowest readings." Limitations of the study included the
lack of "data on whether the participants were using any medication, such
as treatment for high blood pressure, which could have affected the
results." The study authors also emphasized that "the absolute risks
are low: roughly two in 1,000 over 10 years for people with very low blood
pressure, compared with three in 1,000 for those with high blood pressure."
Statins May
Lower Risk For Liver Cancer Among Individuals With Hepatitis B.
HealthDay
(1/27, Mann) reports, "Popular cholesterol-lowering statins may also
lower risk for liver cancer among people with hepatitis B," according to
a study published online in the Journal of Clinical Oncology. Researchers
"in the new study of more than 33,000 individuals with hepatitis B"
found that individuals "who took a statin were less likely to develop
liver cancer, when compared to participants who were not prescribed statins."
The investigators also found that "the longer a person took statins, the
greater the liver-cancer risk reduction."
Combining
Fasting, Chemotherapy May Slow Growth Of Tumors In Mice.
HealthDay
(2/9, Dallas) reports, "Fasting, especially when combined with
chemotherapy, appears to slow the growth of cancerous tumors in mice,"
according to a study published in Science Translational Medicine. In research on
mice, "researchers found that fasting slowed the growth of growth of breast
cancer, melanoma, glioma and human neuroblastoma in mice." The researchers
"noted that results from the initial phase of a clinical trial, which
involved patients with breast, urinary tract and ovarian cancer conducted at the
USC Norris Comprehensive Cancer Center, have been submitted for presentation at
the annual meeting of the American Society of Cancer Oncologists."
AFP
(2/9) reports that the researchers "published findings in 2008 that showed
how fasting protected normal cells against chemotherapy in a study that focused
on one type of cancer and a single chemo drug," and this "study
expands on that research." The UK's Press
Association (2/9) also covers the story.
Global Cancer
Cases Projected To Rise 75 Percent By 2030.
The AP
(6/1) reports, "Global cancer cases are projected to rise 75 percent by
2030, in part because many other diseases are being stamped out and more
developing countries are adopting Western lifestyles linked to cancer,
international cancer experts reported." Although "population growth
and aging explain much of the increase, at least one-fifth of the new cancer
cases will likely be due to preventable factors, the researchers predict."
Bloomberg
News (6/1, Kitamura) reports, "The projection is based on the
United Nations' population forecast, the" International Agency for Research
on Cancer's "database tracking cancer incidence in 184 countries and
expected increases in the rates of colorectal, female breast, prostate and, in
high-income countries, lung cancer in women."
The CNN
(6/1, Falco) "The Chart" blog reports, "The study found that any
reductions in infection-related cancers like stomach, cervical or liver cancer
(still more common in low-income regions of the world), are being offset by 'an
increasing number of new cases that are more associated with reproductive,
dietary and hormonal factors.'" Additionally, "tobacco
usage...contributes to an increasing number of cancer cases."
Reuters
(6/1, Kelland) reports that the projections are published in the journal Lancet
Oncology. Also covering the story are the UK's Press
Association (6/1), Medscape
(6/1, Brooks) and HealthDay
(6/1, Preidt).
Cancer
Survivors May Take More Sick Leave Than Cancer-Free Colleagues.
HealthDay
(6/22, Preidt) reports, "While many long-term cancer survivors return to
work, they take more sick leave than their cancer-free colleagues,"
according to a study published online in the Journal of Cancer Survivorship.
Investigators "analyzed data from more than 2,000 employed cancer
survivors in Norway and more than 3,200 healthy people, and found that 75
percent of cancer survivors took sick leave during the first year after their
diagnosis." Over "the next four years, 23 percent of men and 31
percent of women recovering from cancer took sick leave, compared with 18
percent of healthy men and 27 percent of healthy women."
Data Indicate
Nearly 1.3 Million Individuals In EU Will Die From Cancer This Year.
Reuters
(2/29, Kelland) reports that, according to research published in the Annals of
Oncology, nearly 1.3 million individuals in the EU will die from cancer in 2012.
However, Medscape
(2/29, Nelson) reports that "even though the actual numbers have increased,
the rate continues to decline." Altogether, the "2012 cancer mortality
rates are estimated to be 139 per 100,000 men and 85 per 100,000 women."
That "is a decrease of 10% in men and 7% in women over 2007 - the most
recent World Health Organization (WHO) mortality data for most EU
countries."
The UK's Telegraph
(2/29, Adams) reports, "Better treatment, rather than screening, appears to
be the principal driving force behind the rapid declines," researchers
"concluded, after finding the death rate had dropped faster in the under
50s."
Fasting May
Benefit Cancer Patients Undergoing Chemo.
The Boston
Globe (3/10, Weintraub) reported, "Since three square meals a day
and regular snacks were not always available to our hunter-gatherer ancestors,
the human body may have evolved to perform at its best with short-term feeding
gaps. So sporadic food deprivation might have a positive effect on metabolism,
giving a boost to such things as cancer treatment, Alzheimer's prevention, and
wound healing."
In a related story, the Boston
Globe (3/12, Weintraub) reports, "Research in mice and early
studies of people suggest that cancer patients may benefit from eating no food
for at least two days before chemo and a full day afterward, said Valter Longo,
of the University of Southern California." Longo has performed "case
studies of 10 people, is currently testing the safety of fasting in 18 cancer
patients, and will shortly begin testing its effectiveness in 42 more
Number Of
Cancer Survivors In US Expected To Surge By 2022.
The number
of cancer survivors living in the US is expected to surge by one-third by 2022.
In the UK this means that over 3 million and the USA over 18 million people will
be expected to survive the disease. This estimate comes form a new report from a
collaboration between The American Cancer Society and the National Cancer
Institute called Cancer Treatment and Survivorship Facts and Figures.
They found that even though cancer incidence rates are decreasing in many cases, the number of survivors is growing due to the aging and growth of
the population, as well as improved rates in cancer survival. The report argues that this increase makes it even more
imperative that healthcare providers are aware of the health needs of this
population.
Current Cancer stats
Currently one
in three women and one in two men in Western countries will develop cancer during their
lifetime.
The most common types of cancers among
male survivors in 2012 are prostate cancer (43 percent), colorectal cancer (9
percent) and melanoma (7 percent).
The most common types
of cancers among female survivors are breast cancer (41 percent), uterine (8
percent) and colorectal (8 percent)."
In the USA, there are 58,510 survivors of childhood cancer
and an additional 12,060 children will be diagnosed in 2012,
Report: Number
Of Cancer Survivors In US Will Increase To 18 Million By 2022.
The Los
Angeles Times (3/27, Kaplan, 692K) "Booster Shots" blog reports,
"Better cancer treatments and an aging population will push the number of
cancer survivors in the U.S. to nearly 18 million by 2022, according to a new report
from researchers at the National Cancer Institute." The findings were
"published Wednesday in the journal Cancer Epidemiology, Biomarkers &
Prevention, which is published by the American Assn. for Cancer Research."
On its
website, NBC
News (3/27, Fox) reports, however, that "the growing population of
cancer survivors will put pressure on a healthcare system in which cancer drug
shortages are increasingly common and the demand for oncology services is poised
to outpace the supply of oncologists," according to the researchers.
The Time
(3/27, Sifferlin, 3.38M) "Healthland" blog reports, "While the
survival trend is encouraging, it may come at a price. Cancer survivors
generally have twice the annual medical costs that patients without cancer do,
because of they need routine monitoring for recurring tumors, as well as for
side effects from their treatment or long term effects of their disease."
Medscape
(3/28, Mulcahy) reports, "By 2020, the growth of the cancer survivor
population will lead to an estimated 27% increase in the overall cost of cancer
care from 2010 levels, the investigators note." Medscape adds, "'By
2020, we expect that two thirds of cancer survivors are going to be age 65 or
older,' said senior investigator Julia Rowland, PhD, director of the Office of
Cancer Survivorship at the National Cancer Institute, in a press
statement."
HealthDay
(3/28) reports, "The report, based on an analysis of national data, also
found that patients with certain types of cancers account for a large proportion
of the survivors." For instance, "breast cancer patients account for
22 percent of survivors, while prostate cancer survivors account for 20
percent." However, patients "with lung cancer, the second most
commonly diagnosed cancer, account for only 3 percent of survivors, according to
the report." According to Rowland, "For patients with prostate cancer,
we have a nearly 100 percent five-year survival rate, and breast cancer has made
tremendous strides as well, with five-year survival rising from 75 percent in
1975 to almost 89 percent in 2012," although "we clearly need to have
better diagnostic tools and better treatments for lung cancer."
Obesity May
Impact A Woman's Response To Breast Cancer Treatment.
HealthDay
(7/17, Preidt) reports, "Being obese may affect a woman's response to
breast cancer treatment," according to a study published in the Journal
of Clinical Oncology. In the study, which involved 54 patients, investigators
found that "women with a BMI of 30 to 35 had about three times higher
levels of estrogen in their blood than those with a BMI of less than 25."
Following "treatment with hormone-suppressing drugs, estrogen levels in
the obese women dropped significantly, but still remained at more than double
the levels seen in women of normal weight."
New Study
Finds That Few Oncologists Discuss Exercise With Patients.
HealthDay
(9/3) reports that "even though research has shown that exercise offers
significant benefits in cancer care and recovery, many patients are reluctant
to exercise and few discuss it with their oncologists, according to a new
study." In a news release, Dr. Andrea Cheville, the study's lead author
said, "As doctors, we often tell patients that exercise is important, but
to this point, nobody had studied what patients know about exercise, how they
feel about it and what tends to get in the way." According to the
article, "cancer patients took exercise advice most seriously when it
came directly from an oncologist, but none of the patients in the study said
their oncologist had discussed exercise with them."
UK Men May
Soon Face A One-In-Two Chance Of Developing Cancer In Their Lifetime.
BBC
News (12/19, Roberts) reports on its website, "Men look set to
have a one in two chance of developing cancer in their lifetime, UK experts
predict." This "increase...up from the current 44 in 100 chance,
is largely down to people living longer - age is the biggest cancer risk
factor, says Cancer Research UK." According to BBC News, "The
cancers set to increase the most in men within the next 15 years are bowel,
prostate and skin (melanoma)."
SKIN Products
FDA Issues
Warning On OTC Topical Pain Relievers.
Reuters
(9/14) reports that the Food and Drug Administration issued a Consumer
Warning Thursday cautioning that use of over-the-counter topical pain
relievers products, which contain menthol, methyl salicylate, or capsaicin as
active ingredients, may cause mild to severe skin burns.
According to the AP
(9/14), FDA regulators "say they have received reports of skin injuries
ranging from first- to third-degree chemical burns" caused by the OTC
products; and in some cases, the "burns have required
hospitalization." The agency "says consumers should stop using the
pain relievers if they experience signs of skin injury, such as pain, swelling
or blistering of the skin."
Bloomberg
News (9/14, Edney) adds the FDA said the "majority of second- and
third-degree burns occurred with the use of products containing menthol as the
single active ingredient or having both menthol and methyl salicylate."
The agency said only a few of the "cases involved a capsaicin-containing
product."
CNN
(9/14) in its "The Chart" blog notes that the FDA said it has
"received more than 40 reports of skin injuries" from OTC
"creams, lotions, ointments and patches. Reported brands included Bengay,
Icy Hot, Capzasin, Flexall and Metholatum." The agency said that in
"many cases severe burning or blistering occurred within 24 hours of a
single application" and in some cases, "complications required
hospitalization." But according to Dr. Jane Filie of the FDA's Division
of Nonprescription Regulation Development, "There's no way to predict who
will have this kind of reaction to a topical pain reliever for muscles and
joints."
ABC
News (9/14, Kreimer) in its "Medical Unit" blog reports that
from 1969 to 2011, FDA scientists uncovered 43 skin burn cases "during
safety surveillance" and the agency "noted that they represent only
a small fraction of total consumer usage of these products." But FDA
spokesperson Stephanie Yao said she couldn't "speculate as to whether
this will result in changes to the label." She explained that because OTC
labels are "continually updated, products conforming to a monograph may
be marketed without further FDA clearance."
MedPage
Today (9/14, Petrochko) also covers the FDA's Consumer Warning.
Life Spans For
Least Educated Whites May Be Shrinking.
In a front-page article, the New
York Times (9/21, A1, Tavernise, Subscription Publication) reports that research
suggests that life spans may be shrinking for the "least-educated
whites" in the US. While "the reasons for the decline remain
unclear...researchers offered possible explanations, including a spike in
prescription drug overdoses among young whites, higher rates of smoking among
less educated white women, rising obesity, and a steady increase in the number
of the least educated Americans who lack health insurance." The largest
"declines were for white women without a high school diploma, who lost five
years of life between 1990 and 2008, said S. Jay Olshansky, a public health
professor at the University of Illinois at Chicago and the lead investigator on
the study, published last month in Health Affairs."
Decline In UK
Cancer Death Rates Predicted.
The Minneapolis
Star Tribune (9/26, Stoxen) "Health Check" blog reports that
"the rates of death from cancer are predicted to fall by 16.8% in the
United Kingdom by 2030, according to new statistics released by Cancer Research
UK." The data "show that breast cancer in women, bowel and prostate
cancer will have large reductions – falling by 28% for female breast cancer,
23% for bowel cancer and 16% for prostate cancer."
BBC
News (9/24, Gallagher) reports that approximately "170 UK deaths
per 100,000 of population were from cancer in 2010, and this figure is predicted
to fall to 142 out of every 100,000." The largest decline "is
projected to be in ovarian cancer, with death rates dropping by 43%."
Study: Nearly
170 Million Years Of Healthy Life Lost In 2008 Because Of Cancer.
MedPage
Today (10/16, Smith) reports, "Worldwide, nearly 170 million years
of healthy life were lost in 2008 because of cancer, researchers reported"
in the Lancet. Investigators, "using population-based data - most of it
from cancer registries...calculated rates of years of life lost and years lived
with disability as a result of cancer." The researchers "combined
those figures to derive disability-adjusted life-years (DALYs) lost for 184
countries in 12 world regions. The countries were grouped into four categories
based on their development."
HealthDay
(10/16) reports, "Colorectal, lung, breast and prostate cancers were the
main contributors to total DALYs in most areas, accounting for 18 percent to 50
percent of total cancer burden." Additionally, "infection-related
cancers such as liver, stomach and cervical cancers accounted for a larger part
of overall DALYs in eastern Asia (27 percent of all cancers) and in sub-Saharan
Africa (25 percent of all cancers) than in other regions." Meanwhile,
"the study revealed that improved access to high-quality treatment has not
improved survival for a number of common cancers associated with poor outcomes,
especially lung, stomach, liver and pancreatic cancers."
Medscape
(10/16, Chustecka) reports, "The largest cancer burden of all was for men
in Eastern Europe; this was driven by colorectal, lung, pancreatic, and kidney
cancers."
Study: Cancer
Costs $7.5 Billion Annually In Lost Productivity In US.
HealthDay
(12/18) reports, "The cost of lost productivity among U.S. workers with
cancer is equal to 20 percent of the nation's health care spending, according to
a new study" published in the Journal of Occupational and Environmental
Medicine. Investigators "analyzed national data from 2004 to 2008 and found
that more than 3.3 million American workers are diagnosed with cancer each
year," which "results in more than 33 million disability days per
year, translating to $7.5 billion in lost productivity."
Low
Adiponectin Levels May Be Linked To Higher Risk Of Pancreatic Cancer.
MedPage
Today (12/16, Smith) reported, "Low levels of the obesity-related
hormone adiponectin are associated with an increased risk of pancreatic
cancer," according to a study
published online in the Journal of the National Cancer Institute. Investigators
found, "in a case-control study," that "pancreatic cancer
patients had significantly lower levels of the hormone than controls in blood
samples drawn at least a year before their diagnosis." This
"association was independent of smoking, diabetes, body mass index, and
other known or suspected risk factors for pancreatic cancer."
Statin Use May
Be Linked To Slower Growth Of Inflammatory Breast Cancer.
MedPage
Today (12/11, Bankhead) reports, "Inflammatory breast cancer grew
significantly more slowly in women who had a history of treatment with statin
drugs, findings from a large retrospective review showed." Researchers
found that, "overall, statin use was associated with significant
improvement in progression-free survival (PFS)." The investigators reported
that "analysis by type of statin showed that outcomes with hydrophilic
agents drove the results." The findings were presented at the San Antonio
Breast Cancer Symposium.
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